Abstract: Disclosed herein is a framework for facilitating biological tissue function analysis. In accordance with one aspect, saturation of hemoglobin with oxygen (SPO2) signal data is synchronized with respiration signal data. One or more waveform parameters may be generated based on the synchronized SPO2 signal data and the respiration signal data. One or more respiration-SPO2 parameters may then be determined based on the one or more waveform parameters and used to characterize the biological tissue function.

Abstract: A system for heart performance characterization and abnormality detection includes an acquisition device for acquiring an electrophysiological signal representing heart beat cycles of a patient heart. A detector detects one or more parameters of the electrophysiological signal of parameter type comprising at least one of, (a) amplitude, (b) time duration, (c) peak frequency and (d) frequency bandwidth, of multiple different portions of a single heart beat cycle of the heart beat cycles selected in response to first predetermined data. The multiple different portions of the single heart beat cycle being selected from, a P wave portion, a QRS complex portion, an ST segment portion and a T wave portion in response to second predetermined data. A signal analyzer calculates a ratio of detected parameters of a single parameter type of the multiple different portions of the single heart beat cycle.

Abstract: A system for heart performance characterization and abnormality detection comprises an input processor and a signal processor. The input processor receives first sampled data representing a first signal portion of a heart activity related signal and second sampled data representing a second signal portion of a heart activity related signal. The signal processor determines distribution data associated with degree of similarity between the first and second signal portions by determining a difference between (a) values derived by applying a first function to mean adjusted sampled values of the first signal portion and (b) values derived by applying a second function to mean adjusted sampled values of the second signal portion. In response to the determined distribution data, the signal processor initiates generation of a message associated with the degree of similarity between the first and second signal portions.

Abstract: A system improves detection and diagnosis of blood pressure based cardiac function and tissue activities by analyzing and characterizing cardiac blood pressure signals (including non-invasive and invasive blood pressure, discrete values and continuous waveforms) using pressure signal variation and variability calculation and evaluation. The system combines blood pressure analysis with multi clinical related factors and parameters to detect and quantify cardiac health status and arrhythmia severity. The system determines an accurate time, location and severity of cardiac pathology and events by calculating blood pressure variability and statistical variation. The accurately and reliably identifies cardiac disorders, differentiates cardiac arrhythmias, characterizes pathological severity, predicts the life-threatening events, and supports evaluation of drug delivery effects.

Abstract: A system and method provides monitoring for atrial fibrillation. A data acquisition processor acquires a cardiac signal data stream from a patient and a wave detector detects an R-wave in a cardiac signal of the data stream. A T-wave in the cardiac signal occurring after the detected R-wave and a Q-wave in a subsequent cardiac signal of the data stream is also detected by the wave detector. A filter provides signal gating and extraction of data representing a Region of Interest (ROI) time window from the detected T-wave to the Q-wave. An integration processor detects characteristics of a P wave signal occurring within the ROI time window. At least one of the detected P wave characteristics is compared to characteristics derived from data representing at least one P wave signal and generating an output signal in response to the comparison for use in determining if the patient is in atrial fibrillation.

Abstract: A device interface selectively acquires patient physiological parameter data. An acquisition processor acquires physiological data from a patient. A communication processor is coupled to an optical communication pathway for receiving optical signals from a source. A conversion processor electrically coupled to the acquisition processor and communication processor converts a first optical power signal at a first frequency and received via the optical communication pathway using the communication processor, to a first electrical signal for providing power to the device interface. The conversion processor converts an optical control signal at a second frequency different from the first frequency and received via the optical communication pathway using the communication processor, to a second electrical signal for providing control data to the acquisition processor directing the acquisition processor to acquire at least one physiological parameter from a patient.

Abstract: Disclosed herein is a framework for facilitating adaptive control of monitoring devices. In accordance with one aspect, a position detector detects a chest elevation level and provides chest elevation level data. A processor uses the chest elevation level data to determine a heart elevation level with respect to a reference level. A comparator compares the determined heart elevation level with an elevation level of a monitoring device with respect to the reference level. In response to the comparison, a movement system adjusts the elevation level of the monitoring device.

