Patents by Inventor Hongjie Zhang

Hongjie Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10355230
    Abstract: The invention provides a red organic electroluminescent device, composed of a substrate, an anode layer, an anode modification layer, a hole transporting-electron blocking layer, a hole-dominated light-emitting layer, an electron-dominated light-emitting layer, a hole blocking-electron transporting layer, a cathode modification layer, and a cathode layer arranged in turn, wherein the electron-dominated light-emitting layer is composed of an organic sensitive material, a red organic light-emitting material, and an electron-type organic host material.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: July 16, 2019
    Assignee: Changchung Institute of Applied Chemistry, Chinese Academy of Sciences
    Inventors: Liang Zhou, Hongjie Zhang, Jing Feng
  • Patent number: 10351500
    Abstract: The present invention relates to a composition for preventing or reducing microbial growth, particularly the growth of dermatophytic fungi, and/or aciduric and acidogenic gram-positive bacteria. More particularly, it relates to the use of trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, or its dihydrostilbene derivatives and/or chemical variants as an anti-microbial agent. The present invention further relates to the management of dermatophytosis often caused by dermatophytic fungi and the management of dental caries often mediated by aciduric and acidogenic gram-positive Streptococci. The present invention therefore has applications in preventing, alleviating and/or treating dermatophytosis and dental caries.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 16, 2019
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Hongjie Zhang, Siu Wai Tsang
  • Patent number: 10323012
    Abstract: The present disclosure relates to miliusane and analogs thereof that are useful as anti-virals, such as anti-HIV and anti-influenza virus agents. The present disclosure provides methods for treating viral infections, such as AIDS, HIV, and influenza infections.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: June 18, 2019
    Assignee: Hong Kong Baptist University
    Inventor: Hongjie Zhang
  • Patent number: 10188590
    Abstract: The present invention relates to a skin-protection composition that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, it relates to the usage of Dendrobium ingredients and stilbenoids to reduce the formation of melanin in melanocytes. It also relates to the usage of Dendrobium ingredients and stilbenoids to reduce the generation of reactive oxygen species and oxidative free radicals. This invention relates to the use Dendrobium-derived extracts or ingredients or stilbenoids in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: January 29, 2019
    Assignee: Hong Kong Baptist University
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yu Zhu
  • Patent number: 10177324
    Abstract: Provided is a white organic electroluminescent device, composed of a substrate, an anode layer, an anode modification layer, a hole transporting-electron blocking layer, a hole-dominated light-emitting layer, an electron-dominated light-emitting layer, a hole blocking-electron transporting layer, a cathode modification layer, and a cathode layer arranged in turn, wherein the electron-dominated light-emitting layer is composed of an organic sensitive material, a blue organic light-emitting material, and an electron-type organic host material.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: January 8, 2019
    Assignee: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
    Inventors: Liang Zhou, Hongjie Zhang
  • Publication number: 20180319729
    Abstract: The present invention relates to a composition for preventing or reducing microbial growth, particularly the growth of dermatophytic fungi, and/or aciduric and acidogenic gram-positive bacteria. More particularly, it relates to the use of trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, or its dihydrostilbene derivatives and/or chemical variants as an anti-microbial agent. The present invention further relates to the management of dermatophytosis often caused by dermatophytic fungi and the management of dental caries often mediated by aciduric and acidogenic gram-positive Streptococci. The present invention therefore has applications in preventing, alleviating and/or treating dermatophytosis and dental caries.
    Type: Application
    Filed: July 9, 2018
    Publication date: November 8, 2018
    Inventors: Hongjie ZHANG, Siu Wai TSANG
  • Patent number: 10077477
    Abstract: This invention provides a combination of microRNAs for evaluating the physiological and/or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum/plasma of a subject; and a method for evaluating the physiological and/or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum/plasma of a subject; and a kit for evaluating the physiological and/or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum/plasma of a subject; and a biochip for evaluating the physiological and/or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum/plasma of a subject.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: September 18, 2018
    Assignee: JIANGSU MINGMA BIOTECH CO., LTD.
    Inventors: Chenyu Zhang, Junfeng Zhang, Xi Chen, Yi Ba, Jiangning Chen, Jin Wang, Ke Zeng, Hongjie Zhang
  • Publication number: 20180248138
    Abstract: Provided is a white organic electroluminescent device, composed of a substrate, an anode layer, an anode modification layer, a hole transporting-electron blocking layer, a hole-dominated light-emitting layer, an electron-dominated light-emitting layer, a hole blocking-electron transporting layer, a cathode modification layer, and a cathode layer arranged in turn, wherein the electron-dominated light-emitting layer is composed of an organic sensitive material, a blue organic light-emitting material, and an electron-type organic host material.
    Type: Application
    Filed: November 20, 2014
    Publication date: August 30, 2018
    Inventors: Liang Zhou, Hongjie Zhang
  • Publication number: 20180228709
    Abstract: The present invention relates to a skin-protection composition that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, it relates to the usage of Dendrobium ingredients and stilbenoids to reduce the formation of melanin in melanocytes. It also relates to the usage of Dendrobium ingredients and stilbenoids to reduce the generation of reactive oxygen species and oxidative free radicals. This invention relates to the use Dendrobium-derived extracts or ingredients or stilbenoids in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
    Type: Application
    Filed: March 16, 2018
    Publication date: August 16, 2018
    Inventors: Hongjie ZHANG, Siu Wai TSANG, Yu ZHU
  • Patent number: 10017442
    Abstract: The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol or its derivatives/chemical variants in the manufacture of a medicament for the treatment of tumors or cancers. The dihydrostilbenes can be used in the treatment or delay of progression of a cancer in a patient or used in a pharmaceutical formulation for the aforementioned purposes.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: July 10, 2018
    Assignee: Hong Kong Baptist University
    Inventors: Hongjie Zhang, Siu Wai Tsang
  • Patent number: 10011880
    Abstract: MicroRNAs are provided for evaluating the physiological and/or pathological condition of a subject; and a kit thereof is provided for evaluating the physiological and/or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum/plasma of a subject; and a biochip for evaluating the physiological and/or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum/plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: July 3, 2018
    Assignee: JIANGSU MINGMA BIOTECH CO., LTD.
