Patents by Inventor Huan Shi
Huan Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220202864Abstract: Provided are a BCMA-targeting engineered immune cell and the use thereof. In particular, a CAR specifically targeting BCMA is provided. In the CAR, an antigen binding domain contained therein is a J-derived scFv, having an antibody heavy-chain variable region shown in SEQ ID NO: 9, and an antibody light-chain variable region shown in SEQ ID NO: 10. Also provided are a CAR-T cell containing the CAR, and a duplex CAR and CAR T cells containing the J-derived scFv, and related uses thereof. Compared with CAR-T cells constructed by using other scFvs, the CAR-T cells constructed by the present invention have higher killing effects and tumor clearance ability.Type: ApplicationFiled: May 6, 2020Publication date: June 30, 2022Inventors: Hua ZHANG, Lianjun SHEN, Huan SHI, Wei CAO, Chunhui YANG, Liping LIU
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Publication number: 20220049004Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.Type: ApplicationFiled: May 6, 2020Publication date: February 17, 2022Inventors: Hua ZHANG, Huan SHI, Lianjun SHEN, Wei CAO, Liping LIU
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Publication number: 20210296453Abstract: A split gate structure is disclosed. The split gate structure includes a first polysilicon, a characteristic oxide, and a second polysilicon sequentially disposed in a trench in a vertical direction upward from a bottom of the trench. An upper surface of the characteristic oxide has a height difference less than 1500 ? between a higher center portion and a lower periphery portion. The split gate structure effectively improves the breakdown performance and the IGSS performance. A power MOS device having the split gate structure and a manufacturing method of the split gate structure are also provided.Type: ApplicationFiled: May 14, 2020Publication date: September 23, 2021Inventors: Yuan Cheng ZHENG, Xin Huan SHI
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Patent number: 11127823Abstract: A split gate structure is disclosed. The split gate structure includes a first polysilicon, a characteristic oxide, and a second polysilicon sequentially disposed in a trench in a vertical direction upward from a bottom of the trench. An upper surface of the characteristic oxide has a height difference less than 1500 ? between a higher center portion and a lower periphery portion. The split gate structure effectively improves the breakdown performance and the IGSS performance. A power MOS device having the split gate structure and a manufacturing method of the split gate structure are also provided.Type: GrantFiled: May 14, 2020Date of Patent: September 21, 2021Assignee: HeJian Technology (Suzhou) Co., Ltd.Inventors: Yuan Cheng Zheng, Xin Huan Shi
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Publication number: 20190263918Abstract: Provided herein is a heavy chain constant region comprising a CH1 domain, a hinge region, a CH2 domain and a CH3 domain, wherein the sequences of said CH1 domain and hinge region derive from the sequences of CH1 domain and hinge region in human IgG2, the sequences of said CH2 domain and CH3 domain derive from the sequences of CH2 domain and CH3 domain in human IgGs; and wherein, said antibody heavy chain constant region has an affinity to human Fc?RIIB equal to or higher than the affinity of human IgG1 to human Fc?RIIB, said antibody heavy chain constant region has an I/A ratio equal to or higher than human IgG1 has. Also provided are antibodies or fusion proteins based on a heavy chain constant region according to the above, wherein the antibody heavy chain constant region significantly enhances agonistic activity of the antibodies or fusion proteins and improves efficacy of the antibodies or fusion proteins in treating diseases like tumors and autoimmune diseases.Type: ApplicationFiled: June 8, 2017Publication date: August 29, 2019Inventors: Fubin LI, Xiaobo LIU, Yan ZHANG, Yingjie ZHAO, Huan SHI, Huihui ZHANG
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Patent number: 10256805Abstract: Embodiments of the present disclosure provide a protective circuit to be used in a digital output module, the digital output module comprises a first voltage source and at least an output terminal. The protective circuit comprises: a first sampling unit for sampling a first voltage relevant to the output current from the first voltage source, a first comparing unit for comparing the sampled first voltage with a first reference voltage, a control unit for generating a current regulating signal based on a result from the first comparing unit, and a current regulating unit for regulating the output current from the first voltage source based on the current regulating signal. This protective circuit provides overflowing and short circuit protection, and is cheap in cost.Type: GrantFiled: August 9, 2016Date of Patent: April 9, 2019Assignee: ABB Schweiz AGInventors: Wei Liu, Huan Shi, Axel Lohbeck
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Patent number: 10019269Abstract: A standalone automation device (100) comprises: a removable memory port (101), configured to transmit data between the device (100) and the equipment (200) which also has a removable memory port; a removable memory control unit (102), comprising a signal convertor (112) for converting a removable memory interface to a serial interface; a power supply unit (103), configured to provide power supply when the device (100) is connected to the equipment (200) and disconnected to the field, and an isolation unit (104), configured to isolate the power supply. Compared with the existing prior arts, the proposed solution is convenient for connecting with the computer or cellphone, especially with isolation solution for power supply.Type: GrantFiled: July 4, 2014Date of Patent: July 10, 2018Assignee: ABB Schweiz AGInventors: Xiaobo Wang, Liang He, Huan Shi, Zhe Liu, Axel Lohbeck
