Patents by Inventor Hongliang Chen
Hongliang Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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USE OF SU3327 IN PREPARATION OF MEDICAMENT FOR REDUCING CYTOTOXICITY AND NEPHROTOXICITY OF POLYMYXIN
Publication number: 20250205208Abstract: Use of a C-JUN N-terminal kinase inhibitor, SU3327, in the preparation of a medicament for reducing cytotoxicity and nephrotoxicity of polymyxin, wherein the polymyxin is preferably Polymyxin E. A treatment with a combination of SU3327 and Polymyxin E can significantly inhibit cytotoxicity and nephrotoxicity of Polymyxin E.Type: ApplicationFiled: January 22, 2024Publication date: June 26, 2025Applicants: XIAMEN HANLIXIN PHARMACEUTICAL CO., LTD., CHINA AGRICULTURAL UNIVERSITYInventors: Chongshan DAI, Hongliang CHEN, Congming WU, Hailing ZHENG, Jianzhong SHEN -
Publication number: 20250170106Abstract: The present invention provides use of a C-JUN N-terminal kinase inhibitor, SU3327, in the preparation of a medicament for enhancing the efficacy of polymyxin against bacterial infection, and use of a composition of SU3327 and polymyxin in the preparation of a medicament for an enhanced efficacy against bacterial infection, wherein the polymyxin is preferably Polymyxin E. The invention not only shows an enhanced antibacterial activity of polymyxin by SU3327 in synergy through minimum inhibitory concentration tests in checkerboard assays and in vitro bacterial growth curves, but also confirms the ability of SU3327 to enhance polymyxin along with its effectiveness in vivo in the experiments with a model of mice infected with drug resistant bacteria at the animal level. The invention provides a new use of SU3327 in enhancing antibacterial activities of polymyxin antibiotics, resolving the technical problems such as clinical resistance to polymyxin, low clinical therapeutic index of polymyxin, etc.Type: ApplicationFiled: September 19, 2023Publication date: May 29, 2025Applicants: XIAMEN HANLIXIN PHARMACEUTICAL CO., LTD., CHINA AGRICULTURAL UNIVERSITYInventors: Jianzhong SHEN, Chongshan DAI, Hongliang CHEN, Congming WU, Zhangqi SHEN, Yang WANG
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Patent number: 12077630Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant and at least one catalyst, at least one acetoacetate ester or amide and at least one aminoalcohol or alkylhydroxylamine. Foams so produced emit low levels of formaldehyde, acetaldehyde and propionaldehyde.Type: GrantFiled: August 2, 2018Date of Patent: September 3, 2024Assignee: Dow Global Technologies LLCInventors: Zhengming Tang, Hongliang Chen, Jian Zou, Shaoguang Feng, Steven Zhang, Degang Zhang, Ping Zhang
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Patent number: 11923690Abstract: A wireless charging apparatus for a wireless power transmission system and a method are provided. The apparatus includes a voltage conversion circuit, an excitation coil, n first resonance coils, and a controller, where n is greater than or equal to 3. The voltage conversion circuit is connected to the excitation coil and converts a power grid voltage into a high-frequency alternating current voltage. The excitation coil generates a magnetic field based on the high-frequency alternating current voltage. The n first resonance coils are arranged in different directions and conducts the magnetic field, and the controller monitors power statuses of the first resonance coils, and enable or disable the first resonance coils based on the power statuses.Type: GrantFiled: November 18, 2020Date of Patent: March 5, 2024Assignee: Huawei Technologies Co., Ltd.Inventors: Hongliang Chen, Wei Chen, Changsheng Pei, Yongfa Zhu
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Patent number: 11820855Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant and at least one catalyst, at least one cyclic 1,3-diketone and at least one aminoalcohol or alkylhydroxylamine. Foams so produced emit low levels of formaldehyde, acetaldehyde and propionaldehyde.Type: GrantFiled: August 2, 2018Date of Patent: November 21, 2023Inventors: Hongliang Chen, Zhengming Tang, Jian Zou, Shaoguang Feng, Degang Zhang, Ping Zhang
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Patent number: 11603428Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant and at least one catalyst, a polyethyleneamine mixture having a number average molecular weight of 175 to 450 and an alkali metal, phosphonium or ammonium sulfite. Foams so produced emit low levels of formaldehyde, acetaldehyde, acrolein and propionaldehyde.Type: GrantFiled: August 2, 2018Date of Patent: March 14, 2023Assignee: Dow Global Technologies LLCInventors: Zhengming Tang, Jian Zou, Shaoguang Feng, Yuji Sasaki, Hongliang Chen, Haiying Li, Degang Zhang, Ping Zhang
