Abstract: A single-phase AC/DC electric power conversion apparatus includes an indirect matrix converter having an input interface to receive a first alternating current (AC) signal and an output interface to produce a second AC signal, where the first AC signal has a grid frequency. A transformer has a primary winding and an electrically isolated and magnetically coupled secondary winding. A coupling inductor is connected in series between the output interface of the indirect matrix converter and the primary winding. An H-bridge switching arrangement is connected to the secondary winding and produces an output signal having a DC component and at least one AC component. The at least one AC component has a second order harmonic of the grid frequency. An active filter reduces the second order harmonic AC component. A modular conversion apparatus for three-phase power replicates the single-phase apparatus as a module for each phase and omits the active filter.

Abstract: A bacterial strain of Actinoplanes sp. and and the use thereof. The bacterial strain is named Actinoplanes sp. HS-16-20, whose preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 7294. The bacterial strain can be used to generate Fidaxomicin or analogs thereof or compositions containing Fidaxomicin, such as by aerobically fermenting the strain in nutrient medium containing assimilable carbon and/or nitrogen sources. Fidaxomicin has an inhibitory effect on various gram positive bacteria pathogens, and in particular, on Clostridium difficile.

Abstract: A hybrid switch apparatus includes a gate drive circuit producing a gate drive signal, a GaN high electron mobility transistor (HEMT) having a first gate, a first drain, and a first source. A silicon (Si) MOSFET has a second gate, a second drain, and a second source. The GaN HEMT and the Si MOSFET are connected in a parallel arrangement so that (i) the first drain and the second drain are electrically connected and (ii) the first source and the second source are electrically connected. The second gate is connected to the gate drive circuit output to receive the gate drive signal. A delay block has an input connected to the gate drive circuit output and an delay block output is configured to produce a delayed gate drive signal for driving the GaN HEMT.

Abstract: Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.

Abstract: A power transfer system and method are provided for transferring power from an AC supply outputting a first AC voltage. The system includes a controller and a matrix converter coupled to the AC supply for converting the first AC voltage to a second AC voltage. A primary coil is connected to the matrix converter and a secondary coil is in communication with the primary coil for producing an induced AC voltage. A secondary rectifier is connected to the secondary coil for rectifying the induced AC voltage to produce a secondary DC voltage. A sensor is coupled to the secondary rectifier and to the controller for monitoring the secondary DC voltage and outputting a proportional signal. The controller is configured to control the matrix converter producing a desired second AC voltage at a desired operating frequency and maintain a predetermined secondary DC voltage in response to the signal from the sensor.

Abstract: Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.

Abstract: The hardness of zinc sulfide is increased by adding selective elements within a specified range to the crystal lattice of the zinc sulfide. The increased hardness over conventional zinc sulfide does not substantially compromise the optical properties of the zinc sulfide. The zinc sulfide may be used as a protective coating for windows and domes.

Abstract: The present invention relates to a compound represented by formula (I). The present invention also relates to the use of a compound represented by formula (I) in the treatment of disorders resulting from cell proliferation and/or angiogenesis or disorders associated with or accompanying cell proliferation and/or angiogenesis.

Abstract: An AC/DC conversion apparatus includes first, second, and third AC/DC conversion modules operated by a controller in two modes of operation. In the first mode, the input AC signal is 3-phase and each of the three modules are enabled to handle a respective one of the input phases. In the second mode, the input AC signal is single phase and the first and second modules are enabled to deliver output power based on the single-phase AC input, while the controller actuates an H-bridge switches in the third module to which active filter circuitry is connected, to reduce an AC component in the output signal. The active filter circuitry can be selectively connected to the H-bridge switches when single-phase operation is desired, which circuitry may be disposed in a filter housing having male electrical terminals that cooperate with corresponding female terminals associated with the third module.

Abstract: A single-phase AC/DC electric power conversion apparatus includes an indirect matrix converter having an input interface to receive a first alternating current (AC) signal and an output interface to produce a second AC signal, where the first AC signal has a grid frequency. A transformer has a primary winding and an electrically isolated and magnetically coupled secondary winding. A coupling inductor is connected in series between the output interface of the indirect matrix converter and the primary winding. An H-bridge switching arrangement is connected to the secondary winding and produces an output signal having a DC component and at least one AC component. The at least one AC component has a second order harmonic of the grid frequency. An active filter reduces the second order harmonic AC component. A modular conversion apparatus for three-phase power replicates the single-phase apparatus as a module for each phase and omits the active filter.

Abstract: Disclosed is a preparation method for praziquantel and intermediates thereof. The method includes: obtaining a target product praziquantel by using ?-phenethylamine as an initial raw material through a condensation reaction with chloroacetyl chloride, a substitution reaction with ethanolamine, and an acylation reaction with cyclohexanecarbonyl chloride, followed by an oxidation reaction and cyclization reaction. Also disclosed are two key intermediates, namely, a compound of formula IV and a compound of formula V for preparing praziquantel. The preparation method is reasonable and simple in its technological design, uses moderate reaction conditions, and is economical and environmentally friendly. Additionally, the raw materials are inexpensive and easy to obtain, the key intermediates are easy to prepare, and the total reaction yield and purity of the obtained target compound praziquantel is high, so that industrialized mass production is easy to achieve.

