Abstract: The present disclosure provides, among other things, helper-dependent adenoviral serotype 35 (Ad35) vectors. In various embodiments, helper-dependent Ad35 vectors can be used to deliver a therapeutic payload to a subject in need thereof. Exemplary payloads can encode replacement proteins, antibodies, CARs, TCRs, small RNAs, and genome editing systems. In certain embodiments, a helper-dependent Ad35 vector is engineered for integration of a payload into a host cell genome. The present disclosure further includes methods of gene therapy that include administration of a helper-dependent Ad35 vector to a subject in need thereof.

Abstract: The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.

Abstract: The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.

Abstract: A method for a dynamic inductive wireless power transmission includes providing an AC/DC power converter that receives three-phase power and provides regulated DC output current, connecting a trunk cable to the AC/DC power converter output and to multiple power transmitter modules. The trunk cable connects inputs of the power transmitter modules in series. The power transmitter modules transmit inductive wireless power over an air gap. The method includes providing a system controller that detects a vehicle containing a receiver coil and confirms if the vehicle should receive the inductive wireless power from the multiple power transmitter modules, and includes configuring the system controller to communicate with the AC/DC power converter to maintain the regulated DC output current at a constant value and transmit the inductive wireless power to the vehicle through the multiple power transmitter modules when the vehicle should receive the inductive wireless power.

Abstract: An optical phased array lidar includes: a laser, for emitting a laser signal; an optical beam splitter, for splitting a laser signal into multiple sub-signals, and distributing them to corresponding optical paths; a phase controller connected to the optical beam splitter, for regulating phases of the multiple sub-signals; an optical antenna array based on a one-dimensional grating structure, connected to the phase controller and for uniformly scattering the phase-regulated sub-signals into free space; and a silicon nitride waveguide array, for transmitting the sub-signals and phase-regulated sub-signals to realize the transmission of near-infrared light and visible light. The optical phased array lidar uses a silicon nitride waveguide array for transmission, thereby realizing the transmission of near-infrared light and visible light. In this way, the lidar can work in the visible light band, thereby broadening the working ranging thereof.

Abstract: A dynamic inductive wireless power transmitter (“DIPT”) system is disclosed. In embodiments, a DIPT system includes an AC-to-DC power converter configured to receive three-phase power from an AC utility source. The DIPT system further includes a trunk cable electrically connected to the AC-to-DC power converter and multiple power transmitter modules electrically connected to the trunk cable and connected to each other in series. Each of the multiple power transmitter modules are configured to transmit inductive wireless power over an air gap from the DIPT system to a vehicle containing a receiver coil. The DIPT system further includes a system controller configured to detect a vehicle containing a receiver coil, identify the vehicle containing a receiver coil, and confirm if the vehicle containing a receiver coil should receive inductive wireless power from the DIPT system.

Abstract: An apparatus includes an active bridge section with input terminals that receive power from a constant current source where the active bridge section operates at a fixed switching frequency. The apparatus includes a resonant section with a resonant inductor, a transformer and a resonant capacitor. The inductor is connected in series with a primary winding and the capacitor is connected in parallel with a secondary winding of the transformer. The resonant section is connected to an output of the active bridge section. The apparatus includes an output rectifier section that receives power from the resonant section and includes output terminals for connection to a load, and includes a controller that regulates output voltage to the load where the controller regulates output voltage to the load by controlling switching of the active bridge section. The fixed switching frequency of the active bridge section matches a resonant frequency of the resonant section.

Abstract: An adjustable wide-spectrum wavelength-insensitive directional coupler, comprising a substrate (100). A first-stage directional coupling structure (1), a phase-shifting structure (2), and a second-stage directional coupling structure (3) are sequentially connected and disposed on the substrate (100). The phase-shifting structure (2) comprises a phase-shifting curved waveguide, a phase-shifting straight waveguide (22), and a third modulation component (26), wherein the third modulation component (26) is disposed on the phase-shifting curved waveguide. One end of the phase-shifting curved waveguide is connected to an output end of a directional coupled waveguide I (16) of the first-stage directional coupling structure (1), and the other end of the phase-shifting curved waveguide is connected to an input end of a directional coupled waveguide III (30) of the second-stage directional coupling structure (3).

