Abstract: The present disclosure provides an array substrate and a method for fabricating the same, a method for detecting alignment accuracy, and a liquid crystal display panel, wherein a dummy color resist unit is disposed on a periphery of a display area of a substrate, and a side or a center point of the dummy color resist unit is designed to be at a predetermined distance from an adjacent signal line. Therefore, it is only necessary to measure a distance between the side or the center point of the dummy color resist unit and a signal line adjacent to it, and compare the measured distance with the predetermined distance to estimate alignment accuracy of color resist units. It is not necessary to dispose detection units in a non-display area of the array substrate so that an area of the non-display area can be reduced to achieve ultra-narrow frame design.

Abstract: A geneticall engineered cell. The cell expresses an exogenous receptor binding to an antigen, and expresses increased RUNX3 or exogenous RUNX3. Also provided are a use of the cell and a method for treating tumors.

Abstract: Disclosed is a T cell receptor (TCR) fusion protein (TFP). The fusion protein comprises a TCR subunit (or referred to as a TCR unit) and an antigen recognition unit that recognizes an antigen. The antigen is GPC3 or claudin 18.2. Also disclosed is a T cell containing the fusion protein, a pharmaceutical composition and an application method of using the fusion protein or the T cell to treat diseases such as cancer. The use of TFP or T cells not only inhibits the growth of tumor cells, but also releases fewer cytokines, thereby effectively reducing the possibility of cytokine storms.

Abstract: A compound of Formula (I)) or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: wherein R1 through R3, and L are as defined herein.

Abstract: Embodiments of the instant disclosure relate to novel compositions and methods for treating a subject having homocystinuria. In some embodiments, compositions and methods disclosed herein concern improving efficacy of betaine to reduce dietary compliance requirements and improve outcomes. In accordance with these embodiments, a subject having or suspected of developing homocystinuria can be treated with formate, a salt thereof, a formate derivative or formate precursor or prodrug agent alone or in combination with trimethylglycine or other HCU treatments. In other embodiments, a subject having or suspected of developing homocystinuria can be treated with zinc and/or trimethylglycine and/or formate derivative to treat homocystinuria in the subject. In other embodiments, a subject having or suspected of developing Nonketotic hyperglycinemia (NKH) can be treated with formate, a salt thereof, a formate derivative, or formate precursor or prodrug agent to treat NKH in the subject.

Abstract: The present invention relates to a chemokine expressing cell. Said cell expresses an exogenous IL-21R binding protein or an exogenous IL-21 and an exogenous chemokine. Further provided is a cell expressing an exogenous receptor, an exogenous IL-21R binding protein or an exogenous IL-21 and an exogenous chemokine. The cell involved is not only effective in solid tumor cells in vitro, but also has an excellent killing effect on solid tumor cells in vivo.

Abstract: A monolithic multiferroic heterostructure fabricated using CSD (chemical solution deposition) is disclosed. The monolithic heterostructure includes a substrate, a ferromagnetic layer, a ferroelectric layer, and one or more seed layers that enhance crystallinity and promote high frequency performance.

Abstract: A base station antenna is provided, including at least two antenna sub-arrays. Each antenna sub-array includes a circuit board and two antenna oscillators. The circuit board includes a circuit substrate, and a first and second power divider disposed on a surface of the circuit substrate. The first and second power divider include a first, second and third end. Each antenna oscillator includes two pairs of first and second oscillator units of which polarizations are orthogonal. The second and third end of the first power divider are respectively electrically connected to the first oscillator unit of a first and second antenna oscillator. The second and third end of the second power divider is respectively electrically connected to the second oscillator unit of the first and second antenna oscillator. Two antenna oscillators form a 4T4R transceiving mode. The base station antenna of the present disclosure has the advantage of simple feeding mode.

Abstract: The present invention relates to an immune effector cell which expresses a chimeric antigen receptor targeting GPC3 and exogenous IL12. The present invention further provides a pharmaceutical composition containing the immune effector cell and a method for treating tumor, particularly GPC3 positive tumor by using the immune effector cell or the pharmaceutical composition. The immune effector cell in the present invention is effective to an entity tumor cell in vitro, and is outstanding in effect of extinguishing the entity tumor cell in vivo.

Abstract: The present disclosure provides an array substrate and a method for fabricating the same, a method for detecting alignment accuracy, and a liquid crystal display panel, wherein a dummy color resist unit is disposed on a periphery of a display area of a substrate, and a side or a center point of the dummy color resist unit is designed to be at a predetermined distance from an adjacent signal line. Therefore, it is only necessary to measure a distance between the side or the center point of the dummy color resist unit and a signal line adjacent to it, and compare the measured distance with the predetermined distance to estimate alignment accuracy of color resist units. It is not necessary to dispose detection units in a non-display area of the array substrate so that an area of the non-display area can be reduced to achieve ultra-narrow frame design.