Abstract: A hybrid switch apparatus includes a gate drive circuit producing a gate drive signal, a GaN high electron mobility transistor (HEMT) having a first gate, a first drain, and a first source. A silicon (Si) MOSFET has a second gate, a second drain, and a second source. The GaN HEMT and the Si MOSFET are connected in a parallel arrangement so that (i) the first drain and the second drain are electrically connected and (ii) the first source and the second source are electrically connected. The second gate is connected to the gate drive circuit output to receive the gate drive signal. A delay block has an input connected to the gate drive circuit output and an delay block output is configured to produce a delayed gate drive signal for driving the GaN HEMT.

Abstract: A targeting thymidine kinase photosensitizer and pharmaceutical composition and use for cancer treatment thereof is provided, which improves the selectivity of photosensitizers to tumor cells, has better tolerance, can reach maximum blood concentration in 24 hours, has a bigger conjugated system, a longer absorption wavelength and an advantage in treating depth tumors; the wavelength area does not need to consume much energy of a light-output device and even LEDs can be used, which render PDT more practical and economical. The targeting thymidine kinase photosensitizer can be used for diagnosis and for treating prostatic carcinoma via the guidance of fluorescence imaging. The pharmaceutical composition uses a combination of a chemotherapeutic agent and the targeting thymidine kinase photosensitizer, which further improves the therapeutic effect of the PDT method, expands the application range for tumors and has good effects on metastatic tumors as well.

Abstract: The invention provides a construction method of spinosad heterologous expression strain, a spinosad heterologous expression strain obtained by the method and use thereof in preparing spinosad. The method utilizes a plurality of homologous recombination to replace the erythromycin synthetic gene cluster of Saccharopolyspora erythraea with the spinosad synthetic gene cluster and the rhamnose synthetic gene cluster, such that the Saccharopolyspora erythraea produces spinosad.

Abstract: A method is directed to increasing the hardness of zinc sulfide. The hardness of zinc sulfide is increased by adding selective elements within a specified range to the crystal lattice of the zinc sulfide. The increased hardness over conventional zinc sulfide does not substantially compromise the optical properties of the zinc sulfide. The zinc sulfide may be used as a protective coating for windows and domes.

Abstract: Disclosed are a cyanine dye compound and a preparation method therefor, and a dual-function agent for photodynamic therapy and a preparation method therefor. The provided cyanine dye compound is connected to multiple markers, which improves the accuracy of combination of dye and tumor cells, effectively reduces the background value, and avoids excessive residues in the liver. The provided cyanine dye compound is conjugated with the photosensitizer at 2?? position, so that tumor highly absorbs the conjugates.

Abstract: The present invention provides crystal forms of the compound of (3R,4S)-4-(4-hydroxyphenyl)-3-[3-(4-fluorophenyl)-4-hydroxybut-2(Z)-enyl]-1-(4-fluorophenyl)-2-azetidinone (formula A). The crystal forms can be characterized by X-ray powder diffraction (XRPD) spectra, differential scanning calorimetry (DSC) spectra, infrared absorption spectra and so on. Meanwhile, the present invention also provides methods for preparing the crystal forms of the compound of formula A, pharmaceutical compositions and uses thereof.

Abstract: The present invention provides a weir quench, an apparatus utilizing the weir quench and processes incorporating the same. The weir quench incorporates an inlet having an inner diameter (Di) and an upper chamber having an inner diameter (Duc), wherein the inlet inner diameter (Di) is at least 90% of the upper chamber inner diameter (Duc). The apparatus constitutes a reactor having an outlet with an inner diameter fluidly coupled with the weir quench inlet, wherein the ratio of the reactor oulet inner diameter (Dr) to the weir quench inlet diameter (Di) is greater than one. The weir quench, and apparatus are advantageously utilized in processes utilizing a limiting reagent.

Abstract: In one embodiment, a bidirectional battery charger integrated with renewable energy generation includes a primary side AC/DC rectifier coupled to the electrical grid and a first DC bus, a DC/AC inverter coupled to the first DC bus and a primary winding, a secondary side AC/DC rectifier coupled to a secondary winding and a battery, and a boost converter coupled to a renewable energy generator and the first DC bus. The boost converter includes an active switch controlled by a control algorithm that, when renewable power is available, operates the active switch at a duty cycle that allows power to flow from the renewable energy generator to the first DC bus and on to charge the battery (without passing though the primary side AC/DC rectifier) or on to supply the electrical grid (without passing through the DC/AC inverter and secondary side AC/DC rectifier), and, when not available, disables the active switch.