Patents by Inventor Hongkai Zhang

Hongkai Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200231732
    Abstract: The present invention relates to organic polymer synthetic materials, and discloses a self-curing organic synthetic resin composition for additive manufacturing. The self-curing organic synthetic resin composition includes 30-75% by weight of a linear thermoplastic phenolic resin and 25-70% by weight of a phenol modified furan resin. The self-curing organic synthetic resin composition is prepared through three stages. The linear thermoplastic phenolic resin prepared in stage (1) and the phenol modified furan resin prepared in stage (2) are mixed in a certain weight ratio in stage (3) to obtain the self-curing organic synthetic resin composition for additive manufacturing, which has the advantages of high strength at normal temperature, excellent resistance to high temperature, high activity and excellent collapsibility. Thus, the self-curing organic synthetic resin composition provided in the invention is suitable for additive manufacturing, and particularly for 3D printing in mold casting.
    Type: Application
    Filed: January 14, 2020
    Publication date: July 23, 2020
    Inventors: Jinlong XING, Fan PENG, Hongkai ZHANG, Wen MA, Wen HAN
  • Publication number: 20200190151
    Abstract: The invention provides variant venom peptides and polypeptides that specifically block potassium voltage gated ion channel Kv1.3. The invention also provides methods of inhibiting Kv1.3 channel activity, methods for treating disorders that are associated with undesired or aberrant Kv1.3 channel activity, methods for detecting Kv1.3 expression in target cells such as lymphocytes, and methods for diagnosing diseases or disorders that are associated with aberrant Kv1.3 overexpression.
    Type: Application
    Filed: May 11, 2017
    Publication date: June 18, 2020
    Inventors: Richard A. Lerner, Hongkai Zhang
  • Patent number: 10655124
    Abstract: The invention provides methods for identifying binding partners (e.g., peptide ligands) that binds to a target protein (e.g., a cellular receptor). The methods entail co-localized expression of the target protein and candidate binding partners, and selection of binding partners based on their proximity in the plasma membrane.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: May 19, 2020
    Assignee: The Scripps Research Institute
    Inventors: Richard A. Lerner, Hongkai Zhang, Jia Xie
  • Patent number: 10570031
    Abstract: A hydrogen-enriched water generator and dispenser includes a main casing, a hydrogen water generator supported in the main casing, and a water tank. The hydrogen water generator includes a magnetic field generator and an electrode arrangement supported in the main casing. The water tank is adapted for storing a predetermined amount of regular water. The magnetic field generator is arranged to deliver electromagnetic wave having ultra-long wavelength to the regular water stored in the water tank upon electrolyzing and ionizing by the electrode arrangement, so that the regular water is electrolyzed and ionized to contain a predetermined amount of hydrogen ions for direct consumption.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: February 25, 2020
    Inventor: Hongkai Zhang
  • Patent number: 10494438
    Abstract: The invention provides methods for identifying protein modulators (e.g., antibody agonists) of eukaryotic cells. The methods typically involve expressing a combinatorial agent library (e.g., via lentiviral vectors) inside a eukaryotic cell type (e.g., a mammalian cell) and then directly selecting for agents (e.g., antibodies) that are agonist of a target molecule (e.g., a signaling receptor) that modulates a phenotype of or elicits a cellular response in the cell. Some related methods involve co-culturing a cell expressing a combinatorial agent library and a second cell, and then selecting agents that modulate a phenotype of or elicit a cellular response in the second cell. Preferably, the agents are antibodies and are introduced into and expressed in the starting cells under conditions each individual cell expresses no more than 3 different members of the antibody library.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: December 3, 2019
    Assignee: The Scripps Research Institute
    Inventors: Hongkai Zhang, Ian A. Wilson, Richard A. Lerner
  • Publication number: 20190206095
    Abstract: An image processing method, comprising: acquiring, by a CT scanning system, projection data of an object; and processing, by using a convolutional neural network, the projection data, to acquire an estimated image of the object. The convolutional neural network comprises: a projection domain network for processing input projection data to obtain estimated projection data; an analytical reconstruction network layer for performing analytical reconstruction to obtain a reconstructed image; an image domain network for processing the reconstructed image to obtain an estimated image, a projection layer for performing a projection operation by using a system projection matrix of the CT scanning system, to obtain a projection result of the estimated image; and a statistical model layer for determining consistency among the input projection data, the estimated projection data, and the projection result of the estimated image based on a statistical model.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 4, 2019
    Inventors: Yuxiang XING, Kaichao LIANG, Le SHEN, Li ZHANG, Hongkai YANG, Kejun KANG, Zhiqiang CHEN, Jianmin LI, Yinong LIU
  • Publication number: 20190016774
    Abstract: The invention provides combinatorial peptide or polypeptide libraries that can become membrane tethered once expressed in cells. The invention additionally provides methods for selecting peptide modulators (e.g., agonists) of GPCRs from the combinatorial libraries of the invention. The invention also provides novel GPCR polypeptide modulators, e.g., biased polypeptide agonists of the glucagon-like peptide 1 receptor (GLP-1R). The invention further provides methods of promoting insulin sensitivity, lowering blood glucose, and reducing body weight as well as methods for treating various diseases such as diabetes and obesity.
