Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract: Disclosed are compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract: A safe dart and dartboard assembly includes a safe dart made of light aluminum and having a front head feed with a block magnet having a front end surface, and a dartboard consisting of an attracting board and a frame having a center recess for receiving the attracting board therein. The attracting board has a plurality of score segments marked with a figure and an empty slots bored in boundary lines between every two of the score segments. The dart can be thrown to fly with accelerated speed owing to the gravity center located at the front end of the dart to stand vertically on the attracting board, even if the dart should fall on one of the empty holes, attracted by the comparatively large segment to stand vertically thereon with the flat end surface of the dart being safe to use.