Abstract: A system provides an image acquisition trigger signal compensated for signal processing time delay. An interface receives waveform signal data representing electrical activity of a patient heart over at least one heart beat cycle. A detector detects a particular point associated with a particular signal portion within successive heart beat cycles of the signal data. A first time variation detector provides a first timing adjustment signal in response to detected change in time of occurrence of the detected particular point. A second time variation detector provides a second timing adjustment signal in response to comparison of relative timing of the trigger signal and the detected particular point. An output processor generates the trigger signal in response to the detected particular point and the first timing adjustment signal and the second timing adjustment signal.

Abstract: A system denoises and rejects artifacts from cardiac signals, by accepting a cardiac signal from a patient, processing the cardiac signal from the patient using a frequency band width controllable choke to separate the cardiac signal into predefined frequencies, filtering each of the predefined frequencies to remove dynamic common noise, joining each of the predefined frequencies into a cardiac signal without the dynamic common noise, and providing feedback control of the filtering of each of the predefined frequencies.

Abstract: A system for heart performance characterization uses an interface to receive waveform signal data representing electrical activity of a patient heart over at least one heart beat cycle. The signal processor uses a signal peak and amplitude detector for, identifying a first signal portion of a first heart cycle of the signal data, identifying multiple different amplitude levels within the first signal portion, determining a first area under the waveform in the first signal portion corresponding to at least one particular amplitude level and deriving a parameter in response to the determined first area. The output processor generates an alert message if at least one of, (a) the derived parameter and (b) a difference between the derived parameter and a corresponding derived parameter for a different heart cycle for the same patient, exceeds a predetermined threshold value.

Abstract: A system for heart performance characterization and abnormality detection includes an interface for receiving sampled data representing an electrical signal indicating electrical activity of a patient heart over multiple heart beat cycles and for receiving a pace signal indicating occurrence of a heart pace pulse applied to the heart. A signal processor uses the received sampled data and pace signal in calculating, a first signal characteristic value comprising a time interval between occurrence of the pace pulse and a cardiac cycle characteristic and a second signal characteristic comprising an average of the time intervals determined over a multiple heart cycles. A comparator compares at least one of the first and second characteristic values with a threshold value to provide a comparison indicator. A patient monitor generates an alert message associated with the threshold in response to the comparison indicator indicating a calculated signal characteristic value exceeds the threshold value.

Abstract: A system for adaptively processing patient monitoring signals comprises an input processor for acquiring a signal having amplitude representing electrical activity of a patient heart over time. A signal processor identifies different portions of the signal associated with different phases of cardiac activity by, inverting the signal to provide an inverted signal, aligning the signal and the inverted signal in amplitude during a cardiac rest portion and identifying one or more of the different portions in response to an intersection point of the signal and the inverted signal. Multiple adaptive signal filters are used to filter multiple bandwidths of corresponding different portions of the signal.

Abstract: A method determines cardiac output or stroke volume by receiving signal data representing multiple parameters of a patient concurrently acquired over a particular time period and comprising at least one of, (a) a parameter derived from an ECG waveform of the patient, (b) a parameter derived from a blood pressure signal of the patient, (c) a parameter derived from signal data representing oxygen content of blood of the patient and (d) a parameter derived from a patient cardiac impedance value. A selected parameter of the multiple concurrently acquired parameters is used in calculating a heart stroke volume of the patient comprising volume of blood transferred through the blood vessel in a heart cycle, in response to, a combination of a weighted summation of values of the selected parameter over the particular time period. Data representing the calculated heart stroke volume is provided to a destination device.

Abstract: A system for heart performance characterization and abnormality detection, includes an acquisition device for acquiring an electrophysiological signal representing a heart beat cycle of a patient heart. A detector detects multiple parameters of the electrophysiological signal comprising at least one of, (a) amplitude, (b) time duration, (c) frequency and (d) time-frequency, representative parameters. A signal analyzer calculates at least one ratio of the detected parameters from ratios including, (i) ratio of T wave amplitude to P wave amplitude, (ii) ratio of time duration of ST wave to time duration of PR wave, (iii) ratio of a frequency of a PR wave to a frequency of a RT wave and (iv) ratio of a time-frequency measure of a PR wave to a time-frequency measure of a RT wave. A comparator determines whether a calculated ratio exceeds a predetermined upper limit threshold or a predetermined lower limit threshold.

