Patents by Inventor Hongkai Zhang
Hongkai Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230348891Abstract: Provided is a droplet-based microfluidics platform for functional screening of interacting molecules. The platform is particularly useful for high throughput screening of interacting proteins, such as antibodies or engineered cytokines, which trigger a detectable downstream signaling event.Type: ApplicationFiled: August 20, 2021Publication date: November 2, 2023Inventors: Liang Schweizer, Bingqing Shen, Hongkai Zhang, Yuan Wang, Ruina Jin, Mengshi Huang
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Publication number: 20230061604Abstract: Provided are an anti-OX40 antibody, a composition including the anti-OX40 antibody, a nucleic acid encoding the anti-OX40 antibody, a method for preparing the anti-OX40 antibody, and a use of the anti-OX40 antibody.Type: ApplicationFiled: December 28, 2020Publication date: March 2, 2023Inventors: Hongkai Zhang, Yuan Wang, Yun-Yueh Lu, Yuqiang Shen, Nicola Arturo Aldo Beltraminelli, Liang Schweizer, Francisco Adrian, Klaus Andreas Raue, Qian Zhang, Jinping Gan
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Publication number: 20220324988Abstract: The present invention relates to novel antibodies and antibody fragments that specifically bind to CD40, and compositions, medicaments, combination products and kits comprising the antibodies or antibody fragments. Furthermore, the invention relates to nucleic acids encoding said antibodies or antibody fragments thereof and host cells comprising the same, as well as related uses. Furthermore, the invention relates to therapeutic and diagnostic uses of these antibodies and antibody fragments.Type: ApplicationFiled: April 10, 2020Publication date: October 13, 2022Inventors: Hongkai ZHANG, Yuan WANG
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Patent number: 11434318Abstract: The present invention relates to organic polymer synthetic materials, and discloses a self-curing organic synthetic resin composition for additive manufacturing. The self-curing organic synthetic resin composition includes 30-75% by weight of a linear thermoplastic phenolic resin and 25-70% by weight of a phenol modified furan resin. The self-curing organic synthetic resin composition is prepared through three stages. The linear thermoplastic phenolic resin prepared in stage (1) and the phenol modified furan resin prepared in stage (2) are mixed in a certain weight ratio in stage (3) to obtain the self-curing organic synthetic resin composition for additive manufacturing, which has the advantages of high strength at normal temperature, excellent resistance to high temperature, high activity and excellent collapsibility. Thus, the self-curing organic synthetic resin composition provided in the invention is suitable for additive manufacturing, and particularly for 3D printing in mold casting.Type: GrantFiled: January 14, 2020Date of Patent: September 6, 2022Assignee: KOCEL INTELLIGENT MACHINERY LIMITEDInventors: Jinlong Xing, Fan Peng, Hongkai Zhang, Wen Ma, Wen Han
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Patent number: 10745456Abstract: The invention provides combinatorial peptide or polypeptide libraries that can become membrane tethered once expressed in cells. The invention additionally provides methods for selecting peptide modulators (e.g., agonists) of GPCRs from the combinatorial libraries of the invention. The invention also provides novel GPCR polypeptide modulators, e.g., biased polypeptide agonists of the glucagon-like peptide 1 receptor (GLP-1R). The invention further provides methods of promoting insulin sensitivity, lowering blood glucose, and reducing body weight as well as methods for treating various diseases such as diabetes and obesity.Type: GrantFiled: April 1, 2016Date of Patent: August 18, 2020Assignee: The Scripps Research InstituteInventors: Richard A. Lerner, Hongkai Zhang, Patricia McDonald, Jia Xie, Emmanuel Sturchler, Philip Dawson
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Publication number: 20200231732Abstract: The present invention relates to organic polymer synthetic materials, and discloses a self-curing organic synthetic resin composition for additive manufacturing. The self-curing organic synthetic resin composition includes 30-75% by weight of a linear thermoplastic phenolic resin and 25-70% by weight of a phenol modified furan resin. The self-curing organic synthetic resin composition is prepared through three stages. The linear thermoplastic phenolic resin prepared in stage (1) and the phenol modified furan resin prepared in stage (2) are mixed in a certain weight ratio in stage (3) to obtain the self-curing organic synthetic resin composition for additive manufacturing, which has the advantages of high strength at normal temperature, excellent resistance to high temperature, high activity and excellent collapsibility. Thus, the self-curing organic synthetic resin composition provided in the invention is suitable for additive manufacturing, and particularly for 3D printing in mold casting.Type: ApplicationFiled: January 14, 2020Publication date: July 23, 2020Inventors: Jinlong XING, Fan PENG, Hongkai ZHANG, Wen MA, Wen HAN
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Publication number: 20200190151Abstract: The invention provides variant venom peptides and polypeptides that specifically block potassium voltage gated ion channel Kv1.3. The invention also provides methods of inhibiting Kv1.3 channel activity, methods for treating disorders that are associated with undesired or aberrant Kv1.3 channel activity, methods for detecting Kv1.3 expression in target cells such as lymphocytes, and methods for diagnosing diseases or disorders that are associated with aberrant Kv1.3 overexpression.Type: ApplicationFiled: May 11, 2017Publication date: June 18, 2020Inventors: Richard A. Lerner, Hongkai Zhang
