Patents by Inventor Hongxia Wang
Hongxia Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250145148Abstract: A vehicle drift control method and system, and a vehicle are provided. The vehicle drift control method comprises: in response to a drift operation instruction by a user, obtaining a whole-vehicle required torque and vehicle state parameters; determining a front-axle torque ratio according to the state parameters; determining a front-axle required torque according to the front-axle torque ratio and the whole-vehicle required torque; and performing torque control respectively on a front-axle motor and a rear-axle motor according to the front-axle required torque and the rear-axle required torque, such that the torque distribution between the front and rear axles is more reasonable, and the drift duration and the drift safety are improved.Type: ApplicationFiled: January 7, 2025Publication date: May 8, 2025Inventors: Yubo LIAN, Heping LING, Mingchuan SHI, Hongxia WANG, Luo FU
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Patent number: 12259373Abstract: Disclosed are methods for improving compound detection and characterization. Methods for characterizing a sample are disclosed. The methods can include providing a sample to a liquid chromatography system capable of sample separation to generate sample components; analyzing sample components by multiplexed targeted selected ion monitoring (SIM) to generate an inclusion list; and performing iterative mass spectral data-dependent acquisition (DDA) from the inclusion list, to identify individual sample components thereby characterizing the sample. In one example, multiplexed targeted SIMs and iterative MS2 DDA acquisition is used to increase robust compound identification for cell culture medium analysis.Type: GrantFiled: March 20, 2024Date of Patent: March 25, 2025Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Jikang Wu, Hongxia Wang, Haibo Qiu, Ning Li
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Publication number: 20250090489Abstract: PAMAM-based nanocarriers with high loading efficiency of chemotherapeutics and high cfNA binding ability enable sustained delivery of chemotherapeutics while inhibiting systemic inflammation caused by the chemotherapy. This is useful for treating both primary and metastatic tumors with attenuated cognitive impairment.Type: ApplicationFiled: December 5, 2024Publication date: March 20, 2025Inventors: Kam W. LEONG, Tianyu LI, Tolulope O. AKINADE, Divya BHANSALI, Hongxia WANG
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Publication number: 20250074209Abstract: A vehicle torque control method includes: a wheel speed of a wheel corresponding to a vehicle drive shaft is acquired by a vehicle controller, and an equivalent rotating speed of a motor is calculated based on the wheel speed of the wheel. An actual rotating speed of the motor corresponding to the drive shaft is acquired by the vehicle controller, and based on the equivalent rotating speed of the motor and the actual rotating speed of the motor corresponding to the drive shaft, an equivalent rotating speed difference of the motor corresponding to the drive shaft is calculated. A correcting torque value is acquired by the vehicle controller, based on the equivalent rotating speed difference of the motor corresponding to the drive shaft. An output torque of the motor corresponding to the drive shaft is adjusted by the vehicle controller, based on the correcting torque value.Type: ApplicationFiled: November 19, 2024Publication date: March 6, 2025Inventors: Heping LING, Mingchuan SHI, Hao ZHANG, Chao YIN, Hongxia WANG
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Publication number: 20250059501Abstract: Methods of improving recombinant protein titer and cell titer in cell culture using cell culture media having reduced impurities are provided, and well as cell culture media having reduced impurities that can used for the production of a recombinant protein and cells with improved titer. The cell culture media having reduced impurities comprises a HEPES buffer, and the reduced impurities are HEPES related impurities. In certain aspects, methods and media improve protein titer, cell growth, and/or viable cell density.Type: ApplicationFiled: May 24, 2024Publication date: February 20, 2025Inventors: Reginald Smith, Sarah Nicoletti, Victor Shashilov, Hongxia Wang, Jikang Wu, Abdelqader Zamamiri
