Abstract: Anti-CLDN18.2 antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the diagnostic uses thereof are provided herein.

Abstract: A method, apparatus and computer program product are provided for generating a registered certified seal, sealing an asset, and verifying a sealed asset. In an example embodiment, a method is provided for receiving a request to generate a registered certified seal from an entity, accessing certifier entity data via a uniform resource locator of a certification authority identified by a certifying certificate, and verifying a digitally signed entity certifying certificate. The method further comprises upon verifying the digitally signed entity certifying certificate, receiving seal data comprising a seal data key for a certified seal, and saving the seal data for the entity within a digital seal registry, wherein the digital seal registry is searchable based at least in part on at least a portion of the seal data key.

Abstract: A method, apparatus and computer program product are provided for encrypting and decrypting data using multiple authority keys including receiving, from a first computing device, a data decrypt request to decrypt encrypted data, the data decrypt request comprising a user key, determining that the user key is associated with a key hierarchy that comprises a server key, decrypting the server key using the user key, decrypting the encrypted data using the decrypted server key and permitting access to the decrypted data by the first computing device.

Abstract: A therapeutic hydrogel material is disclosed for the delivery of CAR-T cells that allows their distribution in the tumor resection recess, cavity, or void in combination with platelets decorated with the anti-programmed death-ligand 1 (PDL1) blocking antibody (aPDL1). The delivered hydrogel material acts as a reservoir for both CAR-T cells and platelet-bound aPDL1. Furthermore, inflammation occurring during the surgical wound healing triggers the release of platelet-derived microparticles containing the aPDL1. Cells delivered by the engineered hydrogel show significant control of local and distant tumor recurrence without causing toxic effects. In some embodiments, nanoparticles containing cytokines are also loaded in the therapeutic hydrogel material to maintain the activity and proliferation ability of CAR-T cells.

Abstract: Chimeric antigen receptor T cells (CAR T) therapy reached a milestone in eradicating B-cell malignancies, but beneficial effects in solid tumors are not obtained yet. A porous microneedle patch is disclosed that carries CAR T cells to solid tumors (or other cell types). The device is a honeycomb-like porous microneedle patch that accommodates CAR T cells and allows in situ penetration-media seeding of CAR T cells within post-surgical resection of solid tumors. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immune stimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of diseases. Other cell types may be loaded into the porous microneedles.

Abstract: The vertical counterforce loading device includes a concrete support member, four transfer components, four connection components, a vertical force transmission component and a load test soil layer. The concrete support member is formed by pouring and concreting below the load test soil layer. The four transfer components are divided into two groups to be symmetrically and parallelly anchored in the concrete support member. The vertical force transmission component includes a load plate, a jack, a primary beam and a secondary beam arranged in sequence from bottom to top. The load plate is installed on the load test soil layer. Two secondary beams are connected crosswise to both ends of the primary beam, where end portions of the secondary beams are respectively connected to second ends of the connection components through reinforcement components. The device can improve work efficiency, reduce construction costs and improve safety.

Abstract: A method, apparatus and computer program product are provided for encrypting and decrypting data using multiple authority keys including receiving, from a first computing device, a data decrypt request to decrypt encrypted data, the data decrypt request comprising a user key, determining that the user key is associated with a key hierarchy that comprises a server key, decrypting the server key using the user key, decrypting the encrypted data using the decrypted server key and permitting access to the decrypted data by the first computing device.

Abstract: Provided are anti-CLDN18.2 antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.

Abstract: An image sensor includes a plurality of photodiodes, a plurality of color filters, and a plurality of microlenses. The plurality of photodiodes are arranged as a photodiode array, each of the plurality of photodiodes disposed within respective portions of a semiconductor material with a first lateral area. The plurality of color filters are arranged as a color filter array optically aligned with the photodiode array. Each of the plurality of color filters having a second lateral area greater than the first lateral area. The plurality of microlenses are arranged as a microlens array optically aligned with the color filter array and the photodiode array. Each of the plurality of microlenses have a third later area greater than the first lateral area and less than the second lateral area.

Abstract: A method, apparatus and computer program product are provided for generating a registered certified seal, sealing an asset, and verifying a sealed asset. In an example embodiment, a method is provided for receiving a request to generate a registered certified seal from an entity, accessing certifier entity data via a uniform resource locator of a certification authority identified by a certifying certificate, and verifying a digitally signed entity certifying certificate. The method further comprises upon verifying the digitally signed entity certifying certificate, receiving seal data comprising a seal data key for a certified seal, and saving the seal data for the entity within a digital seal registry, wherein the digital seal registry is searchable based at least in part on at least a portion of the seal data key.

Abstract: The vertical counterforce loading device includes a concrete support member, four transfer components, four connection components, a vertical force transmission component and a load test soil layer. The concrete support member is formed by pouring and concreting below the load test soil layer. The four transfer components are divided into two groups to be symmetrically and parallelly anchored in the concrete support member. The vertical force transmission component includes a load plate, a jack, a primary beam and a secondary beam arranged in sequence from bottom to top. The load plate is installed on the load test soil layer. The number of the secondary beams is two, and the two secondary beams are connected crosswise to both ends of the primary beam. The end portions of the two secondary beams are respectively connected to second ends of the four connection components through reinforcement components.

