Patents by Inventor Howard Bernstein

Howard Bernstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210228124
    Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.
    Type: Application
    Filed: September 8, 2020
    Publication date: July 29, 2021
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
  • Publication number: 20210138050
    Abstract: The present invention provides methods for inducing tolerance or suppressing an immune response to an antigen by passing a cell suspension containing an immune cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell, thereby generating a tolerogenic and/or immunosuppressive immune cell. In some embodiments, the tolerogenic and/or immunosuppressive immune cell is delivered to an individual and presentation of the antigen induces tolerance and/or suppresses an immune response to the antigen.
    Type: Application
    Filed: May 3, 2017
    Publication date: May 13, 2021
    Inventors: Scott LOUGHHEAD, Jonathan B. GILBERT, Howard BERNSTEIN, Armon R. SHAREI, Finola MOORE
  • Publication number: 20210113628
    Abstract: Provided herein are methods and compositions related to bacteria of genus Burkholderia useful as therapeutic agents.
    Type: Application
    Filed: March 12, 2019
    Publication date: April 22, 2021
    Inventors: Scott LOUGHHEAD, LeeAnn TALARICO, Alfonso VICENTE-SUAREZ, Matt BOOTY, Howard BERNSTEIN, Katarina BLAGOVIC, Armon R. SHAREI, Kelan HLAVATY
  • Patent number: 10939860
    Abstract: The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: March 9, 2021
    Assignee: Seventh Sense Biosystems, Inc.
    Inventors: Douglas A. Levinson, Howard Bernstein, Donald E. Chickering, III, Shawn Davis, Ramin Haghgooie, Mark Michelman
  • Publication number: 20210038709
    Abstract: The present application provides immune cells comprising an HPV antigen and an adjuvant, methods of manufacturing such modified immune cells, and methods of using such modified immune cells for treating an HPV-associated disease, preventing an HPV-associated disease and/or for modulating an immune response in an individual with an HPV-associated disease.
    Type: Application
    Filed: March 11, 2019
    Publication date: February 11, 2021
    Inventors: Scott LOUGHHEAD, LeeAnn TALARICO, Alfonso VICENTE-SUAREZ, Matt BOOTY, Howard BERNSTEIN, Katarina BLAGOVIC, Armon R. SHAREI, Kelan HLAVATY, Melissa MYINT
  • Publication number: 20210022681
    Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device.
    Type: Application
    Filed: March 2, 2020
    Publication date: January 28, 2021
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Donald E. Chickering, III, Shawn Davis, Ramin Haghgooie, Howard Bernstein, Douglas A. Levinson
  • Publication number: 20200353155
    Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator.
    Type: Application
    Filed: December 6, 2019
    Publication date: November 12, 2020
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Howard Bernstein, Donald E. Chickering, III, Ping Gong, Shawn Davis
  • Publication number: 20200332243
    Abstract: A system for delivering a payload to a cell that includes: a platform supporting an input container, an output container, and a receiver for receiving all or part of a disposable assembly, the disposable assembly including a preparation vessel and a constriction cartridge. The preparation vessel holds a cell suspension as it is prepared for passage through one or more cell-deforming constrictions, and the constriction cartridge houses a component that includes the one or more cell deforming constrictions. Passage through the cell-deforming constrictions causes perturbations in cell membranes to allow entry of a payload into the cells. The system includes one or more processors configured to receive input from a user and to automatically control pressure, temperature, agitation, and/or flow of the cell suspension as it passes through the input container, through the preparation vessel, through the constriction cartridge, and to the output container.
    Type: Application
    Filed: December 18, 2018
    Publication date: October 22, 2020
    Inventors: Maisam DADGAR, Tarek ABDELJAWAD, Howard BERNSTEIN
  • Patent number: 10799166
    Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: October 13, 2020
    Assignee: Seventh Sense Biosystems, Inc.
    Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
  • Publication number: 20200318066
    Abstract: The present application provides peripheral blood mononuclear cells comprising an antigen, methods of manufacturing such PBMCs, and methods of using such PBMCs, such as for modulating an immune response in an individual. In some embodiments, the PBMCs are conditioned by incubating the PBMC in the presence of an adjuvant.
    Type: Application
    Filed: February 27, 2020
    Publication date: October 8, 2020
    Inventors: Armon R. SHAREI, Howard BERNSTEIN, Scott LOUGHHEAD, Matthew BOOTY, Katarina BLAGOVIC, Kelan HLAVATY, Defne YARAR, Emrah Ilker OZAY, Carolyne Kelly SMITH
  • Patent number: 10543310
    Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: January 28, 2020
    Assignee: Seventh Sense Biosystems, Inc.
    Inventors: Howard Bernstein, Donald E. Chickering, III, Ping Gong, Shawn Davis
  • Publication number: 20200015751
    Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus.
    Type: Application
    Filed: December 1, 2017
    Publication date: January 16, 2020
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Donald E. Chickering, III, Shawn Davis, Ramin Haghgooie, Howard Bernstein, Douglas A. Levinson, Mark Michelman
  • Publication number: 20190382796
    Abstract: The present disclosure pertains to methods and devices for delivering a compound into a cell, including passing a cell suspension through a surface containing pores, wherein the pores deform the cell thereby causing a perturbation of the cell such that the compound enters the cell, wherein the cell suspension is contacted with the compound.
    Type: Application
    Filed: September 2, 2016
    Publication date: December 19, 2019
    Inventors: Jonathan B. GILBERT, Kirubel FREW, Howard BERNSTEIN, Armon R. SHAREI
  • Publication number: 20190336058
    Abstract: In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. In one aspect, the present invention is generally directed to systems and methods for receiving blood from a subject and processing the blood to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.
    Type: Application
    Filed: December 12, 2018
    Publication date: November 7, 2019
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Ramin Haghgooie, Donald E. Chickering, III, Shawn Davis, Mark Michelman, Howard Bernstein, Kristin Horton
  • Publication number: 20190209820
    Abstract: The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.
    Type: Application
    Filed: July 30, 2018
    Publication date: July 11, 2019
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Donald E. Chickering, III, Douglas A. Levinson, Shawn Davis, Ramin Haghgooie, Howard Bernstein, David R. Walt
  • Publication number: 20190111082
    Abstract: The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.
    Type: Application
    Filed: May 3, 2017
    Publication date: April 18, 2019
    Inventors: Jonathan B. GILBERT, Bu WANG, Scott LOUGHHEAD, Howard BERNSTEIN, Armon R. SHAREI, Finola MOORE
  • Publication number: 20190053740
    Abstract: The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject.
    Type: Application
    Filed: March 9, 2018
    Publication date: February 21, 2019
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Howard Bernstein, Donald E. Chickering, III, Douglas A. Levinson, David R. Walt, Shawn Davis, Ramin Haghgooie
  • Patent number: 10188335
    Abstract: In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. In one aspect, the present invention is generally directed to systems and methods for receiving blood from a subject and processing the blood to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: January 29, 2019
    Assignee: Seventh Sense Biosystems, Inc.
    Inventors: Ramin Haghgooie, Donald E. Chickering, III, Shawn Davis, Mark Michelman, Howard Bernstein, Kristin Horton
  • Publication number: 20190017072
    Abstract: The present invention provides methods for delivering a transient and/or reversible complex into a cell including passing a cell suspension through a constriction, wherein said constriction deforms the cell, thereby causing a perturbation of the cell such that the complex enters the cell.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 17, 2019
    Applicant: SQZ Biotechnologies Company
    Inventors: Tia DITOMMASO, Howard BERNSTEIN, Armon R. SHAREI, Jonathan B. GILBERT
  • Publication number: 20180317829
    Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.
    Type: Application
    Filed: June 27, 2017
    Publication date: November 8, 2018
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson