Patents by Inventor Houxing Fan

Houxing Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL CAMPTOTHECIN DERIVATIVE, COMPOSITION COMPRISING SAME AND USE THEREOF
    Publication number: 20230416270
    Abstract: The present invention provides a camptothecin derivative, a composition comprising the same and use thereof. Specifically, the present invention provides a compound of formula (1) and a preparation method therefor, and use of the compound of general formula (1) and optical isomers, crystalline forms and pharmaceutically acceptable salts thereof in the preparation of a medicament for treating cancer.
    Type: Application
    Filed: December 9, 2021
    Publication date: December 28, 2023
    Inventors: Yuli XIE, Gang CAO, Houxing FAN, Lihui QIAN
  • IDH MUTANT INHIBITOR AND USE THEREOF
    Publication number: 20230174550
    Abstract: The present invention relates to a compound of general formula (1a) or general formula (1b) and a method for preparing the same, and use of the compound of general formula (1a) or general formula (1b) and an isomer, a crystalline form, a pharmaceutically acceptable salt, a hydrate or a solvate thereof as an irreversible inhibitor for an IDH mutant in preparing a medicament for resisting a diseases such as a tumor related to an IDH mutant protein.
    Type: Application
    Filed: June 28, 2021
    Publication date: June 8, 2023
    Inventors: Yuli XIE, Houxing FAN, Lihui QIAN
  • NEW PYRAZINE COMPOUND
    Publication number: 20230167099
    Abstract: The present invention relates to a compound as represented by general formula (1), and a preparation method therefor, and the use of the compound as represented by general formula (1) and an isomer, a crystal form, a pharmaceutically acceptable salt, a hydrate or a solvate thereof as an EGFR inhibitor in the preparation of a drug against EGFR-related diseases, such as tumors.
    Type: Application
    Filed: June 1, 2021
    Publication date: June 1, 2023
    Inventors: Yuli XIE, Yingming WU, Houxing FAN, Lihui QIAN
  • PYRAZOLO[3,4-d]PYRIMIDIN-3-ONE DERIVATIVE AS WEE-1 INHIBITOR
    Publication number: 20230159540
    Abstract: The present invention relates to a novel compound of general formula (1) and/or a pharmaceutically acceptable salt thereof, a composition containing the compound of general formula (1) and/or the pharmaceutically acceptable salt thereof, a method for preparing the same, and use of the same as a Wee-1 inhibitor in preparing anti-tumor drugs.
    Type: Application
    Filed: June 16, 2021
    Publication date: May 25, 2023
    Inventors: Yuli XIE, Houxing FAN, Lihui QIAN
  • SPIRO RING-CONTAINING QUINAZOLINE COMPOUND
    Publication number: 20230128824
    Abstract: The present invention relates to a compound of general formula (1) and a preparation method therefor, and use of the compound of formula (1) and isomers, crystalline forms and pharmaceutically acceptable salts thereof as an irreversible inhibitor for a K-Ras G12C mutant protein in preparing a medicament for resisting Ras-related diseases such as tumors.
    Type: Application
    Filed: March 23, 2021
    Publication date: April 27, 2023
    Inventors: Yuli XIE, Houxing FAN, Gang CAO, Lihui QIAN
  • HPK1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20230130909
    Abstract: The present invention relates to a compound of general formula (1) and a preparation method therefor and use of the compound of general formula (1) or isomers, crystalline forms, pharmaceutically acceptable salts, hydrates or solvates thereof as an HPK1 inhibitor. The compound of the present invention can be used for preparing a medicament for treating or preventing related diseases mediated by HPK1.
    Type: Application
    Filed: April 19, 2021
    Publication date: April 27, 2023
    Inventors: Yuli XIE, Houxing FAN, Lihui QIAN
  • SPIRO RING-CONTAINING QUINAZOLINE COMPOUNDS
    Publication number: 20230002382
    Abstract: The present invention relates to a spiro ring-containing quinazoline compound, a preparation method therefor, and use of the compound as a K-Ras G12C inhibitor in preparing antitumor medicaments.
    Type: Application
    Filed: December 25, 2020
    Publication date: January 5, 2023
    Inventors: Yuli XIE, Houxing FAN, Gang CAO, Lihui QIAN
  • NOVEL PYRROLE COMPOUNDS
    Publication number: 20220340565
    Abstract: The invention relates to a series of new pyrrole compounds and preparation methods and uses thereof. Specifically, the present invention relates to compounds as shown in general formula (1) and the preparation method thereof, and the uses of the compound shown in general formula (1) and optical isomers, crystal forms and pharmaceutically acceptable salts in preparation of drugs for prevention or treatment of diseases related to fungal infection.
    Type: Application
    Filed: December 2, 2020
    Publication date: October 27, 2022
    Inventors: Yuli XIE, Houxing FAN, Lihui QIAN
  • NOVEL AURORA KINASE INHIBITORS AND USE THEREOF
    Publication number: 20220324857
    Abstract: The invention relates to a type of novel pyridine compound and a preparation method and application thereof. Specifically, the invention relates to a compound of formula (1) and a preparation method thereof, and an application of the compound of formula (1) and pharmaceutically acceptable salts thereof as aurora kinase inhibitors in preparation of anti-tumor drugs.