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Patent number: 9859800Abstract: Embodiments of the present invention disclose a circuit structure and a method for reducing power consumption of a device including an active module and a passive module. The circuit structure comprises: an active module (22) comprising a main output voltage (221) for powering a load (26) via a first current control device (222) which is configured to control a current passing through the load (26), and an passive module (24) comprising a main output voltage (241) for when the active module (22) fails, powering the load (26) via a second current control device (242) which is configured to control a current passing through the load (26). The passive module (24) further comprises an auxiliary output voltage (243) for when the passive module (24) is in a backup state, powering the second current control device (242) so as to enable the second current control device (242) to be in a switching-on state.Type: GrantFiled: November 15, 2012Date of Patent: January 2, 2018Assignee: ABB Schweiz AGInventors: Huan Shi, Axel Lohbeck
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Publication number: 20160352213Abstract: Embodiments of the present disclosure provide a protective circuit to be used in a digital output module, the digital output module comprises a first voltage source and at least an output terminal. The protective circuit comprises: a first sampling unit for sampling a first voltage relevant to the output current from the first voltage source, a first comparing unit for comparing the sampled first voltage with a first reference voltage, a control unit for generating a current regulating signal based on a result from the first comparing unit, and a current regulating unit for regulating the output current from the first voltage source based on the current regulating signal. This protective circuit provides overflowing and short circuit protection, and is cheap in cost.Type: ApplicationFiled: August 9, 2016Publication date: December 1, 2016Inventors: Wei Liu, Huan Shi, Axel Lohbeck
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Patent number: 9490802Abstract: Disclosed are an apparatus and a method for transmitting an analog signal, and an analog signal multiplexer. The apparatus comprises a photocoupler to receive an input analog signal and transform the input analog signal into an output analog signal, which varies with the input analog signal in a manner of non-linearity. The apparatus further comprises a non-linearity correcting unit to receive the output analog signal and correct the non-linearity to output a corrected output analog signal. An analog signal may be transmitted with a photocoupler.Type: GrantFiled: October 23, 2012Date of Patent: November 8, 2016Assignee: ABB TECHNOLOGY LTD.Inventor: Huan Shi
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Publication number: 20160124758Abstract: A standalone automation device (100) comprises: a removable memory port (101), configured to transmit data between the device (100) and the equipment (200) which also has a removable memory port; a removable memory control unit (102), comprising a signal convertor (112) for converting a removable memory interface to a serial interface; a power supply unit (103), configured to provide power supply when the device (100) is connected to the equipment (200) and disconnected to the field, and an isolation unit (104), configured to isolate the power supply. Compared with the existing prior arts, the proposed solution is convenient for connecting with the computer or cellphone, especially with isolation solution for power supply.Type: ApplicationFiled: July 4, 2014Publication date: May 5, 2016Inventors: XIAOBO WANG, LIANG HE, HUAN SHI, ZHE LIU, AXEL LOHBECK
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Publication number: 20150340958Abstract: Embodiments of the present invention disclose a circuit structure and a method for reducing power consumption of a device including an active module and a passive module. The circuit structure comprises: an active module (22) comprising a main output voltage (221) for powering a load (26) via a first current control device (222) which is configured to control a current passing through the load (26), and an passive module (24) comprising a main output voltage (241) for when the active module (22) fails, powering the load (26) via a second current control device (242) which is configured to control a current passing through the load (26). The passive module (24) further comprises an auxiliary output voltage (243) for when the passive module (24) is in a backup state, powering the second current control device (242) so as to enable the second current control device (242) to be in a switching-on state.Type: ApplicationFiled: November 15, 2012Publication date: November 26, 2015Inventors: HUAN SHI, AXEL LOHBECK
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Publication number: 20150288360Abstract: Disclosed are an apparatus and a method for transmitting an analog signal, and an analog signal multiplexer. The apparatus comprises a photocoupler to receive an input analog signal and transform the input analog signal into an output analog signal, which varies with the input analog signal in a manner of non-linearity. The apparatus further comprises a non-linearity correcting unit to receive the output analog signal and correct the non-linearity to output a corrected output analog signal. An analog signal may be transmitted with a photocoupler.Type: ApplicationFiled: October 23, 2012Publication date: October 8, 2015Inventor: Huan Shi
