Abstract: The present invention relates to compounds of formula (I) wherein G1 to G8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant pathogens. Disclosed herein are the compounds of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and their use in the treatment of antimicrobial infection.

Abstract: A system for cooling a traction battery includes a battery inlet housing having first and second inlets. A first duct is coupled to the first inlet, and a second duct is coupled to the second inlet. A flow guide vane is disposed within the battery inlet housing adjacent to the first inlet. The flow guide vane is positioned to redirect flow from the first duct to mix with flow from the second duct.

Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

Abstract: VAR2CSA-drug conjugates having biological activity are disclosed. Methods associated with preparation and use of such conjugates, as well as pharmaceutical compositions comprising such conjugates, are also disclosed.

Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

Abstract: VAR2CSA-drug conjugates having biological activity are disclosed. Methods associated with preparation and use of such conjugates, as well as pharmaceutical compositions comprising such conjugates, are also disclosed.

Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

Abstract: A method for forming a textile article includes the steps of providing at least one shaping yarn and at least one basic yarn; processing the shaping yarn and the basic yarn to form a primitive textile structure; fitting the primitive textile structure to a shaping mold; applying high temperature to heat the primitive textile structure so as to have the shaping yarn included in the primitive textile structure heated and molten to form a shaping film covering the basic yarn; applying a low temperature to solidify the shaping film that covers the basic yarn so as to fix a shape of the primitive textile structure to form a shaped textile structure; and removing the shaped textile structure of which the shape is fixed from the shaping mold.

Abstract: A display apparatus includes a receiving module, a processing module, a selecting module, a power circuit, and a backlight module. The receiving module receives a pulse width modulating (PWM) signal from an external component. The processing module processes the PWM signal in a predetermined time duration. The selecting module outputs the unadjusted PWM signal to the power circuit in the predetermined time duration, and outputs an adjusted signal after the predetermined duration. The power circuit generates a first driving current for driving the backlight module to emit lights in response to the unadjusted PWM signal while the processing module processes the PWM signal. The backlight module remains a predetermined brightness after the predetermined time.

Abstract: Sulfonamide-containing linkage systems for release of payload compounds from an attached targeting moiety in drug conjugates. The conjugates have the formula of [(P)-(L)]m-(T), wherein (P) is a payload compound, (L) is a linker, (T) is a targeting moiety and m is an integer from 1- to 10. Also provided are pharmaceutical compositions comprising such conjugates and there use in treating cancer.

Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having structure (I).

Abstract: The present disclosure relates to a vehicle battery pack cooling system, including: a housing; a fan attached to the housing; a first section of the housing including a battery module selectively in fluid communication with the fan; a second section of the housing including a battery support device selectively in fluid communication with the fan; and a baffler assembly configured to control fluid communication between the fan and the first and second sections.

Abstract: Air is supplied from a passenger cabin of a vehicle to an intake passage between the passenger cabin and a battery of the vehicle. The vehicle may be an electric vehicle such as a hybrid electric vehicle (HEV) or a battery-only electric vehicle (BEV). A signal indicating a blockage of air flow through the battery is generated in response to a difference in temperature exceeding a predetermined magnitude. The difference in temperature is between (i) the intake passage and (ii) the passenger cabin.

Abstract: A switching circuit includes a first switch, a second switch, and a reservoir capacitor. The first switch includes a first gate, a first source, a first drain, and a first gate-to-source capacitor coupled between the first gate and the first source. The second switch includes a second gate, a second source, a second drain, and a second gate-to-source capacitor coupled between the second gate and the second source. The reservoir capacitor is coupled to both the first gate and the second gate. When the first switch is turned on, the first gate-to-source capacitor is charged by a power voltage source and accumulates charges. When the first switch is turned off, the reservoir capacitor is charged by the charges from the first gate-to-source capacitor. The charges stored in the reservoir can be used to charge the second gate-to-source capacitor.

Abstract: A switching circuit includes a first switch, a second switch, and a reservoir capacitor. The first switch includes a first gate, a first source, a first drain, and a first gate-to-source capacitor coupled between the first gate and the first source. The second switch includes a second gate, a second source, a second drain, and a second gate-to-source capacitor coupled between the second gate and the second source. The reservoir capacitor is coupled to both the first gate and the second gate. When the first switch is turned on, the first gate-to-source capacitor is charged by a power voltage source and accumulates charges. When the first switch is turned off, the reservoir capacitor is charged by the charges from the first gate-to-source capacitor. The charges stored in the reservoir can be used to charge the second gate-to-source capacitor.

Abstract: A display apparatus includes a receiving module, a processing module, a selecting module, a power circuit, and a backlight module. The receiving module receives a pulse width modulating (PWM) signal from an external component. The processing module processes the PWM signal in a predetermined time duration. The selecting module outputs the unadjusted PWM signal to the power circuit in the predetermined time duration, and outputs an adjusted signal after the predetermined duration. The power circuit generates a first driving current for driving the backlight module to emit lights in response to the unadjusted PWM signal while the processing module processes the PWM signal. The backlight module remains a predetermined brightness after the predetermined time.

Abstract: A computer implemented method includes detecting a vehicle state for which a user is to be notified. The method also includes sending a notification for a user regarding the vehicle state. The method further includes receiving a response that a do not disturb mode is enabled for the user. The method additionally includes queuing the notification for later delivery. The method also includes re-sending the notification for the user at a later point in time than when an original notification was sent.

Abstract: Air is supplied from a passenger cabin of a vehicle to an intake passage between the passenger cabin and a battery of the vehicle. The vehicle may be an electric vehicle such as a hybrid electric vehicle (HEV) or a battery-only electric vehicle (BEV). A signal indicating a blockage of air flow through the battery is generated in response to a difference in temperature exceeding a predetermined magnitude. The difference in temperature is between (i) the intake passage and (ii) the passenger cabin.

Abstract: A data synchronizing system includes a plurality of data centers and a data synchronizing controller. The data synchronizing controller is communicatively coupled to the data centers for outputting a synchronizing command and a synchronizing parameter to the data centers periodically. One of the data centers adjusts a data transmitting condition thereof based on the synchronizing parameter so as to synchronize data to another one of the data centers such that each of the data centers has the same data.

Abstract: Air is supplied from a passenger cabin of a vehicle to an intake passage between the passenger cabin and a battery of the vehicle. The vehicle may be an electric vehicle such as a hybrid electric vehicle (HEV) or a battery-only electric vehicle (BEV). A signal indicating a blockage of air flow through the battery is generated in response to a difference in temperature exceeding a predetermined magnitude. The difference in temperature is between (i) the intake passage and (ii) the passenger cabin.