    Type: Application
    Filed: April 1, 2016
    Publication date: January 17, 2019
    Inventors: Richard A. LERNER, Hongkai ZHANG, Patricia MC DONALD, Jia XIE, Emmanuel STURCHLER
  • Publication number: 20180119133
    Abstract: The invention provides methods for identifying binding partners (e.g., peptide ligands) that binds to a target protein (e.g., a cellular receptor). The methods entail co-localized expression of the target protein and candidate binding partners, and selection of binding partners based on their proximity in the plasma membrane.
    Type: Application
    Filed: October 16, 2015
    Publication date: May 3, 2018
    Inventors: Richard A. Lerner, Hongkai Zhang, Jia Xie
  • Publication number: 20180009682
    Abstract: A hydrogen-enriched water generator and dispenser includes a main casing, a hydrogen water generator supported in the main casing, and a water tank. The hydrogen water generator includes a magnetic field generator and an electrode arrangement supported in the main casing. The water tank is adapted for storing a predetermined amount of regular water. The magnetic field generator is arranged to deliver electromagnetic wave having ultra-long wavelength to the regular water stored in the water tank upon electrolyzing and ionizing by the electrode arrangement, so that the regular water is electrolyzed and ionized to contain a predetermined amount of hydrogen ions for direct consumption.
    Type: Application
    Filed: July 5, 2017
    Publication date: January 11, 2018
    Inventor: Hongkai ZHANG
  • Publication number: 20180002425
    Abstract: The invention provides methods for identifying protein modulators (e.g., antibody agonists) of eukaryotic cells. The methods typically involve expressing a combinatorial agent library (e.g., via lentiviral vectors) inside a eukaryotic cell type (e.g., a mammalian cell) and then directly selecting for agents (e.g., antibodies) that are agonist of a target molecule (e.g., a signaling receptor) that modulates a phenotype of or elicits a cellular response in the cell. Some related methods involve co-culturing a cell expressing a combinatorial agent library and a second cell, and then selecting agents that modulate a phenotype of or elicit a cellular response in the second cell. Preferably, the agents are antibodies and are introduced into and expressed in the starting cells under conditions each individual cell expresses no more than 3 different members of the antibody library.
