Abstract: Disclosed are systems biology-based methods for repositioning known pharmaceutical compounds to new indications, through the identification of network-based signatures. In particular, the invention provides new and useful methods for selecting drugs or combinations of drugs (and preferably previously-approved drugs) for use in new therapeutic indications. Also disclosed are methods for identifying anti-breast tumor initiating cell (TIC)-based therapeutics from within populations of target compounds. In illustrative embodiments, the invention provides methods and computer programs for the repositioning of FDA-approved pharmaceutical compounds to new indications using network-based signature analysis coupled with conventional in vitro and in vivo testing of identified drug candidates. The invention also allows identification of drugs or drug combinations for treating unmet medical needs including, for example, “orphan” diseases.

Abstract: The present invention relates to releasable urea linker systems involving amine-containing chemical compounds and biologically active agents. In particular, the present invention relates to reversibly releasable linkers based on intramolecular cyclization-assisted releasable urea linkages to aromatic amine-containing compounds. The present invention also relates to polymeric conjugates of indolinone-based tyrosine kinase inhibitors.

Abstract: An aperture plate for a print head of a printer can include a first layer having a first emissivity which is covered by a second layer having a second emissivity which is less than the first emissivity. In an embodiment, the second layer can be etched at nozzle locations to form openings in the second layer which have widths/areas greater than widths/areas of nozzles formed in the first layer. In another embodiment, the second layer can have a smaller thickness at the nozzle locations and a larger thickness away from the nozzle locations. Forming the openings in the second layer which are larger than the nozzles, or forming the second layer thinner at the nozzle locations prior to forming the nozzles, can provide a well-formed nozzle and an aperture plate having a low emissivity.

Abstract: A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.

Abstract: An ink jet print head front face or nozzle plate having a textured superoleophobic surface that prevents undesirable drooling, wetting and/or adhesion of the ink on the print head. The textured surface includes a rim formed around the nozzle. Also described are methods for forming the textured superoleophobic ink jet print head front face or nozzle plate from silicon having the textured, oleophobic surface.

Abstract: An ink jet print head front face or nozzle plate having a textured superoleophobic surface that prevents undesirable drooling, wetting and/or adhesion of the ink on the print head. The textured surface includes a rim formed around the nozzle. Also described are methods for forming the textured superoleophobic ink jet print head front face or nozzle plate from silicon having the textured, oleophobic surface.

Abstract: A process for preparing a flexible device having a superoleophobic surface comprising providing a flexible substrate; disposing a silicon layer on the flexible substrate; using photolithography to create a textured pattern in the silicon layer on the substrate wherein the textured pattern comprises a groove structure; and chemically modifying the textured surface by disposing a conformal oleophobic coating thereon; to provide a flexible device having a superoleophobic surface.

Abstract: In accordance with the invention, there are printing apparatuses, fuser members, and methods of making fuser members. The printing apparatus can include a fuser member, the fuser member including a substrate. The fuser member can also include one or more functional layers disposed over the substrate and a top coat layer including a fluorinated nanocomposite disposed over the one or more functional layers, wherein the fluorinated nanocomposite includes a plurality of fluorinated carbon nanotubes dispersed in one or more fluoropolymers.

Abstract: The present invention provides polymeric delivery systems including hindered ester moieties. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.

Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

Abstract: A coating for an ink jet printhead front face, wherein the coating comprises a low adhesion coating, wherein when the low adhesion coating is disposed on an ink jet printhead front face surface, jetted drops of ultra-violet gel ink or jetted drops of solid ink exhibit a low sliding angle with the printhead front face surface, wherein the low sliding angle is less than about 1° to less than about 30°. In embodiments, the low adhesion coating is an oleophobic coating that exhibits a contact angle of greater than about 35° with ultra-violet gel ink or solid ink.

Abstract: Disclosed are molecular diagnostic compositions and methods for predicting brain metastasis of breast cancer, as well as methods for drug repositioning to identify existing and new therapeutics for use in developing individualized, patient-specific treatment regimens for improving diagnoses and patient outcomes in individuals at risk for brain metastasis of breast cancer.

Abstract: A mobile device includes a touch screen display and touch screen circuit for receiving touch inputs. A camera configured to acquire one or more images in front of the display. A proximity sensor configured to provide an indication that a user is in close proximity to the touch screen display. A processor being effective to determine, in response to the indication of the proximity sensor, whether the user is in a position to view the display based on the one or more images of the camera. If the proximity sensor provides an indication that the user is in close proximity to the display and the processor determines, based on the one or more images, that the user is in a position to view the display, then at least one of the display and the touch screen circuit are not disabled.

Abstract: An electronic device includes a display screen, a backlight for illuminating the display screen, and a timer for indicating the expiration of a given time period, wherein when the backlight is first turned on, the timer is initialized to indicate if the expiration of a first predetermined illumination time period occurs. An image capture component is operable to acquire one or more images of a scene in front of the display screen; and a processor is operable to analyze the one or more images to determine whether a user is present in front of the display screen, to control the timer if a user is determined to be present such that the timer is reset to indicate if the expiration of a second predetermined illumination time period occurs, and to control the backlight to dim it or turn it off if the timer indicates an expiration has occurred.

Abstract: Systems and methods of inductively heating a fuser member in an electrophotographic device are disclosed. The systems and methods can include a heating component with a susceptor layer comprising carbon nanotubes (CNTs). An excitation unit with an electrical coil can be positioned a proximate distance from the heating component. Current through the electrical coil can inductively heat the susceptor layer and the heating component. The heat from the susceptor layer and the heating component can be used to fuse toner onto an image-receiving substrate. The CNTs can reduce electronic hardware costs in the electrophotographic device in relation to the costs associated with conventional materials.

Abstract: Various embodiments provide oleophobic, low adhesion coatings with high thermal stability and methods of forming and using them in an ink jet printhead, wherein the oleophobic, low adhesion coatings can include a sol-gel cross-linked coating by a self-condensation process of at least a silane-functionalized perfluoropolyether based polymer precursor.

Abstract: A method and apparatus for activating a function of the electronic device is disclosed herewith. The method includes detecting a first input by a motion sensor. Further, the method activates a touch sensor of the electronic device in response to detecting the first input. The method then detects a second input by the motion sensor within a predetermined time period from the first input. Next, the method determines, in response to detecting the second input, whether contact has occurred at the touch sensor and activates a function of the electronic device in response to determining that contact has occurred at the touch sensor when the second input is detected.

Abstract: Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.

Abstract: Polymer conjugates containing nucleotides and/or oligonucleotides are disclosed.

Abstract: The present teachings provide a fuser member. The fuser member includes a substrate, a functional layer disposed on the substrate, and an outer layer disposed on the functional layer. The outer layer includes silicon having a texture, and a conformal oleophobic coating disposed on the silicon.