Abstract: The invention proposed a space vector pulse width modulation (SVPWM) method for any level cascaded H-bridge inverter. The multilevel space vector diagram is re-divided, and the coordinates of the nearest three vectors (NTVs) are directly obtained by judging the position of the reference vector. The duty cycles of the NTVs is calculated through additional vector which is equivalent to the reference vector. Then, the switching states are obtained by zero-sequence component and coordinate transformation, and the desired reference vector is synthesized for the SVPWM modulation. The invention realizes multilevel modulation in Cartesian coordinates without any iterative calculation, and the calculation is independent of the level number. Furthermore, the locating of the reference vector and the calculation of the duty cycles are simplified, and the calculation complexity is reduced.

Abstract: Embodiments of present disclosure relates to an electronic device and a method for current recycling. The electronic device comprises a transmission line, a bias resistor and a DC bias electrical connection. The transmission line is configured to transmit data. The bias resistor is coupled to the transmission line. The DC bias electrical connection is coupled between the bias resistor and a load at a terminal bias voltage. The DC bias electrical connection is configured to provide the bias resistor with the terminal bias voltage in case that DC bias current flows through the transmission line. By utilizing embodiments herein, the electronic device recycles current during data transmission to save power.

Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.

Abstract: Embodiments of the present disclosure provide industrial control apparatus and monitoring methods for industrial control apparatus. The industrial control apparatus comprises: at least one input or output module, each input or output module comprising a fuse adapted to be coupled between a power supply and a user load, and a detection assembly coupled to the fuse and configured to send a detection signal after monitoring that the fuse is blown; and a processing device communicatively coupled to the detection assembly of each input or output module and configured to output information that the input or output module associated with the detection signal is blown. By the aspects of the present disclosure, it is advantageous for an operator to timely obtain information that the fuse is blown and to improve the efficiency of locating and replacing the fuse.

Abstract: Embodiments of present disclosure relate to a protection unit, an ADC module, and a system. The protection unit includes a first terminal; a second terminal; a first switch unit disposed between the first terminal and an output terminal of the protection unit; a second switch unit disposed between the second terminal and a ground of the protection unit; and a positive over voltage protection unit coupled to the first terminal, the first switch unit, and the second switch unit. The protection unit is configured to switch off the first switch unit and the second switch unit when a positive voltage at the first terminal exceeds a positive threshold.

Abstract: A humanized CD 19 antibody, and a chimeric antigen receptor thereof, an immune cell thereof and the use thereof are provided. The humanized CD19 antibody is based on a FMC63 chimeric antibody, which is subjected to humanization modification. A CAR-T and a dual CAR-T cell constructed based on the humanized antibody and the related use thereof are also provided. Compared with a CAR-T cell constructed by using FMC63, the CAR-T cell constructed based on the humanized antibody has higher killing effect and tumor removal ability.

Abstract: Provided are a BCMA-targeting engineered immune cell and the use thereof. In particular, a CAR specifically targeting BCMA is provided. In the CAR, an antigen binding domain contained therein is a J-derived scFv, having an antibody heavy-chain variable region shown in SEQ ID NO: 9, and an antibody light-chain variable region shown in SEQ ID NO: 10. Also provided are a CAR-T cell containing the CAR, and a duplex CAR and CAR T cells containing the J-derived scFv, and related uses thereof. Compared with CAR-T cells constructed by using other scFvs, the CAR-T cells constructed by the present invention have higher killing effects and tumor clearance ability.

Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.

Abstract: A split gate structure is disclosed. The split gate structure includes a first polysilicon, a characteristic oxide, and a second polysilicon sequentially disposed in a trench in a vertical direction upward from a bottom of the trench. An upper surface of the characteristic oxide has a height difference less than 1500 ? between a higher center portion and a lower periphery portion. The split gate structure effectively improves the breakdown performance and the IGSS performance. A power MOS device having the split gate structure and a manufacturing method of the split gate structure are also provided.

Abstract: A split gate structure is disclosed. The split gate structure includes a first polysilicon, a characteristic oxide, and a second polysilicon sequentially disposed in a trench in a vertical direction upward from a bottom of the trench. An upper surface of the characteristic oxide has a height difference less than 1500 ? between a higher center portion and a lower periphery portion. The split gate structure effectively improves the breakdown performance and the IGSS performance. A power MOS device having the split gate structure and a manufacturing method of the split gate structure are also provided.

Abstract: Provided herein is a heavy chain constant region comprising a CH1 domain, a hinge region, a CH2 domain and a CH3 domain, wherein the sequences of said CH1 domain and hinge region derive from the sequences of CH1 domain and hinge region in human IgG2, the sequences of said CH2 domain and CH3 domain derive from the sequences of CH2 domain and CH3 domain in human IgGs; and wherein, said antibody heavy chain constant region has an affinity to human Fc?RIIB equal to or higher than the affinity of human IgG1 to human Fc?RIIB, said antibody heavy chain constant region has an I/A ratio equal to or higher than human IgG1 has. Also provided are antibodies or fusion proteins based on a heavy chain constant region according to the above, wherein the antibody heavy chain constant region significantly enhances agonistic activity of the antibodies or fusion proteins and improves efficacy of the antibodies or fusion proteins in treating diseases like tumors and autoimmune diseases.