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Patent number: 10655124Abstract: The invention provides methods for identifying binding partners (e.g., peptide ligands) that binds to a target protein (e.g., a cellular receptor). The methods entail co-localized expression of the target protein and candidate binding partners, and selection of binding partners based on their proximity in the plasma membrane.Type: GrantFiled: October 16, 2015Date of Patent: May 19, 2020Assignee: The Scripps Research InstituteInventors: Richard A. Lerner, Hongkai Zhang, Jia Xie
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Patent number: 10570031Abstract: A hydrogen-enriched water generator and dispenser includes a main casing, a hydrogen water generator supported in the main casing, and a water tank. The hydrogen water generator includes a magnetic field generator and an electrode arrangement supported in the main casing. The water tank is adapted for storing a predetermined amount of regular water. The magnetic field generator is arranged to deliver electromagnetic wave having ultra-long wavelength to the regular water stored in the water tank upon electrolyzing and ionizing by the electrode arrangement, so that the regular water is electrolyzed and ionized to contain a predetermined amount of hydrogen ions for direct consumption.Type: GrantFiled: July 5, 2017Date of Patent: February 25, 2020Inventor: Hongkai Zhang
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Patent number: 10494438Abstract: The invention provides methods for identifying protein modulators (e.g., antibody agonists) of eukaryotic cells. The methods typically involve expressing a combinatorial agent library (e.g., via lentiviral vectors) inside a eukaryotic cell type (e.g., a mammalian cell) and then directly selecting for agents (e.g., antibodies) that are agonist of a target molecule (e.g., a signaling receptor) that modulates a phenotype of or elicits a cellular response in the cell. Some related methods involve co-culturing a cell expressing a combinatorial agent library and a second cell, and then selecting agents that modulate a phenotype of or elicit a cellular response in the second cell. Preferably, the agents are antibodies and are introduced into and expressed in the starting cells under conditions each individual cell expresses no more than 3 different members of the antibody library.Type: GrantFiled: August 8, 2017Date of Patent: December 3, 2019Assignee: The Scripps Research InstituteInventors: Hongkai Zhang, Ian A. Wilson, Richard A. Lerner
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Publication number: 20190016774Abstract: The invention provides combinatorial peptide or polypeptide libraries that can become membrane tethered once expressed in cells. The invention additionally provides methods for selecting peptide modulators (e.g., agonists) of GPCRs from the combinatorial libraries of the invention. The invention also provides novel GPCR polypeptide modulators, e.g., biased polypeptide agonists of the glucagon-like peptide 1 receptor (GLP-1R). The invention further provides methods of promoting insulin sensitivity, lowering blood glucose, and reducing body weight as well as methods for treating various diseases such as diabetes and obesity.Type: ApplicationFiled: April 1, 2016Publication date: January 17, 2019Inventors: Richard A. LERNER, Hongkai ZHANG, Patricia MC DONALD, Jia XIE, Emmanuel STURCHLER
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Publication number: 20180119133Abstract: The invention provides methods for identifying binding partners (e.g., peptide ligands) that binds to a target protein (e.g., a cellular receptor). The methods entail co-localized expression of the target protein and candidate binding partners, and selection of binding partners based on their proximity in the plasma membrane.Type: ApplicationFiled: October 16, 2015Publication date: May 3, 2018Inventors: Richard A. Lerner, Hongkai Zhang, Jia Xie
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Publication number: 20180009682Abstract: A hydrogen-enriched water generator and dispenser includes a main casing, a hydrogen water generator supported in the main casing, and a water tank. The hydrogen water generator includes a magnetic field generator and an electrode arrangement supported in the main casing. The water tank is adapted for storing a predetermined amount of regular water. The magnetic field generator is arranged to deliver electromagnetic wave having ultra-long wavelength to the regular water stored in the water tank upon electrolyzing and ionizing by the electrode arrangement, so that the regular water is electrolyzed and ionized to contain a predetermined amount of hydrogen ions for direct consumption.Type: ApplicationFiled: July 5, 2017Publication date: January 11, 2018Inventor: Hongkai ZHANG
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Publication number: 20180002425Abstract: The invention provides methods for identifying protein modulators (e.g., antibody agonists) of eukaryotic cells. The methods typically involve expressing a combinatorial agent library (e.g., via lentiviral vectors) inside a eukaryotic cell type (e.g., a mammalian cell) and then directly selecting for agents (e.g., antibodies) that are agonist of a target molecule (e.g., a signaling receptor) that modulates a phenotype of or elicits a cellular response in the cell. Some related methods involve co-culturing a cell expressing a combinatorial agent library and a second cell, and then selecting agents that modulate a phenotype of or elicit a cellular response in the second cell. Preferably, the agents are antibodies and are introduced into and expressed in the starting cells under conditions each individual cell expresses no more than 3 different members of the antibody library.Type: ApplicationFiled: August 8, 2017Publication date: January 4, 2018Inventors: Hongkai Zhang, Ian A. Wilson, Richard A. Lerner
