Patents by Inventor Hua Bai

Hua Bai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200207745
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Application
    Filed: February 25, 2020
    Publication date: July 2, 2020
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • Patent number: 10686385
    Abstract: An apparatus includes a controller, a switching block, and a three-phase bidirectional AC/DC converter. The switching block has a first interface connected to a power grid, a second interface connected to an electric motor, and a third interface connected to the three-phase bidirectional AC/DC converter that includes first, second, and third single-phase AC/DC conversion modules, and which have inputs and outputs joined at an output node, and a respective transformer configured to provide electrical isolation. In a first mode of operation, the switching block connects the power grid to the AC/DC converter for charging a battery connected to the output node and disconnects the electric motor. In a second mode of operation, the switching block disconnects the power grid and connects the electric motor to the AC/DC converter which is controlled to convert DC power drawn from the battery to energize the electric motor.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: June 16, 2020
    Assignee: HELLA GmbH & Co. KGaA
    Inventors: Alan Wayne Brown, Hua Bai
  • Publication number: 20200156025
    Abstract: A device for mixing two gas streams, the device includes: an inner pipe, wherein: the inner pipe is arranged substantially concentrically within an outer pipe and forms an annulus between an outer diameter of the inner pipe and an inner diameter of the outside pipe; the inner pipe is closed at a downstream end; and the inner pipe comprises a plurality of perforations; and the outer pipe, wherein: a downstream end of the outer pipe extends into a reactor; the outer pipe is closed at the downstream end; and the downstream end of the outer pipe comprises a plurality of perforations. The mixed gas stream can enter the reactor. The reactor can be an Oxidative Coupling of Methane (OCM) reactor.
    Type: Application
    Filed: September 25, 2019
    Publication date: May 21, 2020
    Applicant: SABIC Global Technologies, B.V.
    Inventors: Lei CHEN, Sreekanth PANNALA, Robert BROEKHUIS, Hua BAI, Pankaj GAUTAM, David WEST
  • Patent number: 10654836
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: May 19, 2020
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • Patent number: 10650854
    Abstract: A heat-assisted magnetic recording (HAMR) medium has a heat-sink layer, a chemically-ordered FePt (or CoPt) alloy magnetic layer and a MgNiO intermediate layer between the heat-sink layer and the magnetic layer. The intermediate layer is a solid substitution crystalline alloy of the form (Mg(100-y)Niy)O, where y is less than 10 and greater than or equal to 0.5. The magnetic layer may be formed directly on the MgNiO intermediate layer, in which case the MgNiO intermediate layer functions as both a seed layer and a thermal barrier layer. The HAMR medium may also include an optional layer of crystalline “pure” MgO directly below or directly above the MgNiO intermediate layer. If the MgO layer is located directly above the MgNiO intermediate layer then the MgNiO intermediate layer functions primarily as a thermal barrier layer. The HAMR medium with the MgNiO intermediate layer provides a substantial improvement in corrosion resistance.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: May 12, 2020
    Assignee: Western Digital Technologies, Inc.
    Inventors: Hua Yuan, Paul Christopher Dorsey, Fenghua Zong, Shahid Ali Pirzada, Allen Joseph Bourez, Zhaoqiang Bai
  • Patent number: 10560024
    Abstract: In one embodiment, a bidirectional DC/DC converter includes a DC/AC inverter having active switches (e.g., MOSFETs), and an AC/DC rectifier having a capacitor that performs DC-bias current blocking and active switches (e.g., MOSFETs) arranged in a bridge configuration. A microcontroller is coupled to the active switches of the DC/AC inverter and AC/DC rectifier and configured to provide control signals thereto according to a control algorithm that, when power is to flow in a forward direction, sends control signals to operate the active switches of the DC/AC inverter at a duty cycle and to disable the active switches of the AC/DC rectifier, and when power is to flow in a reverse direction, sends control signals to operate the active switches of the DC/AC inverter to disable the active switches of the DC/AC inverter and operates the active switches of the AC/DC rectifier at a duty cycle.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: February 11, 2020
    Assignee: Conductive Holding, LLC
    Inventors: Hua Bai, Alexander Balogh, Xuntuo Wang
  • Patent number: 10526668
