Patents by Inventor Hui Cen
Hui Cen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20190385221Abstract: Systems and methods for an online donation marketplace are provided. An oiler of a non-cash item from a donor to be sold on an online open market is received. The offer includes a pricing structure and a selected charity. The item can be any of a service, a good, or an experience. The offer is displayed to potential buyers, and when buyer requests to make a purchase, the transaction is facilitated and the donated payment is provided to the selected charity. The buyer and donor receive recognition for their charitable activity. Sometimes the donor is a merchant that offers a deal in exchange for a required donation. In other embodiments, a seeker requests an item to be donated by a donor. The seeker can be a buyer, or may be simply a beneficiary of the transaction.Type: ApplicationFiled: June 7, 2019Publication date: December 19, 2019Inventors: Hui Cen, Linjie Zhang, Licen Xu
-
Patent number: 9670476Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: GrantFiled: October 10, 2013Date of Patent: June 6, 2017Assignee: Biotium, Inc.Inventors: Fei Mao, Hui Cen, Wai-Yee Leung
-
Publication number: 20160237421Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: ApplicationFiled: October 10, 2013Publication date: August 18, 2016Applicant: Biotium, Inc.Inventors: Fei Mao, Hui Cen, Wai-Yee Leung
-
Publication number: 20140273151Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: ApplicationFiled: October 10, 2013Publication date: September 18, 2014Applicant: Biotium, Inc.Inventors: Fei Mao, Hui Cen, Wai-Yee Leung
-
Patent number: 8778627Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: GrantFiled: December 14, 2011Date of Patent: July 15, 2014Assignee: Biotium, Inc.Inventors: Fei Mao, Hui Cen, Wai-Yee Leung
-
Patent number: 8586325Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: GrantFiled: May 10, 2013Date of Patent: November 19, 2013Assignee: Biotium, Inc.Inventors: Fei Mao, Hui Cen
-
Publication number: 20130236888Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: ApplicationFiled: May 10, 2013Publication date: September 12, 2013Applicant: Biotium, Inc.Inventors: Fei Mao, Hui Cen
-
Publication number: 20120115129Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: ApplicationFiled: December 14, 2011Publication date: May 10, 2012Applicant: BIOTIUM, INC.Inventors: FEI MAO, HUI CEN, WAI-YEE LEUNG
-
Patent number: 8092784Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: GrantFiled: November 21, 2006Date of Patent: January 10, 2012Assignee: Biotium, Inc.Inventors: Fei Mao, Hui Cen, Wai-yee Leung
-
Patent number: 7705117Abstract: This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.Type: GrantFiled: January 22, 2007Date of Patent: April 27, 2010Assignee: Chiron CorporationInventors: W. Michael Kavanaugh, Hui Cen, Pauline Lee
-
Publication number: 20100062461Abstract: The present invention provides an antibody-based multiplex detection method for identifying one or more epitopes in one or more samples, the method comprising the steps of: (a) contacting each of the samples comprising the epitopes with one or more antibodies specific to the epitopes to be detected; (b) washing unbound antibodies away and eluting bound antibodies from the epitope carriers to provide separate antibody eluates; and (c) detecting and quantifying antibodies in the antibody eluates to generate separate profiles of antibodies for each of the samples. The epitopes to be detected can be located intracellularly, or present on the surface of cells or an artificial surface. In general, the epitopes are derived from protein, polypeptides with or without post-translational modification, carbohydrate, nucleic acid, or lipid.Type: ApplicationFiled: November 13, 2009Publication date: March 11, 2010Applicant: LEAP BIOSCIENCES CORPORATIONInventor: Hui CEN
-
Publication number: 20090148386Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: ApplicationFiled: November 21, 2006Publication date: June 11, 2009Inventors: Fei Mao, Hui Cen, Wai-yee Leung
-
Publication number: 20090081701Abstract: The present invention provides methods of selective enrichment of ligands present in a biological sample. One or a plurality of receptor carriers are used to capture ligands capable of binding to receptors immobilized on the surface of the receptor carriers. Receptor carriers bound with the ligands are separated from the remaining sample and the ligands are then eluted with a ligand elution solution to result in an enriched ligand sample. The enriched ligand sample may be used for further isolation of one or more ligands of interest, or for ligand profiling using 2-D gel electrophoresis coupled with mass spectrometry, for example. Such ligand profiling may have a number of applications, such as disease diagnosis, pathogen detection and drug screening.Type: ApplicationFiled: November 26, 2008Publication date: March 26, 2009Inventor: Hui Cen
-
Publication number: 20080004428Abstract: This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.Type: ApplicationFiled: January 22, 2007Publication date: January 3, 2008Inventors: W. Kavanaugh, Hui Cen, Pauline Lee
-
Patent number: 7276587Abstract: This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.Type: GrantFiled: August 31, 2004Date of Patent: October 2, 2007Assignee: Chiron CorporationInventors: W. Michael Kavanaugh, Hui Cen, Pauline Lee
-
Publication number: 20070161063Abstract: The invention is to methods for screening women for breast cancer and precancer by determining a level of an estrogen-related marker. The invention further provides methods of treating such patients identified as having one or more abnormal ductal epithelial cells and an estrogen-related marker. The invention provides methods for screening patient for hormone replacement therapy (HRT), and of monitoring such patients once they begin HRT. The invention provides methods of treating peri-, menopausal or postmenopausal women for both cancer risk reduction and menopausal symptoms (or other conditions related to lowered systemic estrogen levels). The invention also provides kits for the screening, monitoring, and treating methods described.Type: ApplicationFiled: March 2, 2007Publication date: July 12, 2007Inventors: Susan Love, David Hung, Hui Cen
-
Publication number: 20070003950Abstract: This invention relates generally to the field of target detection. In particular, the present inventions provides for methods and compositions for assaying a plurality of different non-nucleic acid targets or for assaying activities of a plurality of enzymes using, inter alia, oligonucleotide identification (ID) tags.Type: ApplicationFiled: March 17, 2006Publication date: January 4, 2007Applicant: Superarray Bioscience CorporationInventors: Li Shen, Xiang Yu, Hui Cen
-
Publication number: 20050202006Abstract: This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.Type: ApplicationFiled: August 31, 2004Publication date: September 15, 2005Inventors: W. Kavanaugh, Hui Cen, Pauline Lee
-
Publication number: 20050095600Abstract: This invention provides gene-specific probe labeling methods for nucleic acid array detection. In the subject invention, a set of a representational number of distinct gene specific primers is used to generate a sub-population of labeled nucleic acids from each of the different physiological samples. The labeled nucleic acids are then compared to each other by hybridizing to a specially designed nucleic acid array that contains the representational number of distinct genes. The subject methods find use in identifying the expression pattern of the genes of special interest in the physiological samples.Type: ApplicationFiled: October 31, 2003Publication date: May 5, 2005Inventors: Xiang Yu, Li Shen, Xiao Zeng, Ying Han, Kun Lu, Hui Cen
-
Patent number: 6825333Abstract: This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.Type: GrantFiled: August 15, 2000Date of Patent: November 30, 2004Assignee: Chiron CorporationInventors: W. Michael Kavanaugh, Hui Cen, Pauline Lee