Abstract: The present invention discloses an experimental apparatus and experimental method for physical modeling of lithospheric structural deformation. The experimental apparatus comprises a drum centrifuge capsule, a drum centrifuge driving power compartment, a structural deformation device control system and a motion control system; a basket is hung at each end of a cantilever of the centrifuge, a structural deformation experiment box is placed in the basket, and the structural deformation control system accurately controls the deformation of experimental materials in the experiment box and can model structural deformation processes at various lithospheric scales. The experimental apparatus further comprises real-time monitoring cameras and a high-speed image acquisition device.

Abstract: It discloses an experimental apparatus and experimental method for physical modeling of a fluid migration and accumulation process with contemporaneous structural deformation. The experimental apparatus comprises a structural deformation experiment box, a structural deformation control device, a fluid control device and an experimental control device; the structural deformation experiment box is installed in a basket experiment module on a cantilever of a drum centrifuge, the structural deformation control device can extend and compress an experimental model in horizontal and vertical directions; and fluid cylinders of the fluid control device can be filled with fluids or plastic materials.

Abstract: It discloses a hypergravity experimental apparatus and experimental method for interaction between brittle deformation and ductile deformation. The experimental apparatus comprises an experiment module, a control device and a drive device; the drive device comprises a centrifuge for generating a hypergravity environment and a hydraulic press for generating extensional/compressional force in an experiment box; the control device comprises a control terminal, a control cabinet and a hydraulic control station for controlling the operation of the drive device; the experiment module is provided with an experiment box and a transmission device therein, and the transmission device converts a vertical lifting force generated by a hydraulic cylinder controlled by the hydraulic press in the drive device into a horizontal pushing-pulling force.

Abstract: An experimental apparatus comprises a centrifuge basket experiment module, a structural deformation device, an image reflector and a geomorphometer; the centrifuge basket experiment module is installed on a cantilever of a drum centrifuge in a hanging manner during an experiment; the structural deformation device is configured for extending and compressing experimental materials; a mirror panel of the image reflector reflects images inside an experiment box through a transparent window; the geomorphometer can simulate rainfall and recover wastewater, and the apparatus can also heat the experimental materials. An image acquisition device is installed on a bulkhead of the experiment module and the cantilever of the centrifuge to acquire top and side images of the experiment box.

Abstract: Disclosed are an expansion tool assembly, comprising: an expandable tubular; a guide shoe partially inserted into and connected to the lower end of the expandable tubular; a sealing sleeve arranged in the expandable tubular and connected to the upper end of the guide shoe; an expansion assembly comprising an expansion cone and expansion seat disposed inside the expandable tubular, wherein the lower end of the expansion seat is connected with hooks, which can be rested on the upper end of the sealing sleeve; an upper joint that is connected to the upper end of the expansion seat and can be connected to a drill string. A force transfer path can be established via connection between the expansion seat and sealing sleeve, so that expandable tubular weight is borne on the drill string. Unintentional expansion of the expandable tubular, caused by interaction between expandable tubular and expansion cone, can be avoided.

Abstract: Disclosed are an expansion tool assembly, comprising: an expandable tubular; a guide shoe partially inserted into and connected to the lower end of the expandable tubular; a sealing sleeve arranged in the expandable tubular and connected to the upper end of the guide shoe; an expansion assembly comprising an expansion cone and expansion seat disposed inside the expandable tubular, wherein the lower end of the expansion seat is connected with hooks, which can be rested on the upper end of the sealing sleeve; an upper joint that is connected to the upper end of the expansion seat and can be connected to a drill string. A force transfer path can be established via connection between the expansion seat and sealing sleeve, so that expandable tubular weight is borne on the drill string. Unintentional expansion of the expandable tubular, caused by interaction between expandable tubular and expansion cone, can be avoided.

Abstract: It discloses an experimental apparatus and experimental method for physical modeling of a fluid migration and accumulation process with contemporaneous structural deformation. The experimental apparatus comprises a structural deformation experiment box, a structural deformation control device, a fluid control device and an experimental control device; the structural deformation experiment box is installed in a basket experiment module on a cantilever of a drum centrifuge, the structural deformation control device can extend and compress an experimental model in horizontal and vertical directions; and fluid cylinders of the fluid control device can be filled with fluids or plastic materials.

Abstract: An experimental apparatus comprises a centrifuge basket experiment module, a structural deformation device, an image reflector and a geomorphometer; the centrifuge basket experiment module is installed on a cantilever of a drum centrifuge in a hanging manner during an experiment; the structural deformation device is configured for extending and compressing experimental materials; a mirror panel of the image reflector reflects images inside an experiment box through a transparent window; the geomorphometer can simulate rainfall and recover wastewater, and the apparatus can also heat the experimental materials. An image acquisition device is installed on a bulkhead of the experiment module and the cantilever of the centrifuge to acquire top and side images of the experiment box.

Abstract: The present invention discloses an experimental apparatus and experimental method for physical modeling of lithospheric structural deformation. The experimental apparatus comprises a drum centrifuge capsule, a drum centrifuge driving power compartment, a structural deformation device control system and a motion control system; a basket is hung at each end of a cantilever of the centrifuge, a structural deformation experiment box is placed in the basket, and the structural deformation control system accurately controls the deformation of experimental materials in the experiment box and can model structural deformation processes at various lithospheric scales. The experimental apparatus further comprises real-time monitoring cameras and a high-speed image acquisition device.

