Abstract: Described herein is the use of farnesoid X receptor (FXR) agonists, alone or in combination with additional therapies, in the treatment or prevention of diseases, conditions, or disorders that would benefit from therapy with a FXR agonist.

Abstract: Methods for treating a solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Described herein are combination therapies with farnesoid X receptor (FXR) agonists, and methods of using such pharmaceutical compositions in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

Abstract: Described herein are combination therapies with famesoid X receptor (FXR) agonists, and methods of using such pharmaceutical compositions in the treatment of conditions, diseases, or disorders associated with famesoid X receptor activity.

Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.

Abstract: A bidirectional hub assembly includes an axle unit, a hub shell mounted on the axle unit, a driving unit mounted on the axle unit, and a plurality of right-hand-drive and left-hand-drive units that are mounted to the hub shell. Each of the right-hand-drive and left-hand-drive units has a pawl engageable with the driving unit. The bidirectional hub assembly serves as a right-hand-drive hub when the pawl of at least one of the right-hand-drive units is in an enabled state and the pawl of each of the left-hand-drive units is in a disabled state, and serves as a left-hand-drive hub when the pawl of at least one of the left-hand-drive units is in an enabled state and the pawl of each of the right-hand-drive units is in a disabled state.

Abstract: A transmission system includes a hub unit and a crankshaft for being respectively mounted to seat stays and a bottom bracket of a bicycle, a transmission unit and an engaging unit. The transmission unit includes a driving sprocket sleeved on the crankshaft, at least one driven sprocket mounted to the hub unit, and a chain trained on the driving and driven sprockets. The engaging unit includes first and second ratchet members sleeved co-rotatably on the crankshaft, and a resilient element for biasing the first ratchet member toward the second ratchet member. The first ratchet member is slidable relative to the crankshaft and has first ratchet teeth. The second ratchet member is co-rotatable with the driving sprocket and has second ratchet teeth.

Abstract: Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.

Abstract: A bidirectional hub assembly includes an axle unit, a hub shell mounted on the axle unit, a driving unit mounted on the axle unit, and a plurality of right-hand-drive and left-hand-drive units that are mounted to the hub shell. Each of the right-hand-drive and left-hand-drive units has a pawl engageable with the driving unit. The bidirectional hub assembly serves as a right-hand-drive hub when the pawl of at least one of the right-hand-drive units is in an enabled state and the pawl of each of the left-hand-drive units is in a disabled state, and serves as a left-hand-drive hub when the pawl of at least one of the left-hand-drive units is in an enabled state and the pawl of each of the right-hand-drive units is in a disabled state.

Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: A hub module includes an axle member, a hub shell mounted on the axle member, at least two sprocket carriers, and a pair of end caps respectively secured to opposite ends of the axle member. Each of the sprocket carriers includes a carrier body having an outer profile, and a bearing unit mounted in the carrier body. The outer profiles of the carrier bodies of the sprocket carriers are different from each other. The bearing units of the sprocket carriers are the same in total length and inner diameter. Any one of the sprocket carriers is able to be mounted on a carrier-mounting section of the axle member and cooperates with the axle member and the hub shell to serve as a hub assembly.

Abstract: A hub assembly for a bicycle includes a hub shell, a plurality of pawl units, and an annular ratchet member. The hub shell is rotatably mounted on a hub axle, and the annular ratchet member is disposed to rotate with respect to the hub axle. Each pawl unit includes a pawl that is movable between driven and idle positions, an elongated mount that extends to bridge a gap formed in the pawl, and a biasing member that is mounted on the elongated mount to bias the pawl to move to the driven position so as to engage to the annular ratchet member.

Abstract: A modularized hub assembly includes an axle member, a hub shell mounted on the axle member, at least two sprocket carriers alternatively mounted on the axle member, and a pair of end caps respectively secured to opposite ends of the axle member. Each of the sprocket carriers includes a carrier body having an outer profile, and a bearing unit mounted in the carrier body. The outer profiles of the carrier bodies of the sprocket carriers are different from each other. The bearing units of the sprocket carriers are the same in total length and inner diameter for being alternatively mounted on a carrier-mounting section of the axle member.

Abstract: A hub assembly for a bicycle includes a hub shell, a plurality of pawl units, and an annular ratchet member. The hub shell is rotatably mounted on a hub axle, and the annular ratchet member is disposed to rotate with the hub axle. Each pawl unit includes a pawl that is movable between driven and idle positions, an elongated mount that extends to bridge a gap formed in the pawl, and a biasing member that is mounted on the elongated mount to bias the pawl to move to the driven position so as to engage to the annular ratchet member.

Abstract: A cyclic redundancy check generator includes a plurality of shift registers, each shift register corresponding to a coefficient of a general polynomial key word. A plurality of programmable registers are programmed based on a specific polynomial key word. The specific key word programmed to the plurality of programmable registers is compared to the general polynomial key word to determine which shift registers corresponding to coefficients of the general polynomial key word are to take a predetermined value in order to convert the general polynomial key word into the specific polynomial key word.

Abstract: A power-generating wheel hub includes a hub shaft including a mounting section, and a bobbin including a tubular body sleeved around the mounting section, two flange plates connected respectively to two opposite ends of the tubular body, and a coil wound around the tubular body. Two magnetic yoke disks are sleeved on the mounting section adjacent respectively to outer faces of the flange plates, and each includes a plurality of angularly spaced-apart radial protrusions, and a plurality of indentations each formed between two adjacent ones of the radial protrusions. The indentations in the two magnetic yoke disks are staggered axially with respect to each other. Magnetic yoke claws respectively include radial arms inserted respectively into the indentations in the magnetic yoke disks and abutting against the outer faces of the flange plates, and axial arms extending axially from the respective radial arms and arranged annularly around the coil.