Abstract: A donor construct and a gene knockout method, as well as a system and kit for the gene knockout are provided. The donor construct is a linear donor DNA or can be cleaved in a cell to produce the linear donor DNA. The gene knockout method uses a marker gene contained in the donor construct to enrich cells in which a gene is knocked out, thereby improving the efficiency of generating the gene knockout by a sequence-specific nuclease.

Abstract: An electro-optic modulator is disposed on a surface of a substrate including: an optical waveguide layer disposed on the substrate, a modulation electrode disposed on the optical waveguide layer, and a metal electrode disposed on the modulation electrode and electrically connected to the modulation electrode. A first end of the metal electrode is coupled to a radio frequency driver, and receives a modulation signal input by the radio frequency driver. The modulation electrode is configured to perform electro-optic modulation on the optical waveguide layer based on the modulation signal. A second end of the metal electrode is coupled to a direct-current voltage end, and the direct-current voltage end is configured to input a voltage signal and provide a bias voltage for the radio frequency driver by using the metal electrode. This reduces costs and a size of the electro-optic modulator, and is conducive to device miniaturization.

Abstract: Provided is a method of inhibiting viral replication, including contacting one or more cells that has been infected or contacted with a flavivirus with an effective amount of niclosamide, temoporfin, nitazoxanide, tizoxanide, erythrosin B, methylene blue. Contacting one or more cells that have been infected with a flavivirus may include administering the compound to a mammal, a human, or other subject. The flavivirus may be Dengue virus serotype 1, Dengue virus serotype 2, Dengue virus serotype 3, Dengue virus serotype 4, yellow fever virus, West Nile virus, Zika virus, Japanese encephalitis virus, tick-born encephalitis virus, Powassan virus, St. Louis encephalitis virus, or other flavivirus.

Abstract: A target detection method and apparatus are provided. A first image of a target scenario collected by an image sensor is analyzed to obtain one or more first 2D detection boxes of the target scenario, and a three-dimensional point cloud of the target scenario collected by a laser sensor is analyzed to obtain one or more second 2D detection boxes of the target scenario in one or more views (for example, a BEV and/or a PV). Then, comprehensive analysis is performed on a matching degree and confidence of the one or more first 2D detection boxes, and a matching degree and confidence of the one or more second 2D detection boxes, to obtain a 2D detection box of a target. Finally, a 3D model of the target is obtained based on a three-dimensional point corresponding to the 2D detection box of the target.

Abstract: Systems and methods are described to perform wireless communication. The device includes a pre-distortion circuit configured to pre-distort an input signal based on a parameter set including a plurality of coefficients and generate a pre-distorted signal, a power amplifier configured to amplify the pre-distorted signal and generate an output signal, and a parameter obtaining circuit configured to perform an iterative approximation operation based on the output signal and the pre-distorted signal, which change over time, according to an indirect training structure configured to minimize a difference between an intermediate signal obtained based on the output signal and the pre-distorted signal, and obtain the parameter set.

Abstract: A method is provided. The method includes estimating adjacent channel leakage ratios respectively corresponding based on a test output signal output from a power amplifier according to a test input signal corresponding to a plurality of frequencies; selecting a test delay value corresponding to a largest value among the estimated adjacent channel leakage ratios; and providing a supply voltage to the power amplifier based on an envelope signal delayed according to the selected test delay value. For each of the plurality of test delay values, a corresponding adjacent channel leakage ratio is estimated based on a ratio of a magnitude of a component included in the test output signal and a magnitude of an inter-modulated component.

Abstract: A display substrate includes a base substrate and a plurality of insulating layers disposed on a surface of the base substrate. A groove is defined in the insulating layers in a non-display area of the display substrate. An end portion of an alignment layer is disposed in the groove. The groove is capable of controlling a flow of a liquid alignment material to prevent the liquid alignment material from overflowing to an edge of the base substrate. The groove is formed simultaneously in a process of forming contact holes in a display area of the display substrate. Accordingly, a structure corresponding to the end portion of the alignment layer to control the flow of the liquid alignment material is formed without increasing the number of masks.

Abstract: The light emitting assembly includes a substrate (1), a laser light source array, and a lens array. The laser light source array is disposed on the substrate (1), the lens array is disposed on a light emitting side of the laser light source array, one lens (3) in the lens array is disposed opposite to at least one laser light source (2) in the laser light source array, a light emitting surface of the lens (3) is a spherical surface, and at least some laser light sources (2) are eccentrically arranged with corresponding lenses (3). In a manufacturing process, lenses (3) of a same structure and laser light sources (2) of a same structure are used, and eccentric distances between the laser light sources (2) and the lenses (3) are changed, so that light emitting assemblies with different divergence angles can be prepared.

Abstract: A display panel includes a driving circuit and a signal line. The signal line includes at least two main signal sub-lines each including a first end and a second end, the first ends of the at least two main signal sub-lines are electrically coupled to each other, and the second ends thereof are electrically coupled to each other. N main signal sub-lines in the at least two main signal sub-lines are directly electrically coupled to the driving circuit. Each of the N main signal sub-lines is a direct-coupled main signal sub-line, and a main signal sub-line in the at least two main signal sub-lines other than the direct-coupled main signal sub-lines is an indirect-coupled main signal sub-line which is not directly electrically coupled to the driving circuit but electrically coupled to the driving circuit via the direct-coupled main signal sub-line, where N is a positive integer.