    Type: Application
    Filed: August 8, 2017
    Publication date: January 4, 2018
    Inventors: Hongkai Zhang, Ian A. Wilson, Richard A. Lerner
  • Patent number: 9783765
    Abstract: A natural biotech washing agent for the environment, which is truly natural and environment friendly, for removing oil stains and dirt on a clothing object and degrading the oil and dirt at the same time without using any powered tools, comprising a composition by percentage weight containing 0.5% marine alkaloids, 6.5-9.5% surfactant and 2.5-3.5% enzymes as active ingredients. The biotech washing agent is truly meant for the environment in that the composition is natural, the cleaning process is natural and energy-saving, the cleaning effect is great, the end products after cleaning is natural and cause no harm to the environment, and no powered tools is required to achieve the cleaning effect. In addition, the wastewater after the washing process of the present invention can continue to provide a cleaning effect to the sewage and the wastewater.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: October 10, 2017
    Inventor: Hongkai Zhang
  • Patent number: 9738719
    Abstract: Methods for Identifying protein modulators of eukaryotic cells by expressing a combinatorial library of potential agonists inside a eukaryotic cell and then directly selecting for an agonist of a target molecule. Some methods involve co-culturing a cell expressing a combinatorial library of potential agonists and a second cell, and then selecting agents that modulate a phenotype of or a desired cellular response in the second cell. Preferably, the agonists are antibodies introduced into and expressed in the starting cells, such as agonist anti-EpoR, anti-TpoR, or G-CSFR antibodies. Also disclosed are methods for selecting from combinatorial antibody libraries bispecific antibodies that can regulate cell phenotypes.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: August 22, 2017
    Assignee: The Scripps Research Institute
    Inventors: Hongkai Zhang, Ian A. Wilson, Richard A. Lerner
  • Patent number: 9480640
    Abstract: A nano freeze dry process of preparation for a cosmetic composition having a bioactive agent for providing an anti-aging effect on a skin, comprising the steps of: placing the cosmetic composition having a bioactive agent into a capsule container; and nano freeze drying the cosmetic composition by: freezing the cosmetic composition in the capsule container at ?170° C.; increasing the temperature to ?85° C. and allowing sublimation under vacuum condition; then increasing the temperature to 35° C.; and vacuum drying to obtain a final product, wherein a volume of the cosmetic composition remains unchanged after the process, a water content of less than 5% is inside the final, at least 80% of bioactivity of the cosmetic composition is retained, and significant anti-aging effect is observed after a two-day treatment.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: November 1, 2016
    Inventor: Hongkai Zhang
  • Publication number: 20160081911
    Abstract: A nano freeze dry process of preparation for a cosmetic composition having a bioactive agent for providing an anti-aging effect on a skin, comprising the steps of: placing the cosmetic composition having a bioactive agent into a capsule container; and nano freeze drying the cosmetic composition by: freezing the cosmetic composition in the capsule container at ?170° C.; increasing the temperature to ?85° C. and allowing sublimation under vacuum condition; then increasing the temperature to 35° C.; and vacuum drying to obtain a final product, wherein a volume of the cosmetic composition remains unchanged after the process, a water content of less than 5% is inside the final, at least 80% of bioactivity of the cosmetic composition is retained, and significant anti-aging effect is observed after a two-day treatment.
    Type: Application
    Filed: September 24, 2014
    Publication date: March 24, 2016
    Inventor: Hongkai ZHANG
  • Publication number: 20160046893
    Abstract: A natural biotech washing agent for the environment, which is truly natural and environment friendly, for removing oil stains and dirt on a clothing object and degrading the oil and dirt at the same time without using any powered tools, comprising a composition by percentage weight containing 0.5% marine alkaloids, 6.5-9.5% surfactant and 2.5-3.5% enzymes as active ingredients. The biotech washing agent is truly meant for the environment in that the composition is natural, the cleaning process is natural and energy-saving, the cleaning effect is great, the end products after cleaning is natural and cause no harm to the environment, and no powered tools is required to achieve the cleaning effect. In addition, the wastewater after the washing process of the present invention can continue to provide a cleaning effect to the sewage and the wastewater.
    Type: Application
    Filed: August 18, 2014
    Publication date: February 18, 2016
    Inventor: Hongkai ZHANG
  • Publication number: 20150316561
    Abstract: Methods for Identifying protein modulators of eukaryotic cells by expressing a combinatorial library of potential agonists inside a eukaryotic cell and then directly selecting for an agonist of a target molecule. Some methods involve co-culturing a cell expressing a combinatorial library of potential agonists and a second cell, and then selecting agents that modulate a phenotype of or a desired cellular response in the second cell. Preferably, the agonists are antibodies introduced into and expressed in the starting cells, such as agonist anti-EpoR, anti-TpoR, or G-CSFR antibodies. Also disclosed are methods for selecting from combinatorial antibody libraries bispecific antibodies that can regulate cell phenotypes.
    Type: Application
    Filed: August 16, 2013
    Publication date: November 5, 2015
    Inventors: Hongkai Zhang, Ian A. Wilson, Richard A. Lerner