Patents by Inventor Hsing-Wen Sung

Hsing-Wen Sung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticles for protein drug delivery
    Patent number: 7556826
    Abstract: The invention discloses a chewable composition for oral delivery of bioactive agents having nanoparticles that are composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: July 7, 2009
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Publication number: 20090155374
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Application
    Filed: January 15, 2009
    Publication date: June 18, 2009
    Inventors: Hsing-wen Sung, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Publication number: 20090142405
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Application
    Filed: December 4, 2008
    Publication date: June 4, 2009
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7541046
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: June 2, 2009
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for monoclonal antibody delivery
    Patent number: 7541028
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent of monoclonal antibody. The nanoparticles are characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: June 2, 2009
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Mei-Chin Chen, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Publication number: 20090011008
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Application
    Filed: August 7, 2008
    Publication date: January 8, 2009
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Publication number: 20090004266
    Abstract: The invention discloses a chewable composition for oral delivery of bioactive agents having nanoparticles that are composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Application
    Filed: August 28, 2008
    Publication date: January 1, 2009
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7455830
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: November 25, 2008
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Nanoparticles for protein/peptide delivery and delivery means
    Patent number: 7449200
    Abstract: The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are composed of positively charged shell substrate, negatively charged core substrate with encapsulated bioactive agents of proteins or peptides.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: November 11, 2008
    Assignees: GP Medical, Inc., National Tsing Hua Univeristy
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Po-Wei Lee, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Publication number: 20080233200
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Application
    Filed: April 24, 2008
    Publication date: September 25, 2008
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Publication number: 20080213354
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-?-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Application
    Filed: July 26, 2007
    Publication date: September 4, 2008
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Medical device and methods for living cell injection
    Publication number: 20080166329
    Abstract: A novel method, using a thermoreversible MC/PBS/Collagen hydrogel coated on the TCPS dish, for harvesting a living cell sheet or spheroid with ECM. In one application, the obtained living cell sheet/spheroid is administered to a joint adapted for implantation and for cartilage regeneration. In another application, the living cell sheet/spheroid is administered, preferably via percutaneous injection, to an infarcted cardiac tissue as a novel therapy for treating myocardial infarction.
    Type: Application
    Filed: November 26, 2007
    Publication date: July 10, 2008
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for drug delivery
    Publication number: 20080160078
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent of HMG-CoA reductase inhibitors or erythropoietin. The nanoparticles are characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Application
    Filed: January 11, 2008
    Publication date: July 3, 2008
    Inventors: Mei-Chin Chen, Hosheng Tu, Hsing-Wen Sung, Yu-Hsin Lin
  • Nanoparticles for protein drug delivery
    Patent number: 7381716
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: June 3, 2008
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Drug-eluting stent having collagen drug carrier chemically treated with genipin
    Patent number: 7351421
    Abstract: A method for treating vulnerable plaques of a patient, comprising: providing a biodegradable stent comprising a first supporting zone made of a first biodegradable material, wherein the supporting zone comprises at least a portion of continuous circumference of the stent; and a second therapeutic zone made of a second biodegradable material, wherein the therapeutic zone comprises at least one bioactive agent; delivering the biodegradable stent to the vulnerable plaques; orienting the therapeutic zone at about the luminal surface of the vulnerable plaque; and releasing the at least one bioactive agent for treating the vulnerable plaques.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: April 1, 2008
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Peter Y Tu, Hosheng Tu
  • Nanoparticles for targeting hepatoma cells
    Patent number: 7348026
    Abstract: The invention discloses the nanoparticles composed of ?-PGA-PLA block copolymers conjugated with galactosamine as a potential drug delivery system for treating liver cancers.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: March 25, 2008
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Ting-Fan Yang, Chin-Tsung Huang, Hosheng Tu
  • Nanoparticles for targeting hepatoma cells
    Patent number: 7348030
    Abstract: The nanoparticles composed of ?-PGA-PLA block copolymers that are conjugated with galactosamine as a potential drug delivery system and loaded with anticancer drugs for treating liver cancers.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: March 25, 2008
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for targeting hepatoma cells
    Patent number: 7304045
    Abstract: A dual-particle tumor targeting system comprising a first ligand-mediated targeting nanoparticle conjugated with galactosamine and a second EPR-mediated targeting nanoparticle, wherein said first and second nanoparticles are mixed in a solution configured for delivering to a target liver tumor.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: December 4, 2007
    Inventors: Hsing-Wen Sung, Hung-Kun Hsu, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7291598
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: November 6, 2007
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Nanoparticles for protein/peptide delivery and delivery means
    Publication number: 20070243259
    Abstract: The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are composed of positively charged shell substrate, negatively charged core substrate with encapsulated bioactive agents of proteins or peptides.
    Type: Application
    Filed: April 17, 2006
    Publication date: October 18, 2007
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Po-Wei Lee, Hosheng Tu