Abstract: Proposed is a peptide for skin anti-aging and anti-wrinkle, comprising a glycine-histidine-lysine tripeptide and polyarginine linked to the carboxy-terminus of the tripeptide, and a composition for skin anti-aging and anti-wrinkle comprising the peptide. The peptide and composition may enter the cytoplasm more rapidly and efficiently than a conventional GHK tripeptide, and may exhibit skin anti-aging and anti-wrinkle effects similar to those of the GHK tripeptide even at a lower concentration than that of the GHK tripeptide.

Abstract: Proposed is a peptide for skin anti-aging and anti-wrinkle, comprising a glycine-histidine-lysine tripeptide and polyarginine linked to the carboxy-terminus of the tripeptide, and a composition for skin anti-aging and anti-wrinkle comprising the peptide. The peptide and composition may enter the cytoplasm more rapidly and efficiently than a conventional GHK tripeptide, and may exhibit skin anti-aging and anti-wrinkle effects similar to those of the GHK tripeptide even at a lower concentration than that of the GHK tripeptide.

Abstract: The invention relates to a series of pyrrolopyrimidinone derivatives of the formula (1): wherein R1 is H; C1-C3 alkyl optionally substituted with one or more fluoro atoms; or C3-C6 cycloalkyl; R2 is H; a halogen atom; C1-C6 alkyl optionally substituted with OH, C1-C3 alkoxy, C3-C6 cycloalkyl, or with one or more fluoro atoms; C3-C6 cycloalkyl; C2-C6 alkenyl; or C2-C6 alkynyl; R3 is H; C1-C6 alkyl optionally substituted with OH, C1-C3 alkoxy, C3-C6 cycloalkyl, or with one or more fluoro atoms; C3-C6 cycloalkyl; C2-C6 alkenyl; or C2-C6 alkynyl; R4 is C1-C6 alkyl optionally substituted with C3-C6 cycloalkyl or with one or more fluoro atoms; C2-C6 alkenyl; C2-C6 alkynyl; or C3-C6 cycloalkyl; and R5 is SO2NR6R7; NHSO2NR6R7; NHCOCONR6R7; NHSO2R8; NHCOR8; or phenyl or heterocyclyl either of which is optionally substituted with one or more fluoro atoms or C1-C3 alkyl.

Abstract: The invention relates to a series of pyrrolopyrimidinone derivatives of the formula (1), processes for their preparation, intermediates in their preparation, their use as therapeutic agents, and pharmaceutical compositions containing them.

Abstract: A facility for manufacturing semiconductor devices is provided with a diagnosis system for easily monitoring the operation states of various fabrication systems, and controlling them in case of abnormal operation states by means of a sensing signal from the fabrication systems and a control signal from a control system. The fabrication system outputs a sensing signal showing the operation states of the fabrication processes such as temperature, time, pressure, concentration, power, etc. The control system outputs a control signal to the fabrication systems for controlling their operation states via transmit lines connected thereto according to the sensing signal from the fabrication systems or an input signal from a host computer. The diagnosis system analyzes the sensing signal from the fabrication systems and the control signal from the control system so as to assess the operation states of the fabrication systems.