    Type: Application
    Filed: December 2, 2020
    Publication date: October 13, 2022
    Inventors: Yuli XIE, Houxing FAN, Lihui QIAN
  • Acryloyl-containing nuclear transport regulators and uses thereof
    Patent number: 11286247
    Abstract: The invention relates to a series of novel compounds containing acryloyl group. In particular, the invention relates to acryloyl group-containing compounds shown in formula (1) and the preparation method thereof, and application of the compounds shown in formula (1) and pharmaceutically acceptable salts thereof in preparation of medicaments for treating, regulating and/or preventing diseases related to physiological conditions related to CRM1 protein.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: March 29, 2022
    Assignee: WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
    Inventors: Houxing Fan, Yuli Xie
  • COMPOUNDS FOR INHIBITING EGFR KINASE, PREPARATION METHODS AND USES THEREOF
    Publication number: 20210230161
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, a preparation method and application thereof. The compounds can selectively inhibit the activity of epidermal growth factor receptor (EGFR) mutants, and shows good inhibitory effect towards mutant EGFR and anti-proliferative activity against cancer cells. Thus they can be used for treating tumors and related diseases.
    Type: Application
    Filed: March 14, 2021
    Publication date: July 29, 2021
    Inventors: Yuli XIE, Gang CAO, Houxing FAN
  • AURORA KINASE INHIBITORS AND USES THEREOF
    Publication number: 20210198261
    Abstract: The invention relates to a type of novel pyridine compound and a preparation method and application thereof. Specifically, the invention relates to a compound of formula (1) and a preparation method thereof, and an application of the compound of formula (1) and pharmaceutically acceptable salts thereof as aurora kinase inhibitors in preparation of anti-tumor drugs.
    Type: Application
    Filed: March 14, 2021
    Publication date: July 1, 2021
    Inventors: Yuli XIE, Houxing FAN
  • ACRYLOYL-CONTAINING NUCLEAR TRANSPORT REGULATORS AND USES THEREOF
    Publication number: 20210053945
    Abstract: The invention relates to a series of novel compounds containing acryloyl group. In particular, the invention relates to acryloyl group-containing compounds shown in formula (1) and the preparation method thereof, and application of the compounds shown in formula (1) and pharmaceutically acceptable salts thereof in preparation of medicaments for treating, regulating and/or preventing diseases related to physiological conditions related to CRM1 protein.
    Type: Application
    Filed: October 15, 2020
    Publication date: February 25, 2021
    Inventors: Houxing FAN, Yuli XIE
  • Nitroimidazole Compound, Preparation Method Therefor And Use Thereof In Drug Manufacturing
    Publication number: 20170334927
    Abstract: A nitroimidazole compound represented by general formula (I) or an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a preparation method therefore, and use thereof in manufacturing drugs for the treating infectious diseases caused by mycobacterium tuberculosis. Specific groups in general formula (I) are as defined in the specification.
    Type: Application
    Filed: December 11, 2015
    Publication date: November 23, 2017
    Applicant: Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd.
    Inventors: Chuansheng Zhao, Bingbin Zhang, Tongrui Zhou, Tiancai Wang, Jun Sun, Houxing Fan
  • (6,7-dihydro-2-nitro-5H-imidazol[2,1-b][1,3]oxazin-6-yl) amide compounds, preparation methods and uses thereof
    Patent number: 8563547
    Abstract: (6,7-Dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the description. The uses of the compounds in preparing medicaments for treating infectious diseases caused by Mycobacterium tuberculosis, especially infectious diseases caused by multi-drug resistance Mycobacterium tuberculosi are also disclosed.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: October 22, 2013
    Assignee: Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd.
    Inventors: Tiancai Wang, Ting Xin, Houxing Fan, Yilang Chen
  • Benzoxazine oxazolidinone compounds, preparation methods and uses thereof
    Patent number: 8507481
    Abstract: Novel benzoxazine oxazolidinone compounds, preparation methods and uses thereof are disclosed, which belong to the field of pharmacy. More specifically, novel benzoxazine oxazolidinone compounds represented by the following general formula (I), preparation methods and uses thereof in preparing medicament for treating infectious diseases, especially infectious diseases caused by multi-drug resistant bacteria, are disclosed.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: August 13, 2013
    Assignees: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Nanjing Changao Pharmaceutical Science & Technology Co., Limited
    Inventors: Yushe Yang, Qisheng Xin, Houxing Fan, Bin Guo, Xin Liu, Huili He, Wei Li, Zhan Li
  • (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20130143864
    Abstract: (6,7-Dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the description. The uses of the compounds in preparing medicaments for treating infectious diseases caused by Mycobacterium tuberculosis, especially infectious diseases caused by multi-drug resistance Mycobacterium tuberculosi are also disclosed.
    Type: Application
    Filed: October 26, 2012
    Publication date: June 6, 2013
    Inventors: Tiancai Wang, Ting Xin, Houxing Fan, Yilang Chen
  • NOVEL BENZOXAZINE OXAZOLIDINONE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20130123249
    Abstract: Novel benzoxazine oxazolidinone compounds, preparation methods and uses thereof are disclosed, which belong to the field of pharmacy. More specifically, novel benzoxazine oxazolidinone compounds represented by the following general formula (I), preparation methods and uses thereof in preparing medicament for treating infectious diseases, especially infectious diseases caused by multi-drug resistant bacteria, are disclosed.
    Type: Application
    Filed: May 12, 2011
    Publication date: May 16, 2013
    Inventors: Yushe Yang, Qisheng Xin, Houxing Fan, Bin Guo, Xin Liu, Huili He, Wei Li, Zhan Li