Abstract: The present invention relates to a system (10) for planning and/or providing a therapy for neural applications, especially a neurostimulation and/or neurorecording applications, comprising at least one lead (300), the lead (300) having a plurality of electrodes (132) being capable to provide at least one stimulation field (F; F1; F2), further comprising at least one adjustment means (400), the adjustment means (400) being configured such that at least one characteristic parameter of the stimulation field (F; F1; F2) is directly and/or indirectly adjusted in order to establish at least one stimulation field (F; F1; F2) with at least one user defined maximal stimulation field characteristic at at least one user defined radial distance away from the lead (300).

Abstract: The invention relates to an electronic apparatus (100) comprising a charging module (20) for receiving external energy (RF1) and for transferring it to a rechargeable energy storage (10) in a “charging state”. Moreover, the apparatus comprises a processing module which can be operated in a working state that is enabled if the charging module (20) is in the charging state and the apparatus is in a standard operating mode. The processing module may for example be a communication module (30) that can communicate wirelessly in its working state. In the standard operating mode, communication with the apparatus (100) is thus only possible if the apparatus (100) is simultaneously charged. The communication module (30) can therefore be completely switched off during the residual time, thus reducing power consumption and avoiding erroneous communication or misuse.

Abstract: A system for communicating information between at least two medical devices implanted within the body of a subject using volume conduction of electrical signals as a means of communication and wherein one of the implanted medical devices is configured to provide electrical stimulation to the tissue is disclosed. The system comprises a first implant device having at least two transmit electrodes configured to transmit electrical stimulation pulses, wherein one of the electrodes may be a common return electrode, an encoding means configured to employ a channel as a transmitter transmission medium for stimulation pulses and encoding the information into the stimulation pulses, a second implant device having at least two receive electrodes configured to receive the transmitted stimulation pulses with encoded information, and a decoding means configured to decode the information encoded into the stimulation pulses. The disclosed system provides reliable and efficient communication between implantable devices.

Abstract: A method is provided for determining a threshold (81, 82) for spike (12) detection in an electrophysiological signal (11). The method comprises a step of determining an estimated envelope (31) of the electrophysiological signal (11), a step of, based on the estimated envelope (31), determining an estimated Gaussian noise, a step of determining a distribution (51) of instantaneous amplitudes of the estimated Gaussian noise, a step of determining a mode (61) of the distribution (51) of instantaneous amplitudes, and determining the threshold (81, 82) based on the mode (61) of the distribution (51) of instantaneous amplitudes.

Abstract: The disclosure is directed to a deep brain stimulation (DBS) lead having a distal end for providing therapeutic electrical stimulation to tissue in a stimulation target area of a patient's brain, comprising an array of one or more stimulation elements and sensing elements located at the distal end of the lead; each of the one or more stimulation elements is capable of providing electrical stimulation to the brain tissue in the target area; and each of the one or more sensing elements is capable of detecting electrical signals produced by nerve cells within the brain; wherein after the first implantation of the lead into the brain along a trajectory that is pre-determined by non-surgical procedures, the array of stimulation and sensing elements is capable of facilitating the location of the target area and the determination for each of the stimulation elements of the required stimulation parameters needed to provide the therapeutic stimulation to the brain tissue in the stimulation target area, without requiri

Abstract: A neuromimetic device includes a feedforward pathway and a feedback pathway. The device operates in parallel with a suspect neural region, coupled between regions afferent and efferent to the suspect region. The device can be trained to mimic the suspect region while the region is still considered functional; and then replace the region once the region is considered dysfunctional. The device may be particularly useful in treating neuromotor issues such as Parkinson's disease.

Abstract: The invention relates to a system for planning and/or tuning a neuromodulation therapy, comprising: a database means for storing a plurality of data sets, each data set comprising: metadata relating to gender data, age data, local field recordings data, microelectrode recordings data, tissue fiber structures data, demographics data and/or anatomy data of a patient, and spatial data relating to distribution of a stimulation field of a neuromodulation probe; input means for entering at least one filter criterion; filter means for applying the at least one filter criterion on the plurality of data sets to generate a filtered subset of the data sets; merging means for merging the spatial data of the filtered subset to generate a functional data set; and visualization means for computing a three dimensional model of the functional data set and for visualizing an image of the three dimensional model.

Abstract: A system (10) and a method for deep brain stimulation are provided. The system (10) comprises a probe (11) and a processor (14). The probe (11) comprises an array of sensing electrodes (12) for acquiring signals representing neuronal activity at corresponding positions in a brain and an array of stimulation electrodes (12) for applying stimulation amplitudes to corresponding brain regions. The processor (14) is operably coupled to the sensing electrodes (12) and the stimulation electrodes (12) and is arranged for performing the method according to the invention.

Abstract: A neurostimulation device is provided comprising an input, a neurostimulation probe, a stimulation unit and a distribution calculation module. At the input stimulation data is received comprising information relating to a stimulation preferability and an orientation of at least one fiber bundle. The neurostimulation probe comprises an array of stimulation electrodes which are coupled to the stimulation unit. The stimulation unit, in accordance with a specified current distribution, provides currents to the respective stimulation electrodes for generating an electric field gradient. The distribution calculation module is coupled to the input and the stimulation unit for based on the stimulation data determining a preferred position and orientation for the electric field gradient, and based on the preferred position and orientation for the electric field gradient, calculating the specified current distribution.

