Abstract: A control circuit for use with a network and a distributed control system. The control circuit incudes a switch module, a communication interface module coupled to the switch module and configured to convert data sampled from industrial field into a format suitable for being transmitted to the switch module via the network, and a controller module coupled to the switch module and configured to receive the converted data from the switch module and process the converted data. The switch module is configured to enable a communication between the communication interface module and external devices outside the control circuit and a communication between the controller module and the external devices.

Abstract: A bispecific or dual target CAR or CAR-T cells can be used to treat and/or prevent an autoimmune disease. The bispecific CAR may target CD19 and BCMA. The CAR may have a loop structure, which is shown as follow: L-VL, CD19-VH, BCMA-VL, BCMA-VH, CD19-H-TM-C-CD3?; the BCMA-CD19 CAR-T cells transduced by the chimeric antigen receptor targeting CD19 and BCMA can completely block the pathway of producing autoantibodies, and completely cover the B cells, plasmablasts and plasma cells at multiple differentiation stages that produce autoantibodies, so that the dual-target CAR-T therapy designed based on this concept can be aimed at refractory SLE and is expected to achieve faster remission and deeper and lasting curative effect.

Abstract: The invention relates to a process for preparing a berry composition from whole berries having bioactive and/or nutritional compounds of a whole berry and having improved sensory and miscibility/dispersibility properties. The process comprises the steps of providing whole berries, grinding said whole berries to obtain a whole berry suspension and micronizing said whole berry suspension. In particular, the process does not comprise any step of removal of the inherent insoluble fibers coming from the whole berries. The invention also relates to a berry composition, to oral compositions comprising such as berry composition and to the use of such compositions.

Abstract: A network device for an automation system includes a network switch, wherein the network device is configured to access non-volatile storage to which the network device is communicatively coupled to obtain provisioning data for the network switch, wherein the provisioning data comprises data enabling the network device to obtain at least a baseline configuration for the network switch. The provisioning data comprises data enabling the network device comprising the network switch to obtain the at least baseline configuration for the network switch.

Abstract: A controller for a process control system is configured to detect an adapter type of at least one adapter communicatively coupled to the controller, wherein the at least one adapter is for coupling at least one field device of an automation system to the process control system; to select a communications protocol according to the detected adapter type, wherein the communications protocol is for communicating with the at least one field device; and to communicate with the at least one field device using the selected communications protocol to control an industrial process carried out by the automation system.

Abstract: A process control system comprising at least one module termination unit, at least one adapter module arranged on the module termination unit and configured to communicate with a field device, and at least one controller module arranged on the module termination unit and configured to process data from the adapter module, wherein the adapter module and the controller module are connected to each other by a peer-to-peer connection, in particular through the module termination unit.

Abstract: Provided herein is a heavy chain constant region comprising a CH1 domain, a hinge region, a CH2 domain and a CH3 domain, wherein the sequences of said CH1 domain and hinge region derive from the sequences of CH1 domain and hinge region in human IgG2, the sequences of said CH2 domain and CH3 domain derive from the sequences of CH2 domain and CH3 domain in human IgGs; and wherein, said antibody heavy chain constant region has an affinity to human Fc?RIIB equal to or higher than the affinity of human IgG1 to human Fc?RIIB, said antibody heavy chain constant region has an I/A ratio equal to or higher than human IgG1 has. Also provided are antibodies or fusion proteins based on a heavy chain constant region according to the above, wherein the antibody heavy chain constant region significantly enhances agonistic activity of the antibodies or fusion proteins and improves efficacy of the antibodies or fusion proteins in treating diseases like tumors and autoimmune diseases.

Abstract: Embodiments of present disclosure relate to an input/output (I/O) module and a control system. The I/O module includes at least two coreless communication transformers arranged in parallel, each coreless communication transformer which includes a printed circuit board. The I/O module also includes a primary winding and a secondary winding disposed on opposite sides of the PCB, and at least two closed wires disposed coaxially on the PCB and arranged around the primary winding or inside the primary winding. The crosstalk of the I/O module is reduced and the communication robustness of the I/O module is improved.

Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.

Abstract: A coreless planar coil and a power transformer. The coreless planar coil includes a coil body arranged in a plane and configured to produce an alternating magnetic field for delivering signal or power; and a first metal ring arranged around the coil body in the plane and configured to produce a first magnetic field having a direction opposite to the alternating magnetic field produced by the coil body.

