Patents by Inventor Hugh D. C. Smyth
Hugh D. C. Smyth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11969511Abstract: Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.Type: GrantFiled: September 3, 2021Date of Patent: April 30, 2024Assignees: UNM Rainforest Innovations, Board of Regents, The University of Texas SystemInventors: Marek A. Osinski, Hugh D. C. Smyth, Leisha Marie Armijo, Hennaka Mudiyanselage Herath Nihal Bandara
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Publication number: 20240041805Abstract: The present disclosure provides pharmaceutical compositions of niclosamide and a protein that may be administered via inhalation These compositions may be used in nebulized, nasal, and inhaler formats. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer.Type: ApplicationFiled: September 17, 2021Publication date: February 8, 2024Inventors: Hugh D.C. SMYTH, Ashlee BRUNAUGH, Zachary N. WARNKEN, Hyo-Jong SEO
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Publication number: 20230381434Abstract: Devices and methods for nasal administration of a pharmaceutical composition. In certain embodiments, the devices comprises a reservoir, a conduit in fluid communication with the reservoir, and an anatomic positioning device configured to position the conduit in a nasal cavity of a user. Particular embodiments include an actuator configured to transfer the pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit.Type: ApplicationFiled: June 1, 2023Publication date: November 30, 2023Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Hugh D.C. SMYTH, Robert O. WILLIAMS, III, Zachary WARNKEN, Yang LU
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Publication number: 20230293832Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.Type: ApplicationFiled: January 19, 2023Publication date: September 21, 2023Inventors: Nicola Jeanne Maynard, Hugh D.C. Smyth
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Patent number: 11571528Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.Type: GrantFiled: June 4, 2020Date of Patent: February 7, 2023Assignee: UNM Rainforest InnovationsInventors: Nicola Jeanne Maynard, Hugh D. C. Smyth
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Publication number: 20220023204Abstract: Dry powder compositions comprising biologically active polynucleotide molecules and methods for the manufacture of such dry powders are provided. In some aspects, dry powders of the embodiment comprise expressible or regulatory (e.g., siRNA) polynucleotide molecules complexed with nanoparticles. Dry powders comprising viable virus and bacteria are also provided.Type: ApplicationFiled: April 20, 2021Publication date: January 27, 2022Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Hugh D.C. SMYTH, Hairui ZHANG, Zhengrong CUI, Jieliang WANG, Haiyue XU, Yajie ZHANG, Debadyuti GHOSH, Jasmim LEAL, Melissa SOTO, Robert O. WILLIAMS, III, Chaeho MOON, Sawittree SAHAKIJPIJARN
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Publication number: 20210393815Abstract: Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.Type: ApplicationFiled: September 3, 2021Publication date: December 23, 2021Inventors: Marek A. Osinski, Hugh D. C. Smyth, Leisha Marie Armijo, Hennaka Mudiyanselage Herath Nihal Bandara
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Publication number: 20210322445Abstract: The present disclosure provides pharmaceutical compositions of niclosamide that may be administered either orally or by inhalation. These compositions may allow the achievement of a therapeutically effective dose of niclosamide to the lungs or the gastrointestinal tract. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer.Type: ApplicationFiled: April 1, 2021Publication date: October 21, 2021Inventors: Robert O. Williams, III, Hugh D.C. Smyth, Zachary N. Warnken, Miguel Orlando Jara Gonzalez, Hyo-Jong Seo, Ashlee D. Brunaugh, Matthew Herpin
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Patent number: 11135325Abstract: Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.Type: GrantFiled: February 9, 2016Date of Patent: October 5, 2021Inventors: Marek A. Osinski, Hugh D. C. Smyth, Leisha Marie Armijo, Hennaka Mudiyanselage Herath Nihal Bandara
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Publication number: 20200368461Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.Type: ApplicationFiled: June 4, 2020Publication date: November 26, 2020Inventors: Nicola Jeanne Maynard, Hugh D.C. Smyth
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Patent number: 10702664Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.Type: GrantFiled: August 14, 2017Date of Patent: July 7, 2020Assignee: STC.UNMInventors: Nicola Jeanne Maynard, Hugh D. C. Smyth
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Publication number: 20200046919Abstract: Devices and methods for nasal administration of a pharmaceutical composition. In certain embodiments, the devices comprises a reservoir, a conduit in fluid communication with the reservoir, and an anatomic positioning device configured to position the conduit in a nasal cavity of a user. Particular embodiments include an actuator configured to transfer the pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit.Type: ApplicationFiled: October 3, 2017Publication date: February 13, 2020Inventors: Hugh D.C. SMYTH, Robert O. WILLIAMS, III, Zachary WARNKEN, Yang LU
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Publication number: 20190321477Abstract: Disclosed herein are nucleic acid delivery systems and methods of use.Type: ApplicationFiled: June 27, 2017Publication date: October 24, 2019Inventors: Hugh D.C. Smyth, Hairui Zhang, Silvia Ferrati
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Publication number: 20180021463Abstract: Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.Type: ApplicationFiled: February 9, 2016Publication date: January 25, 2018Inventors: Marek A. Osinski, Hugh D.C. Smyth, Leisha Marie Armijo, Hennaka Mudiyanselage Herath Nihal Bandara
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Publication number: 20170340845Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.Type: ApplicationFiled: August 14, 2017Publication date: November 30, 2017Inventors: Nicola Jeanne Maynard, Hugh D.C. Smyth
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Patent number: 9731088Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.Type: GrantFiled: June 15, 2015Date of Patent: August 15, 2017Assignee: STC.UNMInventors: Nicola Jeanne Maynard, Hugh D. C. Smyth
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Patent number: 9492625Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.Type: GrantFiled: November 12, 2010Date of Patent: November 15, 2016Assignee: STC.UNMInventors: Hugh D. C. Smyth, Parthiban Selvam, Charles Randall Truman
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Patent number: 9370514Abstract: Processes for preparing micronized particles comprising a poorly water soluble bioactive agent are provided. The processes utilize a superheated aqueous phase which can serve as the continuous phase of an emulsion. The superheated aqueous phase can be used to melt poorly water soluble bioactive agents and/or matrix materials which them form molten droplets dispersed within the superheated aqueous phase. The size and size distribution of the molten droplets can be controlled using a variety of suitable methods. The molten droplets can then be cooled to form micronized particles comprising the poorly water soluble bioactive agent. If desired, the cooling rate can be selected to control the crystalline morphology of the resulting micronized particles.Type: GrantFiled: August 13, 2014Date of Patent: June 21, 2016Assignee: Board of Regents, The University of Texas SystemInventors: Hugh D. C. Smyth, Matt Herpin
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Publication number: 20150343158Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.Type: ApplicationFiled: June 15, 2015Publication date: December 3, 2015Inventors: Nicola Jeanne Maynard, Hugh D.C. Smyth
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Patent number: 8962063Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.Type: GrantFiled: August 27, 2010Date of Patent: February 24, 2015Assignee: ST.UNMInventors: Hugh D. C. Smyth, Martin J. Donovan