Abstract: The invention relates to the field of medicinal chemistry, and discloses a class of biphenyl derivatives with PD-1/PD-L1 inhibitory activity, and a preparation method and use thereof. The invention further discloses a composition containing the biphenyl derivatives with PD-1/PD-L1 inhibitory activity or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier, and applications of the composition in preparation of PD-1/PD-L1 inhibitors. The compounds of the invention are useful in the therapy used to treat tumors.

Abstract: A method and device for controlling viscosity of asphalt rubber based on a current variation are provided. The method includes processing asphalt rubber raw materials with a first preset proportion, and shearing the processed asphalt rubber; obtaining a shearing current, pumping and discharging the sheared asphalt rubber; obtaining a discharging current, and obtaining the viscosity of the pumped asphalt rubber according to the discharging current and the viscosity-discharging current correlation relationship. The method includes comparing the viscosity with a preset viscosity; outputting the pumped asphalt rubber as finished asphalt rubber when the viscosity is equal to the preset viscosity. The method includes adjusting the viscosity according to the discharging current. Double-current control is adopted, so that the whole-process control of the processing viscosity of the asphalt rubber is realized, and the control accuracy of the viscosity is improved.

Abstract: A semiconductor module includes: a frame part; a semiconductor device mounted on an upper surface of the frame part; a heat sink joined to a lower surface of the frame part; an insulation sheet provided on a lower surface of the heat sink; and a sealing member sealing the frame part, the semiconductor device, and the heat sink to form a module body, wherein a thickness of the heat sink is equal to or larger than 50% of a thickness of the module body.

Abstract: Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by modulating the transcriptional activation of PMT genes mediated by members of the ERF family and/or Myc family of transcription factors. Novel nucleotide sequences encoding the Myc family of transcription factors are also provided.

Abstract: A connector includes an insulation housing formed with a plurality of terminal slots, and a plurality of terminals inserted into the plurality of terminal slots. Each of the plurality of terminals has a pin protruding from a bottom of the insulation housing for insertion into a terminal hole in a circuit board. At least one latch is formed on the insulation housing for insertion and locking into a latch hole defined in the circuit board.

Abstract: A BIOS error locating method and apparatus, a device, and a storage medium are provided. The method includes: acquiring one or more MAP files which are generated during a compilation process of a BIOS and used for recording an entry address offset of each function; recording a base address of each function module after the BIOS is started, so as to obtain a base address log file; in response to occurrence of an EXCEPTION error during an execution process of the BIOS, executing an Exception handling function, so as to determine, according to the base address log file and the one or more MAP files, a target function that results in the EXCEPTION error; and recording a name of the target function in a serial log, and sending the serial log to a BMC.

Abstract: The present invention provides a pharmaceutical composition for treating myocardial ischemia, comprising Salvia Miltiorrhiza medicinal material 250-700 parts by weight, Radix Notoginseng medicinal material 50-150 parts by weight, Borneolum Syntheticum 3-9 parts by weight, and ranolazine 25-100 parts by weight. According to a further aspect of the present invention, there is provided a use of a pharmaceutical composition for preparation of a medicine for prevention and/or treatment of myocardial ischemia.

Abstract: A sensing component of a gyroscope and an opto-MEMS gyroscope comprising said sensing component are provided, the sensing component comprising, a frame; a proof mass configured to be displaced in response to a Coriolis force applied to the sensing component; and a photonic crystal cavity comprising, a first photonic crystal coupled to the proof mass; and a second photonic crystal coupled to the frame; wherein the first and second photonic crystals each comprises an array of holes formed thereon; wherein the photonic crystal cavity is configured to generate an optical output in response to the Coriolis force, and wherein the sensing component is configured to measure the Coriolis force based on changes in the optical output.

Abstract: An intraocular pressure (IOP) includes a transmission film component, which is in direct contact with intraocular aqueous humor and configured to sense pressure fluctuations in the intraocular aqueous humor; a reflective film component set on an inner side of the transmission film component; and an adhesion layer component set on an inner layer of the reflective film component and configured to connect to an attachment device. An enclosed space formed by the reflective film component and the transmission film component constitutes a resonance chamber, which is filled with a filling medium. When a pressure in the intraocular aqueous humor is changed, the transmission film component is deformed, resulting in a change in a near-infrared (NIR) spectrum reflected by the reflective film component; the TOP is detected according to the change of the NIR spectrum.

