Patents by Inventor Hugh D. C. Smyth

Hugh D. C. Smyth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120207913
    Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.
    Type: Application
    Filed: August 27, 2010
    Publication date: August 16, 2012
    Applicant: STC UNM
    Inventors: Hugh D.C. Smyth, Martin J. Donovan
  • Patent number: 8205612
    Abstract: Dry powder aerosol generators and related methods are provided. The dry powder aerosol generator includes a dispersion chamber having an internal cavity therein capable of receiving a dry powdered drug. The dispersion chamber includes a dosing port defined therein that is in fluid communication with the internal cavity. A dosing chamber for receiving a test subject is attachable to the dosing port, such that, when an airflow is created within the internal cavity, any dry powdered drug contained therein may fluidize and travel into the dosing chamber to provide opportunity for inhalation of the dry powdered drug by a test subject contained within the dosing chamber.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: June 26, 2012
    Assignee: The University of North Carolina at Chapel Hill, NC
    Inventors: Anthony J. Hickey, Hugh D. C. Smyth, Martin J. Telko
  • Publication number: 20120108676
    Abstract: Disclosed are aerosol-mediated methods for synthesizing particles for biomedical and drug delivery applications. The method is based on the production of particles from sprayed polymeric micro or nano-droplets obtained by, for example, an air-jet nebulization process that is followed by gelation and/or hardening in a crosslinking fluid, non-solvent, precipitating solvent, or supercritical fluid.
    Type: Application
    Filed: November 1, 2011
    Publication date: May 3, 2012
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hugh D.C. Smyth, Ibrahim M. El-Sherbiny
  • Patent number: 8165460
    Abstract: An apparatus for generating an aerosol of a therapeutic agent and methods of using the same are disclosed. The apparatus comprises a heating element having a surface and a composition coating at least a portion of the heating element surface. The composition comprises a carrier and a therapeutic agent, wherein when the heating element surface is heated to at least the vaporization point of the carrier, the carrier vaporizes and releases the therapeutic agent from the composition as an aerosol. The heating element can be a coiled filament. The therapeutic agent can be a small molecule, a polynucleotide, a polypeptide, or a recombinant virus. The apparatus can be incorporated into a delivery device, such as a metered dose inhaler or an exposure chamber.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: April 24, 2012
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Anthony J. Hickey, Hugh D. C. Smyth
  • Patent number: 8156829
    Abstract: Methods of modulating a characteristic of a pharmaceutical compound spray by acoustic measurement and control of the pharmaceutical spray are disclosed. The methods include analyzing a selected characteristic of a pharmaceutical compound spray utilizing acoustic measurement to develop corresponding acoustic data. The methods further include controlling the selected characteristic by applying acoustic excitation to the pharmaceutical compound spray in accordance with the acoustic data developed.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: April 17, 2012
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Hugh D. C. Smyth, Anthony J. Hickey, Sorin M. Mitran
  • Publication number: 20110253140
    Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 ?m. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.
    Type: Application
    Filed: July 30, 2009
    Publication date: October 20, 2011
    Applicant: STC.UNM
    Inventors: Hugh D.C. Smyth, Martin Donovan
  • Publication number: 20080223364
    Abstract: Dry powder aerosol generators and related methods are provided. The dry powder aerosol generator includes a dispersion chamber having an internal cavity therein capable of receiving a dry powdered drug. The dispersion chamber includes a dosing port defined therein that is in fluid communication with the internal cavity. A dosing chamber for receiving a test subject is attachable to the dosing port, such that, when an airflow is created within the internal cavity, any dry powdered drug contained therein may fluidize and travel into the dosing chamber to provide opportunity for inhalation of the dry powdered drug by a test subject contained within the dosing chamber.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 18, 2008
    Inventors: Anthony J. Hickey, Hugh D. C. Smyth, Martin J. Telko
  • Publication number: 20080199161
    Abstract: An apparatus for generating an aerosol of a therapeutic agent and methods of using the same are disclosed. The apparatus comprises a heating element having a surface and a composition coating at least a portion of the heating element surface. The composition comprises a carrier and a therapeutic agent, wherein when the heating element surface is heated to at least the vaporization point of the carrier, the carrier vaporizes and releases the therapeutic agent from the composition as an aerosol. The heating element can be a coiled filament. The therapeutic agent can be a small molecule, a polynucleotide, a polypeptide, or a recombinant virus. The apparatus can be incorporated into a delivery device, such as a metered dose inhaler or an exposure chamber.
    Type: Application
    Filed: October 26, 2005
    Publication date: August 21, 2008
    Inventors: Anthony J. Hickey, Hugh D.C. Smyth
  • Publication number: 20080121228
    Abstract: Methods of modulating a characteristic of a pharmaceutical compound spray by acoustic measurement and control of the pharmaceutical spray are disclosed. The methods include analyzing a selected characteristic of a pharmaceutical compound spray utilizing acoustic measurement to develop corresponding acoustic data. The methods further include controlling the selected characteristic by applying acoustic excitation to the pharmaceutical compound spray in accordance with the acoustic data developed.
    Type: Application
    Filed: October 26, 2005
    Publication date: May 29, 2008
    Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Hugh D.C. Smyth, Anthony J. Hickey, Sorin M. Mitran