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Publication number: 20250050731Abstract: A vehicle torque control method, comprising: acquiring a front axle equivalent axle speed and a rear axle equivalent axle speed of a vehicle, and determining an equivalent axle speed difference between front axles and rear axles of the vehicle according to the front axle equivalent axle speed and the rear axle equivalent axle speed; determining a drive shaft torque adjustment value according to the equivalent axle speed difference; and adjusting an output torque of a drive shaft motor according to the drive shaft torque adjustment value. Also disclosed are a vehicle torque control apparatus, an electronic device, a storage medium, and a vehicle.Type: ApplicationFiled: October 31, 2024Publication date: February 13, 2025Inventors: Heping LING, Mingchuan SHI, Hongxia WANG, Hao ZHANG, Binhao ZHOU
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Patent number: 12172106Abstract: The present invention provides methods to quickly and efficiently assess the effect of antibody variants, including PTMs, e.g., glycosylation, oxidation, and deamidation variants, on the binding between the antibody and FcRn. In particular, the present invention is based, at least in part, on the development of an online, two dimension liquid chromatography (2D-LC) method for assessing binding between antibody variants and FcRn. In one aspect, the online 2D-LC is coupled with mass spectrometry (MS). The present invention allows for differentiation of antibody variants by peak pattern and retention time profile by affinity chromatography, and identification of these variants by mass spectrometry analysis.Type: GrantFiled: August 8, 2019Date of Patent: December 24, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Hongxia Wang, Haibo Qiu, Ning Li, Xueqing Zhao
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Patent number: 12169203Abstract: Methods for detecting and/or discriminating between post-translational modification variants of an antibody of interest in a sample. The methods including: contacting a sample comprising one or more antibodies of interest with a protease to digest the sample into antibody fragments; separating antibody fragments by molecular weight and/or charge in one or more capillaries using capillary electrophoresis; eluting separated antibody fragments from the one or more capillaries; and determining the mass of the eluted antibody fragments by mass spec analysis, thereby detecting and/or discriminating between post-translational modification variants of the antibody of interest.Type: GrantFiled: January 30, 2020Date of Patent: December 17, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Hongxia Wang, Haibo Qiu, Ning Li
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Patent number: 12092193Abstract: A planetary bevel gear automatic limited slip differential includes five portions that are a main differential, a planetary bevel gear controller, a left drive axle shaft, a right drive axle shaft, and clutches. The planetary bevel gear controller includes an outer control unit and an inner control unit, the outer control unit includes four planetary bevel gears on an outer layer and a bevel gear fixed on a housing, and the inner control unit includes inner planetary bevel gears on an inner side and two bevel gears which have the same parameters and are meshed with the planetary bevel gears. The bevel gears are fixedly connected with outer rings of two overrunning clutches, respectively, and inner rings of the overrunning clutches and the right drive axle shaft are connected together by splines.Type: GrantFiled: January 16, 2024Date of Patent: September 17, 2024Inventors: Qinghe Guo, Yurong Chen, Wen Cheng, Renjun Liu, Shenghuai Wang, Hongxia Wang, Xiaohui Chen, Guanqin Liu, Yongping Shen, Huiyuan Li, Huihui Zhou, Mengchao Wang, Suiyu Yin, Longyong Gan
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Publication number: 20240230604Abstract: Disclosed are methods for improving compound detection and characterization. Methods for characterizing a sample are disclosed. The methods can include providing a sample to a liquid chromatography system capable of sample separation to generate sample components; analyzing sample components by multiplexed targeted selected ion monitoring (SIM) to generate an inclusion list; and performing iterative mass spectral data-dependent acquisition (DDA) from the inclusion list, to identify individual sample components thereby characterizing the sample. In one example, multiplexed targeted SIMs and iterative MS2 DDA acquisition is used to increase robust compound identification for cell culture medium analysis.Type: ApplicationFiled: March 20, 2024Publication date: July 11, 2024Inventors: Jikang Wu, Hongxia Wang, Haibo Qiu, Ning Li