Abstract: The present invention relates to a novel compound, which has cancer therapeutic activity. The present invention also relates to a preparation method for the compound and a pharmaceutical composition comprising the compound.

Abstract: Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by modulating the transcriptional activation of PMT genes mediated by members of the ERF family and/or Myc family of transcription factors. Novel nucleotide sequences encoding the Myc family of transcription factors are also provided.

Abstract: The present disclosure provides a selection method of base asphalt for rubber asphalt based on grey relational analysis, which belongs to the technical field of selection methods of base asphalt. The selection method includes the following steps: determining factors affecting the performance of rubber asphalt and rubber asphalt performance evaluation indicators; ranking the factors affecting the performance of rubber asphalt according to respective affecting degrees thereof on each of the rubber asphalt performance evaluation indicators by using a grey relational method; and determining affecting factors of chemical components of base asphalt to the performance of rubber asphalt, and selecting base asphalt according to the affecting factors. The present disclosure uses the grey relational analysis method to systematically study the influences of chemical components of base asphalt on the performance of rubber asphalt.

Abstract: A method for analyzing signal irregularity of radiation in a lightning leader is provided, which relates to a field of lightning signal processing and includes: S1: acquiring electric field signals; S2: dividing the electric field signals into multiple segments according to time, and calculating an average sample entropy value of each segment of the electric field signals; S3: dividing the multiple segments of electric field signals into three regions according to the time, quantifying irregularity of radiation of the three regions in the leader according to sample entropies and performing classification based on numerical variation characteristics of the irregularity; S4: comparing the classified data with lightning positioning data to form an analysis database; and S5: acquiring real-time electric field signals, calculating average sample entropy values of the electric field signals, and predicting development characteristics of irregular radiation in the lightning leader.

Abstract: A high-voltage permanent magnet frequency conversion all-in-one machine according to an embodiment of the present disclosure includes a frequency converter configured to perform frequency conversion on a high-voltage alternating current, and output at least three alternating currents, a permanent magnet motor configured to receive the alternating currents subjected to the frequency conversion and output from the frequency converter, to drive the motor to operate, and a controller configured to control the frequency converter to perform the frequency conversion on the high-voltage alternating current, and control an operation state of the permanent magnet motor.

Abstract: Provided are an oxazino-quinazoline and oxazino-quinoline type compound, a preparation method, and uses thereof. More particularly provided is a compound shown in formula (I), an isomer, a hydrate, a solvate, a pharmaceutically acceptable salt, a prodrug thereof, a preparation method, and uses thereof in preparing a drug acting as a kinase inhibitor.

Abstract: The present invention relates to an urea-substituted aromatic ring-linked dioxinoquinoline compound of formula (I), or a pharmaceutically acceptable salt or a hydrate thereof. The invention also provides a preparation method of the compound of formula (I) and a pharmaceutically acceptable salt thereof, as well as uses thereof as a drug, wherein the drug acting as a tyrosine kinase (i.e. VEGFR-2, C-RAF, B-RAF, and RET) inhibitor is used for treating disorders related to tyrosine kinase.

Abstract: A method and device for controlling viscosity of asphalt rubber based on a current variation are provided. The method includes processing asphalt rubber raw materials with a first preset proportion, and shearing the processed asphalt rubber; obtaining a shearing current, pumping and discharging the sheared asphalt rubber; obtaining a discharging current, and obtaining the viscosity of the pumped asphalt rubber according to the discharging current and the viscosity-discharging current correlation relationship. The method includes comparing the viscosity with a preset viscosity; outputting the pumped asphalt rubber as finished asphalt rubber when the viscosity is equal to the preset viscosity. The method includes adjusting the viscosity according to the discharging current. Double-current control is adopted, so that the whole-process control of the processing viscosity of the asphalt rubber is realized, and the control accuracy of the viscosity is improved.

Abstract: A fiber optic cable distribution box has an interface compartment for interfacing a first set of fibers when routed inside the compartment, with a second set of fibers associated with a fiber optic cable that is routed to the box. A drum region is disposed beneath the interface compartment. The drum region includes a cylindrical wall for supporting a fiber optic cable wound about the wall. The drum region is formed so that the box can turn about the axis of the cylindrical wall when a cable is paid out from the drum region. The interface compartment and the drum region are constructed so that the first set of fibers inside the interface compartment, originate from an inside end portion of the cable wound on the drum region.