Abstract: Methods of tests that assess the expression of DPC4 (SMAD4) to identify subjects with pancreatic cancer that are likely or unlikely to respond to treatment with BTK inhibitors; methods of treating subjects based on identification of said subjects as likely to respond to treatment with BTK inhibitors; therapeutic targets for cancers, particularly cancers with inactivated DPC4 gene or protein; methods of screening of new therapeutic agents using the target; pharmaceutical composition comprising BTK inhibitors, such as PCI-32765 or derivatives thereof, for cancer treatment; and kits that facilitate the performance of the methods are disclosed.

Abstract: A close-coupling shared storage architecture of double-wing expandable multiprocessor is provided in the close-coupling shared storage architecture with p processors scale, the close-coupling shared storage architecture of double-wing expandable multiprocessor comprises: j processor modules PMs; wherein, each processor module is formed by coupling and cross-jointing i processors Cs, and each processor is directly connected with a node controller NC through only one link; each processor module PM comprises 2 pairing node controllers NCs, and each node controller NC is connected with the processors through m links and is connected with an interconnect network through n links; the interconnect network comprises two groups, and each group comprises k cross switch route chips NRs, each of which has q ports. By adopting the connection method above, the close-coupling shared storage architecture of double-wing expandable multiprocessor is formed.

Abstract: A close-coupling shared storage architecture of double-wing expandable multiprocessor is provided in the close-coupling shared storage architecture with p processors scale, the close-coupling shared storage architecture of double-wing expandable multiprocessor comprises: j processor modules PMs; wherein, each processor module is formed by coupling and cross-jointing i processors Cs, and each processor is directly connected with a node controller NC through only one link; each processor module PM comprises 2 pairing node controllers NCs, and each node controller NC is connected with the processors through m links and is connected with an interconnect network through n links; the interconnect network comprises two groups, and each group comprises k cross switch route chips NRs, each of which has q ports. By adopting the connection method above, the close-coupling shared storage architecture of double-wing expandable multiprocessor is formed.