Abstract: The invention relates to heterocyclic compounds, compositions including the compounds and methods of using and methods of making thereof. The compounds (and compositions) are useful, inter alia, in modulating IL-12 production and processes mediated by IL-12.

Abstract: A silicon-containing polytrimethylene homo- or copolyether wherein at least a portion of the polymer end groups are silicon-containing end groups having the formula: —OSi(X)(Y)(Z), where X and Y are groups that are easily displaceable from silicon by reaction with water and/or alcohols, and Z is selected from the group consisting of (a) C1-C20 linear or branched alkyl groups, (b) cycloaliphatic groups, (c) aromatic groups, each of (a), (b) and (c) being optionally substituted with a member selected from the group consisting of O, N, P and S, (d) hydrogen, and (e) groups that are easily displaceable from silicon by water and/or alcohol.

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.

Abstract: A system for communicating across conventional HVAC wiring is provided. The system includes a communication device having a communication module capable of inducing low power, high frequency current signals into a single control wire coupling, for example, a thermostat with a compressor. The communication module includes a power supply module that draws power sufficient to operate the communication module from the existing HVAC wiring, so as to eliminate any need for batteries or external power sources. A second communication module may be coupled to the single control wire. The second communication module operates as a transceiver sending communication signals to, and receiving communication signals from, the communication module. In one embodiment, the communication module is disposed within a building, for example coupled to an electronic thermostat, while the second communication module is disposed outside the building near the compressor.

Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

Abstract: This invention relates to compounds having a formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, prodrug or polymorph thereof wherein X is —C(Rg)?N-A. The invention also relates to methods of treating IL-12 overproduction-related disorders, methods of treating or preventing disorders related with excessive bone loss, methods for inhibiting osteoclast formation, and methods for treating or preventing a disorder associated with excessive bone resorption.

Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

Abstract: This invention features compounds of formula (I): pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12-related diseases and disorders.

Abstract: A process is provided comprising contacting 1,3-propanediol with a suitable polymerization catalyst to produce polytrimethylene ether glycol or random polytrimethylene ether ester, wherein the 1,3-propanediol comprises about 10 microg/g or less peroxide compounds, based on the weight of 1,3-propanediol, and about 100 microg/g or less carbonyl compounds based on the weight of the 1,3-propanediol. Preferably, the 1,3-propanediol comprises about 100 microg/g or less of monofunctional alcohol compounds based on the weight of the PDO. In addition, polytrimethylene ether glycol and random polytrimethylene ether ester prepared by the process.

Abstract: A process for making partially aromatic polyamides is provided in which an aromatic dicarboxylic acid component, at least 20-100% by weight of the dicarboxylic acid in the acid component is in the form of an alkylated ester, and a diamine component, comprising a diamine having from 6-12 carbon atoms, are admixed in the presence of water and with heating to form polyamide having from 1-100% on a molar basis of N-alkylated amide and amine groups. The polyamides are particularly useful in the manufacture of products intended for use at elevated temperatures or products in which retention of properties at elevated temperatures is required, including articles using injection molding technology, parts for automotive end-uses and electronics. The polyamides can also be formed into films and fibers for use in associated products.

Abstract: A multi-stage process for the manufacture of branched aliphatic polyamides is provided. The process comprises the steps, in sequence, of feeding to a reactor a slurry of at least one aliphatic dinitrile, and at least one aliphatic diamine, at least one of which is branched, in the presence of 0.05 to 2% by weight of a phosphorous-containing compound, with the incremental addition of water, heating the slurry to a temperature of at least 270° C. while maintaining a pressure of at least 1.2 Mpa, venting water, ammonia and other volatile matter from the reactor while maintaining the temperature and pressure, maintaining the temperature for a further period of time while reducing the pressure to at least atmospheric pressure and then discharging the polyamide so formed. Polyamides made by this process are substantially the same as corresponding polyamides made by the conventional salt-strike process, and can be used in molding, coating and film applications.

Abstract: An improved gas distribution system (10) is provided. The system reduces the number of particles settling on semiconductor wafers (38, 40, 42) during processing. The system includes gas tubes (44, 46,48, 50) having gas inlets (52, 54, 56, 58, 60, 62). The gas inlets are offset from the center line (74, 76) of corresponding wafers, and offset from the inlets of neighboring gas tubes. The inlets are also directed along lines (90, 92, 94, 96) which do not intersect corresponding wafers (38, 40, 42). The gas tubes (44, 46,48, 50) each include a removable cap (110) to provide easy cleaning. Additionally, the gas tubes (44, 46,48, 50) each include an alignment slot (114) for accurate alignment of the tube and inlets.

Abstract: In an electronic coin telephone set, a fraud prevention arrangement prevents fraudulent coin tones originating at a telephone transmitter from being provided to a central office over a coin subscriber loop. The arrangement comprises a first and second transmission channel for alternately connecting the transmitter to the central office and also a fraud filter disposed in the second transmission channel. The fraud filter attenuates a selected frequency originating at the transmitter that is indicative of coin deposits. When coin deposits are not required by the central office, the transmitter is connected to the central office through the first transmission channel. When coin deposits are required by the central office, however, the arrangement connects the transmitter to the central office through the second transmission channel thereby avoiding the fraudulent generating of coin tones through the telephone transmitter.

Abstract: This invention pertains to a microcomputer controlled coin telephone set which prevents coin call fraud and performs all of the coin discrimination functions. The microcomputer also checks the operational readiness of the telephone set to prevent the acceptance of coins into a hopper for late collection by a coin box unless or until the set is fully functional.

Abstract: A microcomputer controlled coin telephone set prevents coin call fraud and also checks the operational readiness of the telephone set to prevent the acceptance of coins into a hopper for later collection by a coin box unless or until the set is fully functional. Capable of being interrogated remotely, a local memory is used for storing coin deposit information and generating coin deposit signals in order of deposit to a central office. In those instances where the line power drops below that necessary for full operation as a coin telephone, low power sensing circuits convert the telephone to the POTS mode which allows speech and dialing capabilities. Similarly, any type of chute failure, or a full hopper causes the telephone to revert to the POTS mode. While in the POTS mode, any coins deposited in the telephone are returned to the customer.