Patents by Inventor Hongsheng Xie

Hongsheng Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11998584
    Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
    Type: Grant
    Filed: December 31, 2017
    Date of Patent: June 4, 2024
    Assignee: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin Zhao, Qingliang Yang, Yuanyuan Huang, Linyao Zhao, Shun Gai, Hangbo Ye, Jun Lei, Yifang Xu, Mingjun Cao, Huihui Guo, Junxiang Jia, Qianqian Tong, Wenjun Li, Xiaomai Zhou, Hongsheng Xie, Lu Bai, Xiang Cai, Xiaotao Zhuo, Xiuzheng Zhang, Jun Zheng
  • Patent number: 11779663
    Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: October 10, 2023
    Assignee: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Robert Yongxin Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Linyao Zhao, Hangbo Ye, Huihui Guo, Qianqian Tong, Minjun Cao, Junxiang Jia, Chengyu Yang, Wenjun Li, Xiaomai Zhou, Hongsheng Xie, Chen Lin, Zhixiang Guo, Zhicang Ye
  • Publication number: 20230165930
    Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: January 19, 2023
    Publication date: June 1, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Shun GAI, Hangbo YE, Jun LEI, Yifang XU, Mingjun CAO, Huihui GUO, Junxiang JIA, Qianqian TONG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Lu BAI, Xiang CAI, Xiaotao ZHUO, Xiuzheng ZHANG, Jun ZHENG
  • Publication number: 20230165931
    Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: January 19, 2023
    Publication date: June 1, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Shun GAI, Hangbo YE, Jun LEI, Yifang XU, Mingjun CAO, Huihui GUO, Junxiang JIA, Qianqian TONG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Lu BAI, Xiang CAI, Xiaotao ZHUO, Xiuzheng ZHANG, Jun ZHENG
  • Publication number: 20230149502
    Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: January 19, 2023
    Publication date: May 18, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Shun GAI, Hangbo YE, Jun LEI, Yifang XU, Mingjun CAO, Huihui GUO, Junxiang JIA, Qianqian TONG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Lu BAI, Xiang CAI, Xiaotao ZHUO, Xiuzheng ZHANG, Jun ZHENG
  • Publication number: 20230115871
    Abstract: The present invention relates to the conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.
    Type: Application
    Filed: June 24, 2019
    Publication date: April 13, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Linyao ZHAO, Yuanyuan HUANG, Hangbo YE, Shun GAI, Junxiang JIA, Lu BAI, Wenjun LI, Zhixiang GUO, Chen LIN, Jun ZHENG, Huihui GUO, Minjun CAO, Xiangfei KONG, Yong DU, Yifang XU, Xiaomai ZHOU, Hongsheng XIE, Xiuzhen ZHANG, Miaomiao CHEN, Xiaolei LIU, Xiang CAI, Binbin CHEN, Yanlei YANG, Lingli ZHANG
  • Publication number: 20230071112
    Abstract: The present invention relates to linkers having a group of propioloyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
    Type: Application
    Filed: June 8, 2022
    Publication date: March 9, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Yongxin Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Huihui GUO, Xiaomai ZHOU, Hongsheng XIE, Haifeng ZHU, Yifang XU, Qianqian TONG, Junxiang JIA, Minjun CAO, Wenjun LI, Shuihong GAO, Zhixiang GUO, Lu BAI, Chen LI, Yanlei YANG, Chunyan WANG, Zhichang YE
  • Publication number: 20230057350
    Abstract: Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: January 31, 2019
    Publication date: February 23, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Jun LEI, Yuanyuan HUANG, Linyao ZHAO, Hangbo YE, Shun GAI, Mingjun CAO, Qianqian TONG, Lu BAI, Zhixiang GUO, Chengyu YANG, Xiaomai ZHOU, Hongsheng XIE, Yifang XU, Huihui GUO, Junxiang JIA, Jun ZHENG, Cheng LIN, Xiaotao ZHUO, Wenjun LI, Yong DU, Xiangfei KONG, Binbin CHEN, Yanlei YANG, Yanhong TONG, Xiaoxiao CHEN, Yanhua LI, Xiuzheng ZHANG, Juan LAI
  • Publication number: 20230010108
    Abstract: The present invention relates to a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (a dual-linker) containing a 2,3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.