Abstract: An electrical module, a backplane for the electrical module, and a method of replacing a fuse for the electrical module. The electrical module includes a circuit board which has a power input port for inputting electric power to electrically drive an external device coupled to the electrical module. The electrical module also includes a fuse holder electrically coupled to the power input port and adapted to receive a fuse. A fuse detecting circuit is arranged on the circuit board and electrically coupled to the fuse via the fuse holder to detect a status of the fuse. An output port is arranged on the circuit board and coupled to the fuse detecting circuit to at least output detecting signals about the status of the fuse to a controller.

Abstract: Embodiments of present disclosure relates to an electronic device and a method for current recycling. The electronic device comprises a transmission line, a bias resistor and a DC bias electrical connection. The transmission line is configured to transmit data. The bias resistor is coupled to the transmission line. The DC bias electrical connection is coupled between the bias resistor and a load at a terminal bias voltage. The DC bias electrical connection is configured to provide the bias resistor with the terminal bias voltage in case that DC bias current flows through the transmission line. By utilizing embodiments herein, the electronic device recycles current during data transmission to save power.

Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.

Abstract: Embodiments of the present disclosure provide industrial control apparatus and monitoring methods for industrial control apparatus. The industrial control apparatus comprises: at least one input or output module, each input or output module comprising a fuse adapted to be coupled between a power supply and a user load, and a detection assembly coupled to the fuse and configured to send a detection signal after monitoring that the fuse is blown; and a processing device communicatively coupled to the detection assembly of each input or output module and configured to output information that the input or output module associated with the detection signal is blown. By the aspects of the present disclosure, it is advantageous for an operator to timely obtain information that the fuse is blown and to improve the efficiency of locating and replacing the fuse.

Abstract: Embodiments of present disclosure relate to a protection unit, an ADC module, and a system. The protection unit includes a first terminal; a second terminal; a first switch unit disposed between the first terminal and an output terminal of the protection unit; a second switch unit disposed between the second terminal and a ground of the protection unit; and a positive over voltage protection unit coupled to the first terminal, the first switch unit, and the second switch unit. The protection unit is configured to switch off the first switch unit and the second switch unit when a positive voltage at the first terminal exceeds a positive threshold.

Abstract: A humanized CD 19 antibody, and a chimeric antigen receptor thereof, an immune cell thereof and the use thereof are provided. The humanized CD19 antibody is based on a FMC63 chimeric antibody, which is subjected to humanization modification. A CAR-T and a dual CAR-T cell constructed based on the humanized antibody and the related use thereof are also provided. Compared with a CAR-T cell constructed by using FMC63, the CAR-T cell constructed based on the humanized antibody has higher killing effect and tumor removal ability.

Abstract: Provided are a BCMA-targeting engineered immune cell and the use thereof. In particular, a CAR specifically targeting BCMA is provided. In the CAR, an antigen binding domain contained therein is a J-derived scFv, having an antibody heavy-chain variable region shown in SEQ ID NO: 9, and an antibody light-chain variable region shown in SEQ ID NO: 10. Also provided are a CAR-T cell containing the CAR, and a duplex CAR and CAR T cells containing the J-derived scFv, and related uses thereof. Compared with CAR-T cells constructed by using other scFvs, the CAR-T cells constructed by the present invention have higher killing effects and tumor clearance ability.

Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.

Abstract: A split gate structure is disclosed. The split gate structure includes a first polysilicon, a characteristic oxide, and a second polysilicon sequentially disposed in a trench in a vertical direction upward from a bottom of the trench. An upper surface of the characteristic oxide has a height difference less than 1500 ? between a higher center portion and a lower periphery portion. The split gate structure effectively improves the breakdown performance and the IGSS performance. A power MOS device having the split gate structure and a manufacturing method of the split gate structure are also provided.

Abstract: A split gate structure is disclosed. The split gate structure includes a first polysilicon, a characteristic oxide, and a second polysilicon sequentially disposed in a trench in a vertical direction upward from a bottom of the trench. An upper surface of the characteristic oxide has a height difference less than 1500 ? between a higher center portion and a lower periphery portion. The split gate structure effectively improves the breakdown performance and the IGSS performance. A power MOS device having the split gate structure and a manufacturing method of the split gate structure are also provided.