Abstract: A method, apparatus and computer program product are provided for generating a registered certified seal, sealing an asset, and verifying a sealed asset. In an example embodiment, a method is provided for receiving a request to generate a registered certified seal from an entity, accessing certifier entity data via a uniform resource locator of a certification authority identified by a certifying certificate, and verifying a digitally signed entity certifying certificate. The method further comprises upon verifying the digitally signed entity certifying certificate, receiving seal data comprising a seal data key for a certified seal, and saving the seal data for the entity within a digital seal registry, wherein the digital seal registry is searchable based at least in part on at least a portion of the seal data key.

Abstract: An image sensor includes a plurality of photodiodes, a plurality of color filters, and a plurality of microlenses. The plurality of photodiodes are arranged as a photodiode array, each of the plurality of photodiodes disposed within respective portions of a semiconductor material with a first lateral area. The plurality of color filters are arranged as a color filter array optically aligned with the photodiode array. Each of the plurality of color filters having a second lateral area greater than the first lateral area. The plurality of microlenses are arranged as a microlens array optically aligned with the color filter array and the photodiode array. Each of the plurality of microlenses have a third later area greater than the first lateral area and less than the second lateral area.

Abstract: A method, apparatus and computer program product are provided for receiving, from a computing device, a password and at least one recovery element, deriving a password derived encryption key based at least in part on the password, deriving a recovery element derived encryption key based at least in part on the at least one recovery element; encrypting a master encryption key stored in temporary memory using the password derived encryption key to generate a password encryption key cipher for storage in non-transitory memory, encrypting the master encryption key stored in the temporary memory using the recovery element derived encryption key to generate a recovery element encryption key cipher for storage in the non-transitory memory, and upon encrypting the master encryption key using the password derived encryption key and the recovery element derived encryption key, clearing the master encryption key from the temporary memory.

Abstract: A method, apparatus and computer program product are provided for transferring ownership of a digital asset including receiving, from a first computing device, a digital asset identifier, receiving a request to transfer ownership of the digital asset to be associated with a second computing device, deriving a first owner key from the digital asset identifier, deriving a digital asset key from the first owner key, generating, in response to the request, a second owner key, and verifying that the second computing device has ownership of the digital asset by verifying the digital asset key derived from the second owner key is related to at least one key of a digital asset key pair.

Abstract: A method, apparatus and computer program product are provided for encrypting and decrypting data using multiple authority keys including receiving, from a first computing device, a data decrypt request to decrypt encrypted data, the data decrypt request comprising a user key, determining that the user key is associated with a key hierarchy that comprises a server key, decrypting the server key using the user key, decrypting the encrypted data using the decrypted server key and permitting access to the decrypted data by the first computing device.

Abstract: The invention relates to an overvoltage protection arrangement having: a plurality of planar varistors 2, 21, 22, which are arranged on a first side of a supporting plate 7; at least one gas arrester 10; and at least one thermal disconnection device, which is in close thermal contact with at least one of the varistors. The aforementioned components are surrounded by an outer housing 1, and electrical connection means 6, 61 for soldering to a printed circuit board are also provided on the second side of the supporting plate. The varistors 2, 21, 22 have a parallel stack arrangement, which is delimited on each of two opposing sides by an insulating partition wall 3, 31 which can be attached to the supporting plate.

Abstract: A method, apparatus and computer program product are provided for generating a registered certified seal, sealing an asset, and verifying a sealed asset. In an example embodiment, a method is provided for receiving a request to generate a registered certified seal from an entity, accessing certifier entity data via a uniform resource locator of a certification authority identified by a certifying certificate, and verifying a digitally signed entity certifying certificate. The method further comprises upon verifying the digitally signed entity certifying certificate, receiving seal data comprising a seal data key for a certified seal, and saving the seal data for the entity within a digital seal registry, wherein the digital seal registry is searchable based at least in part on at least a portion of the seal data key.

Abstract: The invention relates to an overvoltage protection arrangement having: a plurality of planar varistors 2, 21, 22, which are arranged on a first side of a supporting plate 7; at least one gas arrester 10; and at least one thermal disconnection device, which is in close thermal contact with at least one of the varistors. The aforementioned components are surrounded by an outer housing 1, and electrical connection means 6, 61 for soldering to a printed circuit board are also provided on the second side of the supporting plate. The varistors 2, 21, 22 have a parallel stack arrangement, which is delimited on each of two opposing sides by an insulating partition wall 3, 31 which can be attached to the supporting plate.

Abstract: This invention relates to a bridged polyethylene glycol-aliphatic polyester block copolymer, which can be used in the production of delivery carriers for micromolecular chemotherapeutic drugs and nucleic acid drugs. Nanoscale pharmaceutical carriers produced from the bridged block polymer may be subjected to specific degradation under pH environments in tumor tissues or tumor cells so as to change the structure of nanoparticles, enhance cell uptake or intracellular drug release, and improve the sensitivity of tumor cells to drugs.