Patents by Inventor Huang-Ge Zhang

Huang-Ge Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6419919
    Abstract: The present invention provides a method of increasing adenoviral gene expression in a tissue of an animal, comprising the step of administering to said animal a pharmacologically effective dose of tumor necrosis factor binding protein. Also provided is a various method of method of reducing an inflammatory response associated with adenoviral administration in a tissue of an animal, comprising the step of administering to said animal a pharmacologically effective dose of tumor necrosis factor binding protein.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: July 16, 2002
    Inventors: John D. Mountz, Huang-Ge Zhang, Tong Zhou, Carl K. Edwards, III
  • Patent number: 6383794
    Abstract: The present invention discloses a method of producing large-scale recombinant adeno-associated virus stocks by infection of cells with at least one recombinant adenovirus vector(s). The vector(s) encode a therapeutic gene flanked by the terminal repeat ends of adeno-associated virus and the adeno-associated virus rep and cap genes. Transfection with two recombinant adenovirus vector(s) instead of two plasmids plus adenovirus results in the large scale, high titer production of recombinant adeno-associated virus with little to no contaminating adenovirus present.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: May 7, 2002
    Assignee: UAB Research Foundation
    Inventors: John D. Mountz, Huang-Ge Zhang
  • Publication number: 20010008881
    Abstract: The present invention provides a method of increasing adenoviral gene expression in a tissue of an animal, comprising the step of administering to said animal a pharmacologically effective dose of tumor necrosis factor binding protein. Also provided is a various method of method of reducing an inflammatory response associated with adenoviral administration in a tissue of an animal, comprising the step of administering to said animal a pharmacologically effective dose of tumor necrosis factor binding protein.
    Type: Application
    Filed: November 6, 1998
    Publication date: July 19, 2001
    Inventors: JOHN D. MOUNTZ, HUANG-GE ZHANG, TONG ZHOU, CARL K. EDWARDS