Abstract: Embodiments of the present disclosure provide a protective circuit to be used in a digital output module, the digital output module comprises a first voltage source and at least an output terminal. The protective circuit comprises: a first sampling unit for sampling a first voltage relevant to the output current from the first voltage source, a first comparing unit for comparing the sampled first voltage with a first reference voltage, a control unit for generating a current regulating signal based on a result from the first comparing unit, and a current regulating unit for regulating the output current from the first voltage source based on the current regulating signal. This protective circuit provides overflowing and short circuit protection, and is cheap in cost.

Abstract: A standalone automation device (100) comprises: a removable memory port (101), configured to transmit data between the device (100) and the equipment (200) which also has a removable memory port; a removable memory control unit (102), comprising a signal convertor (112) for converting a removable memory interface to a serial interface; a power supply unit (103), configured to provide power supply when the device (100) is connected to the equipment (200) and disconnected to the field, and an isolation unit (104), configured to isolate the power supply. Compared with the existing prior arts, the proposed solution is convenient for connecting with the computer or cellphone, especially with isolation solution for power supply.

Abstract: Embodiments of the present invention disclose a circuit structure and a method for reducing power consumption of a device including an active module and a passive module. The circuit structure comprises: an active module (22) comprising a main output voltage (221) for powering a load (26) via a first current control device (222) which is configured to control a current passing through the load (26), and an passive module (24) comprising a main output voltage (241) for when the active module (22) fails, powering the load (26) via a second current control device (242) which is configured to control a current passing through the load (26). The passive module (24) further comprises an auxiliary output voltage (243) for when the passive module (24) is in a backup state, powering the second current control device (242) so as to enable the second current control device (242) to be in a switching-on state.

Abstract: Embodiments of the present disclosure provide a protective circuit to be used in a digital output module, the digital output module comprises a first voltage source and at least an output terminal. The protective circuit comprises: a first sampling unit for sampling a first voltage relevant to the output current from the first voltage source, a first comparing unit for comparing the sampled first voltage with a first reference voltage, a control unit for generating a current regulating signal based on a result from the first comparing unit, and a current regulating unit for regulating the output current from the first voltage source based on the current regulating signal. This protective circuit provides overflowing and short circuit protection, and is cheap in cost.

Abstract: Disclosed are an apparatus and a method for transmitting an analog signal, and an analog signal multiplexer. The apparatus comprises a photocoupler to receive an input analog signal and transform the input analog signal into an output analog signal, which varies with the input analog signal in a manner of non-linearity. The apparatus further comprises a non-linearity correcting unit to receive the output analog signal and correct the non-linearity to output a corrected output analog signal. An analog signal may be transmitted with a photocoupler.

Abstract: A standalone automation device (100) comprises: a removable memory port (101), configured to transmit data between the device (100) and the equipment (200) which also has a removable memory port; a removable memory control unit (102), comprising a signal convertor (112) for converting a removable memory interface to a serial interface; a power supply unit (103), configured to provide power supply when the device (100) is connected to the equipment (200) and disconnected to the field, and an isolation unit (104), configured to isolate the power supply. Compared with the existing prior arts, the proposed solution is convenient for connecting with the computer or cellphone, especially with isolation solution for power supply.

Abstract: Embodiments of the present invention disclose a circuit structure and a method for reducing power consumption of a device including an active module and a passive module. The circuit structure comprises: an active module (22) comprising a main output voltage (221) for powering a load (26) via a first current control device (222) which is configured to control a current passing through the load (26), and an passive module (24) comprising a main output voltage (241) for when the active module (22) fails, powering the load (26) via a second current control device (242) which is configured to control a current passing through the load (26). The passive module (24) further comprises an auxiliary output voltage (243) for when the passive module (24) is in a backup state, powering the second current control device (242) so as to enable the second current control device (242) to be in a switching-on state.

Abstract: Disclosed are an apparatus and a method for transmitting an analog signal, and an analog signal multiplexer. The apparatus comprises a photocoupler to receive an input analog signal and transform the input analog signal into an output analog signal, which varies with the input analog signal in a manner of non-linearity. The apparatus further comprises a non-linearity correcting unit to receive the output analog signal and correct the non-linearity to output a corrected output analog signal. An analog signal may be transmitted with a photocoupler.

Abstract: Embodiments of the present invention provide a DC-DC converter, an input/output (I/O) module including the DC-DC converter, and a method for controlling DC-DC converter. The converter can comprise a planar transformer (2); a first switch element (3) connected between one end of primary winding of the planar transformer and a ground potential, and a second switch element (4) connected between the other end of the primary winding of the planar transformer and a ground potential. The first and second switch elements (3; 4) are respectively controlled to be closed alternately.