Patents by Inventor Hongbo Zhang

Hongbo Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230159502
    Abstract: Indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).
    Type: Application
    Filed: April 2, 2021
    Publication date: May 25, 2023
    Inventors: Simon GIROUX, Michael Philip CLARK, Michael Aaron BRODNEY, Philippe Marcel NUHANT, Emily Elizabeth ALLEN, Robert Francis FIMOGNARI, Jr., Mariam ZAKY, Michael John BOYD, David D. DEININGER, Hu ZHANG, Hongbo DENG, Philip Noel COLLIER, Brad MAXWELL, Nathan D. WAAL, Steven M. RONKIN, Jian WANG, Qing TANG, Gabrielle Simone FLEMING, Peter JONES, Diane Marie BOUCHER, Lev T.D. FANNING, Amy B. HALL, Dennis James HURLEY, Mac Arthur JOHNSON, Jr., John Patrick MAXWELL, Rebecca Jane SWETT, Timothy Lewis TAPLEY, Stephen A. THOMSON, Veronique DAMAGNEZ, Kevin Michael COTTRELL, Upul Keerthi BANDARAGE
  • Publication number: 20230158745
    Abstract: A 3D printing device and method for integrated manufacturing of functionally gradient materials and three-dimensional structures. The device includes an active and passive mixing and printing module and a constraining and sacrificial layer printing module. An input end of the active mixing module connects to multiple anti-settling feeding modules, and an output end of the active mixing module connects to the passive mixing and printing module. The passive mixing and printing module and the constraining and sacrificial layer printing module are mounted on one side of an XYZ three-axis module. The constraining and sacrificial layer printing module connects to a constraining and sacrificial layer feeding module and prints and forms a functionally gradient three-dimensional structure.
    Type: Application
    Filed: February 2, 2021
    Publication date: May 25, 2023
    Applicants: QINGDAO UNIVERSITY OF TECHNOLOGY, QINGDAO 5D INTELLIGENT ADDITIVE MANUFACTURING TECHNOLOGY CO., LTD.
    Inventors: Hongbo LAN, Pengfei GUO, Xin LIN, Guangming ZHANG, Xiaoyang ZHU, Jiawei ZHAO, Quan XU, Jianjun YANG
  • Publication number: 20230124543
    Abstract: A method for analyzing signal irregularity of radiation in a lightning leader is provided, which relates to a field of lightning signal processing and includes: S1: acquiring electric field signals; S2: dividing the electric field signals into multiple segments according to time, and calculating an average sample entropy value of each segment of the electric field signals; S3: dividing the multiple segments of electric field signals into three regions according to the time, quantifying irregularity of radiation of the three regions in the leader according to sample entropies and performing classification based on numerical variation characteristics of the irregularity; S4: comparing the classified data with lightning positioning data to form an analysis database; and S5: acquiring real-time electric field signals, calculating average sample entropy values of the electric field signals, and predicting development characteristics of irregular radiation in the lightning leader.
    Type: Application
    Filed: June 15, 2022
    Publication date: April 20, 2023
    Applicants: Nantong University, Institute of Atmospheric Physics, Chinese Academy of Sciences
    Inventors: Zilong MA, Rubin JIANG, Xiushu QIE, Hongyan XING, Hongbo ZHANG
  • Publication number: 20230065347
    Abstract: A high-voltage permanent magnet frequency conversion all-in-one machine according to an embodiment of the present disclosure includes a frequency converter configured to perform frequency conversion on a high-voltage alternating current, and output at least three alternating currents, a permanent magnet motor configured to receive the alternating currents subjected to the frequency conversion and output from the frequency converter, to drive the motor to operate, and a controller configured to control the frequency converter to perform the frequency conversion on the high-voltage alternating current, and control an operation state of the permanent magnet motor.
