Patents by Inventor Howard Bernstein
Howard Bernstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190111082Abstract: The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.Type: ApplicationFiled: May 3, 2017Publication date: April 18, 2019Inventors: Jonathan B. GILBERT, Bu WANG, Scott LOUGHHEAD, Howard BERNSTEIN, Armon R. SHAREI, Finola MOORE
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Publication number: 20190053740Abstract: The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject.Type: ApplicationFiled: March 9, 2018Publication date: February 21, 2019Applicant: Seventh Sense Biosystems, Inc.Inventors: Howard Bernstein, Donald E. Chickering, III, Douglas A. Levinson, David R. Walt, Shawn Davis, Ramin Haghgooie
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Patent number: 10188335Abstract: In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. In one aspect, the present invention is generally directed to systems and methods for receiving blood from a subject and processing the blood to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.Type: GrantFiled: July 22, 2015Date of Patent: January 29, 2019Assignee: Seventh Sense Biosystems, Inc.Inventors: Ramin Haghgooie, Donald E. Chickering, III, Shawn Davis, Mark Michelman, Howard Bernstein, Kristin Horton
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Publication number: 20190017072Abstract: The present invention provides methods for delivering a transient and/or reversible complex into a cell including passing a cell suspension through a constriction, wherein said constriction deforms the cell, thereby causing a perturbation of the cell such that the complex enters the cell.Type: ApplicationFiled: January 11, 2017Publication date: January 17, 2019Applicant: SQZ Biotechnologies CompanyInventors: Tia DITOMMASO, Howard BERNSTEIN, Armon R. SHAREI, Jonathan B. GILBERT
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Publication number: 20180317829Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: ApplicationFiled: June 27, 2017Publication date: November 8, 2018Applicant: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Publication number: 20180310884Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus.Type: ApplicationFiled: December 1, 2017Publication date: November 1, 2018Applicant: Seventh Sense Biosystems, Inc.Inventors: Donald E. Chickering, III, Shawn Davis, Ramin Haghgooie, Howard Bernstein, Douglas A. Levinson, Mark Michelman
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Publication number: 20180242890Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device.Type: ApplicationFiled: September 1, 2017Publication date: August 30, 2018Applicant: Seventh Sense Biosystems, Inc.Inventors: Donald E. Chickering, III, Shawn Davis, Ramin Haghgooie, Howard Bernstein, Douglas A. Levinson
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Publication number: 20180245089Abstract: The present disclosure pertains to methods for delivering a compound into a cell comprising a cell wall, including passing a cell suspension through a constriction, wherein said constriction deforms the cell comprising a cell wall, thereby causing a perturbation of the cell such that the compound enters the cell, wherein said cell suspension is contacted with the compound.Type: ApplicationFiled: September 2, 2016Publication date: August 30, 2018Inventors: Armon R. SHAREI, Howard BERNSTEIN, Jonathan B. GILBERT
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Publication number: 20180132774Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: ApplicationFiled: June 27, 2017Publication date: May 17, 2018Applicant: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Publication number: 20170281852Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator.Type: ApplicationFiled: November 11, 2016Publication date: October 5, 2017Applicant: Seventh Sense Biosystems, Inc.Inventors: Howard Bernstein, Donald E. Chickering, III, Ping Gong, Shawn Davis
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Patent number: 9775551Abstract: The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.Type: GrantFiled: July 13, 2015Date of Patent: October 3, 2017Assignee: Seventh Sense Biosystems, Inc.Inventors: Howard Bernstein, Donald E. Chickering, III, Douglas A. Levinson, David R. Walt, Shawn Davis, Ramin Haghgooie, Robert S. Langer, Timothy M. Blicharz
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Patent number: 9730624Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: GrantFiled: July 11, 2014Date of Patent: August 15, 2017Assignee: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Publication number: 20170215790Abstract: The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments.Type: ApplicationFiled: October 11, 2016Publication date: August 3, 2017Applicant: Seventh Sense Biosystems, Inc.Inventors: Douglas A. Levinson, Howard Bernstein
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Publication number: 20170154164Abstract: The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments.Type: ApplicationFiled: April 9, 2015Publication date: June 1, 2017Applicant: Seventh Sense Biosystems, Inc.Inventors: Douglas A. Levinson, Howard Bernstein, Donald E. Chickering, III
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Publication number: 20170127990Abstract: The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.Type: ApplicationFiled: December 21, 2016Publication date: May 11, 2017Applicant: Seventh Sense Biosystems, Inc.Inventors: Douglas A. Levinson, Howard Bernstein, Donald E. Chickering, III, Shawn Davis, Ramin Haghgooie, Mark Michelman
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Publication number: 20170127991Abstract: The present invention generally relates to systems and methods for receiving blood (or other bodily fluids) from a subject, e.g., from or beneath the skin of a subject. In some cases, the blood (or other bodily fluids) may be deposited on a membrane or other substrate. For example, blood may be absorbed in a substrate, and dried in some cases to produce a dried blood spot. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood. The substrate, in some embodiments, may comprise filter paper or cotton-based paper. After absorption of some blood onto the substrate, the substrate may be removed from the device and shipped or analyzed. In some cases, the device itself may be shipped or analyzed.Type: ApplicationFiled: May 17, 2016Publication date: May 11, 2017Applicant: Seventh Sense Biosystems, Inc.Inventors: Howard Bernstein, Donald E. Chickering, III, Shawn Davis, Ping Gong, Kristin Horton, Scott James
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Publication number: 20170120022Abstract: The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.Type: ApplicationFiled: August 9, 2016Publication date: May 4, 2017Applicant: Seventh Sense Biosystems, Inc.Inventors: Donald E. Chickering, III, Douglas A. Levinson, Shawn Davis, Ramin Haghgooie, Howard Bernstein, David R. Walt
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Publication number: 20160038068Abstract: The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject.Type: ApplicationFiled: April 17, 2015Publication date: February 11, 2016Applicant: Seventh Sense Biosystems, Inc.Inventors: Donald E. Chickering, III, Howard Bernstein, Shawn Davis, Ramin Haghgooie, Douglas A. Levinson, Mark Michelman, Ping Gong
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Publication number: 20150320349Abstract: In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. In one aspect, the present invention is generally directed to systems and methods for receiving blood from a subject and processing the blood to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.Type: ApplicationFiled: July 22, 2015Publication date: November 12, 2015Applicant: Seventh Sense Biosystems, Inc.Inventors: Ramin Haghgooie, Donald E. Chickering, III, Shawn Davis, Mark Michelman, Howard Bernstein, Kristin Horton
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Publication number: 20150313522Abstract: The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.Type: ApplicationFiled: July 13, 2015Publication date: November 5, 2015Applicant: Seventh Sense Biosystems, Inc.Inventors: Howard Bernstein, Donald E. Chickering, III, Douglas A. Levinson, David R. Walt, Shawn Davis, Ramin Haghgooie, Robert S. Langer, Timothy M. Blicharz