Patent number: 10836796
Abstract: The present invention is related to novel cytotoxic agents, derivatives of Amanita toxins of Formula (I), wherein , -----, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, L, m, n and Q are defined herein, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.
Type:
Grant
Filed:
April 20, 2016
Date of Patent:
November 17, 2020
Assignee:
HANGZHOU DAC BIOTECH CO., LTD.
Inventors:
Robert Yongxin Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Hangbo Ye, Chengyu Yang, Huihui Guo, Xiaomai Zhou, Hongsheng Xie, Qianqian Tong, Minjun Cao, Linyao Zhao, Junxiang Jia, Wenjun Li, Xiaotao Zuo, Chen Lin, Yifang Xu, Zixiang Guo
Publication number: 20200215206
Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
Type:
Application
Filed:
February 4, 2016
Publication date:
July 9, 2020
Applicants:
SUZHOU M-CONJ BIOTECH CO., LTD., HANGZHOU DAC BIOTECH CO., LTD.
Inventors:
Robert Yongxin Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Linyao Zhao, Hangbo Ye, Huihui Guo, Qianqian Tong, Minjun Cao, Junxiang Jia, Chengyu Yang, Wenjun Li, Xiaomai Zhou, Hongsheng Xie, Chen Lin, Zhixiang Guo, Zhicang Ye
Publication number: 20200079820
Abstract: The present invention is related to novel cytotoxic agents, derivatives of Amanita toxins of Formula (I), wherein , - - - , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, L, m, n and Q are defined herein, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.
Type:
Application
Filed:
April 20, 2016
Publication date:
March 12, 2020
Applicant:
Hangzhou DAC Biotech Co., Ltd.
Inventors:
Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Chengyu YANG, Huihui GUO, Xiaomai ZHOU, Hongsheng XIE, Qianqian TONG, Minjun CAO, Linyao ZHAO, Junxiang JIA, Wenjun LI, Xiaotao ZUO, Chen LIN, Yifang XU, Zixiang GUO
Publication number: 20200069814
Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.
Type:
Application
Filed:
April 6, 2017
Publication date:
March 5, 2020
Applicant:
Hangzhou DAC Biotech Co., Ltd.
Inventors:
Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU