Patents by Inventor Hsien-Yeh Chen

Hsien-Yeh Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11952498
    Abstract: Disclosed herein are a colored functionalized paracyclophane represented by Formula (I) and a colored chemical film represented by Formula (II): wherein A, o, and p in Formula (I) and Formula (II) are as defined herein. The colored chemical film may be formed from the colored functionalized [2,2]paracyclophane by chemical vapor deposition.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: April 9, 2024
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Hsien-Yeh Chen, Sheng-Tung Huang
  • Publication number: 20220195199
    Abstract: Disclosed herein are a colored functionalized paracyclophane represented by Formula (I) and a colored chemical film represented by Formula (II): wherein A, o, and p in Formula (I) and Formula (II) are as defined herein. The colored chemical film may be formed from the colored functionalized [2,2]paracyclophane by chemical vapor deposition.
    Type: Application
    Filed: February 4, 2021
    Publication date: June 23, 2022
    Inventors: Hsien-Yeh CHEN, Sheng-Tung HUANG
  • Patent number: 11161957
    Abstract: The present invention provides a 3D porous structure of parylene including a poly-p-xylylenes structure having a plurality of pores. The poly-p-xylylenes structure has a porosity. According to an embodiment of the present invention, the size of the porous structure is between 20 nm and 5 cm. According to an embodiment of the present invention, the porosity is between 55% and 85%. According to an embodiment of the present invention, the porous structure further includes a plurality of target molecules. According to an embodiment of the present invention, the pores of the poly-p-xylylenes structure include pore sizes of different sizes. The pore sizes are varying in a gradient. According to an embodiment of the present invention, the porous structure is formed integrally.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: November 2, 2021
    Assignee: MAY-HWA ENTERPRISE CORPORATION
    Inventors: Hsien-Yeh Chen, Hsing-Ying Tung
  • Patent number: 10939976
    Abstract: Disclosed is a minimally invasive instrument with instant force feedback function, including a minimally invasive device, a sensing device, a computing device, and a warning device. The minimally invasive device may have an invasive portion, which may enter the human body to perform surgical operations. The sensing device is provided on the invasive portion of the minimally invasive device and may include a flexible conductive film, a plurality of bionic films and a plurality of liquid beads. The plurality of bionic films may be provided on a flexible conductive film. Each of the plurality of liquid beads may be covered by each of the plurality of bionic films. The computing device may be electrically connected to the flexible conductive film. The warning device may receive a warning signal and generate a warning message.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: March 9, 2021
    Assignee: Show-Chwan Memorial Hospital
    Inventors: Shih-Chi Chan, Kai-Che Liu, Shih-Wei Huang, Hsien-Yeh Chen, Tien-Li Chang
  • Patent number: 10336692
    Abstract: The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3?-dithiodipropionic acid (DPDPA) and N-ethyl-N?-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: July 2, 2019
    Assignee: MAY-HWA ENTERPRISE CORPORATION
    Inventors: Hsien-Yeh Chen, Zhen-Yu Guan, Chih-Yu Wu
  • Patent number: 10246412
    Abstract: The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3?-dithiodipropionic acid (DPDPA) and N-ethyl-N?-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: April 2, 2019
    Assignee: MAY-HWA ENTERPRISE CORPORATION
    Inventors: Hsien-Yeh Chen, Zhen-Yu Guan, Chih-Yu Wu
  • Publication number: 20190021808
    Abstract: Disclosed is a minimally invasive instrument with instant force feedback function, including a minimally invasive device, a sensing device, a computing device, and a warning device. The minimally invasive device may have an invasive portion, which may enter the human body to perform surgical operations. The sensing device is provided on the invasive portion of the minimally invasive device and may include a flexible conductive film, a plurality of bionic films and a plurality of liquid beads. The plurality of bionic films may be provided on a flexible conductive film. Each of the plurality of liquid beads may be covered by each of the plurality of bionic films. The computing device may be electrically connected to the flexible conductive film. The warning device may receive a warning signal and generate a warning message.
    Type: Application
    Filed: May 23, 2018
    Publication date: January 24, 2019
    Inventors: Shih-Chi Chan, Kai-Che Liu, Shih-Wei Huang, Hsien-Yeh Chen, Tien-Li Chang
  • Publication number: 20180273898
    Abstract: The present invention provides a biological material including a parylene C film; and first proteins which are adsorbed on the surface of the parylene C film. According to an embodiment of the present invention, the biological material further includes second proteins different from the first proteins adsorbed on the surface of the parylene C film. According to an embodiment of the present invention, the first proteins or the second proteins include BMP-2, fibronectin or PRP.
    Type: Application
    Filed: May 4, 2017
    Publication date: September 27, 2018
    Inventors: Hsien-Yeh Chen, Zhen-Yu Guan
  • Publication number: 20180265460
    Abstract: The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3?-dithiodipropionic acid (DPDPA) and N-ethyl-N?-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 20, 2018
    Inventors: Hsien-Yeh Chen, Zhen-Yu Guan, Chih-Yu Wu
  • Publication number: 20180243081
    Abstract: The present invention provides a method of forming an intraocular lens. First, a chemical vapor deposition (CVD) process is performed to form a first poly-p-xylylene film, following by placing a solution drop on the first poly-p-xylylene film. A chemical vapor deposition encapsulation process is performed to form a second poly-p-xylylene film on the first poly-p-xylylene film and the solution drop.