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Patent number: 12031151Abstract: Methods of improving recombinant protein titer and cell titer in cell culture using cell culture media having reduced impurities are provided, and well as cell culture media having reduced impurities that can used for the production of a recombinant protein and cells with improved titer. The cell culture media having reduced impurities comprises a HEPES buffer, and the reduced impurities are HEPES related impurities. In certain aspects, methods and media improve protein titer, cell growth, and/or viable cell density.Type: GrantFiled: January 19, 2022Date of Patent: July 9, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Reginald Smith, Sarah Nicoletti, Victor Shashilov, Hongxia Wang, Jikang Wu, Abdelqader Zamamiri
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Publication number: 20240183998Abstract: An ARAIM availability prediction method under a complex terrain environment is provided. The method includes: 1) selecting positioning points according to an air line; 2) calculating terrain shielding angles; 3) predicting visible satellites; 4) determining a fault mode that needs to be monitored; 5) calculating a positioning error variance, an influence coefficient of a nominal deviation, and a variance of a solution separation test statistic; and 6) calculating a threshold of a solution separation test, calculating a protection level, and determining availability. According to the method, the terrain shielding angles are calculated based on terrain model data, and the visible satellites are predicted based on ephemeris data or almanac data to further calculate a protection level, while determining the availability; and the accuracy of availability prediction can, by considering the effect of terrain barriers on the prediction of the visible satellites, be improved to ensure the safety of aircrafts.Type: ApplicationFiled: April 24, 2023Publication date: June 6, 2024Applicant: Beihang UniversityInventors: Yanbo ZHU, Zhipeng WANG, Kun FANG, Jingtian DU, Hongxia WANG
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Publication number: 20240185595Abstract: A method for evaluating quality of a point cloud map based on matching includes the following steps: S1, acquiring the to-be-evaluated point cloud map as a point cloud matching algorithm input; S2, acquiring a point cloud sample set for matching; S3, matching by using a point cloud matching algorithm, and iterating to obtain estimated three-dimensional coordinate system transforms; S4, calculating point cloud matching errors; and S5, taking an obtained quality evaluation score of the to-be-evaluated point cloud map as a point cloud matching algorithm output. The method for evaluating the quality of the point cloud map based on matching can evaluate the quality of the point cloud map in a full-automatic manner without the dependence on truth values and artificial calibration, so as to improve the quality evaluation efficiency of the point cloud map.Type: ApplicationFiled: April 24, 2023Publication date: June 6, 2024Applicant: Beihang UniversityInventors: Zhipeng WANG, Hongxia WANG, Kun FANG, Jiahao XU, Zhiqiang DAN
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Patent number: 11959897Abstract: Disclosed are methods for improving compound detection and characterization. Methods for characterizing a sample are disclosed. The methods can include providing a sample to a liquid chromatography system capable of sample separation to generate sample components; analyzing sample components by multiplexed targeted selected ion monitoring (SIM) to generate an inclusion list; and performing iterative mass spectral data-dependent acquisition (DDA) from the inclusion list, to identify individual sample components thereby characterizing the sample. In one example, multiplexed targeted SIMs and iterative MS2 DDA acquisition is used to increase robust compound identification for cell culture medium analysis.Type: GrantFiled: May 31, 2022Date of Patent: April 16, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Jikang Wu, Hongxia Wang, Haibo Qiu, Ning Li
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Publication number: 20240053359Abstract: The present invention pertains to methods for characterizing proteins in a sample using native capillary electrophoresis-mass spectrometry. The present invention pertains to methods for detecting and/or discriminating between post-translational modification variants of an antibody of interest in a sample, detecting and/or discriminating between antibodies in an antibody mixture, and characterizing monospecific antibody side products in a bispecific antibody sample.Type: ApplicationFiled: June 1, 2023Publication date: February 15, 2024Inventors: Hongxia Wang, Haibo Qiu, Ning Li, Zhijie Wu
