Patents by Inventor Huang-Ge Zhang

Huang-Ge Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136997
    Abstract: Provided are compositions that include an isoamyl alcohol (IAA) sequestration agent, wherein the IAA sequestration agent includes an IAA binding moiety. In some embodiments, the IAA binding moiety is a nucleotide sequence or a peptide or polypeptide (e.g., and antibody or a fragment thereof that includes a paratope) to which IAA binds. In some embodiments, the composition further includes comprising a pharmaceutically acceptable carrier, excipient, or diluent, optionally a pharmaceutically acceptable carrier, excipient, or diluent that is pharmaceutically acceptable for use in a human. The presently disclosed subject matter also provides oligonucleotides, optionally further including a tag, and/or the oligonucleotide includes at least one modified base. Also provided are methods for using the same to reduce and/or delay cognitive decline associated with neurodegenerative disease and/or for sequestering isoamyl alcohol (IAA) produced by microbiota in the gut of subjects.
    Type: Application
    Filed: May 31, 2024
    Publication date: May 1, 2025
    Inventor: Huang-Ge Zhang
  • Patent number: 12268785
    Abstract: Compositions are provided that comprise a microvesicle derived from an edible plant. The microvesicles are coated with a plasma membrane derived from a targeting cell and can further be utilized to encapsulate a therapeutic agent. Methods for treating an inflammatory disorder and/or a cancer are further provided and include the step of administering to a subject an effective amount of a composition that includes a microvesicle coated with a plasma membrane derived from a targeting cell.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: April 8, 2025
    Assignee: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Patent number: 12036262
    Abstract: Provided are methods for modulating gut microbiota in subjects. In some embodiments, the methods include administering to a subject an effective amount of a composition that includes a first edible plant-derived nanoparticle encapsulating an effective amount of RNA. Also provided are methods for preventing and/or treating gut dysbiosis, methods for modulating bacterial growth, methods for modulating inflammatory cytokines, methods for reducing migration of bacterial from the gut to gut-associated bloodstream, and compositions for use in the presently disclosed methods, including pharmaceutical compositions.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: July 16, 2024
    Assignee: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Patent number: 11890382
    Abstract: Compositions comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods of treating an inflammatory disorder and methods of treating a cancer are further provided and include administering an effective amount of a composition comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: February 6, 2024
    Assignee: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20230355525
    Abstract: An exosomal composition is provided that includes a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions that contain the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.
    Type: Application
    Filed: June 26, 2023
    Publication date: November 9, 2023
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20230248649
    Abstract: An exosomal composition is provided that includes a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions comprising the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.
    Type: Application
    Filed: March 31, 2023
    Publication date: August 10, 2023
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge ZHANG
  • Publication number: 20230210971
    Abstract: Provided are compositions and methods for using the same. In some embodiments, the compositions include an EPELN encapsulating and/or having associated therewith an active agent and a plasma membrane derived from a tumor and/or cancer cell coating the EPELN. In some embodiments, the active agent is a therapeutic agent or an immune response modifier, and in some embodiments the plasma membrane has one or more tumor-associated and/or cancer-associated antigens. Also provided are methods for using the compositions for treating tumors and/or cancers, inducing anti-tumor and/or anti-cancer immune responses, activating antigen-presenting cells, targeting CD11c dendritic cells, and preventing or reducing metastasis.
    Type: Application
    Filed: August 17, 2022
    Publication date: July 6, 2023
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20230201244
    Abstract: Provided are methods for inhibiting immune responses against microbial antigens. In some embodiments, the methods include administering to the subject a composition containing a plurality of plant-derived exosome-like particles to inhibit immune esponses against microbial antigens. Also provided are methods for inhibiting development of septic shock in subjects, for inhibiting development of cytokine storm in subjects, and for inhibiting SARS-CoV-2-induced cytopathogenic effect. Also provided are compositions that include an exosome-derived nanoparticle comprising a first lipid bilayer and a second lipid bilayer coating the exosome-like nanoparticle and/or fused with the first lipid bilayer, wherein the second lipid bilayer comprises a targeting molecule, and methods for using the compositions to treat diseases, disorders, and conditions and/or to target a therapeutic agent to a cell, tissue, and/or organ of interest.
    Type: Application
    Filed: May 24, 2021
    Publication date: June 29, 2023
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20230181670
    Abstract: Methods for treating alcohol induced liver injury include administering to a subject an effective amount of a ginger-derived nanoparticle. Methods for decreasing nuclear factor erythroid-2 related factor (Nrf2) activation in a hepatocyte are also provided and include contacting the hepatocyte with an effective amount of a ginger-derived nanoparticle. Pharmaceutical preparations including ginger-derived nanoparticles are further provided.
    Type: Application
    Filed: November 14, 2022
    Publication date: June 15, 2023
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20230149316
    Abstract: Compositions that include a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods for treating an inflammatory disorder and methods for treating a cancer are further provided and include administering an effective amount of a composition that includes a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.