Abstract: A display substrate is provided, including: a base (1); and a plurality of pixel units (10) located on the base (1) and arranged in an array, where the display substrate further includes a plurality of data lines (25), and for each of the plurality of data lines (25), the data line (25) extends along a column direction and is located between adjacent first pixel unit (10A) and second pixel unit (10B) in a row direction, the data line (25) is arranged in a different layer from a first pixel electrode (40A) of the first pixel unit (10A) and a second pixel electrode (40B) of the second pixel unit (10B), and the data line (25) includes a first branch line (252) and a second branch line (253) that are connected in parallel and extend in the column direction; an orthographic projection of the first branch line (252) on the base (1) at least partially overlaps with an orthographic projection of the first pixel electrode (40A) on the base (1); an orthographic projection of the second branch line (253) on the base (1)

Abstract: A cold-hot component support structure, comprising a base and a connected support connected on the base by a bolt, wherein a bolt mounting hole is provided on the connected support, and an upper end face and a lower end face of the connected support are provided with an upper heat insulation block and a lower heat insulation block respectively. The lower heat insulation block is provided with a limit hole connecting the bolt mounting hole, and the upper heat insulation block is extended with a limit sleeve inserted in the limit hole. The supported support is clamped between the upper heat insulation block and the lower heat insulation block by an insertion structure between the upper heat insulation block and the lower heat insulation block, and an inner wall of a bolt hole on the connected support is insulated by the limit sleeve, so as to realize effective heat insulation of the connected support and reduce heat loss of the connected support.

Abstract: Provided is a method of inhibiting viral replication, including contacting one or more cells that has been infected or contacted with a flavivirus with an effective amount of niclosamide, temoporfin, nitazoxanide, tizoxanide, erythrosin B, methylene blue. Contacting one or more cells that have been infected with a flavivirus may include administering the compound to a mammal, a human, or other subject. The flavivirus may be Dengue virus serotype 1, Dengue virus serotype 2, Dengue virus serotype 3, Dengue virus serotype 4, yellow fever virus, West Nile virus, Zika virus, Japanese encephalitis virus, tick-born encephalitis virus, Powassan virus, St. Louis encephalitis virus, or other flavivirus.

Abstract: The disclosure can provide a method for converting an image, an apparatus for converting an image, an electronic device, and a storage medium. The method includes: obtaining an image in RAW format; obtaining a semantic analysis result of the image in RAW format by inputting the image in RAW format into a pre-trained first network model; the first network model being obtained by training based on a labeled training sample corresponding to each of a plurality of first training samples, the first training sample being a sample image in RAW format, and the labeled training sample being a sample image in RAW format obtained by labeling a semantic analysis result on the corresponding first training sample; and determining an image in RGB (Red-Green-Blue) format corresponding to the image in RAW format based on the semantic analysis result of the image in RAW format.

Abstract: The embodiments of the present disclosure propose a shift register, a driving method thereof, a gate driving circuit and a display apparatus. The shift register comprises an input sub-circuit coupled to an input terminal and a pull-up node, and configured to charge the pull-up node under control of an input signal from the input terminal; an output sub-circuit coupled to a clock signal terminal, the pull-up node, and an output terminal, and configured to transmit a clock signal from the clock signal terminal to the output terminal under control of the pull-up node; and an output shaping sub-circuit coupled to the clock signal terminal, the output terminal, and a first voltage signal terminal, and configured to transmit a first voltage signal from the first voltage signal terminal to the output terminal under control of the clock signal.

Abstract: According to some embodiments, a semiconductor substrate processing apparatus includes a housing, a plasma source unit, an electrostatic chuck, and a ring unit. The housing encloses a process chamber. The plasma source unit is connected to the housing, and includes a shower head and a fixing ring positioned to support the shower head. The shower head includes an upper electrode mounted on the fixing ring, and includes injection holes passing through part of the upper electrode and configured to inject gas into the chamber. The electrostatic chuck is connected to the housing and includes a lower electrode, and is for mounting a semiconductor substrate thereon. The ring unit is mounted on an edge portion of the electrostatic chuck, and includes a focus ring and a cover ring surrounding the focus ring. One of the lower electrode and the upper electrode is connected to a high frequency power supply, and the other of the lower electrode and the upper electrode is connected to ground.

Abstract: Provided is an array substrate including: a base substrate, a plurality of pixel units and a plurality of touch signal lines that are arranged on the base substrate. At least one pixel unit includes a plurality of sub-pixels. Two touch signal lines are arranged in the pixel unit, and the two touch signal lines are located on a side of a data line connected with one sub-pixel of the pixel unit.

Abstract: The disclosure relates to the technical field of sterilizing and disinfecting materials, and specifically relates to an ?-substituted phenyl structure-containing compound, a preparation method thereof, and a disinfectant. The ?-substituted phenyl structure-containing compound according to the disclosure could achieve a bactericidal effect by promoting the coagulation and denaturation of the protein of pathogenic microorganisms. In particular, it has a good killing effect on pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis var. niger spores. Besides, it has no corrosive effect on metals, no irritating odor, good water solubility, and is green and environmentally friendly. Therefore, it could be widely used in various industries as an effective ingredient of a disinfectant.

Abstract: The disclosure provides a surgical apparatus comprising: a steerable member that is bendable and comprises a plurality of bending segments with channels therein; and a plurality of bending actuation wires that are arranged to pass through the steerable member and cause the steerable member to bend, the steerable member comprising at least one outwardly opening lumen through which the bending actuation wires pass.