Abstract: A spiking neuron reinforcing circuit and a spiking neuron reinforcing method are provided.

Abstract: A many-core definable distributed shared storage structure is provided.

Abstract: An embedded-oriented configurable many-core processor is disclosed, which includes: an on-chip data-bus system, an on-chip event-bus system, a data connection line, a routing unit and a core. The on-chip data-bus system includes multiple transverse data-bus and vertical data-bus. The multiple transverse data-bus and vertical data-bus are staggered transversely and vertically to form N intersections, each intersection of the N intersections is correspondingly provided with a routing unit, and adjacent routing units are connected by transverse data-bus or vertical data-bus. The on-chip event-bus system includes: an event control unit, an event bus and an event signal line. Each event control unit is connected with the event bus, and is connected with the corresponding core and routing unit through the event signal line.

Abstract: Provided are a compound used as a BCR-ABL inhibitor, namely a compound of formula (I), or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition comprising the compound. Moreover, the present invention relates to a use of the compound in the preparation of a drug for treating BCR-ABL related diseases.

Abstract: A pharmaceutical combination comprising an ALK inhibitor, in free form or a pharmaceutically acceptable salt thereof, and a SHP2 inhibitor, in free form or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract: Methods registering an extravascular image with an intravascular image include obtaining a first feature information of a blood vessel segment in the intravascular image and obtaining a second feature information of a reference blood vessel in the extravascular image, where the reference blood vessel is an entire blood vessel in which the blood vessel segment is located. The methods also include performing a primary registration on the first and second feature information to obtain a third feature information that includes external contour and external branch information of a target blood vessel segment in the extravascular image, corresponding to the blood vessel segment. A secondary registration is performed on the first and third feature information to obtain a target registration result. The method can implement fast and accurate registration of the external image and the intravascular image. The methods enable a corresponding apparatus computing device, and storage medium.

Abstract: A training method and apparatus for angiography image processing and a method and apparatus for automatically processing a vessel image. The training method includes obtaining training data that includes original angiography image data and local segmentation result data of a side branch vessel. The local segmentation result data of the side branch vessel are local segmentation image data of the side branch vessel on a main branch vessel determined from an original angiography image. A neural network is trained according to the obtained training data to make the neural network perform local segmentation on the side branch vessel on the determined main branch vessel in the original angiography image. The training method can obtain the neural network for performing local segmentation on the side branch vessel, thereby realizing improvement of segmentation accuracy while improving segmentation efficiency, and avoiding missing segmentation and wrong segmentation of the side branch vessel.

Abstract: A device for sand sampling through a water method includes a sampling cylinder and a triaxial sampler, where the sampling cylinder includes a cylinder, two ends of the cylinder being hermetically provided with an upper sealing cover and a lower sealing cover separately, one ends, facing inside of the cylinder, of the upper sealing cover and the lower sealing cover being provided with water-permeable stones, one end, facing outside of the cylinder, of the upper sealing cover being connected to a control valve, and the control valve being in communication with the inside of the cylinder; and the sampling cylinder is arranged in the triaxial sampler when sand sampling is performed through a water method, a lower end of the triaxial sampler is provided with a test operation table, and an upper end of the triaxial sampler is nested inside a restraint ring.

Abstract: Provided is a new application of a chemokine receptor CCR6 inhibitor in preventing the recurrence of psoriasis. Specifically, provided is a use of the chemokine receptor CCR6 inhibitor for preparing a preparation or composition that is administered to a subject so as to prevent the recurrence of psoriasis in the subject. Also provided is a pharmaceutical product that prevents the recurrence of psoriasis. Using the provided drug products may effectively prevent or alleviate the recurrence of psoriasis.

Abstract: The present invention relates to a pharmaceutical combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor or pharmaceutically acceptable salt thereof, and (b) at least one c-Met receptor tyrosine kinase inhibitor or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly a c-Met dependent proliferative disease; a pharmaceutical composition comprising such combination; a method of treating a subject having a proliferative disease comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of proliferative disease; and a commercial package comprising such combination.

Abstract: The present invention relates to the combination of the HDM2-p53 interaction inhibitor drug (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one [HDM201] and an anti-TIM-3 antibody molecule as TIM-3 inhibitor. The present invention further relates to the use of said combination in the treatment of cancer, in particular hematological tumors. The present invention further relates to dose and dosing regimen related to this combination cancer treatment.