    Abstract: Provided are a Streptomyces (Streptomyces hygroscopicus) HS7522 and a method for preparing milbemycin A4 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7522 of the present invention is deposited in “China General Microbiological Culture Collection Center” with an accession number of CGMCC No. 9671 on Sep. 16, 2014.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: January 7, 2020
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Yun Teng, Meidong Xu, Meiyi Mo, Zhihui He, Zhengjie Chen, Lianiqing Jiang, Hua Bai
  • Patent number: 10527574
    Abstract: A system, device, and method for receiving, preparing and identifying a biological sample. Some parts may be user held and actuated. The sample may be detected by an array of sensors. The system may comprise reusable and disposable components arranged to be connected together. The biological sample may contain nucleic acids, proteins, or other molecules to be detected.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: January 7, 2020
    Assignee: DNAE GROUP HOLDINGS LIMITED
    Inventors: Panteleimon Athanasiou, Alpesh Patel, David Whitaker, Hua Bai, John Palmer-Felgate, Daniel Coomber-Alford, Jessica Fisher, Chad Schneider, Alex Flamm, Ben Lane, Samuel Reed
  • Patent number: 10519148
    Abstract: The present invention relates to an acrylic acid derivative as shown in general formula (I), a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, the preparation method thereof, a pharmaceutical composition containing same, and the use thereof as therapeutic agents, in particular as selective estrogen receptor degraders (SERD), wherein the substituents of general formula (I) are the same as those defined in the description.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: December 31, 2019
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Dongliang Guan, Shouyi Sheng, Hua Bai
  • Patent number: 10519500
    Abstract: A method of preparing a crystalline copper-based coordination polymer comprises preparing a mixture of copper ions and a first quaternized carboxylate pyridyl ligand; adding a second polypyridyl ligand; and forming crystals of a copper-based coordination polymer therefrom. The crystalline copper-based coordination polymer is suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. A method of detecting at least a first target nucleic acid sequence, in particular from a viral RNA, in particular it is Flavivirus RNA, in a sample is also provided. Further provided is a kit including the crystalline copper-based coordination polymer and an oligonucleotide probe.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: December 31, 2019
    Assignees: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY, SOUTHERN MEDICAL UNIVERSITY
    Inventors: Jin-Xiang Chen, Bao-Ping Xie, Gui-Hua Qiu, Pei-Pei Hu, Zhen Liang, Ye-Mei Liang, Bin Sun, Li-Ping Bai, Zhi-Hong Jiang
  • Patent number: 10508112
    Abstract: Intermediate compounds for the preparation of Praziquantel are provided. In particular, the intermediate compounds provided include a compound of formula (IV) and a compound of formula (V). Also provided are processes for preparing the intermediate compounds. Additionally, the raw materials are inexpensive and easy to obtain, the key intermediates are easy to prepare, and the total reaction yield and purity of the obtained target compound Praziquantel is high, so that industrialized mass production of Praziquantel using the intermediate compounds is easy to achieve.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: December 17, 2019
    Assignees: Zhejiang Hisun Pharmaceutical Co., Ltd., Shanghai Institute of Pharmaceutical Industry
    Inventors: Fuli Zhang, Zhezhou Yang, Rusheng Bao, Weiwei Xu, Hua Bai
  • Publication number: 20190336929
    Abstract: The invention relates to a device (100) for injecting and mixing a reactive fluid in a flow of a process fluid for the preparation of polyolefins, comprising: an annular part (101) having an outer wall and an inner wall (102), wherein the annular part (101) is arranged for having a flow of the process fluid in a transport direction (F); a support structure (103) connected to the inner wall (102) of the annular part (101); an injector part (104) mounted on the support structure (103), wherein the injector part (104) is cylindrically shaped and wherein the cylindrical axis A-A? of the injector part is parallel with a central axis of the annular part and is in the central part of the annular part (101); wherein the injector part (104) comprises a nozzle (105) for injecting the reactive fluid, disposed at a downstream side of the injector part relative to the transport direction (F); a supply channel (106) extending from the outer wall of the annular part (101) through the support structure (103) to the nozzle (1
    Type: Application
    Filed: January 4, 2018
    Publication date: November 7, 2019
    Inventors: Carolina De Los Angeles Toloza Porras, Diego Mauricio Castaneda Zuniga, Hua Bai, Robert Cornelis Van Bodegom, Mohsen Nikkhoo, Bas Eugene Hans Megens
  • Patent number: 10399992
    Abstract: Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: September 3, 2019
