Patents by Inventor Hubert Koster

Hubert Koster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160349268
    Abstract: The invention relates to a process for isolating and/or characterising biomolecules and/or biomolecule fragments, in particular proteins and/or protein fragments, comprising the steps: provision of an immobilized compound IC through the interaction of a capture compound CC and the target compound T and a carrier compound CCB, carrying out a division step, in which a cleavable function F is cleaved, and a division compound DC is produced, and isolation and/or characterisation of said division compound DC. The invention relates further to a carrier compound CCB, a capture compound CC, a precursor compound PC and a division compound DC.
    Type: Application
    Filed: January 28, 2015
    Publication date: December 1, 2016
    Applicant: CAPROTEC BIOANALYTICS GMBH
    Inventors: Hubert KOSTER, Mathias DREGER, Simon MICHAELIS, Thomas LENZ, Jelena MILIC, Michael SEFKOW
  • Patent number: 9034798
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: May 19, 2015
    Assignee: CAPROTEC BIOANALYTICS GMBH
    Inventors: Hubert Köster, Daniel Paul Little, Suhaib Mahmood Siddiqi, Matthew Peter Grealish, Subramanian Marappan, Chester Frederick Hassman, III, Ping Yip
  • Publication number: 20150005194
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Application
    Filed: May 9, 2014
    Publication date: January 1, 2015
    Applicant: Sequenom, Inc.
    Inventors: Andreas BRAUN, Hubert Köster, Dirk Van Den Boom, Ping Yip, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Patent number: 8821816
    Abstract: Provided herein are substrates for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis. Each spot includes 3-hydroxypicolinic acid matrix and no analyte.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: September 2, 2014
    Assignee: Agena Biosciences, Inc.
    Inventors: Daniel P. Little, Maryanne J. O'Donnell-Maloney, Charles R. Cantor, Hubert Köster
  • Patent number: 8818735
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: August 26, 2014
    Assignee: Sequenom, Inc.
    Inventors: Andreas Braun, Hubert Köster, Dirk Johannes Van Den Boom, Ping Yip, Charles Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Patent number: 8758995
    Abstract: This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Probes may be affixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: June 24, 2014
    Assignee: Sequenom, Inc.
    Inventors: Charles R. Cantor, Hubert Koster
  • Patent number: 8569481
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Each compound has the formula: wherein: Z is a trityl derivative; X, the reactivity function, covalently binds to amino acid side chains of proteins; Y, the selectivity function, modulates binding of X to the amino acid side chains in proteins such that X binds to fewer proteins when Y is present than in its absence; and Q permits separation or immobilization of the capture compound. Automated systems for performing the methods also are provided.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: October 29, 2013
    Assignee: Pharmaceuticals, Inc.
    Inventors: Hubert Köster, Suhaib Siddigi, Daniel P. Little
  • Publication number: 20120301882
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Application
    Filed: June 28, 2012
    Publication date: November 29, 2012
    Applicant: SEQUENOM, INC.
    Inventors: Hubert Köster, Andreas BRAUN, Dirk Van Den Boom, Yip Ping, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Patent number: 8229677
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: July 24, 2012
    Assignee: Sequenom, Inc.
    Inventors: Andreas Braun, Hubert Koster, Dirk Van den Boom, Ping Yip, Charles Rodi, Liyan He, Norman Chiu, Christiane Jurinke
  • Publication number: 20110269643
    Abstract: Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided.
    Type: Application
    Filed: May 2, 2011
    Publication date: November 3, 2011
    Applicant: SEQUENOM, INC.
    Inventor: Hubert Köster
  • Publication number: 20110172111
    Abstract: This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include DNA or RNA in biological samples such as patient biopsies and environmental samples.
    Type: Application
    Filed: August 6, 2010
    Publication date: July 14, 2011
    Applicant: SEQUENOM, INC.
    Inventors: Charles Cantor, Hubert Köster
  • Publication number: 20110118136
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Each compound has the formula: wherein: Z is a trityl derivative; X, the reactivity function, covalently binds to amino acid side chains of proteins; Y, the selectivity function, modulates binding of X to the amino acid side chains in proteins such that X binds to fewer proteins when Y is present than in its absence; and Q permits separation or immobilization of the capture compound. Automated systems for performing the methods also are provided.
    Type: Application
    Filed: November 2, 2010
    Publication date: May 19, 2011
    Inventors: Hubert Köster, Suhaib Siddigi, Daniel P. Little
  • Patent number: 7858560
    Abstract: Capture Collections of capture compounds and collections thereof and methods using the compounds collections for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds in the collections are multifunctional reagents that provide for the separation and isolation of biomolecules in complex protein mixtures. In the collections, each and every compound in the collection, has the formula: Z is a trityl derivative, each of m and n independently is an integer that is 1 to 100; X, the reactivity function, covalently binds to amino acid side chains of biomolecules; Y, the selectivity function, modulates binding of X to the amino acid side chains in biomolecules such that X binds to fewer biomolecules when the selectivity moiety Y is present than in its absence; and Q permits separation or immobilization of capture compounds in the collection.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: December 28, 2010
    Assignee: caprotec bioanalytics GmbH
    Inventors: Hubert Köster, Suhaib Siddiqi, Daniel P. Little
  • Publication number: 20100298168
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Application
    Filed: April 7, 2010
    Publication date: November 25, 2010
    Inventors: Hubert Köster, Daniel Paul Little, Suhaib Mahmood Siddiqi, Matthew Peter Grealish, Subramanian Marappan, Chester Frederick Hassman, III
  • Publication number: 20100292930
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Application
    Filed: December 21, 2009
    Publication date: November 18, 2010
    Applicant: SEQUENOM, INC.
    Inventors: Hubert Köster, Andreas Braun, Dirk Van Den Boom, Yip Ping, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Publication number: 20100248264
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Application
    Filed: February 26, 2010
    Publication date: September 30, 2010
    Inventors: Hubert Kõster, Daniel Paul Little, Suhaib Mahmood Siddiqi, Matthew Peter Grealish, Subramanian Marappan, Chester Frederick Hassman, III, Ping Yip
  • Patent number: 7803529
    Abstract: This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include DNA or RNA in biological samples such as patient biopsies and environmental samples.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: September 28, 2010
    Assignee: Sequenom, Inc.
    Inventors: Charles Cantor, Hubert Köster
  • Patent number: 7759065
    Abstract: Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided. In some embodiments, a process comprises: amplifying one or more target nucleic acid molecules from a biological sample; ionizing and volatilizing the amplified product; and analyzing a product by mass spectrometry to determine an observed molecular mass of the product.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: July 20, 2010
    Assignee: Sequenom, Inc.
    Inventor: Hubert Köster
  • Patent number: 7668658
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: February 23, 2010
    Assignee: Sequenom, Inc.
    Inventors: Hubert Köster, Andreas Braun, Dirk Van Den Boom, Yip Ping, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Patent number: RE44693
    Abstract: Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are described. As compared to “flat” surfaces, beads linked to a solid support provide an increased surface area for immobilization of nucleic acids. Furthermore, by selecting a bead with the desired functionality, a practitioner can select a functionalization chemistry for immobilizing nucleic acids, which is different from the chemistry of the solid support.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: January 7, 2014
    Assignee: Sequenom, Inc.
    Inventors: Hubert Köster, David M. Lough