Abstract: A pharmaceutical combination comprising (a) a compound of formula (I), or pharmaceutically acceptable salts thereof; and (b) one or more at least one compound targeting, decreasing or inhibiting the intrinsic ATPase activity of Hsp90 and/or degrading, targeting, decreasing or inhibiting the Hsp90 client proteins via the ubiquitin proteosome pathway; the uses of such combination in the treatment or prevention of proliferative diseases; and methods of treating a subject suffering from a proliferative disease; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract: The present invention relates to a pharmaceutical combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor or pharmaceutically acceptable salt thereof, and (b) at least one c-Met receptor tyrosine kinase inhibitor or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly a c-Met dependent proliferative disease; a pharmaceutical composition comprising such combination; a method of treating a subject having a proliferative disease comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of proliferative disease; and a commercial package comprising such combination.

Abstract: A locking mechanism includes a first locking member positioned on the first object and a second locking member positioned on the second object. The second locking member can be moved to engage with or disengage from the first locking member. The second object defines at least one through hole for allowing insertion of the disassembly tool to push the second locking member, which disengages the second locking member from the first locking member.

Abstract: A fastening mechanism for fastening a first object to a second object, the fastening mechanism includes a first fastening member, a driven member, a linkage member, and a first supporting member. The first fastening member is rotatably secured to the second object. The driven member is rotatably secured to the second object. The linkage member is connected between the fastening member and the driven member. The first supporting member protrudes from the second object to support the first object. When an external force is exerted on the driven member, the driven member is capable of rotating to pull the linkage member, thus the linkage member pulls the first fastening member to rotate toward the first supporting member and sandwiches the first object between the first fastening member and the first supporting member so that the first object is fastened to the second object.

Abstract: An electronic device includes a housing, and a card holding mechanism for holding an electronic card. The housing defines a through hole, and the card holding mechanism may be inserted into the housing via the through hole. The card holding mechanism includes a tray for receiving the electronic card, an operating component, and a transmission component. The operating component moves from a latched position to an unlatched position, the transmission component is driven by the operating component to rotate and drive the tray to eject from the housing.

Abstract: An electronic device includes a printed circuit board (PCB), at least one socket mounted to the PCB, at least one connector inserted into the at least one socket, a first member mounted to the PCB, a second member mounted to the PCB, and a first cover. The first cover covers and presses against the at least one connector, the first cover includes a first end for being fixed to the first member and a second end opposite to the first end for being fixed to the second member. At least one of the first member and the second member is soldered to the PCB, and a soldered area of the at least one of the first member and the second member is larger than a predetermined value.

Abstract: The present invention relates to a pharmaceutical combination comprising a 2-carboxamide cycloamino urea derivative compound of formula (I) and inhibitors of Heat Shock Protein 90, and the uses of such combinations in the treatment of proliferative diseases, more specifically PI3K dependent diseases, more specifically PI3K-alpha dependent diseases.

Abstract: A system, method, and computer program for selecting modification features on a solid model that is manipulated in a computer having software instructions, comprising: a computer system, wherein the computer system includes a memory, a processor, a user input device, and a display device; a computer generated geometric model stored in the memory in the memory of the computer system; and wherein the computer system selects a modification feature directly on a solid model using a computer peripheral input that communicates a modification intent from a user; suggests a plurality of additional selection features to include with the modification feature; verifies that the included plurality of additional selection features conforms to the modification intent by a visual highlighting; modifies the solid model according to the modification intent that results in a modified solid model and modified visual display information; and displays the modified solid model using the modified visual display information to the u

Abstract: Product Data Management (PDM) systems and methods. A method includes receiving a target body and a tool body, and evaluating a body type of the target body and a body type of the tool body. The method includes evaluating interactions between the target body and the tool body, and applying comparison criteria to determine spatial relation and relative convexity of an intersection between the target body and the tool body. The method includes identifying tool face regions of the tool body based on the evaluations and the determined spatial relation and relative convexity of the intersection. The method includes adding the tool face regions to the target body to produce a modified target body.