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Patent number: 11545640Abstract: Disclosed are a series of photoisomeric compounds, preparation method therefor and device comprising the compounds, wherein a photoisomeric compound-graphene molecular junction device is formed by linking the photoisomeric compound to a gap of two-dimensional monolayer graphene having a nano-gap array via an amide covalent bond. When a single photoisomeric compound is bridged to the gap of the two-dimensional monolayer graphene having a nano-gap array, the devices have a reversible light-controlled switching function and a reversible electrically-controlled switching function. A molecular switch device prepared by the method can achieve a high reversibility and a good reproducibility. The number of light-controlled switching cycles can exceed 104, and the number of electrically-controlled switching cycles can reach about 105 or greater. Moreover, the above-mentioned reversible molecular switch device remains stable within a period of more than one year.Type: GrantFiled: January 27, 2021Date of Patent: January 3, 2023Assignee: PEKING UNIVERSITYInventors: Xuefeng Guo, Chuancheng Jia, Na Xin, Hongliang Chen, Mingliang Li, Dahui Qu
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Patent number: 11479650Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant and at least one catalyst, at least one cyclic 1,3-diketone compound, at least one aminoalcohol or alkylhydroxylamine and an alkali metal, phosphonium or ammonium sulfite. Foams so produced emit low levels of formaldehyde, acetaldehyde, acrolein and propionaldehyde.Type: GrantFiled: August 2, 2018Date of Patent: October 25, 2022Assignee: Dow Global Technologies LLCInventors: Zhengming Tang, Jian Zou, Shaoguang Feng, Yuji Sasaki, Hongliang Chen, Degang Zhang, Ping Zhang
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Patent number: 11453742Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant, at least one catalyst, and certain aldehyde-suppressing additives. Foams so produced emit low levels of formaldehyde, acetaldehyde and propionaldehyde.Type: GrantFiled: August 2, 2018Date of Patent: September 27, 2022Assignee: Dow Global Technologies LLCInventors: Zhengming Tang, Hongliang Chen, Jian Zou, Shaoguang Feng, Degang Zhang, Ping Zhang
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Publication number: 20210309789Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant, at least one catalyst, and certain aldehyde-suppressing additives. Foams so produced emit low levels of formaldehyde, acetaldehyde and propionaldehyde.Type: ApplicationFiled: August 2, 2018Publication date: October 7, 2021Inventors: Zhengming Tang, Hongliang Chen, Jian Zou, Shaoguang Feng, Degang Zhang, Ping Zhang
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Publication number: 20210301065Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant and at least one catalyst, a polyethyleneamine mixture having a number average molecular weight of 175 to 450 and an alkali metal, phosphonium or ammonium sulfite. Foams so produced emit low levels of formaldehyde, acetaldehyde, acrolein and propionaldehyde.Type: ApplicationFiled: August 2, 2018Publication date: September 30, 2021Inventors: Zhengming Tang, Jian Zou, Shaoguang Feng, Yuji Sasaki, Hongliang Chen, Haiying Li, Degang Zhang, Ping Zhang
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Publication number: 20210292508Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant and at least one catalyst, at least one cyclic 1,3-diketone compound, at least one aminoalcohol or alkylhydroxylamine and an alkali metal, phosphonium or ammonium sulfite. Foams so produced emit low levels of formaldehyde, acetaldehyde, acrolein and propionaldehyde.Type: ApplicationFiled: August 2, 2018Publication date: September 23, 2021Inventors: Zhengming Tang, Jian Zou, Shaoguang Feng, Yuji Sasaki, Hongliang Chen, Degang Zhang, Ping Zhang
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Publication number: 20210234109Abstract: Disclosed are a series of photoisomeric compounds, preparation method therefor and device comprising the compounds, wherein a photoisomeric compound-graphene molecular junction device is formed by linking the photoisomeric compound to a gap of two-dimensional monolayer graphene having a nano-gap array via an amide covalent bond. When a single photoisomeric compound is bridged to the gap of the two-dimensional monolayer graphene having a nano-gap array, the devices have a reversible light-controlled switching function and a reversible electrically-controlled switching function. A molecular switch device prepared by the method can achieve a high reversibility and a good reproducibility. The number of light-controlled switching cycles can exceed 104, and the number of electrically-controlled switching cycles can reach about 105 or greater. Moreover, the above-mentioned reversible molecular switch device remains stable within a period of more than one year.Type: ApplicationFiled: January 27, 2021Publication date: July 29, 2021Inventors: Xuefeng GUO, Chuancheng JIA, Na XIN, Hongliang CHEN, Mingliang LI, Dahui QU
