Patents by Inventor Hsing-Wen Sung

Hsing-Wen Sung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genipin-crosslinked gelatin microspheres as drug carrier
    Patent number: 7282220
    Abstract: A pharmaceutical microsphere comprises a bioactive agent and a biological carrier that encapsulates the bioactive agent, wherein the biological carrier is crosslinked with a crosslinking agent.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: October 16, 2007
    Inventors: Hsing-Wen Sung, Huang-Chien Liang, Wen-Hsiang Chang, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7282194
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-?-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: October 16, 2007
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for monoclonal antibody delivery
    Publication number: 20070237831
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent of monoclonal antibody. The nanoparticles are characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Application
    Filed: May 12, 2006
    Publication date: October 11, 2007
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Mei-Chin Chen, Hosheng Tu
  • Nanoparticles for drug delivery
    Publication number: 20070237827
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent of HMG-CoA reductase inhibitors or erythropoietin. The nanoparticles are characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Application
    Filed: May 26, 2006
    Publication date: October 11, 2007
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Mei-Chin Chen, Hosheng Tu
  • Nanoparticles for paracellular drug delivery
    Patent number: 7265090
    Abstract: The invention discloses the nanoparticles composed of chitosan/poly-?-glutamic acid characterized with a positive surface charge and their enhanced permeability through Caco-2 cells for paracellular drug delivery.
    Type: Grant
    Filed: January 4, 2005
    Date of Patent: September 4, 2007
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Hosheng Tu
  • Method of forming multicellular spheroids from the cultured cells
    Publication number: 20070148767
    Abstract: Provided herein are methods for producing multicellular spheroids or embryoid bodies suitable for providing cells in large scale for various medical applications. In one embodiment, a method of forming embryoid bodies is provided, which comprises culturing undifferentiated HES cells in a culture vessel pre-coated with cellulose and/or its derivatives. In another embodiment, a method of forming hepatic spheroids is provided, which comprises culturing hepatocytes in a culture vessel pre-coated with cellulose and/or its derivatives.
    Type: Application
    Filed: December 28, 2005
    Publication date: June 28, 2007
    Inventors: Mei-Ju Yang, Wann-Hsin Chen, Pei-Ju Lin, Chun-Hung Chen, Hsing-Wen Sung
  • Drug-eluting biodegradable stent
    Publication number: 20070141100
    Abstract: The present invention relates to a drug-loaded biodegradable stent and methods for treating vulnerable plaques of a patient comprising a plurality of layers or zones, each layer or zone comprising its own specific biodegradation rate and its specific drug loading characteristics. In one embodiment, the layers and zones are configured and arranged, in combination, radially, circumferentially and longitudinally.
    Type: Application
    Filed: November 5, 2004
    Publication date: June 21, 2007
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Hosheng Tu, Peter Tu
  • Nanoparticles for protein drug delivery
    Publication number: 20070116772
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Application
    Filed: April 5, 2006
    Publication date: May 24, 2007
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Medical device with living cell sheet
    Publication number: 20070116678
    Abstract: A novel method, using a thermoreversible MC/PBS/Collagen hydrogel coated on the TCPS dish, for harvesting a living cell sheet with ECM. The obtained living cell sheet is administered to a joint adapted for implantation and for cartilage regeneration.
    Type: Application
    Filed: April 27, 2006
    Publication date: May 24, 2007
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Publication number: 20070116771
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Application
    Filed: April 5, 2006
    Publication date: May 24, 2007
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Living cell sheet
    Publication number: 20070092493
    Abstract: A novel method, using a thermoreversible MC/PBS/Collagen hydrogel coated on the TCPS dish, for harvesting a living cell sheet with ECM. The coated hydrogel system is reusable and can be used for culturing a multi-layer cell sheet. The obtained living cell sheets may be used for tissue reconstructions.
    Type: Application
    Filed: October 24, 2005
    Publication date: April 26, 2007
    Inventors: Hsing-Wen Sung, Chun-Hung Chen, Hosheng Tu
  • Biodegradable occlusive device with moisture memory
    Publication number: 20070014831
    Abstract: The present invention relates to a biodegradable occlusive device and methods for treating aneurysm of a patient comprising deploying a flexible biodegradable occlusive device with a moisture memory and a controlled biodegradation, and deploying a retaining stent for preventing the occlusive device from being inadvertently dislodged from the sac.