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Publication number: 20150270783Abstract: Embodiments of the present invention provide a DC-DC converter, an input/output (I/O) module including the DC-DC converter, and a method for controlling DC-DC converter. The converter can comprise a planar transformer (2); a first switch element (3) connected between one end of primary winding of the planar transformer and a ground potential, and a second switch element (4) connected between the other end of the primary winding of the planar transformer and a ground potential. The first and second switch elements (3; 4) are respectively controlled to be closed alternately.Type: ApplicationFiled: November 8, 2012Publication date: September 24, 2015Applicant: ABB Technology Ltd.Inventors: Haoran Li, Huan Shi, Axel Lohbeck
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Publication number: 20150237730Abstract: A control system may include a plurality of terminal boards. Each of the plurality of terminal boards may at least include a power pin. The definition of the power pin on at least one of the plurality of terminal boards may be different from the definition of the power pin on another one of the plurality of terminal boards. Thus, if the at least one of the plurality of terminal boards is connected to a wrong input/output module, the input/output module will not get a process power supplied via the power pin on the terminal board. Therefore, a wrong input/output signal will not be transferred, and the input/output module will not be damaged even if a higher process voltage is provided by a wrong terminal board.Type: ApplicationFiled: October 23, 2012Publication date: August 20, 2015Applicant: ABB TECHNOLOGY LTD.Inventors: Wei Liu, Huan Shi, Jincheng Li, Haoran Li, Axel Lohbeck
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Patent number: 8878605Abstract: An amplifier circuit includes a digital amplifier configured to amplify an input signal to output a first output signal, an analog amplifier configured to amplify the input signal to output a second output signal, a check circuit configured to produce a check signal responsive to frequencies of the input signal, and a selector circuit configured to select and output one of the first output signal and the second output signal in response to the check signal.Type: GrantFiled: March 7, 2014Date of Patent: November 4, 2014Assignee: Fujitsu LimitedInventors: Huan Shi, Hisanori Murata
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Patent number: 8854868Abstract: Embodiments of the invention provide a sense amplifier, a SRAM chip comprising the sense amplifier and a method of performing read operation on the SRAM chip. The sense amplifier according to embodiments of the invention comprises an additional driving assist portion, which further takes a global data bus as input, the driving assist portion is configured to enable the sense amplifier to provide assisted driving for other sense amplifiers. With the solution according to embodiments of the invention, driving capability of a sense amplifier on global data bus can be enhanced.Type: GrantFiled: July 31, 2013Date of Patent: October 7, 2014Assignee: International Business Machines CorporationInventors: Hai Tao Cao, Xiao Li Hu, Qing Ql Li, Huan Shi
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Publication number: 20140184332Abstract: An amplifier circuit includes a digital amplifier configured to amplify an input signal to output a first output signal, an analog amplifier configured to amplify the input signal to output a second output signal, a check circuit configured to produce a check signal responsive to frequencies of the input signal, and a selector circuit configured to select and output one of the first output signal and the second output signal in response to the check signal.Type: ApplicationFiled: March 7, 2014Publication date: July 3, 2014Applicant: FUJITSU LIMITEDInventors: Huan Shi, Hisanori Murata
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Publication number: 20140036579Abstract: Embodiments of the invention provide a sense amplifier, a SRAM chip comprising the sense amplifier and a method of performing read operation on the SRAM chip. The sense amplifier according to embodiments of the invention comprises an additional driving assist portion, which further takes a global data bus as input, the driving assist portion is configured to enable the sense amplifier to provide assisted driving for other sense amplifiers. With the solution according to embodiments of the invention, driving capability of a sense amplifier on global data bus can be enhanced.Type: ApplicationFiled: July 31, 2013Publication date: February 6, 2014Applicant: International Business Machines CorporationInventors: Hai Tao Cao, Xiao Li Hu, Qing QL Li, Huan Shi
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Patent number: 5658022Abstract: This is a pipe connector improvement structure. Which consists a penetrated connector with extended stem, a rotator, two sealing rings, a socket and are assembled together by a nut. The rotator is a sphere drilled through by a hole. Sealing rings are circular ring shape. The socket has a concave spherical surface in the front end, also has two sections of thread on the outer surface. The nut has inner thread with a smaller radius arc holding surface in the front end. With all listed above components assembled together will facilitate free rotation and bending of the pipe connector.Type: GrantFiled: July 27, 1995Date of Patent: August 19, 1997Inventors: Wu-Huan Shi, Yi-Chang Tung