    Type: Application
    Filed: April 25, 2018
    Publication date: August 30, 2018
    Inventors: Hsien-Yeh Chen, Shih-Kang Fan, Jyun-Ting Wu
  • Patent number: 10035875
    Abstract: A patterned film structure consists of a substrate and of a patterned polymeric layer which selectively covers and exposes part of the surface of the substrate. The patterned polymeric layer is selected form at least one of an unsubstituted poly-para-xylylene and a substituted poly-para-xylylene.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: July 31, 2018
    Assignee: MAY-HWA ENTERPRISE CORPORATION
    Inventors: Hsien-Yeh Chen, Chih-Yu Wu
  • Publication number: 20180201749
    Abstract: The present invention provides a 3D porous structure of parylene including a poly-p-xylylenes structure having a plurality of pores. The poly-p-xylylenes structure has a porosity. According to an embodiment of the present invention, the size of the porous structure is between 20 nm and 5 cm. According to an embodiment of the present invention, the porosity is between 55% and 85%. According to an embodiment of the present invention, the porous structure further includes a plurality of target molecules. According to an embodiment of the present invention, the pores of the poly-p-xylylenes structure include pore sizes of different sizes. The pore sizes are varying in a gradient. According to an embodiment of the present invention, the porous structure is formed integrally.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 19, 2018
    Inventors: Hsien-Yeh Chen, Hsing-Ying Tung
  • Patent number: 9862799
    Abstract: Provided is a poly-p-xylyene having at least one chemically active functional group present in a form of particles. In an embodiment, the functionalized poly-p-xylylene is synthesized via CVD, and electrospinning is then performed at a relatively low polymer concentration, so as to produce functionalized poly-p-xylylene particles. The functionalized poly-p-xylyene particles have a particle size at nano-scale or micro-scale. Such functionalized poly-p-xylyene particles can be applied to biological fields extensively.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: January 9, 2018
    Assignee: MAY-HWA ENTERPRISE CORPORATION
    Inventors: Hsien-Yeh Chen, Hsin-Ying Ho, Ho-Yi Sun, Cheng-Yuan Fang
  • Publication number: 20170349697
    Abstract: A patterned film structure consists of a substrate and of a patterned polymeric layer which selectively covers and exposes part of the surface of the substrate. The patterned polymeric layer is selected form at least one of an unsubstituted poly-para-xylylene and a substituted poly-para-xylylene.
    Type: Application
    Filed: March 7, 2017
    Publication date: December 7, 2017
    Inventors: Hsien-Yeh Chen, Chih-Yu Wu
  • Patent number: 9771324
    Abstract: The present invention provides a method of forming N-hydroxysuccinimide ester-functionalized paracyclophane. The present method is carried out by adding 4-carboxyl-paracyclophane into N,N?-Dicyclohexylcarbodiimide (DCC) and N-Hydroxysuccinimide (NHS) to form N-hydroxysuccinimide ester-functionalized paracyclophane. The present invention further provides a chemical film on a substrate and a method of forming the same, wherein the chemical film includes N-hydroxysuccinimide ester-functionalized poly-para-xylylene.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: September 26, 2017
    Inventor: Hsien-Yeh Chen
  • Publication number: 20170172728
    Abstract: The present invention provides an intraocular lens, including a first poly-p-xylylene film, a second poly-p-xylylene film and a liquid drop. The liquid drop is disposed between the first poly-p-xylylene film and the second poly-p-xylylene. The present invention further provides a method of forming the same.
    Type: Application
    Filed: January 18, 2016
    Publication date: June 22, 2017
    Inventors: Hsien-Yeh Chen, Shih-Kang Fan, Jyun-Ting Wu
  • Publication number: 20170166520
    Abstract: The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3?-dithiodipropionic acid (DPDPA) and N-ethyl-N?-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.
    Type: Application
    Filed: June 16, 2016
    Publication date: June 15, 2017
    Inventors: Hsien-Yeh Chen, Zhen-Yu Guan, Chih-Yu Wu
  • Patent number: 9320835
    Abstract: Provided are a polymer composition on a substrate and a surface modification method which is non-selective to substrate materials. Chemical vapor deposition polymerization is used to deposit a maleimide-functionalized poly-p-xylylene coating on a substrate. The substrate is readily available to perform a thiol-maleimide coupling reaction under mild conditions so as to modify the surface thereof. Furthermore, through a tailored thiol-terminal molecule, a designer surface can be created via thiol-maleimide coupling on a substrate, and the resulting surface can exhibit various desired biological functions for biotechnological applications. Therefore, this modification technique can be applied to biological fields extensively.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: April 26, 2016
    Assignee: National Taiwan University
    Inventors: Hsien-Yeh Chen, Sheng-Tung Huang, Meng-Yu Tsai
  • Publication number: 20150307653
    Abstract: Provided is a poly-p-xylyene having at least one chemically active functional group present in a form of particles. In an embodiment, the functionalized poly-p-xylylene is synthesized via CVD, and electrospinning is then performed at a relatively low polymer concentration, so as to produce functionalized poly-p-xylylene particles. The functionalized poly-p-xylyene particles have a particle size at nano-scale or micro-scale. Such functionalized poly-p-xylyene particles can be applied to biological fields extensively.
    Type: Application
    Filed: October 31, 2014
    Publication date: October 29, 2015
    Inventors: Hsien-Yeh Chen, Hsin-Ying Ho, Ho-Yi Sun, Cheng-Yuan Fang
  • Publication number: 20150252162
    Abstract: The present invention concerns an anti-microbial modified material and an anti-microbial modification method, obtained by a bonding of a compound represented by formula (I) with a benzoyl-containing photoinitiator via a photoreaction. For the substrate surface modified by the anti-microbial modification method of the invention, the formation of the biofilm can be drastically diminished and a strong bactericidal capability may be afforded.
    Type: Application
    Filed: July 10, 2014
    Publication date: September 10, 2015
    Inventors: Hsien-Yeh Chen, Chih-Hao Chang, Che-Wei Hsu, Ting-Ju Lin, Shu-Yun Yeh