Abstract: The present invention provides methods for treating or ameliorating metabolic diseases, cholestatic liver diseases, or organ fibrosis, which comprises administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising an isoxazole derivative, a racemate, an enantiomer, or a diastereoisomer thereof, or a pharmaceutically acceptable salt of the derivative, the racemate, the enantiomer, or the diastereoisomer.

Abstract: A secondary battery comprises an electrode assembly, a can, and an insulator. The electrode assembly includes a first electrode, a separator, and a second electrode alternately stacked and wound. The can has an accommodation part accommodating the electrode assembly therein, and the can comprises a first can and a second can having cylindrical shapes open in a direction facing each other. The insulator insulates an overlapping portion between the first can and the second can. The first can is electrically connected to the first electrode, and the second can is electrically connected to the second electrode. The insulator has a short-circuit induction through-part defined by a through-hole or a cutoff line, such that a short circuit occurs between the first can and the second can through the short-circuit induction through-part when it is deformed in shape as heat or a pressure is applied to contract or expand the insulator.

Abstract: The present disclosure relates to a novel PLK1 degradation inducing compound having a structure according to Formula I, a method for preparing the same, and the use thereof. The compounds of the present disclosure exhibit an effect of inducing PLK1 degradation. Therefore, the compounds of the present disclosure may be effectively utilized for preventing or treating PLK1-related diseases.

Abstract: A glass article includes lithium aluminosilicate, includes a first surface, a second surface opposed to the first surface, a first compressive region extending from the first surface to a first compression depth, a second compressive region extending from the second surface to a second compression depth, and, a tensile region disposed between the first compression depth and the second compression depth, where a stress profile of the first compressive region has a first local minimum point at which the stress profile is convex downward and a first local maximum point at which the stress profile is convex upward, where a depth of the first local maximum point is greater than a depth of the first local minimum point, and where a stress of the first local maximum point is greater than a compressive stress of the first local minimum point.

Abstract: A method for diagnosing cancer of unknown primary site by using artificial intelligence is disclosed. A method for diagnosing cancer of unknown primary site by using artificial intelligence, according to one embodiment of the present invention, includes the steps of: generating gene expression pattern information of a sample collected from tissue in which metastatic cancer has occurred; removing gene expression pattern information derived from pre-learned tissue from the gene expression pattern information of the sample collected from the tissue in which the metastatic cancer has occurred; comparing the gene expression pattern information from which the gene expression pattern information derived from the tissue has been removed with pre-learned gene expression pattern information for each cancer type; and specifying a primary site of the sample collected from the tissue in which the metastatic cancer has occurred.

Abstract: A 3D spring array device includes: a fixed body having an internal space therein; a moving body positioned in a center of an x-y-z orthogonal coordinate system in the internal space, wherein the moving body is configured to be fastenable to the end effector of the mechanical impedance estimating robot; and a first spring, a second spring, a third spring, a fourth spring, a fifth spring, a sixth spring, a seventh spring, and an eighth spring and configured to connect the fixed body to the moving body in the internal space.

Abstract: The present disclosure relates to a superconductor including magnesium diboride and a production method therefor. A superconductor having a high critical current density at a certain temperature and under a certain magnetic field may be obtained by doping magnesium diboride with liquid chloroform during the production of the superconductor.

Abstract: There is provided a method of processing uplink Ethernet packets of an aggregation node included in a distributed antenna system, the method includes: receiving a plurality of uplink Ethernet packets; summing the plurality of received uplink Ethernet packets; and transmitting the summed uplink Ethernet packets in an uplink direction.

Abstract: A positive electrode active material for a secondary battery including: a lithium complex transition metal oxide which contains nickel (Ni) and cobalt (Co), and contains at least one selected from the group consisting of manganese (Mn) and aluminum (Al); and a composite coating portion which is formed on a surface of the lithium complex transition metal oxide is provided. The lithium complex transition metal oxide has a nickel (Ni) content of 65 mol % or more with respect to the total transition metal content, and the composite coating portion contains cobalt (Co) and boron (B), and contains at least one selected from the group consisting of lanthanum (La), titanium (Ti), and aluminum (Al).