Abstract: An apparatus includes an active bridge section with input terminals that receive power from a constant current source where the active bridge section operates at a fixed switching frequency. The apparatus includes a resonant section with a resonant inductor, a transformer and a resonant capacitor. The inductor is connected in series with a primary winding and the capacitor is connected in parallel with a secondary winding of the transformer. The resonant section is connected to an output of the active bridge section. The apparatus includes an output rectifier section that receives power from the resonant section and includes output terminals for connection to a load, and includes a controller that regulates output voltage to the load where the controller regulates output voltage to the load by controlling switching of the active bridge section. The fixed switching frequency of the active bridge section matches a resonant frequency of the resonant section.

Abstract: An apparatus for zero voltage switching includes a ZVS assist circuit connected between a switching node and a negative connection of a converter. The switching node is located between first and second switches of a switching leg of the converter. The converter is fed by a constant current source and feeds a constant current load. The ZVS assist circuit includes a ZVS inductance, a first ZVS switch that allows current through the ZVS inductance to change a voltage of the switching node to a condition for zero voltage switching of the first switch of the switching leg, and a second ZVS switch that allows current through the ZVS inductance to change the voltage of the switching node to a condition for zero voltage switching of the second switch of the switching leg. Current through the first ZVS switch is opposite current through the second ZVS switch.

Abstract: An apparatus for zero voltage switching includes a ZVS assist circuit connected between a switching node and a negative connection of a converter. The switching node is located between first and second switches of a switching leg of the converter. The converter is fed by a constant current source and feeds a constant current load. The ZVS assist circuit includes a ZVS inductance, a first ZVS switch that allows current through the ZVS inductance to change a voltage of the switching node to a condition for zero voltage switching of the first switch of the switching leg, and a second ZVS switch that allows current through the ZVS inductance to change the voltage of the switching node to a condition for zero voltage switching of the second switch of the switching leg. Current through the first ZVS switch is opposite current through the second ZVS switch.

Abstract: A power supply includes an active bridge section with input terminals that receive power from a constant current source where the active bridge section operates at a fixed switching frequency. The power supply includes a resonant section with a resonant inductor and a resonant capacitor. The resonant section is connected to an output of the active bridge section. The power supply includes an output rectifier that receives power from the resonant section and includes output terminals for connection to a load and a controller that regulates output current to the load where the controller regulates output current to the load by controlling switching of the active bridge section. The fixed switching frequency of the active bridge section matches a resonant frequency of the resonant section.

Abstract: The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.

Abstract: A power transmitter module is disclosed. In embodiments, a power transmitter module includes a module LC input filter configured to receive regulated DC current, a module transmitter circuit configured to receive the regulated DC current from the module LC input filter and generate a high-frequency AC current. A power transmitter module further includes a module transmitter coil and compensation circuit comprising a transmitter coil, and a first capacitor in parallel with the transmitter coil. The module transmitter coil and compensation circuit are configured to receive the high-frequency AC current from the module transmitter circuit and generate a time-varying magnetic field emitted from the transmitter coil. Additionally, a power transmitter module further includes a module controller configured to receive a power transmission input signal and further configured to control a state of the module transmitter circuit based on the power transmission input signal.

Abstract: An adjustable wide-spectrum wavelength-insensitive directional coupler, comprising a substrate (100). A first-stage directional coupling structure (1), a phase-shifting structure (2), and a second-stage directional coupling structure (3) are sequentially connected and disposed on the substrate (100). The phase-shifting structure (2) comprises a phase-shifting curved waveguide, a phase-shifting straight waveguide (22), and a third modulation component (26), wherein the third modulation component (26) is disposed on the phase-shifting curved waveguide. One end of the phase-shifting curved waveguide is connected to an output end of a directional coupled waveguide I (16) of the first-stage directional coupling structure (1), and the other end of the phase-shifting curved waveguide is connected to an input end of a directional coupled waveguide III (30) of the second-stage directional coupling structure (3).

Abstract: The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.

Abstract: A power supply includes an active bridge section with input terminals that receive power from a constant current source where the active bridge section operates at a fixed switching frequency. The power supply includes a resonant section with a resonant inductor and a resonant capacitor. The resonant section is connected to an output of the active bridge section. The power supply includes an output rectifier that receives power from the resonant section and includes output terminals for connection to a load and a controller that regulates output current to the load where the controller regulates output current to the load by controlling switching of the active bridge section. The fixed switching frequency of the active bridge section matches a resonant frequency of the resonant section.

Abstract: The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.