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Publication number: 20230313056Abstract: An anti-coking equipment, a preparation method therefor, and the use thereof. The preparation method comprises: bringing a low-oxygen partial pressure gas into contact with an equipment for reaction to obtain an anti-coking equipment containing an oxide film on the inner surface, wherein the dew point of the low-oxygen partial pressure gas is -40° C. to 40° C. A dense and stable oxide film is formed on the inner surface of the equipment prepared by the method, which can inhibit or slow down the catalytic coking phenomenon, reduce the degree of equipment carburization, and prolong the service life of the equipment.Type: ApplicationFiled: June 22, 2021Publication date: October 5, 2023Inventors: Hongxia WANG, Guoqing WANG, Shenxiang WANG, Jingsheng JIA, Lijun ZHANG
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Patent number: 11674579Abstract: A planetary gear train automatic limited slip differential may consist of a main differential, a planetary gear train differential controller, a left axle shaft, a right axle shaft, and a clutch. The planetary gear train differential controller may be composed of a first planetary gear train differential controller unit and a second planetary gear train differential controller unit. The first planetary gear train differential controller unit may be composed of a first planetary gear train and a first overrunning clutch connected to the first planetary gear train. The second planetary gear train differential controller unit may be composed of a second planetary gear train and a second overrunning clutch connected to the second planetary gear train.Type: GrantFiled: October 13, 2022Date of Patent: June 13, 2023Assignee: Hubei University of Automotive TechnologyInventors: Yurong Chen, Shenghuai Wang, Aihong Gong, Zhen Wang, Xueliang Zhou, Wen Cheng, Aihua Ren, Zhangdong Sun, Hongxia Wang, Weidong Yan, Qiang Liu, Guoxing Sun, Chunlong Zou, Junjie Liu, Tao Chen, Shuo Cheng, Yu Wang, Wenlong Jia, Suiyu Yin, Longyong Gan, Rengan Wei
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Publication number: 20230150844Abstract: An apparatus for metal-ion removal includes a conduit including an inlet to receive a liquid and an outlet to discharge the liquid, a first porous electrode and a second porous electrode disposed in the conduit, and a power source configured to provide power to the first porous electrode and the second porous electrode. The first porous electrode and the second porous electrode are separated by a gap. The first porous electrode is extended in a first direction. A flow direction of the liquid in the conduit is not in parallel with the first direction.Type: ApplicationFiled: November 12, 2021Publication date: May 18, 2023Inventors: Hongxia Wang, Yu Zhu, Wanyue Li
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Publication number: 20230124568Abstract: A planetary gear train automatic limited slip differential may consist of a main differential, a planetary gear train differential controller, a left axle shaft, a right axle shaft, and a clutch. The planetary gear train differential controller may be composed of a first planetary gear train differential controller unit and a second planetary gear train differential controller unit. The first planetary gear train differential controller unit may be composed of a first planetary gear train and a first overrunning clutch connected to the first planetary gear train. The second planetary gear train differential controller unit may be composed of a second planetary gear train and a second overrunning clutch connected to the second planetary gear train.Type: ApplicationFiled: October 13, 2022Publication date: April 20, 2023Applicant: Hubei University of Automotive TechnologyInventors: Yurong CHEN, Shenghuai WANG, Aihong GONG, Zhen WANG, Xueliang ZHOU, Wen CHENG, Aihua REN, Zhangdong SUN, Hongxia WANG, Weidong YAN, Qiang LIU, Guoxing SUN, Chunlong ZOU, Junjie LIU, Tao CHEN, Shuo CHENG, Yu WANG, Wenlong JIA, Suiyu YIN, Longyong GAN, Rengan WEI
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Patent number: D992495Type: GrantFiled: September 16, 2021Date of Patent: July 18, 2023Assignee: QINGDAO DOUBLESTAR TIRE INDUSTRIAL CO., LTD. (CN)Inventors: Jun Wang, Lihua Ma, Lei Han, Ying Wei, Feng Zhang, Hongxia Wang, Xiaohong Li, Guiqin Sun, Zhen Wang