    Type: Application
    Filed: November 10, 2020
    Publication date: March 2, 2023
    Inventors: Chenglin SONG, Hongbo ZHANG, Xian LIU, Xufeng YANG
  • Patent number: 11548900
    Abstract: Provided are an oxazino-quinazoline and oxazino-quinoline type compound, a preparation method, and uses thereof. More particularly provided is a compound shown in formula (I), an isomer, a hydrate, a solvate, a pharmaceutically acceptable salt, a prodrug thereof, a preparation method, and uses thereof in preparing a drug acting as a kinase inhibitor.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: January 10, 2023
    Assignee: BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    Inventors: Qiang Zhang, Shannan Yu, Zhongxiang Wang, Shouye Feng, Nanqiao Zheng, Hailong Yang, Leifu Yang, Hongbo Zhang, Likai Zhou, Zhanqiang Xu
  • Patent number: 11479559
    Abstract: The present invention relates to an urea-substituted aromatic ring-linked dioxinoquinoline compound of formula (I), or a pharmaceutically acceptable salt or a hydrate thereof. The invention also provides a preparation method of the compound of formula (I) and a pharmaceutically acceptable salt thereof, as well as uses thereof as a drug, wherein the drug acting as a tyrosine kinase (i.e. VEGFR-2, C-RAF, B-RAF, and RET) inhibitor is used for treating disorders related to tyrosine kinase.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: October 25, 2022
    Assignee: BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    Inventors: Qiang Zhang, Shannan Yu, Zhongxiang Wang, Shouye Feng, Yansheng Liu, Xingfu Li, Hongbo Zhang, Leifu Yang, Hailong Yang, Likai Zhou, Nanqiao Zheng, Chenming Hu, Zhanqiang Xu
  • Publication number: 20220267677
    Abstract: A method and device for controlling viscosity of asphalt rubber based on a current variation are provided. The method includes processing asphalt rubber raw materials with a first preset proportion, and shearing the processed asphalt rubber; obtaining a shearing current, pumping and discharging the sheared asphalt rubber; obtaining a discharging current, and obtaining the viscosity of the pumped asphalt rubber according to the discharging current and the viscosity-discharging current correlation relationship. The method includes comparing the viscosity with a preset viscosity; outputting the pumped asphalt rubber as finished asphalt rubber when the viscosity is equal to the preset viscosity. The method includes adjusting the viscosity according to the discharging current. Double-current control is adopted, so that the whole-process control of the processing viscosity of the asphalt rubber is realized, and the control accuracy of the viscosity is improved.
    Type: Application
    Filed: February 25, 2022
    Publication date: August 25, 2022
    Applicants: GUANGXI TRANSPORTATION SCIENCE AND TECHNOLOGY GROUP CO., LTD., GUANGXI JIAOKE NEW MATERIALS TECHNOLOGY CO.,LTD.
    Inventors: Honggang ZHANG, Hongbo ZHANG, Haitao YUAN, Jizong TAN, Baolin XIONG, Yong WANG, Jianchun YAN, Yehao YIN, Xiaolei WANG
  • Patent number: 11407760
    Abstract: The present invention relates to a dioxinoquinoline compound of formula (I) or a pharmaceutically acceptable salt thereof. The invention also provides a preparation method of the compound of formula (I) and a pharmaceutically acceptable salt thereof, as well as uses thereof as a drug, wherein the drug acting as a tyrosine kinase (i.e. VEGFR-2 and c-MET) inhibitor is used for treating disorders related to tyrosine kinase.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: August 9, 2022
    Assignee: BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    Inventors: Qiang Zhang, Shannan Yu, Zhongxiang Wang, Shouye Feng, Yueming Sun, Yansheng Liu, Hongbo Zhang, Leifu Yang, Hailong Yang, Likai Zhou, Nanqiao Zheng, Chenming Hu, Zhanqiang Xu
  • Publication number: 20220187273
    Abstract: The present disclosure provides a selection method of base asphalt for rubber asphalt based on grey relational analysis, which belongs to the technical field of selection methods of base asphalt. The selection method includes the following steps: determining factors affecting the performance of rubber asphalt and rubber asphalt performance evaluation indicators; ranking the factors affecting the performance of rubber asphalt according to respective affecting degrees thereof on each of the rubber asphalt performance evaluation indicators by using a grey relational method; and determining affecting factors of chemical components of base asphalt to the performance of rubber asphalt, and selecting base asphalt according to the affecting factors. The present disclosure uses the grey relational analysis method to systematically study the influences of chemical components of base asphalt on the performance of rubber asphalt.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 16, 2022
    Inventors: Honggang ZHANG, Hua TAN, Jizong TAN, Haitao YUAN, Hongbo ZHANG, Baolin XIONG, Jianping XIONG, Zehua XIE, Dongliang KUANG
  • Publication number: 20220153787
    Abstract: Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by modulating the transcriptional activation of PMT genes mediated by members of the ERF family and/or Myc family of transcription factors. Novel nucleotide sequences encoding the Myc family of transcription factors are also provided.