    Type: Application
    Filed: October 12, 2018
    Publication date: January 12, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Hangbo YE, Xiaotao ZHUO, Chengyu YANG, Jun LEI, Yifang XU, Huihui GUO, Wenjun LI, Shun GAI, Lu BAI, Zhixiang GUO, Junxiang JIA, Jun ZHENG, Xiaomai ZHOU, Hongsheng XIE, Qianqian TONG, Mingjun CHAO, Yanhong TONG, Zhicang YE, Chen LIN, Yanlei YANG, Binbin CHEN
  • Publication number: 20230001001
    Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.
    Type: Application
    Filed: July 30, 2021
    Publication date: January 5, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU
  • Publication number: 20220378951
    Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
    Type: Application
    Filed: June 23, 2021
    Publication date: December 1, 2022
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Linyao ZHAO, Hangbo YE, Huihui GUO, Qianqian TONG, Minjun CAO, Junxiang JIA, Chengyu YANG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Chen LIN, Zhixiang GUO, Zhicang YE
  • Publication number: 20220323602
    Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
    Type: Application
    Filed: June 8, 2022
    Publication date: October 13, 2022
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Yongxin Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Huihui GUO, Xiaomai ZHOU, Hongsheng XIE, Haifeng ZHU, Yifang XU, Qianqian TONG, Junxiang JIA, Minjun CAO, Wenjun LI, Shuihong GAO, Zhixiang GUO, Lu BAI, Chen LI, Yanlei YANG, Chunyan WANG, Zhichang YE
  • Publication number: 20220313837
    Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
    Type: Application
    Filed: June 8, 2022
    Publication date: October 6, 2022
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Yongxin Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Huihui GUO, Xiaomai ZHOU, Hongsheng XIE, Haifeng ZHU, Yifang XU, Qianqian TONG, Junxiang JIA, Minjun CAO, Wenjun LI, Shuihong GAO, Zhixiang GUO, Lu BAI, Chen LI, Yanlei YANG, Chunyan WANG, Zhichang YE
  • Publication number: 20220313838
    Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
    Type: Application
    Filed: June 8, 2022
    Publication date: October 6, 2022
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Yongxin Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Huihui GUO, Xiaomai ZHOU, Hongsheng XIE, Haifeng ZHU, Yifang XU, Qianqian TONG, Junxiang JIA, Minjun CAO, Wenjun LI, Shuihong GAO, Zhixiang GUO, Lu BAI, Chen LI, Yanlei YANG, Chunyan WANG, Zhichang YE
  • Publication number: 20220313836
    Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
    Type: Application
    Filed: June 8, 2022
    Publication date: October 6, 2022
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Yongxin Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Huihui GUO, Xiaomai ZHOU, Hongsheng XIE, Haifeng ZHU, Yifang XU, Qianqian TONG, Junxiang JIA, Minjun CAO, Wenjun LI, Shuihong GAO, Zhixiang GUO, Lu BAI, Chen LI, Yanlei YANG, Chunyan WANG, Zhichang YE
  • Publication number: 20210393790
    Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.
    Type: Application
    Filed: July 30, 2021
    Publication date: December 23, 2021
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU
  • Publication number: 20210369855
    Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.
    Type: Application
    Filed: July 28, 2021
    Publication date: December 2, 2021
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU
  • Publication number: 20210353777
    Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
    Type: Application
    Filed: July 13, 2021
    Publication date: November 18, 2021
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Linyao ZHAO, Hangbo YE, Huihui GUO, Qianqian TONG, Minjun CAO, Junxiang JIA, Chengyu YANG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Chen LIN, Zhixiang GUO, Zhicang YE
  • Publication number: 20210346523
    Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
    Type: Application
    Filed: July 13, 2021
    Publication date: November 11, 2021
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Linyao ZHAO, Hangbo YE, Huihui GUO, Qianqian TONG, Minjun CAO, Junxiang JIA, Chengyu YANG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Chen LIN, Zhixiang GUO, Zhicang YE
  • Publication number: 20210308277
    Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl(acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
    Type: Application
    Filed: November 14, 2016
    Publication date: October 7, 2021
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Yongxin Robert Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Hangbo Ye, Linyao Zhao, Chengyu Yang, Huihui Guo, Xiaomai Zhou, Hongsheng Xie, Haifeng Zhu, Yifang Xu, Qianqian Tong, Junxiang Jia, Minjun Cao, Wenjun Li, Shuihong Gao, Zhixiang Guo, Lu Bai, Chen LI, Yanlei YANG, Chunyan WANG, Zhichang YE