Abstract: Bispecific monoclonal antibodies and methods for treating cancer are set forth herein.

Abstract: A method for adjusting and controlling a boundary of graphene, comprising: providing an insulating substrate and placing the insulating substrate in a growth chamber; and feeding first reaction gas into the growth chamber, the first reaction gas at least comprising carbon source gas, and controlling a flow rate of the first reaction gas to forming a graphene structure having a first boundary shape on a surface of the insulating substrate through controlling a flow rate of the first reaction gas. The present invention realizes the controllability of the boundary of the graphene by adjusting the ratio of the carbon source gas to catalytic gas in the growth process of graphene on the surface of the substrate; the present invention can enable graphene to sequentially continuously grow by changing growth conditions on the basis of already formed graphene, so as to change the original boundary shape of the graphene.

Abstract: Bispecific monoclonal antibodies and methods for treating cancer are set forth herein.

Abstract: The present disclosure provides methods for treating a human patient diagnosed with a cancer, comprising administering a therapeutically effective amount of a PRMT5 (protein arginine methyltransferase 5) inhibitor, certain methods comprising (i) administering to the patient initial doses of at least about 0.1 mg per day of the PRMT5 inhibitor that is (1S,2R,3S,5R)-3-(2-(2-amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol or a pharmaceutically acceptable addition salt or solvate thereof for an initial dosing period of about 5 to about 21 days; and (ii) administering to the patient subsequent doses of at least about 0.1 mg per day of the PRMT5 inhibitor for one or more subsequent dosing periods of about 5 to about 21 days each. In these methods, a first subsequent dosing period is separated in time from the initial dosing period by at least about 5 days and the subsequent dosing periods are separated in time from each other by at least about 5 days.

Abstract: The disclosure provides a method, an apparatus, and a device for calculating a short-circuit current of a battery. The method includes: obtaining an integral state of charge and a current state of charge of the battery; calculating a first difference based on the integral state of charge and the current state of charge; calculating the short-circuit current of the battery based on the first difference; obtaining a first real state of charge and a second real state of charge; updating the first real state of charge and the second real state of charge based on a temperature-impedance table and the short-circuit current of the battery; calculating a second difference based on the updated first real state of charge and the updated second real state of charge; and updating the short-circuit current of the battery based on the second difference.

Abstract: A microwave plasma gasification and recycle integrated system for domestic garbage. The system is fixed in a garbage truck compartment with a garbage inlet, and includes a closed chain-plate type feeder, a shredding machine, and a closed magnetic separator which are connected in sequence. The magnetic separator is further separately connected to a microwave plasma gasification furnace and a metal recycle tank. The microwave plasma gasification furnace is further separately connected to a stink processor, a plastic residue recycle tank, an integrated sewage treatment device, and a residue smashing machine. The stink processor is connected to a gas recycle tank. Both the residue smashing machine and the integrated sewage treatment device are connected to an aerobic fermentation tank. The aerobic fermentation tank is connected to a decomposed material recycle tank by means of a decomposed material forming and screening machine.

Abstract: An optical system allows sharing of optical components and seed and pump light to achieve desired optical amplification in laser light while reducing the number of optical components and complexity of the overall optical system and achieving improved performance in lasers and reduced cost in fabrication and final lasers for large scale production of such lasers. Different optical gain sections can be used to allow for sharing of seed and pump light and sharing of optical components while providing multi-stage optical amplification.

Abstract: A stand-alone sensor includes a main part, a sensing head mounting on the main part, and a movable shield retractably disposed in the main part. The movable shield is rotatable around the sensing head when protruded from the main part.

Abstract: Agents that specifically bind TIGIT are disclosed. The TIGIT-binding agents may include polypeptides, antibodies, and/or bispecific agents. Also disclosed are methods of using the agents for enhancing the immune response and/or treatment of diseases such as cancer.

Abstract: Described herein are methods of treating multiple myeloma with clinically proven safe and effective amounts of an antibody that specifically recognizes CD38 with bortezomib, melphalan, and prednisone. Also described are methods of selling or offering for sale an antibody that specifically recognizes CD38 or pharmaceutical compositions thereof with bortezomib, melphalan, and prednisone.

Abstract: The present disclosure relates generally processes and systems for converting a mixture of light hydrocarbons to liquid transportation fuels by first cracking the light hydrocarbons to an intermediate comprising olefins, which is converted by contacting with a catalyst comprising at least one zeolite in two separate conversion stages with an intervening recovery of liquid product. The first stage conversion favors oligomerization of larger olefins to form diesel range products that are collected prior to directing unconverted smaller olefins to be oligomerized in a second stage conversion conducted at a higher temperature and lower pressure.

Abstract: The present invention relates to methods of treating cancers with antagonistic anti-PD-1 antibodies, formulations of the antagonistic anti-PD-1 antibodies and drug products of the anti-PD-1 antibodies.

Abstract: A stand-alone sensor includes a main part, a sensing head mounting on the main part, and a movable shield retractably disposed in the main part. The movable shield is rotatable around the sensing head when protruded from the main part.

Abstract: Embodiments of the present disclosure are directed towards techniques and configurations to provide solder contacts for electrical connection in socket assemblies. In one embodiment, a solder contact may be disposed on the bottom surface of a die package such that the solder contact is conductively coupled to electrical contacts of the die package. The solder contacts may be disposed to be coupled to pins of a socket assembly, to provide conductive coupling of the electrical contacts of the die package and the pins of the socket assembly. The solder may be selected to be sufficiently soft to provide for better electrical conduction. The pins may also be configured to penetrate the solder contact to provide for better electrical conduction. Other embodiments may be described and/or claimed.

Abstract: The present invention concerns the synthesis of dry powdered manganese complexes using spray-drying or freeze-drying methods.

Abstract: The present disclosure relates generally processes and systems for converting a mixture of light hydrocarbons to liquid transportation fuels by first cracking the light hydrocarbons to an intermediate comprising olefins, which is converted by contacting with a catalyst comprising at least one zeolite in two separate conversion stages with an intervening recovery of liquid product. The first stage conversion favors oligomerization of larger olefins to form diesel range products that are collected prior to directing unconverted smaller olefins to be oligomerized in a second stage conversion conducted at a higher temperature and lower pressure.

Abstract: A method for adjusting and controlling a boundary of graphene, comprising: providing an insulating substrate and placing the insulating substrate in a growth chamber; and feeding first reaction gas into the growth chamber, the first reaction gas at least comprising carbon source gas, and controlling a flow rate of the first reaction gas to forming a graphene structure having a first boundary shape on a surface of the insulating substrate through controlling a flow rate of the first reaction gas. The present invention realizes the controllability of the boundary of the graphene by adjusting the ratio of the carbon source gas to catalytic gas in the growth process of graphene on the surface of the substrate; the present invention can enable graphene to sequentially continuously grow by changing growth conditions on the basis of already formed graphene, so as to change the original boundary shape of the graphene.

Abstract: Agents that specifically bind TIGIT are disclosed. The TIGIT-binding agents may include polypeptides, antibodies, and/or bispecific agents. Also disclosed are methods of using the agents for enhancing the immune response and/or treatment of diseases such as cancer.

Abstract: Agents that specifically bind PD-L1 are disclosed. The PD-L1-binding agents may include polypeptides, antibodies, bispecific agents, homodimeric molecules, and/or heterodimeric molecules. Also disclosed are methods of using the agents for enhancing the immune response and/or treatment of diseases such as cancer.

Abstract: The present invention concerns the synthesis of dry powdered manganese complexes using spray-drying or freeze-drying methods.