    Type: Application
    Filed: November 2, 2021
    Publication date: May 19, 2022
    Applicant: University of Virginia Patent Foundation
    Inventors: Michael Paul Timko, Paul J. Rushton, Sheng-Cheng Han, Hongbo Zhang, Marta Tatiana Bokowiec
  • Patent number: 11210292
    Abstract: Embodiments of the present invention relate to the field of computer technologies, and provide a search method and apparatus to resolve a problem that a reference text, of a text in a professional field, that is determined by using the prior art has relatively low accuracy. The method includes: obtaining n named entities in a current to-be-analyzed target case (S300); determining a first characteristic and a second characteristic (S301); generating, based on the first characteristic and the second characteristic and according to a preset vector generation rule, a target characteristic vector corresponding to the target case (S302); obtaining each historical case in a database and a characteristic vector corresponding to each historical case (S303); and separately calculating a similarity between the target characteristic vector and the characteristic vector corresponding to each historical case, and selecting a historical case whose similarity result meets a preset condition as a reference case (S304).
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: December 28, 2021
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Yasheng Wang, Yang Zhang, Hongbo Zhang
  • Publication number: 20210391659
    Abstract: A connector includes an insulation housing formed with a plurality of terminal slots, and a plurality of terminals inserted into the plurality of terminal slots. Each of the plurality of terminals has a pin protruding from a bottom of the insulation housing for insertion into a terminal hole in a circuit board. At least one latch is formed on the insulation housing for insertion and locking into a latch hole defined in the circuit board.
    Type: Application
    Filed: June 14, 2021
    Publication date: December 16, 2021
    Applicant: Tyco Electronics (Shanghai) Co. Ltd.
    Inventors: Bo Chen, Hongbo Zhang, Jianding Du
  • Patent number: 11168118
    Abstract: Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by modulating the transcriptional activation of PMT genes mediated by members of the ERF family and/or Myc family of transcription factors. Novel nucleotide sequences encoding the Myc family of transcription factors are also provided.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: November 9, 2021
    Assignee: University of Virginia Patent Foundation
    Inventors: Michael Paul Timko, Paul J Rushton, Sheng-Cheng Han, Hongbo Zhang, Marta Tatiana Bokowiec
  • Patent number: 11013694
    Abstract: The present invention relates to a preparation method for a traditional Chinese medicine drop pill and a traditional Chinese medicine micro drop pill prepared by using the method, and in particular, the present invention relates to a micro drop pill preparation method with high drug-loading capacity, simple preparation process and high production rate and a micro drop pill prepared by using the method. Specially, The drop pill preparation method used comprises the following steps: (1) material melting step: heat melting a medicine and a drop pill matrix to obtain a molten medicine liquid; (2) dropping step: delivering the molten medicine liquid to a dripper, and acquiring medicine drops of the molten medicine liquid by means of vibration dropping; and, (3) condensation step: cooling the medicine drops with a cooling gas to obtain micro drop pills.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: May 25, 2021
    Assignee: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Xijun Yan, Naifeng Wu, Kaijing Yan, Xiaobing Sun, Shunnan Zhang, Zhengliang Ye, Hai'ou Dong, Hongbo Zhang, Wensheng Zhang, Lihong Zhou, Chenming Li, Cong Chen, Xiaofeng Liu, Shiqing Wang, Changsheng Rong, Yongfeng Zheng, Lijun Fan
  • Publication number: 20210137959
    Abstract: The present invention relates to agents that induce mitochondrial unfolded protein response (UPRmt) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of muscle stem senescence.