Abstract: The present invention relates to a method for purification of hemopexin and haptoglobin and provides a method in which a solution containing hemopexin and haptoglobin is titrated to a range of specific pH values without a step of precipitating haptoglobin by salt addition, followed by separating and purifying hemopexin and haptoglobin individually.

Abstract: Provided are a display apparatus and a method of manufacturing the display apparatus. The display apparatus includes a first barrier layer including a first display area, a second display area including transmission areas, and a non-display area, a first base layer on a lower surface of the first barrier layer, and defining a first opening that overlaps the second display area, a second base layer on an upper surface of the first barrier layer, and defining second openings that respectively overlap the transmission areas, a second barrier layer on an upper surface of the second base layer and defining third openings that overlap the second openings, main pixel electrodes over the second barrier layer in the first display area, and auxiliary pixel electrodes over the second barrier layer in the second display area.

Abstract: Proposed is a nitinol nanofiber with an average surface roughness that is enhanced through mechanical and chemical treatments. The enhanced surface roughness improves biocompatibility and promotes tissue growing, thereby improving the bioavailability of the nitinol nanofiber. The nitinol nanofiber undergoes infrared irradiation whereby the nitinol fiber exhibits improved tensile strength, elastic modulus, and maximum restorative stress. Therefore, fatigue fraction does not easily occur in the nitinol fiber even when the nitinol nanofiber has a constant roughness. The present invention provides bio-use or medical nitinol nanofibers that are highly biocompatible.

Abstract: Disclosed are device implementations for a hybrid energy harvesting device and methods for harvesting mechanical energy from the ambient. The various device implementations utilize a combination of electrostatic energy conversion and piezoelectric energy conversion elements. The method simultaneously converts mechanical energy into electrical charge by electrostatic and piezoelectric energy harvesting. The devices include a piezoelectric harvester including a pair of electrodes and piezoelectric nanocomposite polymer, an electrostatic harvester including an electret film and a pair of electrostatic electrodes.

Abstract: The present invention relates to a technology for analyzing and detecting/diagnosing a target nucleic acid. When the detection system according to the present invention is used, effective real-time detection or diagnosis efficiency can be obtained while problems such as noise are minimized. In particular, since, by using a house-keeping gene according to a method of use, the expression difference of the target nucleic acid can be corrected, and direct real-time target nucleic acid detection is possible, it can be effectively used for detecting various nucleic acids and diagnosing various diseases thereby.

Abstract: A manufacturing method of a cover window is provided. The method including: irradiating a laser at a plurality of first positions on a first surface of a glass, the laser having a focus value for each of the first positions; irradiating a laser at a plurality of second positions on a second surface of the glass, the laser having a focus value for each of the second positions; forming a curved portion on the first surface of the glass and a step portion on the second surface of the glass by etching the irradiated first and second positions of the glass; and forming a printed layer on the step portion in the second surface of the glass.

Abstract: Open block-based read offset compensation in read operation of memory device is disclosed. For example, a memory device includes an array of memory cells arranged in a plurality of blocks and a peripheral circuit coupled to the array of memory cells. The peripheral circuit is configured to, in response to a block of the plurality of blocks being an open block, perform a read operation on a memory cell of the array of memory cells in the block using a compensated read voltage. The compensated read voltage has an offset from a default read voltage of the block.

Abstract: A semiconductor package includes a package substrate having a first side and an opposite second side, a semiconductor chip on the first side of the package substrate, a capacitor on the second side of the package substrate, a plurality of connecting terminals on the second side of the package substrate, and a metal line within a trench in the package substrate. The trench extends in a first direction, and the metal line is between the capacitor and the plurality of connecting terminals. The metal line is spaced apart from the capacitor in a second direction that is transverse to the first direction, and a distance between the metal line and the capacitor is 100 ?m or more and 1000 ?m or less.