Patents by Inventor Hugh D. C. Smyth

Hugh D. C. Smyth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220023204
    Abstract: Dry powder compositions comprising biologically active polynucleotide molecules and methods for the manufacture of such dry powders are provided. In some aspects, dry powders of the embodiment comprise expressible or regulatory (e.g., siRNA) polynucleotide molecules complexed with nanoparticles. Dry powders comprising viable virus and bacteria are also provided.
    Type: Application
    Filed: April 20, 2021
    Publication date: January 27, 2022
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hugh D.C. SMYTH, Hairui ZHANG, Zhengrong CUI, Jieliang WANG, Haiyue XU, Yajie ZHANG, Debadyuti GHOSH, Jasmim LEAL, Melissa SOTO, Robert O. WILLIAMS, III, Chaeho MOON, Sawittree SAHAKIJPIJARN
  • Publication number: 20210393815
    Abstract: Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.
    Type: Application
    Filed: September 3, 2021
    Publication date: December 23, 2021
    Inventors: Marek A. Osinski, Hugh D. C. Smyth, Leisha Marie Armijo, Hennaka Mudiyanselage Herath Nihal Bandara
  • Publication number: 20210322445
    Abstract: The present disclosure provides pharmaceutical compositions of niclosamide that may be administered either orally or by inhalation. These compositions may allow the achievement of a therapeutically effective dose of niclosamide to the lungs or the gastrointestinal tract. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer.
    Type: Application
    Filed: April 1, 2021
    Publication date: October 21, 2021
    Inventors: Robert O. Williams, III, Hugh D.C. Smyth, Zachary N. Warnken, Miguel Orlando Jara Gonzalez, Hyo-Jong Seo, Ashlee D. Brunaugh, Matthew Herpin
  • Patent number: 11135325
    Abstract: Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: October 5, 2021
    Inventors: Marek A. Osinski, Hugh D. C. Smyth, Leisha Marie Armijo, Hennaka Mudiyanselage Herath Nihal Bandara
  • Publication number: 20200368461
    Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.
    Type: Application
    Filed: June 4, 2020
    Publication date: November 26, 2020
    Inventors: Nicola Jeanne Maynard, Hugh D.C. Smyth
  • Patent number: 10702664
    Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: July 7, 2020
    Assignee: STC.UNM
    Inventors: Nicola Jeanne Maynard, Hugh D. C. Smyth
  • Publication number: 20200046919
    Abstract: Devices and methods for nasal administration of a pharmaceutical composition. In certain embodiments, the devices comprises a reservoir, a conduit in fluid communication with the reservoir, and an anatomic positioning device configured to position the conduit in a nasal cavity of a user. Particular embodiments include an actuator configured to transfer the pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit.
    Type: Application
    Filed: October 3, 2017
    Publication date: February 13, 2020
    Inventors: Hugh D.C. SMYTH, Robert O. WILLIAMS, III, Zachary WARNKEN, Yang LU
  • Publication number: 20190321477
    Abstract: Disclosed herein are nucleic acid delivery systems and methods of use.
    Type: Application
    Filed: June 27, 2017
    Publication date: October 24, 2019
    Inventors: Hugh D.C. Smyth, Hairui Zhang, Silvia Ferrati
  • Publication number: 20180021463
    Abstract: Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.
    Type: Application
    Filed: February 9, 2016
    Publication date: January 25, 2018
    Inventors: Marek A. Osinski, Hugh D.C. Smyth, Leisha Marie Armijo, Hennaka Mudiyanselage Herath Nihal Bandara
  • Publication number: 20170340845
    Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.
    Type: Application
    Filed: August 14, 2017
    Publication date: November 30, 2017
    Inventors: Nicola Jeanne Maynard, Hugh D.C. Smyth
  • Patent number: 9731088
    Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: August 15, 2017
    Assignee: STC.UNM
    Inventors: Nicola Jeanne Maynard, Hugh D. C. Smyth
  • Patent number: 9492625
    Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: November 15, 2016
    Assignee: STC.UNM
    Inventors: Hugh D. C. Smyth, Parthiban Selvam, Charles Randall Truman
  • Patent number: 9370514
    Abstract: Processes for preparing micronized particles comprising a poorly water soluble bioactive agent are provided. The processes utilize a superheated aqueous phase which can serve as the continuous phase of an emulsion. The superheated aqueous phase can be used to melt poorly water soluble bioactive agents and/or matrix materials which them form molten droplets dispersed within the superheated aqueous phase. The size and size distribution of the molten droplets can be controlled using a variety of suitable methods. The molten droplets can then be cooled to form micronized particles comprising the poorly water soluble bioactive agent. If desired, the cooling rate can be selected to control the crystalline morphology of the resulting micronized particles.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: June 21, 2016
    Assignee: Board of Regents, The University of Texas System
    Inventors: Hugh D. C. Smyth, Matt Herpin
  • Publication number: 20150343158
    Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.
    Type: Application
    Filed: June 15, 2015
    Publication date: December 3, 2015
    Inventors: Nicola Jeanne Maynard, Hugh D.C. Smyth
  • Patent number: 8962063
    Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: February 24, 2015
    Assignee: ST.UNM
    Inventors: Hugh D. C. Smyth, Martin J. Donovan
  • Publication number: 20150050345
    Abstract: Processes for preparing micronized particles comprising a poorly water soluble bioactive agent are provided. The processes utilize a superheated aqueous phase which can serve as the continuous phase of an emulsion. The superheated aqueous phase can be used to melt poorly water soluble bioactive agents and/or matrix materials which them form molten droplets dispersed within the superheated aqueous phase. The size and size distribution of the molten droplets can be controlled using a variety of suitable methods. The molten droplets can then be cooled to form micronized particles comprising the poorly water soluble bioactive agent. If desired, the cooling rate can be selected to control the crystalline morphology of the resulting micronized particles.
    Type: Application
    Filed: August 13, 2014
    Publication date: February 19, 2015
    Inventors: Hugh D.C. Smyth, Matt Herpin
  • Patent number: 8715770
    Abstract: A device for coating dry powder microparticles onto a surface may include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: May 6, 2014
    Assignee: STC.UNM
    Inventors: Parthiban Selvam, Hugh D. C. Smyth, Martin Donovan
  • Patent number: 8652366
    Abstract: Disclosed are aerosol-mediated methods for synthesizing particles for biomedical and drug delivery applications. The method is based on the production of particles from sprayed polymeric micro or nano-droplets obtained by, for example, an air-jet nebulization process that is followed by gelation and/or hardening in a crosslinking fluid, non-solvent, precipitating solvent, or supercritical fluid.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: February 18, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Hugh D. C. Smyth, Ibrahim M. El-Sherbiny
  • Publication number: 20120328768
    Abstract: A device for coating dry powder microparticles onto a surface may include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.
    Type: Application
    Filed: March 9, 2011
    Publication date: December 27, 2012
    Applicant: STC.UNM
    Inventors: Parthiban Selvam, Hugh D.C. Smyth, Martin Donovan
  • Publication number: 20120234322
    Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.
    Type: Application
    Filed: November 12, 2010
    Publication date: September 20, 2012
    Applicant: STC.UNM
    Inventors: Hugh D.C. Smyth, Parthiban Selvam, Charles Randall Truman