Abstract: The present invention relates to a system (10) for planning and/or providing a therapy for neural applications, especially a neurostimulation and/or neurorecording applications, comprising at least one lead (300), the lead (300) having a plurality of electrodes (132) being capable to provide at least one stimulation field (F; F1; F2), further comprising at least one adjustment means (400), the adjustment means (400) being configured such that at least one characteristic parameter of the stimulation field (F; F1; F2) is directly and/or indirectly adjusted in order to establish at least one stimulation field (F; F1; F2) with at least one user defined maximal stimulation field characteristic at at least one user defined radial distance away from the lead (300).

Abstract: A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes.

Abstract: A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes.

Abstract: The present invention regards a probe for deep brain stimulation (DBS), with high overall impedance, but low overall resistance. This is achieved since the probe comprises a structure comprising at least two interconnected spirals, wherein said two spirals have different direction of rotation. A system for deep brain stimulation comprising the probe, a power source and an electrode is also disclosed.

Abstract: A method of manufacturing a personalized radio frequency (RF) coil array for magnetic resonance (MR) imaging guided interventions includes: acquiring diagnostic image data reflecting the anatomy of a portion of a patient's body; planning an intervention on the basis of the diagnostic image data, wherein a field of the intervention within the patient's body portion is determined; and arranging one or more RF coils on a substrate which is adapted to the patient's anatomy, in such a manner that the signal-to-noise ratio of MR signal acquisition via the one or more RF coils from the field of the intervention is optimized.

Abstract: A neurostimulation device is provided comprising an input, a neurostimulation probe, a stimulation unit and a distribution calculation module. At the input stimulation data is received comprising information relating to a stimulation preferability and an orientation of at least one fiber bundle. The neurostimulation probe comprises an array of stimulation electrodes which are coupled to the stimulation unit. The stimulation unit, in accordance with a specified current distribution, provides currents to the respective stimulation electrodes for generating an electric field gradient. The distribution calculation module is coupled to the input and the stimulation unit for based on the stimulation data determining a preferred position and orientation for the electric field gradient, and based on the preferred position and orientation for the electric field gradient, calculating the specified current distribution.

Abstract: The invention relates to a method for determining at least one applicable path (32) for the movement of an object, especially of a surgical and/or diagnostical device, in human tissue (14) or animal tissue by means of a data set of intensity data obtained by a 3D imaging technique, the applicable path (32) of movement connecting a starting position (28) of the device with a defined target location (30).

Abstract: The invention relates to an optical storage medium comprising below an entrance face (EF) a higher recording stack (ST0) comprising a higher recording layer (L0) and at least a lower recording stack (ST1), said lower recording stack (ST1) being recorded or read back by a radiation beam (4) entering into the optical storage medium through the entrance face (EF) with a wavelength (?), focused on said lower recording stack (ST1) and transmitted through the higher recording stack (ST0), a recording of the higher recording layer (L0) causing an optical thickness variation between recorded and unrecorded areas of said first recording layer (L0), which is included into the range [0.03?, 0.125?].

Abstract: The present invention regards a guiding tool for neurosurgery. The guiding tool comprises subunits and a holder. The subunits are arranged in the holder so that holes for guiding a probe are created in the interface between said subunits, which allows easy release of the probe. The invention further regards a system for guiding neurosurgery probes.

Abstract: A device for planning a neuromodulation therapy, whereby the device comprises receiving means to receive brain default mode network data of a patient, template means comprising a template brain default mode network data, normalizing means being configured such that normalized patient brain default mode network data can be prepared on the basis on the received brain default mode network data and the template brain default mode network data, storage means comprising a brain default mode network database and comparison means configured such that the normalized patient brain default mode network data and the data contained in the brain default mode network database can be compared.

Abstract: The invention relates to a probe for an implantable electro-stimulation device. The probe (20) has a distal end (12) and a proximal end (13), and moreover comprises: one or more electrodes (11) a shield (21) of conducting material covering a major part of the probe, said shield extending from the vicinity of at least one of the one or more electrodes (11) towards the proximal end (13) or towards the distal end (12) of the probe (20); and a layer (22a, 22b) of insulating material covering part of the shield (21) in the vicinity of the at least one of the one or more electrodes. The shield protects wires (14), extending from electrodes to the proximal end of the probe, from undesired interference of external RF fields. The exposed part of the shield not covered by the layer of insulating material serves as a return electrode for the electrostimulation signal path.