    Type: Application
    Filed: September 14, 2022
    Publication date: May 18, 2023
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20230108385
    Abstract: Microvesicle compositions and methods of use thereof are provided. The microvesicle composition includes a miRNA encapsulated by a microvesicle, wherein the microvesicle is derived from an edible plant. The method of use thereof includes treating a cancer in a subject by administering to the subject an effective amount of a microvesicle composition.
    Type: Application
    Filed: May 26, 2022
    Publication date: April 6, 2023
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20220288130
    Abstract: Provided are methods for increasing insulin sensitivity in subjects. In some embodiments, the method include administering to the subject an effective amount of a composition comprising a lipid bilayer, wherein the lipid bilayer is low in total phosphatidylcholine (PC) or has been treated to reduce total PC.
    Type: Application
    Filed: August 14, 2020
    Publication date: September 15, 2022
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20220142937
    Abstract: Provided are methods for preventing and/or treating oral diseases, disorders, and/or conditions. In some embodiments, the methods relate to administering to the oral cavity of a subject in need thereof a composition that includes an effective amount of ginger-derived exosome-like nanoparticles (GELNs) or a biologically active component thereof. Also provided are methods for preventing and/or treating periodontitis, methods for reducing growth of and/or pathogenicity of microorganisms in the oral cavities of subjects, methods for reducing microorganismal motility, and methods for reducing bone loss in the oral cavities of subjects associated with infection with microorganisms. Also provided are compositions that can be employed in the disclosed methods.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 12, 2022
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20210236612
    Abstract: Provided are compositions and methods for using the same. In some embodiments, the compositions include an EPELN encapsulating and/or having associated therewith an active agent and a plasma membrane derived from a tumor and/or cancer cell coating the EPELN. In some embodiments, the active agent is a therapeutic agent or an immune response modifier, and in some embodiments the plasma membrane has one or more tumor-associated and/or cancer-associated antigens. Also provided are methods for using the compositions for treating tumors and/or cancers, inducing anti-tumor and/or anti-cancer immune responses, activating antigen-presenting cells, targeting CD1 lc dendritic cells, and preventing or reducing metastasis.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 5, 2021
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20210085744
    Abstract: Provided are methods for modulating gut microbiota in subjects. In some embodiments, the methods include administering to a subject an effective amount of a composition that includes a first edible plant-derived nanoparticle encapsulating an effective amount of RNA. Also provided are methods for preventing and/or treating gut dysbiosis, methods for modulating bacterial growth, methods for modulating inflammatory cytokines, methods for reducing migration of bacterial from the gut to gut-associated bloodstream, and compositions for use in the presently disclosed methods, including pharmaceutical compositions.
    Type: Application
    Filed: November 21, 2018
    Publication date: March 25, 2021
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20210030829
    Abstract: Provided are methods for treating tumors and/or cancers. In some embodiments, the methods relate to administering to a subject in need thereof an effective amount of a nanoparticle derived from an edible plant and an effective amount of an autologous exosome. Also provided are methods for enhancing accumulation of nanoparticles in the lungs of subjects, methods for delivering agents to the liver, brain, and/or bones of subjects, and methods for delivering agents across the blood-brain barrier of subjects.
    Type: Application
    Filed: March 6, 2019
    Publication date: February 4, 2021
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Patent number: 10815520
    Abstract: Methods for diagnosis or prognosis of a cancer in a subject include isolating one or more nanovesicles from a biological sample obtained from the subject, determining the amount in the biological sample of the one or more nanovesicles, and comparing the amount of the one or more nanovesicles to a control level to thereby diagnose the cancer. The one or more nanovesicles are obtained by depleting the biological sample of exosomes prior to the isolation of the nanovesicles. Methods for identifying a tumor metastasis in a subject are also provided and include fractionating a biological sample from a subject to obtain a fraction including one or more exosomes and one or more nanovesicles having a diameter of about 8-12 nm, and then isolating the one or more nanovesicles to diagnose the tumor metastasis.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: October 27, 2020
    Assignee: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Patent number: 10799457
    Abstract: An exosomal composition is provided that comprises a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions comprising the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: October 13, 2020
    Assignee: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20200206297
    Abstract: Methods for treating alcohol induced liver injury include administering to a subject an effective amount of a ginger-derived nanoparticle. Methods for decreasing nuclear factor erythroid-2 related factor (Nrf2) activation in a hepatocyte are also provided and include contacting the hepatocyte with an effective amount of a ginger-derived nanoparticle. Pharmaceutical preparations including ginger-derived nanoparticles are further provided.
    Type: Application
    Filed: March 11, 2020
    Publication date: July 2, 2020
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Publication number: 20200188311
    Abstract: Compositions comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods of treating an inflammatory disorder and methods of treating a cancer are further provided and include administering an effective amount of a composition comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.
    Type: Application
    Filed: April 12, 2019
    Publication date: June 18, 2020
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang