Patents by Inventor Hubert Sturm

Hubert Sturm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification process
    Patent number: 6313289
    Abstract: Crystalline 2-(amninothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)acetic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-[2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid with an amine of formula N(R1)(R2)(R3), wherein R1, R2, and R3 have various meanings, a crystalline sulphuric acid addition salt of a 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid; and the use of these salts in the production of cefixime, e.g. in form of a trihydrate.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: November 6, 2001
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Ludwig Miller, Hubert Sturm, Werner Veit, Martin Decristoforo, Siegfried Wolf
  • Process for the production of cephalosporines
    Patent number: 6169180
    Abstract: The invention relates to a new economical and simple process, using a new intermediate compound, for the production of 3′-substituted 7-amino-3-propenyl-4-cephem-carboxylic acid derivatives of formula wherein R is hydrogen, a negative charge or a silyl protecting group, Ro is hydrogen or methoxy, R1 is hydrogen or a silyl protecting group and X is the radical of a nucleophile, and their acid addition salts.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: January 2, 2001
    Assignee: Biochemie Gesellschaft
    Inventors: Johannes Ludescher, Hubert Sturm, Josef Wieser
  • Cephalosporin compounds
    Patent number: 6093813
    Abstract: Cephalosporin derivatives of formula II ##STR1## wherein R.sup.a denotes hydrogen or a silyl group; R.sup.b denotes a group of formula --OR.sup.e, wherein R.sup.e denotes hydrogen or alkyl; and R.sup.c and R.sup.d together denote a bond; in free form or in salt form.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: July 25, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Johannes Ludescher, Hubert Sturm, Josef Wieser
  • Cephalosporin synthesis
    Patent number: 6063917
    Abstract: A process for the production of a compound of formula ##STR1## wherein R.sup.a denotes hydrogen or silyl;R.sup.b denotes a group of formula --OR.sup.e, whereinR.sup.e denotes hydrogen or alkyl; andR.sup.c and R.sup.d together denote a bond;in free form or in salt form,which process comprises the step of spitting, in the presence of ozone, the double bond in position 3 of the ring structure of a compound of formula III ##STR2## wherein R.sub.2 and R.sub.3 are the same or different and independently of each other denote hydrogen or an organic group, and X.sup.- denotes the anion of an inorganic or organic acid and optionally silylating the amine group in position 7 of the ring system.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: May 16, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Johannes Ludescher, Hubert Sturm, Josef Wieser
  • 3-imino-cephalosporins
    Patent number: 6034237
    Abstract: 3-Imino-cephalosporin derivatives of formula II ##STR1## wherein Y denotes alkyl, aryl or heterocyclyl; and R.sup.a and R.sup.d denote hydrogen or a silyl group; in free form or in salt form, and methods of preparation.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: March 7, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Johannes Ludescher, Hubert Sturm, Josef Wieser
  • Cephalosporin synthesis
    Patent number: 5856474
    Abstract: Cephalosporin derivatives of formula ##STR1## wherein R.sub.1 signifies hydrogen or a silyl protecting group, processes for their production and their use as intermediate products.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: January 5, 1999
    Assignee: Biochemie Gesellschaft, m.b.H.
    Inventors: Gerd Ascher, Johannes Ludescher, Hubert Sturm, Josef Wieser
  • Cephalosporines
    Patent number: 5686604
    Abstract: The invention relates to a new economical and simple process, using a new intermediate compound, for the production of 3'-substituted 7-amino-3-propenyl-4-cephem-carboxylic acid derivatives of formula ##STR1## wherein R is hydrogen, a negative charge or a silyl protecting group, R.sub.o is hydrogen or methoxy, R.sub.1 is hydrogen or a silyl protecting group and X is the radical of a nucleophile, and their acid addition salts.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: November 11, 1997
    Assignee: Biochemie Gesellschaft
    Inventors: Johannes Ludescher, Hubert Sturm, Josef Wieser
  • Process for the production of cephalosporines and novel intermediates in this process
    Patent number: 5644052
    Abstract: The invention relates to a new economical and simple process, using a new intermediate compound, for the production of 3'-substituted 7-amino-3-propenyl-4-cephem-carboxylic acid derivatives of formula ##STR1## wherein R is hydrogen, a negative charge or a silyl protecting group, R.sub.o is hydrogen or methoxy, R.sub.1 is hydrogen or a silyl protecting group and X is the radical of a nucleophile, and their acid addition salts.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: July 1, 1997
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Hubert Sturm, Josef Wieser
  • Cephalosporin intermediate products
    Patent number: 5585485
    Abstract: A cephalosporin intermediate of the formula ##STR1## where R.sub.3 is carboxyl, carboxylate, or a carboxylic acid ester group and,R.sub.8 and R.sub.9 are each independently hydrogen, halogen,(C.sub.1-4) alkyl, hydroxy, carboxamido,(C.sub.1-4) alkoxycarbonyl, amino,mono- (C.sub.1-4) alkylamino, di- (C.sub.1-4) alkylamino, ortogether are a 5 or 6-membered carbocyclic ring or an alkali metal, alkaline earth metal, or acid addition salt thereof. Valuable cephalosporin antibiotics can be produced from the cephalosporin intermediate products of formula I.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 17, 1996
    Assignee: Biochemie Gesellschaft m.b.h.
    Inventors: Gerd Ascher, Hubert Sturm, Heinrich Thaler, Werner Veit
  • Process for the production of 7-ACA derivatives
    Patent number: 5580978
    Abstract: The invention provides an improved process for the production of 7-amino-3-alkoxymethlycephem-4-carboxyl acid derivatives.
    Type: Grant
    Filed: April 13, 1995
    Date of Patent: December 3, 1996
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Bernhard C. Prager, Hubert Sturm
  • 2-(2-aminothiazol-4-yl)-2-oxoacetic acid derivatives
    Patent number: 5484928
    Abstract: Compound of formula IVe ##STR1## where Het is 2-pyridyl or 2-benzothiazolyl, are useful as acylating agents in preparing 7-[2-(2-amino-4-thiazol)-2-oxoacetyl]-cephalosporin intermediates.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: January 16, 1996
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Hubert Sturm, Heinrich Thaler, Werner Veit
  • Process for the production of cephalosporines
    Patent number: 5401841
    Abstract: The invention relates to a new, economical and simple process for the production of 3-vinylcephalosporin compounds of formula ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and denote hydrogen or an organic radical.
    Type: Grant
    Filed: May 28, 1993
    Date of Patent: March 28, 1995
    Assignee: Sandoz Ltd.
    Inventors: Gerd Ascher, Johannes Ludescher, Hubert Sturm
  • Cephalosporin derivative
    Patent number: 5138049
    Abstract: The invention relates to a nitrate of (6R,7R)-7-{[2-(2-amino-4-thiazolyl)]-2-oxoacetamido}-3-(1,2,3-thiadizol-5- yl)thiomethyl-3-cephem-4-carboxylic acid, a process for its production and its use.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: August 11, 1992
    Assignee: Biochemie
    Inventors: Gerd Ascher, Hubert Sturm