    Type: Application
    Filed: July 12, 2005
    Publication date: January 18, 2007
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Hosheng Tu
  • Crosslinkable biological material and medical uses
    Patent number: 7101857
    Abstract: A method for promoting angiogenesis in a patient comprising providing crosslinkable biological solution to the target tissue, wherein the crosslinkable biological solution is loaded with at least one angiogenic agent. In one embodiment, the at least one angiogenic agent is a non-protein factor selected from a group consisting of ginsenoside Rg1, ginsenoside Re, combination thereof and the like. In another embodiment, the crosslinkable biological solution of the present invention is broadly defined in a form or phase of solution, paste, gel, suspension, colloid or plasma that may be solidifiable thereafter.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: September 5, 2006
    Assignee: GP Medical, Inc.
    Inventors: Hsing-Wen Sung, Huang-chien Liang, Hosheng Tu
  • Drug-eluting biodegradable stent
    Publication number: 20060177480
    Abstract: The present invention relates to a biodegradable stent comprising a luminal surface portion with a second degree of crosslink, an outer surface portion with a first degree of crosslink, and a wall between the luminal and outer surface portions, wherein the wall comprises a crosslinked material characterized by the first degree of crosslink not less than the second degree of crosslink.
    Type: Application
    Filed: May 17, 2005
    Publication date: August 10, 2006
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Publication number: 20060147539
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-?-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Application
    Filed: November 21, 2005
    Publication date: July 6, 2006
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for targeting hepatoma cells
    Publication number: 20060115537
    Abstract: A dual-particle tumor targeting system comprising a first ligand-mediated targeting nanoparticle conjugated with galactosamine and a second EPR-mediated targeting nanoparticle, wherein said first and second nanoparticles are mixed in a solution configured for delivering to a target liver tumor.
    Type: Application
    Filed: January 10, 2006
    Publication date: June 1, 2006
    Inventors: Hsing-Wen Sung, Hung-Kun Hsu, Hosheng Tu
  • Nanoparticles for paracellular drug delivery
    Publication number: 20060073210
    Abstract: The invention discloses the nanoparticles composed of chitosan/poly-?-glutamic acid characterized with a positive surface charge and their enhanced permeability through Caco-2 cells for paracellular drug delivery.
    Type: Application
    Filed: January 4, 2005
    Publication date: April 6, 2006
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for targeting hepatoma cells
    Publication number: 20060073209
    Abstract: The invention discloses the nanoparticles composed of ?-PGA-PLA block copolymers conjugated with galactosamine as a potential drug delivery system for treating liver cancers.
    Type: Application
    Filed: October 5, 2004
    Publication date: April 6, 2006
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Ting-Fan Yang, Chin-Tsung Huang, Hosheng Tu
  • Medical use of aglycon geniposidic acid
    Publication number: 20060034885
    Abstract: The present invention relates to a drug-loaded biodegradable stent and methods for treating vulnerable plaques of a patient comprising a plurality of layers or zones, each layer or zone comprising its own specific biodegradation rate and its specific drug loading characteristics. In one embodiment, the layers and zones are configured and arranged, in combination, radially, circumferentially and longitudinally.
    Type: Application
    Filed: August 27, 2004
    Publication date: February 16, 2006
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Chin-Tsung Huang, Hosheng Tu
  • Acellular biological material chemically treated with genipin
    Patent number: 6998418
    Abstract: A method for promoting autogenous ingrowth of damaged or diseased tissue selected from a group consisting of ligaments, tendons, muscle and cartilage, the method comprising a step of surgically repairing the damaged or diseased tissue by attachment of a tissue graft, wherein the tissue graft is formed from a segment of connective tissue protein after an acellularization process, the segment being crosslinked with genipin, its analog or derivatives. The genipin-fixed acellular tissue provides a microenvironment for tissue regeneration adapted for use as a biological implant device due to its low cytotoxicity.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: February 14, 2006
    Assignee: GP Medical, Inc.
    Inventors: Hsing-Wen Sung, Huang-Chien Liang, Hosheng Tu