Abstract: A pharmaceutical combination comprising an ALK inhibitor, in free form or a pharmaceutically acceptable salt thereof, and a SHP2 inhibitor, in free form or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract: Methods for accurately modeling blends in a solid model and corresponding systems and computer-readable mediums. A method includes receiving a solid model including a plurality of faces and bosses, and identifying a pocket from the plurality of faces, including one or more pocket edges to be blended. The method includes performing an analyze pockets process on the pocket and identifying at least one of a tool type, a tool method, or a tool dimension for machining the pocket. The method includes performing a blend pocket process to model blends on the pocket edges and adding blends to the solid model at the pocket edges in a predefined order, according to the blend pocket analysis, to produce a modified solid model. The method includes displaying the modified solid model by the data processing system.

Abstract: The present invention relates to a pharmaceutical combination which comprises (a) at least one antibody molecule (e.g., humanized antibody molecules) that bind to Programmed Death 1 (PD-1), and (b) a HDM2-p53 interaction inhibitor, said combination for simultaneous, separate or sequential administration for use in the treatment of a proliferative disease, a pharmaceutical composition comprising such combination; a method of treating a subject having a proliferative disease comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of proliferative disease; and a commercial package comprising such combination; said proliferative disease being a TP53 wildtype tumor, in particular TP53 wildtype renal cell carcinoma (RCC) or TP53 wildtype colorectal cancer (CRC).

Abstract: The present invention relates to a loaded-to-frame detection equipment for backfill grouting of a shield tunnel, including an automatic loaded-to-frame transmission apparatus, a ground penetrating radar, and an intelligent backfill grouting processing and analysis software. The equipment is integrated by using software and hardware, and can implement real-time visual detection of a backfill grouting layer in a shield construction process. The loaded-to-frame automatic transmission apparatus mainly includes a track, a synchronous belt, a transmission mechanism, a servo machine, and a drive and reducer; and a new air-coupled radar detection apparatus is carried on the loaded-to-frame automatic transmission apparatus and is installed on a shield frame. With the shield performs tunneling, circular detection on a grouting body of the shield and visual layered display of the grouting body are implemented.

Abstract: An instruction set may comprise one or more instruction statements, which may include keywords that are not definitive and each of which may corresponds to multiple elements on a user interface which is subject to testing. The closer the format of the instruction statements is to a natural spoken language, the more likely ambiguity may occur in instruction statement interpretation. The present application provides systems, methods and computer readable media for ambiguity resolution in instruction statement interpretation. The methods include resolving ambiguity in interpreting an instruction statement of an instruction set based on one or more criteria.

Abstract: The present invention relates to a pharmaceutical combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor or pharmaceutically acceptable salt thereof, and (b) at least one c-Met receptor tyrosine kinase inhibitor or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly a c-Met dependent proliferative disease; a pharmaceutical composition comprising such combination; a method of treating a subject having a proliferative disease comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of proliferative disease; and a commercial package comprising such combination.

Abstract: The present invention relates to a pharmaceutical combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor or pharmaceutically acceptable salt thereof, and (b) at least one c-Met receptor tyrosine kinase inhibitor or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly a c-Met dependent proliferative disease; a pharmaceutical composition comprising such combination; a method of treating a subject having a proliferative disease comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of proliferative disease; and a commercial package comprising such combination.

Abstract: A pharmaceutical combination comprising an ALK inhibitor, in free form or a pharmaceutically acceptable salt thereof, and a SHP2 inhibitor, in free form or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract: The present invention relates to a loaded-to-frame detection equipment for backfill grouting of a shield tunnel, including an automatic loaded-to-frame transmission apparatus, a ground penetrating radar, and an intelligent backfill grouting processing and analysis software. The equipment is integrated by using software and hardware, and can implement real-time visual detection of a backfill grouting layer in a shield construction process. The loaded-to-frame automatic transmission apparatus mainly includes a track, a synchronous belt, a transmission mechanism, a servo machine, and a drive and reducer; and a new air-coupled radar detection apparatus is carried on the loaded-to-frame automatic transmission apparatus and is installed on a shield frame. With the shield performs tunneling, circular detection on a grouting body of the shield and visual layered display of the grouting body are implemented.