Abstract: A locking mechanism includes a first locking member positioned on the first object and a second locking member positioned on the second object. The second locking member can be moved to engage with or disengage from the first locking member. The second object defines at least one through hole for allowing insertion of the disassembly tool to push the second locking member, which disengages the second locking member from the first locking member.

Abstract: An electronic device includes a printed circuit board (PCB), at least one socket mounted to the PCB, at least one connector inserted into the at least one socket, a first member mounted to the PCB, a second member mounted to the PCB, and a first cover. The first cover covers and presses against the at least one connector, the first cover includes a first end for being fixed to the first member and a second end opposite to the first end for being fixed to the second member. At least one of the first member and the second member is soldered to the PCB, and a soldered area of the at least one of the first member and the second member is larger than a predetermined value.

Abstract: An electronic device includes a housing, and a card holding mechanism for holding an electronic card. The housing defines a through hole, and the card holding mechanism may be inserted into the housing via the through hole. The card holding mechanism includes a tray for receiving the electronic card, an operating component, and a transmission component. The operating component moves from a latched position to an unlatched position, the transmission component is driven by the operating component to rotate and drive the tray to eject from the housing.

Abstract: A fastening mechanism for fastening a first object to a second object, the fastening mechanism includes a first fastening member, a driven member, a linkage member, and a first supporting member. The first fastening member is rotatably secured to the second object. The driven member is rotatably secured to the second object. The linkage member is connected between the fastening member and the driven member. The first supporting member protrudes from the second object to support the first object. When an external force is exerted on the driven member, the driven member is capable of rotating to pull the linkage member, thus the linkage member pulls the first fastening member to rotate toward the first supporting member and sandwiches the first object between the first fastening member and the first supporting member so that the first object is fastened to the second object.

Abstract: The invention discloses a method for transferring desktop information of a PC to a video communication terminal. The method includes steps as follow: capturing desktop information of a PC after having received a triggering command, and converting a format of the PC desktop information into a format of the a video communication terminal; encoding the converted desktop format in a mode ensured by the local video communication terminal; sending the coded bit stream to the local video communication terminal; receiving the said coded bit stream by the local video communication terminal, and transferring to a remote video communication terminal after being processed. The invention also discloses an apparatus for transferring desktop information of a PC to a video communication terminal that includes a background processing-device and a terminal processing-device.

Abstract: A system, method, and computer program for selecting modification features on a solid model that is manipulated in a computer having software instructions, comprising: a computer system, wherein the computer system includes a memory, a processor, a user input device, and a display device; a computer generated geometric model stored in the memory in the memory of the computer system; and wherein the computer system selects a modification feature directly on a solid model using a computer peripheral input that communicates a modification intent from a user; suggests a plurality of additional selection features to include with the modification feature; verifies that the included plurality of additional selection features conforms to the modification intent by a visual highlighting; modifies the solid model according to the modification intent that results in a modified solid model and modified visual display information; and displays the modified solid model using the modified visual display information to the u

Abstract: This invention discloses a method of configuring a device property of a storage device for a Windows operating system. A step (A) is to code a lower-level filter driver for intercepting and processing an I/O request packet (IRP) that queries a storage device property. The IRP of the step (A) is passed through the lower-level filter driver. A step (B) is to insert the lower-level filter driver between a storage class driver and a bus filter driver. A step (C) is to change an original device property of the IRP corresponding to the storage device when the computer is booted and the lower-level filter driver is executed.

Abstract: The invention discloses a method for transferring desktop information of a PC to a video communication terminal. The method includes steps as follow: capturing desktop information of a PC after having received a triggering command, and converting a format of the PC desktop information into a format of the a video communication terminal; encoding the converted desktop format in a mode ensured by the local video communication terminal; sending the coded bit stream to the local video communication terminal; receiving the said coded bit stream by the local video communication terminal, and transferring to a remote video communication terminal after being processed. The invention also discloses an apparatus for transferring desktop information of a PC to a video communication terminal that includes a background processing-device and a terminal processing-device.