Abstract: A system for heart performance characterization and abnormality detection processes a heart electrical activity signal in determining multiple first signal characteristic values over multiple heart cycles. A first signal characteristic value substantially comprises a time interval between a peak of a P wave to a peak of a succeeding R wave representing a repolarization time interval in an individual heart cycle and the signal processor uses a peak detector and time detector for identifying the peaks and detecting a time difference between the identified peaks. A comparator compares at least one of the multiple first signal characteristic values or a value derived from the multiple first signal characteristic values with a threshold value to provide a comparison indicator. A patient monitor in response to the comparison indicator indicating a calculated signal characteristic value exceeds the threshold value, generates an alert message associated with the threshold.

Abstract: A system provides heart ablation unit control. The system includes an input processor for acquiring electrophysiological signal data from multiple tissue locations of a heart and data indicating tissue thickness at the multiple tissue locations. A signal processor processes the acquired electrophysiological signal data to identify location of particular tissue sites of the multiple tissue locations exhibiting electrical abnormality in the acquired electrophysiological signal data and determines an area of abnormal tissue associated with individual sites of the particular sites. An ablation controller automatically determines ablation pulse characteristics for use in ablating cardiac tissue at an individual site of the particular tissue sites in response to the acquired data indicating the thickness of tissue and determined area of abnormality of the individual site.

Abstract: A system for heart performance characterization and abnormality detection includes an interface for receiving sampled data representing an electrical signal indicating electrical activity of a patient heart over multiple heart beat cycles. A signal processor automatically, decomposes the received sampled data to multiple different subcomponent signals in the time domain. The signal processor associates individual decomposed subcomponents with corresponding different cardiac rotors and determined characteristics of the subcomponents indicating relative significance of the rotors in a cardiac atrial condition. A reproduction device provides data indicating the subcomponent characteristics indicating relative significance of the rotors in a cardiac atrial condition.

Abstract: A system for heart performance characterization and abnormality detection comprises an input processor and at least one signal processor. The input processor receives, sampled data representing a patient blood pressure signal and a concurrently acquired electrocardiogram (ECG) signal representing heart electrical activity of the patient. The at least one signal processor, synchronizes the patient blood pressure signal and the heart electrical activity signal, identifies at least two points of a heart electrical activity signal cycle, integrates signal data values representing the amplitude of the patient blood pressure signal of a segment between the identified two points to derive an integral value over time duration of the segment representing an area under the blood pressure signal waveform between the identified two points and in response to the derived integral value, initiates generation of a message associated with a medical condition of the patient.

Abstract: A system and method provide detecting and monitoring cardiac electrophysiological changes by determining differences between a reference signal representing a heartbeat signal and an analysis signal representing another heartbeat signal. A set of signal data consisting of a number of heartbeat signals is acquired as a function of time. Individual heartbeat signals within the set of acquired signals are identified, an individual signal comprising data values representing a plurality of sample points during a single heartbeat. One of the identified individual signals or a derived signal representing an average of a subset of the identified individual signals is selected as an analysis signal. A reference signal is identified. The sample points of the reference signal are aligned with the sample points of the analysis signal. A single value representative of mutual correspondence between the sample points of the reference signal and the corresponding sample points of the analysis signal is calculated.

Abstract: A system for heart performance characterization and abnormality detection includes an interface for receiving an electrical signal comprising a pressure indicative waveform indicating a heart blood pressure of a patient over a heart beat cycle. A timing detector determines multiple different time periods in at least one heart cycle from the pressure indicative waveform. A patient monitor monitors the multiple different time periods and in response to detection of a variation in at least one of the multiple different time periods exceeding a predetermined threshold or range, generates an alert message associated with the variation.