Abstract: System for providing a stimulus comprising a probe with multiple electrodes each capable of providing a particular current to surrounding tissue a generator for providing to each of the electrodes the particular current a controller for controlling the generator to provide current to the electrodes to achieve a desired electrical field around the probe.

Abstract: A neurostimulation device is provided comprising an input, a neurostimulation probe, a stimulation unit and a distribution calculation module. At the input stimulation data is received comprising information relating to a stimulation preferability and an orientation of at least one fiber bundle. The neurostimulation probe comprises an array of stimulation electrodes which are coupled to the stimulation unit. The stimulation unit, in accordance with a specified current distribution, provides currents to the respective stimulation electrodes for generating an electric field gradient. The distribution calculation module is coupled to the input and the stimulation unit for based on the stimulation data determining a preferred position and orientation for the electric field gradient, and based on the preferred position and orientation for the electric field gradient, calculating the specified current distribution.

Abstract: A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes.

Abstract: A neuromimetic device includes a feedforward pathway and a feedback pathway. The device operates in parallel with a suspect neural region, coupled between regions afferent and efferent to the suspect region. The device can be trained to mimic the suspect region while the region is still considered functional; and then replace the region once the region is considered dysfunctional. The device may be particularly useful in treating neuromotor issues such as Parkinson's disease.

Abstract: The present invention relates to a device for planning a neuromodulation therapy, whereby the device comprises receiving means to receive brain default mode network data of a patient, template means comprising a template brain default mode network data, normalizing means being configured such that normalized patient brain default mode network data can be prepared on the basis on the received brain default mode network data and the template brain default mode network data, storage means comprising a brain default mode network data base and comparison means configured such that the normalized patient brain default mode network data and the data contained in the brain default mode network data base can be compared

Abstract: A system (10) and method (20) for planning a neurosurgical operation are provided the system (10) comprises an input (11) for receiving functional data (25) and anatomical data of a brain region (31), and a processor (12) configured to perform the method (20) according to the invention. The method (20) comprises analyzing (26) the functional data (25) to form a network representation (27) of functional connections, mapping the network representation (27) of the functional connections and the anatomical data to a common coordinate system, determining an expected function loss associated with a simulated removal of network nodes (32) or network connections (42) from the network representation (27), and identifying critical network connections and/or critical network nodes based on the expected function loss.

Abstract: A method and a control system (20) are provided for determining a relation between stimulation settings for a brain stimulation probe (10) and a corresponding V-field. The brain stimulation probe (10) comprises multiple stimulation electrodes (11). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (11).

Abstract: The invention relates to a method of manufacturing a personalized RF coil array for MR imaging guided interventions. The method comprises the steps of: —acquiring diagnostic image data reflecting the anatomy of a portion of a patient's body (10); —planning an intervention on the basis of the diagnostic image data, wherein a field of the intervention within the patient's body (10) portion is determined; —arranging one or more RF antennae (11, 12, 13) on a substrate (19), which is adapted to the patient's anatomy, in such a manner that the signal-to-noise ratio of MR signal acquisition via the one or more RF antennae (11, 12, 13) from the field of the intervention is optimized. Moreover, the invention relates to a computer program and to a computer workstation.

Abstract: A neuromimetic device includes a feedforward pathway and a feedback pathway. The device operates in parallel with a suspect neural region, coupled between regions afferent and efferent to the suspect region. The device can be trained to mimic the suspect region while the region is still considered functional; and then replace the region once the region is considered dysfunctional. The device may be particularly useful in treating neuromotor issues such as Parkinson's disease.

Abstract: The present invention relates to a probe system for brain applications, especially for neurostimulation and/or neurorecording, comprising at least one lead for brain applications with a first number of stimulation and/or recording electrodes, the lead being connectable to a low-count connector element or having a low-count connector element, whereby the low-count connector element has a second number of connector contacts, whereby the second number of connector contacts is lower than the first number of the electrodes, whereby the low-count connector element is configured such that the low-count connector element can be directly and/or indirectly connected to at least one pulse generator, whereby the probe system further comprises a power-management unit, a controller unit, a communication unit, and a switching unit. Furthermore, the present invention relates to a deep brain stimulation system, a low-count connector element, and to a method of manufacturing a probe system for a deep brain stimulation system.

Abstract: The disclosure is directed to a deep brain stimulation (DBS) lead having a distal end for providing therapeutic electrical stimulation to tissue in a stimulation target area of a patient's brain, comprising an array of one or more stimulation elements and sensing elements located at the distal end of the lead; each of the one or more stimulation elements is capable of providing electrical stimulation to the brain tissue in the target area; and each of the one or more sensing elements is capable of detecting electrical signals produced by nerve cells within the brain; wherein after the first implantation of the lead into the brain along a trajectory that is pre-determined by non-surgical procedures, the array of stimulation and sensing elements is capable of facilitating the location of the target area and the determination for each of the stimulation elements of the required stimulation parameters needed to provide the therapeutic stimulation to the brain tissue in the stimulation target area, without requiri