Abstract: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.

Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Abstract: Compounds and compositions for treating disorders related to TRPA1 are described herein.

Abstract: A method and system for shedding loads based upon a power system characteristic, such as voltage or frequency, is provided. In one embodiment, a remote party, such as a power generator or utility, transmits a signal to a control device proximately located with a load device. Upon receipt of the signal, the control device measures the power system characteristic for a predetermined time to establish a baseline threshold. The control device then monitors the power system characteristic. When the power system characteristic falls outside the baseline threshold, the control device sheds load. In one embodiment, the loads are prioritized such that the load of least importance may be shed first.

Abstract: A system for communicating across conventional HVAC wiring is provided. The system includes a communication device having a communication module capable of inducing low power, high frequency current signals into a single control wire coupling, for example, a thermostat with a compressor. The communication module includes a power supply module that draws power sufficient to operate the communication module from the existing HVAC wiring, so as to eliminate any need for batteries or external power sources. A second communication module may be coupled to the single control wire. The second communication module operates as a transceiver sending communication signals to, and receiving communication signals from, the communication module. In one embodiment, the communication module is disposed within a building, for example coupled to an electronic thermostat, while the second communication module is disposed outside the building near the compressor.

Abstract: A method (700) and system (100) for facilitating direct load control in an HVAC system while maintaining customer comfort is provided. A local controller (101) coupled to a HVAC system, receives direct load control signals from a remote source (111), such as an energy provider or utility. An analysis module (106) concurrently monitors the ambient temperature at the customer location. Where the ambient temperature reaches or exceeds a maximum temperature set point, the analysis module (106) modifies the load control signals to cause a local load (102), such as an air conditioner or heat pump, to maintain a customer comfort level.

Abstract: Compounds and compositions for treating disorders related to TRPA1 are described herein.

Abstract: A system for communicating across conventional HVAC wiring is provided. The system includes a communication device having a communication module capable of inducing low power, high frequency current signals into a single control wire coupling, for example, a thermostat with a compressor. The communication module includes a power supply module that draws power sufficient to operate the communication module from the existing HVAC wiring, so as to eliminate any need for batteries or external power sources. A second communication module may be coupled to the single control wire. The second communication module operates as a transceiver sending communication signals to, and receiving communication signals from, the communication module. In one embodiment, the communication module is disposed within a building, for example coupled to an electronic thermostat, while the second communication module is disposed outside the building near the compressor.

Abstract: A system for communicating across conventional HVAC wiring is provided. The system includes a communication device having a communication module capable of inducing low power, high frequency current signals into a single control wire coupling, for example, a thermostat with a compressor. The communication module includes a power supply module that draws power sufficient to operate the communication module from the existing HVAC wiring, so as to eliminate any need for batteries or external power sources. A second communication module may be coupled to the single control wire. The second communication module operates as a transceiver sending communication signals to, and receiving communication signals from, the communication module. In one embodiment, the communication module is disposed within a building, for example coupled to an electronic thermostat, while the second communication module is disposed outside the building near the compressor.

Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Abstract: A process for producing polytrimethylene ether glycol by polycondensing 1,3-propanediol using a catalyst comprising an acid and a base, at a temperature of from about 165 to about 175° C.

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Abstract: A system for communicating across conventional HVAC wiring is provided. The system includes a communication device having a communication module capable of inducing low power, high frequency current signals into a single control wire coupling, for example, a thermostat with a compressor. The communication module includes a power supply module that draws power sufficient to operate the communication module from the existing HVAC wiring, so as to eliminate any need for batteries or external power sources. A second communication module may be coupled to the single control wire. The second communication module operates as a transceiver sending communication signals to, and receiving communication signals from, the communication module. In one embodiment, the communication module is disposed within a building, for example coupled to an electronic thermostat, while the second communication module is disposed outside the building near the compressor.

Abstract: A system for communicating across conventional HVAC wiring is provided. The system includes a communication device having a communication module capable of inducing low power, high frequency current signals into a single control wire coupling, for example, a thermostat with a compressor. The communication module includes a power supply module that draws power sufficient to operate the communication module from the existing HVAC wiring, so as to eliminate any need for batteries or external power sources. A second communication module may be coupled to the single control wire. The second communication module operates as a transceiver sending communication signals to, and receiving communication signals from, the communication module. In one embodiment, the communication module is disposed within a building, for example coupled to an electronic thermostat, while the second communication module is disposed outside the building near the compressor.

Abstract: A system for communicating across conventional HVAC wiring is provided. The system includes a communication device having a communication module capable of inducing low power, high frequency current signals into a single control wire coupling, for example, a thermostat with a compressor. The communication module includes a power supply module that draws power sufficient to operate the communication module from the existing HVAC wiring, so as to eliminate any need for batteries or external power sources. A second communication module may be coupled to the single control wire. The second communication module operates as a transceiver sending communication signals to, and receiving communication signals from, the communication module. In one embodiment, the communication module is disposed within a building, for example coupled to an electronic thermostat, while the second communication module is disposed outside the building near the compressor.

Abstract: A method and system for shedding loads based upon a power system characteristic, such as voltage or frequency, is provided. In one embodiment, a remote party, such as a power generator or utility, transmits a signal to a control device proximately located with a load device. Upon receipt of the signal, the control device measures the power system characteristic for a predetermined time to establish a baseline threshold. The control device then monitors the power system characteristic. When the power system characteristic falls outside the baseline threshold, the control device sheds load. In one embodiment, the loads are prioritized such that the load of least importance may be shed first.

Abstract: A system for communicating across conventional HVAC wiring is provided. The system includes a communication device having a communication module capable of inducing low power, high frequency current signals into a single control wire coupling, for example, a thermostat with a compressor. The communication module includes a power supply module that draws power sufficient to operate the communication module from the existing HVAC wiring, so as to eliminate any need for batteries or external power sources. A second communication module may be coupled to the single control wire. The second communication module operates as a transceiver sending communication signals to, and receiving communication signals from, the communication module. In one embodiment, the communication module is disposed within a building, for example coupled to an electronic thermostat, while the second communication module is disposed outside the building near the compressor.

Abstract: The invention relates to cyclic hydrazone compounds, compositions including the cyclic hydrazone compounds and methods of using and methods of making thereof. The compounds (and compositions) are useful, inter alia, in modulating IL-12 production and processes mediated by IL-12.

Abstract: A curable thermoplastic elastomeric composition comprising: (a) polytrimethylene ether ester elastomer; (b) crosslinkable poly(meth)acrylate rubber; and (c) a crosslinking system to crosslink the rubber. A melt processible thermoplastic elastomeric composition comprising: (a) a continuous phase comprising polytrimethylene ether ester elastomer; and (b) crosslinked poly(meth)acrylate rubber disperse phase.