    Type: Application
    Filed: January 14, 2021
    Publication date: May 13, 2021
    Inventors: HONGBO ZHANG, KEIR MENZIES, JOHAN AUWERX, DONGRYEOL RYU
  • Publication number: 20210130239
    Abstract: The present invention discloses a high-strength prestressed composite ceramic and a preparation method thereof, and belongs to a ceramic reinforcing technology in the field of high-performance structural ceramics. Firstly, more than two kinds of bondable ceramics need to be determined to form a composite ceramic of a matrix material and a surface layer material, the matrix material should have sufficient strength and a higher expansion coefficient, and the surface layer material should have a lower expansion coefficient and a higher elastic modulus, realizing the balance of the surface layer compressive stress and the matrix tensile stress are formed after high-temperature co-sintering; and the surface layer compressive stress can greatly improve the bending strength of the composite ceramic.
    Type: Application
    Filed: August 22, 2020
    Publication date: May 6, 2021
    Inventors: Yiwang BAO, Fenghua KUANG, Hongbo ZHANG, Detian WAN
  • Patent number: 10980809
    Abstract: The present invention relates to a urea-substituted aromatic ring-linked dioxinoquinazoline and a urea-substituted aromatic ring-linked dioxinoquinoline of Formula (I), or a pharmaceutically acceptable salt thereof or a hydrate thereof. Also provided are the preparation of the compound as shown in Formula (I) and the pharmaceutically acceptable salt thereof and the use thereof as a drug. The drug is used as an inhibitor of tyrosine kinases (e.g., VEGFR-2, C-RAF, B-RAF) for treating tyrosine kinase-related diseases.
    Type: Grant
    Filed: February 11, 2018
    Date of Patent: April 20, 2021
    Assignee: BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    Inventors: Qiang Zhang, Hongbo Zhang, Leifu Yang, Hailong Yang, Likai Zhou, Nanqiao Zheng, Shannan Yu, Zhongxiang Wang, Shouye Feng, Zhanqiang Xu
  • Publication number: 20210040114
    Abstract: Provided are an oxazino-quinazoline and oxazino-quinoline type compound, a preparation method, and uses thereof. More particularly provided is a compound shown in formula (I), an isomer, a hydrate, a solvate, a pharmaceutically acceptable salt, a prodrug thereof, a preparation method, and uses thereof in preparing a drug acting as a kinase inhibitor.
    Type: Application
    Filed: March 5, 2019
    Publication date: February 11, 2021
    Inventors: Qiang Zhang, Shannan Yu, Zhongxiang Wang, Shouye Feng, Nanqiao Zheng, Hailong Yang, Leifu Yang, Hongbo Zhang, Likai Zhou, Zhanqiang Xu
  • Patent number: 10905704
    Abstract: The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of muscle stem senescence.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: February 2, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Hongbo Zhang, Keir Menzies, Johan Auwerx, Dongryeol Ryu
  • Patent number: RE49385
    Abstract: A fiber optic cable distribution box has an interface compartment for interfacing a first set of fibers when routed inside the compartment, with a second set of fibers associated with a fiber optic cable that is routed to the box. A drum region is disposed beneath the interface compartment. The drum region includes a cylindrical wall for supporting a fiber optic cable wound about the wall. The drum region is formed so that the box can turn about the axis of the cylindrical wall when a cable is paid out from the drum region. The interface compartment and the drum region are constructed so that the first set of fibers inside the interface compartment, originate from an inside end portion of the cable wound on the drum region.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: January 24, 2023
    Assignee: CommScope Technologies LLC
    Inventors: Daniel Hendrickson, Hongbo Zhang