Abstract: It discloses a hypergravity experimental apparatus and experimental method for interaction between brittle deformation and ductile deformation. The experimental apparatus comprises an experiment module, a control device and a drive device; the drive device comprises a centrifuge for generating a hypergravity environment and a hydraulic press for generating extensional/compressional force in an experiment box; the control device comprises a control terminal, a control cabinet and a hydraulic control station for controlling the operation of the drive device; the experiment module is provided with an experiment box and a transmission device therein, and the transmission device converts a vertical lifting force generated by a hydraulic cylinder controlled by the hydraulic press in the drive device into a horizontal pushing-pulling force.

Abstract: The present invention discloses an expandable liner hanger system comprising a central pipe and an expandable pipe, with an expansion cone provided therebetween the central pipe and expandable pipe in a way that the expansion cone is movable along the central pipe, so that the expandable pipe is expanded; wherein, the expansion cone comprises an expansion cone seat move along the central pipe, and an expansion cone sleeve fitted over the expansion cone seat, the connection between the expansion cone seat and the expansion cone sleeve is configured in a way that the expansion cone sleeve can move upward together with the expansion cone seat along the central pipe so that the expandable pipe is expanded, and the central pipe can drive the expansion cone seat to disengage from the expansion cone sleeve.

Abstract: The present invention discloses an expandable liner hanger system comprising a central pipe and an expandable pipe, with an expansion cone provided therebetween the central pipe and expandable pipe in a way that the expansion cone is movable along the central pipe, so that the expandable pipe is expanded; wherein, the expansion cone comprises an expansion cone seat move along the central pipe, and an expansion cone sleeve fitted over the expansion cone seat, the connection between the expansion cone seat and the expansion cone sleeve is configured in a way that the expansion cone sleeve can move upward together with the expansion cone seat along the central pipe so that the expandable pipe is expanded, and the central pipe can drive the expansion cone seat to disengage from the expansion cone sleeve.

Abstract: A mechanical and hydraulic dual-effect expansion device for well drilling with expandable tubular technology includes an anchor having a lower end connected to an upper end of an insertion connection tube via a coupling, a hydraulic cylinder assembly comprising a hydraulic cylinder and a piston tube movably disposed within an inner cavity of the hydraulic cylinder, and a variable-diameter expansion cone assembly comprising a sealing cone portion and a variable-diameter expansion cone portion, wherein the sealing cone portion has an upper end connected to a lower end of the piston tube and a lower end connected to an upper end of the variable-diameter expansion cone portion. The mechanical and hydraulic dual-effect expansion device can facilitate completion of construction operations of an expandable tubular in a casing and an openhole system.

Abstract: Methods of tests that assess the expression of DPC4 (SMAD4) to identify subjects with pancreatic cancer that are likely or unlikely to respond to treatment with BTK inhibitors; methods of treating subjects based on identification of the subjects as likely to respond to treatment with BTK inhibitors; therapeutic targets for cancers, particularly cancers with inactivated DPC4 gene or protein; methods of screening of new therapeutic agents using the target; pharmaceutical composition comprising BTK inhibitors, such as PCI-32765 or derivatives thereof, for cancer treatment; and kits that facilitate the performance of the methods are disclosed.

Abstract: A mechanical and hydraulic dual-effect expansion device for well drilling with expandable tubular technology includes an anchor having a lower end connected to an upper end of an insertion connection tube via a coupling, a hydraulic cylinder assembly comprising a hydraulic cylinder and a piston tube movably disposed within an inner cavity of the hydraulic cylinder, and a variable-diameter expansion cone assembly comprising a sealing cone portion and a variable-diameter expansion cone portion, wherein the sealing cone portion has an upper end connected to a lower end of the piston tube and a lower end connected to an upper end of the variable-diameter expansion cone portion. The mechanical and hydraulic dual-effect expansion device can facilitate completion of construction operations of an expandable tubular in a casing and an openhole system.

Abstract: The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.

Abstract: The present invention relates compositions, methods and kits for characterizing the type of and screening for the existence or predisposition for small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). The invention also relates to a method of treating a mammalian subject having SCCOHT or a predisposition for SCCOHT.

Abstract: Methods of tests that assess the expression of DPC4 (SMAD4) to identify subjects with pancreatic cancer that are likely or unlikely to respond to treatment with BTK inhibitors; methods of treating subjects based on identification of the subjects as likely to respond to treatment with BTK inhibitors; therapeutic targets for cancers, particularly cancers with inactivated DPC4 gene or protein; methods of screening of new therapeutic agents using the target; pharmaceutical composition comprising BTK inhibitors, such as PCI-32765 or derivatives thereof, for cancer treatment; and kits that facilitate the performance of the methods are disclosed.

Abstract: Methods of tests that assess the expression of DPC4 (SMAD4) to identify subjects with pancreatic cancer that are likely or unlikely to respond to treatment with BTK inhibitors; methods of treating subjects based on identification of the subjects as likely to respond to treatment with BTK inhibitors; therapeutic targets for cancers, particularly cancers with inactivated DPC4 gene or protein; methods of screening of new therapeutic agents using the target; pharmaceutical composition comprising BTK inhibitors, such as PCI-32765 or derivatives thereof, for cancer treatment; and kits that facilitate the performance of the methods are disclosed.

Abstract: The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.