Abstract: The present disclosure provides in vitro methods for predicting a compound's ability to inhibit multinucleate cell production resulting from post-mitotic cell fusion during a process of Daughter Number Variation (DNV) in mitosis. Compounds identified by this method can be used in cancer treatment, either alone or in combination with other known cancer drugs. The present invention also provides methods of personalized cancer treatment for a patient having a malignant tumor.

Abstract: A method for identifying one or more genomic variations in human genomic DNA, comprising employment of Alu, MIR and SVA sequence-based PCR primers and performing an inter-transposable-element (ITE) polymerase chain reaction on the assay mixture to produce an array of amplicons comprising the ITE genomic segments. Also provided the use of the method for identifying one or more genomic variants associated with a trait or a disease.

Abstract: The present disclosure provides in vitro methods for predicting a compound's ability to inhibit multinucleate cell production resulting from post-mitotic cell fusion during a process of Daughter Number Variation (DNV) in mitosis. Compounds identified by this method can be used in cancer treatment, either alone or in combination with other known cancer drugs. The present invention also provides methods of personalized cancer treatment for a patient having a malignant tumor.

Abstract: Methods are disclosed for manufacturing a coated contact lens that comprises a polymeric lens body comprising an acid group, a first coating polymer comprising a first amine group ionically bound to the acid group, and a second coating bound to the first coating polymer through covalent linkage between a nitrogen atom of a second amine group on the first coating polymer and an amine-reactive group of the second coating polymer. In some examples the lenses exhibit improved surface properties compared to uncoated lenses, such as reduced adhesion, increased wettability, increased lubricity, and/or increased lipid resistance.

Abstract: The present disclosure embodiment may disclose translation methods and systems. The translation method may include: obtaining a content to be translated in a first language; translating the content to be translated in the first language into a pre-translated content including a second language; correcting the pre-translated content including the second language; and determining a final translated content based on a correction result. The present disclosure may improve the accuracy of machine translation and the efficiency of manual revision by translating part of the content to be translated in advance and correcting and identifying part of the pre-translated content including the second language.

Abstract: A method for identifying one or more genomic variations in human genomic DNA, comprising employment of Alu, MIR and SVA sequence-based PCR primers and performing an inter-transposable-element (ITE) polymerase chain reaction on the assay mixture to produce an array of amplicons comprising the ITE genomic segments. Also provided the use of the method for identifying one or more genomic variants associated with a trait or a disease.

Abstract: A low-power transmitter for transmitting digital signals from an integrated chip is described herein. The transmitter includes a voltage-mode transmitter driver comprised of a plurality of driver slices, which includes an up-cell having a first resistor and a first transistor, and a down-cell having a second resistor, a second transistor, and a third transistor. A calibration circuit drives a replica circuit to a desired impedance by adjusting a first gate voltage applied to the first transistor of the replica of the up-cell and adjusting a second gate voltage applied to the third transistor of the replica of the down-cell. The calibrated first gate voltage is applied to the first transistor and to the second transistor of each of the plurality of driver slices and the calibrated second gate voltage is applied to the third transistor of each of the plurality of driver slices.

Abstract: Systems for calibrating impedances caused by a first component and a second component of a voltage-mode transmitter driver are described herein. The first component includes a first transistor and a first resistor connected to the first transistor, wherein the first component is connected to a voltage source and an output end of the voltage-mode transmitter driver, respectively. The second component includes a second transistor and a second resistor connected to the second transistor, wherein the second component is connected to the output end of the voltage-mode transmitter driver, and a third transistor, respectively. A first gate of the third transistor is applied with a first tunable gate voltage, and the first tunable gate voltage is configured to be tuned to calibrate a first impedance between the output end and a ground to match with a second impedance between the voltage source and the output end.

Abstract: The compound levorotatory-tetrahydropalmatine and pharmaceutical compositions thereof are provided for the treatment of ‘depressant disorders’, ‘bipolar and related disorders’, ‘manic episodes’ and ‘anxiety disorders’ as these disorders are defined in Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5).

Abstract: Systems for calibrating impedances caused by a first component and a second component of a voltage-mode transmitter driver are described herein. The first component includes a first transistor and a first resistor connected to the first transistor, wherein the first component is connected to a voltage source and an output end of the voltage-mode transmitter driver, respectively. The second component includes a second transistor and a second resistor connected to the second transistor, wherein the second component is connected to the output end of the voltage-mode transmitter driver, and a third transistor, respectively. A first gate of the third transistor is applied with a first tunable gate voltage, and the first tunable gate voltage is configured to be tuned to calibrate a first impedance between the output end and a ground to match with a second impedance between the voltage source and the output end.

Abstract: A low-power transmitter for transmitting digital signals from an integrated chip is described herein. The transmitter includes a voltage-mode transmitter driver comprised of a plurality of driver slices, which includes an up-cell having a first resistor and a first transistor, and a down-cell having a second resistor, a second transistor, and a third transistor. A calibration circuit drives a replica circuit to a desired impedance by adjusting a first gate voltage applied to the first transistor of the replica of the up-cell and adjusting a second gate voltage applied to the third transistor of the replica of the down-cell. The calibrated first gate voltage is applied to the first transistor and to the second transistor of each of the plurality of driver slices and the calibrated second gate voltage is applied to the third transistor of each of the plurality of driver slices.

Abstract: Compositions comprising extracts prepared from mixtures of the herbal plants Radix Bupleurum chinense DC (“B”), Rhizoma Corydalis yanhusuo WT Wang (“Y”), Caulis Polygonum multiflorum Thunb (“P”) and Flos Albizia julibrissin Durazz (“A”) are provided. The BYP, BYA, BPA, BY, BP, YP and BYPA extracts significantly decreased one or more of the effects of accelerated aging in mice exposed to D-galactose, including spatial memory deficit, and elevated oxidative stress marker malondialdehyde and pro-inflammatory cytokines TNF-alpha and IL-6 in the brain, indicating efficacy in reducing the damage of aging, and preventing and treating Alzheimer's disease and/or Parkinson's disease. Anxiolysis by the BYA, BPA, YPA, BA and PA extracts indicates efficacy for treating anxiety disorders, and the sedative effect of the BYA, YPA and PA extracts indicates efficacy for treating sleep disorders.

Abstract: A dispersed mobile-phase countercurrent chromatography system is described in which solutes are carried by a stream of dispersed mobile phase solvent through a column, or array of serially-connected columns, of stationary phase solvent with which the mobile phase solvent is immiscible. Solutes carried along by the stream of dispersed mobile-phase solvent will be equilibrated between the mobile-phase solvent and the stationary-phase solvent. Because the mobile-phase is dispersed into mini-droplets much smaller in diameter than the column of stationary phase, the enhanced surface/volume ratio of the droplets expedites countercurrent equilibration of different solutes between the mobile-phase solvent and the stationary-phase solvent in accordance with the distribution-coefficients of the solutes between the two solvents.

Abstract: Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings.

Abstract: The compound levorotatory-tetrahydropalmatine and pharmaceutical compositions thereof are provided for the treatment of ‘depressant disorders’, ‘bipolar and related disorders’, ‘manic episodes’ and ‘anxiety disorders’ as these disorders are defined in Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5).

Abstract: A micro speaker includes a planar diaphragm, spacers respectively disposed at one side surface of the planar diaphragm, an upper plate and a lower plate, one or more magnets and a circuit board. The planar diaphragm includes a vibrating diaphragm and a coil conductor. The coil conductor is stretched and bonded onto the vibrating diaphragm via an adhesive layer on the upper side surface of the planar diaphragm; the coil conductor is electrically connected to the circuit board. The speaker in this present invention can get a diameter of 15 mm or less, and a height is 5 mm or less.

Abstract: A micro speaker includes a planar diaphragm, spacers respectively disposed at one side surface of the planar diaphragm, an upper plate and a lower plate, one or more magnets and a circuit board. The planar diaphragm includes a vibrating diaphragm and a coil conductor. The coil conductor is stretched and bonded onto the vibrating diaphragm via an adhesive layer on the upper side surface of the planar diaphragm; the coil conductor is electrically connected to the circuit board. The speaker in this present invention can get a diameter of 15 mm or less, and a height is 5 mm or less.

Abstract: Methods are disclosed for manufacturing a coated contact lens that comprises a polymeric lens body comprising an acid group, a first coating polymer comprising a first amine group ionically bound to the acid group, and a second coating bound to the first coating polymer through covalent linkage between a nitrogen atom of a second amine group on the first coating polymer and an amine-reactive group of the second coating polymer. In some examples the lenses exhibit improved surface properties compared to uncoated lenses, such as reduced adhesion, increased wettability, increased lubricity, and/or increased lipid resistance.

Abstract: Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.

Abstract: Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.