Abstract: The invention provides an antenna element and a manufacturing method of the antenna element. The antenna element includes a main body and a feeding board. The main body has an insulation bracket and a conductive layer by way of electroplating or lasering. The insulation bracket includes a base, first support legs and second support legs. The conductive layer includes a radiation layer covering the top surface, a coupling layer covering the bottom surface and coupled to the radiation layer, a feeding column layer covering the outer surface of each first support leg and a branch layer covering the outer surface of each second support leg. By virtue of the configuration, it is unnecessary to assemble the main body additionally, so that the consistency of the antenna element is improved.

Abstract: A compound of Formula (I) or or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: Formula (I) wherein R1 and Y are as defined herein.

Abstract: The invention provides a neural electrode, including a current generation device, a first and a second electrode. The current generation device is connected to the first and second electrodes through a conductive metal wire respectively. At least one of the first and second electrodes is a graphene electrode. The graphene electrode has soft texture and desirable stability to tolerate the repeated pressing and folding treatment, very high charge injection efficiency, and desirable in vivo stability, and is configured to electrically stimulate tissues and organs such as hearts and nerves to promote electrical stimulation and repair of neurons, to further promote regeneration of neural functions. The invention further provides use of a mineralized three-dimensional porous graphene foam material to prepare a bone defect filler. The bone defect filler has desirable biological compatibility, promotes cell proliferation, and accelerates and induces osteogenic differentiation of bone marrow mesenchymal stem cells.

Abstract: Provided in the present invention is an antibody for anti-claudin 18A2 and an immune effector cell targeting claudin 18A2. Also provided are methods for inducing cell death and treating tumours.

Abstract: Disclosed herein is a hair care product is provided, which comprises an oil-in-water emulsion A and an oil-in-water emulsion C, wherein emulsion A has a pH-value from greater than 7.0 to 12.0 and contains: a1) at least one cationic surfactant A, and a2) at least one amino-functionalized silicone A; and emulsion C has a pH-value from 2.0 to lower than 7.0, and contains: c1) at least one cationic surfactant C, wherein surfactant A and surfactant C may be identical with or different from each other, and c2) at least one silicone C, wherein silicone C and the amino-functionalized silicone A may be identical with or different from each other, wherein emulsion A and emulsion C are separated from each other before use. Also disclosed herein is a process for hair caring by using the hair care product as contemplated herein.

Abstract: Disclosed in the present invention is a genetically engineered cell, expressing an exogenous receptor that specifically binds to a target antigen and exogenous CCL21, and capable of further expressing an IL-7R binding protein or exogenous IL-7 that promotes cell proliferation. Also disclosed are an expression construct comprising an exogenous CCL21 expression cassette, and a vector containing same, a virus, and a pharmaceutical composition comprising said cell. Also disclosed is an application for the cell, the expression construct, the vector, and the virus in the preparation of drugs for inhibiting tumours or inhibiting pathogens.

Abstract: The present application provides an in-vitro committed differentiation method for inducing human induced pluripotent stem cells (hiPSCs) into Leydig cells (LCs) by neural crest stem cells (NCSCs). The hiPS-derived LCs is verified by an animal model to have the capacity of regenerating senile or injured LCs, so that a new treatment for supplementing testosterone is provided for patients suffering from hypogonadism, particularly for patients suffering from late-onset hypogonadism (LOH).

Abstract: The invention provides lipid A mimics in which one or both of the sugar residues of a natural lipid A disaccharide backbone has been replaced with an aromatic group. These lipid A mimics may further differ from a natural lipid A molecule with respect to other structural characteristics, such as, a different number of phosphate groups present, changes in the number, structure and location of lipid chains and/or changes in the spacing and linkage of the sugar residues (or their aromatic replacements). The lipid A mimics may be lipid A agonists and as such may be useful as immunostimulatory agents in inducing or patenting an antibody and/or cell-mediated immune response, or may be lipid A antagonists and as such may be useful in treating or preventing a lipopolysaccharide (LPS)/lipid A-mediated disease or disorder. Also provided are methods for preparing the lipid A mimics.

Abstract: A mast erection system includes a first mast erection apparatus that is adapted to pivotably raise a drilling rig mast of a drilling rig assembly to an intermediate raised position wherein the drilling rig mast is oriented at a first acute angle relative to a horizontal plane, and a second mast erection apparatus that is adapted to further pivotably raise the drilling rig mast from the intermediate raised position at the first acute angle to a fully raised position wherein the drilling rig mast is oriented at a second angle relative to the horizontal plane that is greater than the first acute angle.

Abstract: The invention provides an antenna element and a manufacturing method of the antenna element. The antenna element includes a main body and a feeding board. The main body has an insulation bracket and a conductive layer by way of electroplating or lasering. The insulation bracket includes a base, first support legs and second support legs. The conductive layer includes a radiation layer covering the top surface, a coupling layer covering the bottom surface and coupled to the radiation layer, a feeding column layer covering the outer surface of each first support leg and a branch layer covering the outer surface of each second support leg. By virtue of the configuration, it is unnecessary to assemble the main body additionally, so that the consistency of the antenna element is improved.