    Inventors: Chenyu Zhang, Junfeng Zhang, Xi Chen, Yi Ba, Jiangning Chen, Jin Wang, Ke Zeng, Hongjie Zhang
  • Patent number: 9963485
    Abstract: New anticancer and anti-obesity agents based on cyclic peptide compounds are isolated from the stem barks of Maytenus variabilis (Loes.) C. Y. Cheng (Celastraceae). The invention also includes its preparation and application method for treating cancer and obesity diseases.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: May 8, 2018
    Assignee: Hong Kong Baptist University
    Inventor: Hongjie Zhang
  • Publication number: 20180118647
    Abstract: The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol or its derivatives/chemical variants in the manufacture of a medicament for the treatment of tumors or cancers. The dihydrostilbenes can be used in the treatment or delay of progression of a cancer in a patient or used in a pharmaceutical formulation for the aforementioned purposes.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 3, 2018
    Inventors: Hongjie ZHANG, Siu Wai TSANG
  • Patent number: 9956152
    Abstract: A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: May 1, 2018
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yu Zhu
  • Patent number: 9931476
    Abstract: The present invention discloses a disposable safety self-destruction insulin needle. The invention uses a sleeve-connected linkage structure and realizes an instant reset of the safety sleeve by means of the spring located in the middle axis so as to ensure that the needle tube is not exposed and preferably realizes a tilting and deflection of the self-destruction pressure base due to a plurality of flexible plates unevenly distributed on the inner wall in the needle base so as to finally ensure that the insulin needle cannot be used a second time, in so doing the safety self-destruction operation of the insulin needle is realized.
    Type: Grant
    Filed: November 1, 2015
    Date of Patent: April 3, 2018
    Assignee: Beipu Medical Technology Co., Ltd.
    Inventors: Hongjie Zhang, Linfeng Zhang
  • Publication number: 20180085344
    Abstract: The present invention relates to a group of derivatives synthesized based on the ent-kaurane diterpenoid flexicaulin A and the methods to synthesize such diterpenoid derivatives. In particular, the chemical entities of such synthetic diterpene compounds in the manufacture of a medicament is for the treatment of tumors or cancers.
    Type: Application
    Filed: September 21, 2017
    Publication date: March 29, 2018
    Inventors: Hongjie ZHANG, Man Shing Ricky WONG, Lei GUO, Siu Wai TSANG, Kanglun LIU, Tongxin ZHANG
  • Publication number: 20180065946
    Abstract: The present disclosure relates to miliusane and analogs thereof that are useful as anti-virals, such as anti-HIV and anti-influenza virus agents. The present disclosure provides methods for treating viral infections, such as AIDS, HIV, and influenza infections.
    Type: Application
    Filed: November 3, 2017
    Publication date: March 8, 2018
    Inventor: Hongjie Zhang
  • Patent number: 9877931
    Abstract: The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs). One embodiment of the present invention also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment of the present invention also has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: January 30, 2018
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yegao Chen
  • Patent number: 9856028
    Abstract: An integrated pylon structure for a propulsion system is suitable for one end to be connected to an aircraft wing and the other end to be connected to an aircraft engine. The pylon structure includes a pylon box section (110) formed from an upper and a lower bean, a frame (100) and a side wall panel. The pylon structure has a thrust reverser hood connection structure, provided on the side wall and connected with a nacelle thrust reverser hood having a front fixed hood (301) and a rear movable hood (302). A guide rail allows the rear movable hood to slide and open relative to the pylon box section. The engine thrust reverser hood is directly connected to the side wall of the pylon box section and a guide rail on the side wall guides the opening of the thrust reverser hood.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: January 2, 2018
    Assignees: Commercial Aircraft Corporation of China, LTD, COMMERCIAL AIRCRAFT CORPORATION OF CHINA, LTD SHANGHAI AIRCRAFT DESIGN AND RESEARCH INSTITUTE
    Inventors: Guanghui Wu, Kecen Han, Liangdao Zhou, Qifeng Yu, Guozheng Lin, Hongjie Zhang, Shibiao Zhang, Haojie Weng, Haisha Guo, Pengfei Zhang, Xiaonan Li, Shiwei Ma, Yinyin Hu, Sen Peng, Honggang Tang, Mingpeng Yan
  • Publication number: 20170352824
    Abstract: The invention provides a blue organic electroluminescent device, composed of a substrate, an anode layer, an anode modification layer, a hole transporting-electron blocking layer, a hole-dominated light-emitting layer, an electron-dominated light-emitting layer, a hole blocking-electron transporting layer, a cathode modification layer, and a cathode layer arranged in turn, wherein the electron-dominated light-emitting layer is composed of an organic sensitive material, a blue organic light-emitting material, and an electron-type organic host material.
    Type: Application
    Filed: November 20, 2014
    Publication date: December 7, 2017
    Inventors: Liang Zhou, Hongjie Zhang, Yunlong Jiang