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Publication number: 20210189054Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant and at least one catalyst, at least one cyclic 1,3-diketone and at least one aminoalcohol or alkylhydroxylamine. Foams so produced emit low levels of formaldehyde, acetaldehyde and propionaldehyde.Type: ApplicationFiled: August 2, 2018Publication date: June 24, 2021Inventors: Hongliang Chen, Zhengming Tang, Jian Zou, Shaoguang Feng, Degang Zhang, Ping Zhang
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Publication number: 20210163670Abstract: Polyurethane foams are made by curing a reaction mixture that contains an aromatic polyisocyanate, at least one isocyanate-reactive material having an average functionality of at least 2 and an equivalent weight of at least 200 per isocyanate-reactive group, at least one blowing agent, at least one surfactant and at least one catalyst, at least one acetoacetate ester or amide and at least one aminoalcohol or alkylhydroxylamine. Foams so produced emit low levels of formaldehyde, acetaldehyde and propionaldehyde.Type: ApplicationFiled: August 2, 2018Publication date: June 3, 2021Inventors: Zhengming TANG, Hongliang Chen, Jian Zou, Shaoguang Feng, Steven Zhang, Degang Zhang, Ping Zhang
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Publication number: 20210075261Abstract: A wireless charging apparatus for a wireless power transmission system. The apparatus includes a voltage conversion circuit, an excitation coil, n first resonance coils, and a controller, where n is greater than or equal to 3. The voltage conversion circuit is connected to the excitation coil and converts a power grid voltage into a high-frequency alternating current voltage. The excitation coil generates a magnetic field based on the high-frequency alternating current voltage. The n first resonance coils are arranged in different directions and conducts the magnetic field, and the controller monitors power statuses of the first resonance coils, and enable or disable the first resonance coils based on the power statuses.Type: ApplicationFiled: November 18, 2020Publication date: March 11, 2021Inventors: Hongliang CHEN, Wei CHEN, Changsheng PEI, Yongfa ZHU
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Publication number: 20200212328Abstract: Disclosed are a series of photoisomeric compounds, preparation method therefor and device comprising the compounds. A photoisomeric compound-grephene molecular junction device is formed by linking the photoisomeric compound to a gap of two-dimensional monolayer graphene having a nano-gap array via an amide covalent bond. When a single photoisomeric compound is bridged to the gap of the two-dimensional monolayer graphene having a nano-gap array, the devices have a reversible light-controlled switching function and a reversible electrically-controlled switching function. A molecular switch device prepared by the method can achieve high reversibility and good reproducibility. The number of light-controlled switching cycles can exceed 104, and the number of electrically-controlled switching cycles can reach about 105 or greater. The reversible molecular switch device remains stable within a period of more than one year.Type: ApplicationFiled: May 24, 2017Publication date: July 2, 2020Inventors: Xuefeng GUO, Chuancheng JIA, Na XIN, Hongliang CHEN, Mingliang LI, Dahui QU
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Publication number: 20190258609Abstract: A method for avoiding file deadlock during concurrent access of a sqlite database is disclosed, wherein, in a software design stage, divide the client sqlite database from one into two or more, and each sqlite database is corresponding to the requirement of a certain type of writing operation of the software system. Respectively classify all the data tables used in the software according to the different types of writing operation and place them in different sqlite database files. This could ensure that different types of writing operations are respectively corresponding to different files, and when multiple threads of the application software generate writing operations at the same time, since they respectively write into different physical disk files, so as to avoid the problem that one sqlite database file cannot be concurrently written by multiple threads at the same time.Type: ApplicationFiled: May 7, 2019Publication date: August 22, 2019Inventors: Jinyuan Zou, Hongliang Chen
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Patent number: D849601Type: GrantFiled: October 6, 2017Date of Patent: May 28, 2019Assignee: Zhejiang Doohan Technology Co., Ltd.Inventors: Guande Li, Hongliang Chen
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Patent number: D866674Type: GrantFiled: April 2, 2018Date of Patent: November 12, 2019Assignee: Guangzhou Ekai Electronic Technology Co., Ltd.Inventors: Guande Li, Hongliang Chen