Abstract: A multi-stack optical data storage medium for recording and reading using a focused radiation beam entering through an entrance face of the medium has a first substrate with a first guide groove having a depth GL0<80 nm and a full half maximum width WL0<350 nm, where a first recording stack is formed over the first substrate and includes a recordable type recording layer formed in the first guide groove. A first reflective layer is present between the first recording layer and the first substrate. A second recording stack has a recordable type recording layer formed a second guide groove of a second substrate, where the second recording stack is present at a position closer to the entrance face than the first recording stack. A transparent spacer layer is sandwiched between the first and second recording stacks. The first L0 guide groove has a depth GL0<100 nm.

Abstract: The invention relates to an optical storage medium comprising below an entrance face (EF) a higher recording stack (ST0) comprising a higher recording layer (L0) and at least a lower recording stack (ST1), said lower recording stack (ST1) being recorded or read back by a radiation beam (4) entering into the optical storage medium through the entrance face (EF) with a wavelength (?), focused on said lower recording stack (ST1) and transmitted through the higher recording stack (ST0), a recording of the higher recording layer (L0) causing an optical thickness variation between recorded and unrecorded areas of said first recording layer (L0), which is included into the range [0.03?, 0.125?].

Abstract: A stimulation apparatus includes a stimulation lead (102), a multiplexer (114), a stimulation signal generator (116), and a signal detector (120). The stimulation lead (102) includes a plurality of stimulation electrodes (112) disposed in an array about a distal portion of the lead body (110). The arrangement of the electrodes (112) facilitates the controlled steering of stimulating electrical field (118) in three dimensions. Four dimensional field steering may also be provided.

Abstract: The invention relates to a method for determining at least one applicable path (32) for the movement of an object, especially of a surgical and/or diagnostical device, in human tissue (14) or animal tissue by means of a data set of intensity data obtained by a 3D imaging technique, the applicable path (32) of movement connecting a starting position (28) of the device with a defined target location (30).

Abstract: The disclosure is directed to a deep brain stimulation (DBS) lead having a distal end for providing therapeutic electrical stimulation to tissue in a stimulation target area of a patient's brain, comprising an array of one or more stimulation elements and sensing elements located at the distal end of the lead. After the first implantation of the lead into the brain along a trajectory that is pre-determined by non-surgical procedures, the array of stimulation and sensing elements is capable of facilitating the location of the target area and the determination for each of the stimulation elements of the required stimulation parameters needed to provide the therapeutic stimulation to the brain tissue in the stimulation target area, without requiring any additional implantations of the lead after the first implantation.

Abstract: A multi-stack optical data storage medium (30) for recording and reading using a focused radiation beam (40) entering through an entrance face (41) of the medium (30) is described. It has a first substrate (31a) with present on a side thereof a first recording stack (33) named L0, comprising a recordable type L0 recording layer (35), formed in a first L0 guide groove (38a, 38b). A first reflective layer (39) is present between the first L0 recording layer (35) and the first substrate (31a). A second substrate (31b) with present on a side thereof a second recording stack (32) named L1 is present at a position closer to the entrance face (41) than the L0 recording stack (33) and formed in a second L1 guide groove (37). A transparent spacer layer (36) is sandwiched between the recording stacks (32, 33). The first L0 guide groove (38a, 38b) has a depth GL0<100 nm. In this way a relatively high reflection value of the L0 stack is achieved at a radiation beam wavelength of approximately 655 nm.

Abstract: A method for determining an applicable path of movement of an object in human or animal tissue is based on intensity data obtained by a 3D imaging technique. The applicable path of movement connects a starling position of the object with a defined target location. The method includes defining the target location of a reference point of the object and choosing at least one possible starting position of the reference point of the object. Further, the method includes determining a candidate path of movement between the corresponding possible starling position and the defined target location. Next, the candidate path of movement is evaluated for being an applicable path. The candidate path is evaluated based on information about local intensity extrema and/or intensity variation resulting from the intensity data along the candidate path of movement.

Abstract: A method and control system for determining and applying stimulation settings for a brain stimulation probe (10, 12) is provided. The brain stimulation probe (10, 12) comprises a plurality of stimulation electrodes (11). The method comprises for multiple stimulation electrodes (11) of the plurality of stimulation electrodes (11): applying a test current and determining a corresponding patient response, determining a volume of influence based (32, 52, 71, 91) on the test current and a position of the stimulation electrode (11), combining the volume of influence (32, 52, 71, 91) and the corresponding patient response with generalized anatomic knowledge of stimulation induced behavior for associating the volume of influence (32, 52, 71, 91) to an anatomic structure (33, 43, 53), and determining an intersection (41, 51) of the volume of influence (32, 52, 71, 91) and the associated anatomic structure (33, 43, 53).