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Patent number: 9783765Abstract: A natural biotech washing agent for the environment, which is truly natural and environment friendly, for removing oil stains and dirt on a clothing object and degrading the oil and dirt at the same time without using any powered tools, comprising a composition by percentage weight containing 0.5% marine alkaloids, 6.5-9.5% surfactant and 2.5-3.5% enzymes as active ingredients. The biotech washing agent is truly meant for the environment in that the composition is natural, the cleaning process is natural and energy-saving, the cleaning effect is great, the end products after cleaning is natural and cause no harm to the environment, and no powered tools is required to achieve the cleaning effect. In addition, the wastewater after the washing process of the present invention can continue to provide a cleaning effect to the sewage and the wastewater.Type: GrantFiled: August 18, 2014Date of Patent: October 10, 2017Inventor: Hongkai Zhang
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Patent number: 9738719Abstract: Methods for Identifying protein modulators of eukaryotic cells by expressing a combinatorial library of potential agonists inside a eukaryotic cell and then directly selecting for an agonist of a target molecule. Some methods involve co-culturing a cell expressing a combinatorial library of potential agonists and a second cell, and then selecting agents that modulate a phenotype of or a desired cellular response in the second cell. Preferably, the agonists are antibodies introduced into and expressed in the starting cells, such as agonist anti-EpoR, anti-TpoR, or G-CSFR antibodies. Also disclosed are methods for selecting from combinatorial antibody libraries bispecific antibodies that can regulate cell phenotypes.Type: GrantFiled: August 16, 2013Date of Patent: August 22, 2017Assignee: The Scripps Research InstituteInventors: Hongkai Zhang, Ian A. Wilson, Richard A. Lerner
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Patent number: 9480640Abstract: A nano freeze dry process of preparation for a cosmetic composition having a bioactive agent for providing an anti-aging effect on a skin, comprising the steps of: placing the cosmetic composition having a bioactive agent into a capsule container; and nano freeze drying the cosmetic composition by: freezing the cosmetic composition in the capsule container at ?170° C.; increasing the temperature to ?85° C. and allowing sublimation under vacuum condition; then increasing the temperature to 35° C.; and vacuum drying to obtain a final product, wherein a volume of the cosmetic composition remains unchanged after the process, a water content of less than 5% is inside the final, at least 80% of bioactivity of the cosmetic composition is retained, and significant anti-aging effect is observed after a two-day treatment.Type: GrantFiled: September 24, 2014Date of Patent: November 1, 2016Inventor: Hongkai Zhang
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Publication number: 20160081911Abstract: A nano freeze dry process of preparation for a cosmetic composition having a bioactive agent for providing an anti-aging effect on a skin, comprising the steps of: placing the cosmetic composition having a bioactive agent into a capsule container; and nano freeze drying the cosmetic composition by: freezing the cosmetic composition in the capsule container at ?170° C.; increasing the temperature to ?85° C. and allowing sublimation under vacuum condition; then increasing the temperature to 35° C.; and vacuum drying to obtain a final product, wherein a volume of the cosmetic composition remains unchanged after the process, a water content of less than 5% is inside the final, at least 80% of bioactivity of the cosmetic composition is retained, and significant anti-aging effect is observed after a two-day treatment.Type: ApplicationFiled: September 24, 2014Publication date: March 24, 2016Inventor: Hongkai ZHANG
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Publication number: 20160046893Abstract: A natural biotech washing agent for the environment, which is truly natural and environment friendly, for removing oil stains and dirt on a clothing object and degrading the oil and dirt at the same time without using any powered tools, comprising a composition by percentage weight containing 0.5% marine alkaloids, 6.5-9.5% surfactant and 2.5-3.5% enzymes as active ingredients. The biotech washing agent is truly meant for the environment in that the composition is natural, the cleaning process is natural and energy-saving, the cleaning effect is great, the end products after cleaning is natural and cause no harm to the environment, and no powered tools is required to achieve the cleaning effect. In addition, the wastewater after the washing process of the present invention can continue to provide a cleaning effect to the sewage and the wastewater.Type: ApplicationFiled: August 18, 2014Publication date: February 18, 2016Inventor: Hongkai ZHANG
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Publication number: 20150316561Abstract: Methods for Identifying protein modulators of eukaryotic cells by expressing a combinatorial library of potential agonists inside a eukaryotic cell and then directly selecting for an agonist of a target molecule. Some methods involve co-culturing a cell expressing a combinatorial library of potential agonists and a second cell, and then selecting agents that modulate a phenotype of or a desired cellular response in the second cell. Preferably, the agonists are antibodies introduced into and expressed in the starting cells, such as agonist anti-EpoR, anti-TpoR, or G-CSFR antibodies. Also disclosed are methods for selecting from combinatorial antibody libraries bispecific antibodies that can regulate cell phenotypes.Type: ApplicationFiled: August 16, 2013Publication date: November 5, 2015Inventors: Hongkai Zhang, Ian A. Wilson, Richard A. Lerner