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Jinqing Zhong, Xuyang Zhao, Hua Bai, Yongxiang Gong, Xinlong Zhang, Qifeng Zhu, Weiwei Liu, Ya Zhou
  • Patent number: 10378849
    Abstract: A testing device for study of a magnetized plasma artillery and gunpowder, comprising a pedestal, wherein a top end of the pedestal is provided with a sliding slot for mounting a buffer device, which penetrates through an upper part of the pedestal along a front-rear direction. The sliding slot for mounting the buffer device is internally provided with a buffering slider, which can slide back and forth along the sliding slot for mounting the buffer device. A top end of the buffering slider is provided with a gunpowder combustion chamber fixing groove, which penetrates through an upper part of the buffering slider along the front-rear direction. The gunpowder combustion chamber fixing groove is internally provided with a gunpowder combustion chamber, and an upper part of the gunpowder combustion chamber is provided with a positioning ferrule for fixing the gunpowder combustion chamber.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: August 13, 2019
    Assignee: PEOPLE'S LIBERATION ARMY ARMY ACADEMY OF ARMORED FORCES
    Inventors: Baoquan Mao, Xianghua Bai, Yuying Yang, Hua Li, Zhenhui Xu, Cheng Li, Shuai Feng, Rui Zhu, Zhiqian Wang, Tianyi Zhang
  • Patent number: 10364219
    Abstract: Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: July 30, 2019
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Hua Bai, Xuyang Zhao, Yuncai Zhang, Xufei Li, Yong Zhang, Dezhou Xu, Li Zhang, Xiaojie Xu, Qifeng Zhu, Xiaoming Wang, Zhiqing Yang, Zehua Zhong, Jian Zhang
  • Patent number: 10334850
    Abstract: The present invention relates to a recombinant microorganism expressing avermectin or analogs thereof and construction method thereof, and also relates to a method of producing avermectin or analogs thereof using the recombinant microorganism, and avermectin or analogs thereof obtained using the method. In addition, the present invention further relates to uses of the avermectin or analogs thereof as insecticides. Using the recombinant microorganism of the present invention to produce avermectin or analogs thereof has numerous advantages, for example comprising at least one of the following: good stability, high yield, simple process, environmentally friendly, and greatly saving of production costs.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: July 2, 2019
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Jun Huang, Jidong Wang, Anliang Chen, Aiwen Deng, Jiatan Lin, Zhen Yu, Meihong Li, Na Li, Haibin Wang, Linghui Zheng, Hua Bai
  • Patent number: 10316052
    Abstract: A fidaxomicin purification method, comprising: fermenting Actinoplanes sp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the fermented liquid, soaking mycelium in an organic solvent, and filtering to obtain a solution containing fidaxomicin; treating the solution with nanofiltration concentrate, and separating to obtain fidaxomicin crude product; conducting preparative column chromatography on the fidaxomicin crude product, eluting with an acid aqueous solution containing an organic solvent, and separating to obtain the refined fidaxomicin product.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: June 11, 2019
    Assignee: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
    Inventors: Huijun Ren, Daochao Li, Xuexiao Ying, Feng Chen, Linghui Zheng, Lingping Wang, Hua Bai
  • Publication number: 20190161476
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Application
    Filed: May 19, 2017
    Publication date: May 30, 2019
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • Publication number: 20190152986
    Abstract: The present invention relates to the field of pharmaceuticals, especially to the field of veterinary drugs, and more particularly to a crystal form of milbemycin A3 oxime, able to be characterized by the X-ray powder diffraction spectrogram, infrared absorption (IR) spectrogram, differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA), etc. Furthermore, the present invention also relates to a method for preparing the crystal form of milbemycin A3 oxime and to a use of the crystal form of milbemycin A3 oxime as an insecticidal and acaricidal agent.
    Type: Application
    Filed: July 4, 2017
    Publication date: May 23, 2019
    Inventors: Yun TENG, Hongbing XU, Lianqing JIANG, Zhengjie CHEN, Hua BAI
  • Patent number: 10287545
    Abstract: Provided are a Streptomyces (Streptomyces hygroscopicus) HS7523 and a method for preparing milbemycin A3 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7523 is deposited in “China General Microbiological Culture Collection Center” with an accession number of CGMCC No. 9672 on Sep. 16, 2014.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: May 14, 2019
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Yun Teng, Meidong Xu, Meiyi Mo, Zhihui He, Zhengjie Chen, Lianiqing Jiang, Hua Bai