Abstract: The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.

Abstract: A drive method for a display panel, and a display apparatus. The drive method includes: when current original gray-scale values corresponding to sub-pixels in the same region are the same in a plurality of continuous display frames, converting the current original gray-scale values into a first target gray-scale value and a second target gray-scale value; in a current display frame of the plurality of continuous display frames, controlling a data voltage corresponding to the first target gray-scale value to be input to a first sub-pixel unit in the region, and controlling a data voltage corresponding to the second target gray-scale value to be input to a second sub-pixel unit in the region, where each of the first sub-pixel unit and the second sub-pixel unit includes at least one sub-pixel.

Abstract: Disclosed are a dimmable panel (001) and a display device. The dimmable panel includes a first substrate (101) and a second substrate (102) that are arranged opposite each other; a first electrode (103) and a second electrode (104) that are insulated from each other and located between the first substrate (101) and the second substrate (102), where the first electrode (103) and the second electrode (104) are located in a dimmable area (AA), at least one of the first electrode (103) and the second electrode (104) includes a plurality of strip-shaped electrodes, extension trends of all the strip-shaped electrodes are approximately the same, and orthographic projections of the strip-shaped electrodes on the first substrate (101) do not overlap each other; and a liquid crystal layer (105) located between the first substrate (101) and the second substrate (102), where the liquid crystal layer (105) is located in the dimmable area (AA).

Abstract: Embodiments of the present disclosure provide a haptics panel and a driving method thereof, and a haptics apparatus. The driving method includes: receiving a touch signal, and judging a touch position of a user on the haptics panel according to the touch signal; judging a characteristic frequency area to which the touch position belongs; determining characteristic mode displacement field distribution of the base substrate according to the characteristic frequency area to which the touch position belongs, wherein the characteristic mode displacement field distribution contains vibration displacement phase information at each position of the base substrate; dividing a plurality of piezoelectric devices arranged in an array contained in the haptics panel into at least one vibration area according to the vibration displacement phase information of the characteristic mode displacement field distribution; and loading voltage signals on at least part of the piezoelectric devices in the vibration area.

Abstract: A pharmaceutical composition and use of a multi-kinase inhibitor. The present invention relates to the technical field of medicines, and relates to the pharmaceutical composition and use of the multi-kinase inhibitor. The pharmaceutical composition comprises: (a) a compound represented by general formula (I) or a pharmaceutically acceptable salt, a stereoisomer or a crystal form thereof, wherein P1, W1, Y1, and Ar in general formula (I) are as described herein; and (b) a paclitaxel drug. Variables in the general formula are as defined in the description. Studies have shown that the compound of general formula (I) or the pharmaceutically acceptable salt, stereoisomer or crystal form thereof in the present invention has a significant synergistic interaction with the paclitaxel drug in combination for treating cancers.

Abstract: A high-throughput 3D printing system for preparing multi-component, small sized samples, includes a raw material supply module, providing a various kinds of metal powders for printing small sized samples; the first mixer module, mixing the metal powders obtained from the raw material supply module to generate the first blended metal powders; the second mixer module, mixing the first mixed metal powders, in order to generate the second blended metal powders for printing small sized samples; the first printing module, printing the secondary blended metal powder into a small-sized sample; a control module, controlling other functional modules of the high-throughput 3D printing system for generating small-size samples.

Abstract: A passenger guidance system, elevator system, and passenger guidance method for elevators. The passenger guidance system includes: a sensor, arranged to collect object feature data of a passenger going towards an elevator; a processing device, in communication with the sensor and an elevator system, for receiving the object feature data and comparing the object feature data with stored passenger information to learn information of a target floor of a successfully matched passenger, and learning a target elevator currently dispatched corresponding to the target floor according to elevator running information of the elevator system; and a guidance device, in communication with the processing device, for forming a sign to at least guide the successfully matched passenger to go towards the target elevator. The present invention can be applied to humanistically and intelligently guide the passenger to reach the target elevator, and bring good elevator taking experience to users.

Abstract: Methods, computer program products, and/or systems are provided that perform the following operations: identifying a first workload being processed by a first plurality of sites in a cluster; identifying, from the first plurality of sites: (i) a first site as a primary site for the first workload, and (ii) one or more secondary sites for the first workload; identifying a communication link issue between the first site and at least one of the one or more secondary sites; splitting the cluster into sub-clusters based, at least in part, on the communication link issue, wherein the first site is included in a first sub-cluster of the sub-clusters and the at least one of the one or more secondary sites is included in a sub-cluster of the sub-clusters that is different from the first sub-cluster; and instructing the first sub-cluster to locally process the first workload.

Abstract: A controller of a buck-boost conversion circuit and a mode switching method thereof are provided. The controller control operations of multiple switches of the buck-boost conversion circuit to convert an input voltage into an output voltage and provide an output current. The controller includes a slope compensation circuit, a control loop, and a mode switching circuit. The slope compensation circuit generates a slope compensation signal according to a mode switching signal of a current cycle. The control loop is coupled to the slope compensation circuit and the switches respectively, and is configured to generate multiple switch control signals according to the slope compensation signal, a feedback voltage related to the output voltage, and a current sense signal related to the output current to control the operations of the switches respectively. The mode switching circuit is coupled to the slope compensation circuit and the control loop.

Abstract: Provided is a beam-column joint of a prefabricated self-centering RC (Reinforced Concrete) frame based on an SMA (Shape Memory Alloy) material, including an RC precast column, an RC precast beam, and self-centering energy dissipation dampers arranged, and a friction energy dissipation damper. The self-centering energy dissipation damper includes an SMA kernel, an upper restraint cover plate, a lower restraint cover plate, a column-end connection reinforcing plate and a beam-end connection reinforcing plate, and a set energy dissipation gap is reserved between the SMA kernel and the upper restraint cover plate. The friction energy dissipation damper includes an in-column embedded connecting plate and a beam-end embedded connecting plate.

Abstract: Provided herein are substantially all-poly ethylene films, and in particular blown biaxially oriented all-polyethylene films. The films can be multi-layer, and can be produced using a double bubble process. Particular multi-layer films include at least two skin layers, and al least one core layer disposed directly or indirectly between the at least two skin layers. The film composes: a narrow-composition-distribution metallocene linear low density? polyethylene (narrow-CD mLLDPE), a long-chain-branched metallocene linear low density? polyethylene (LCB mLLDPE), and, optionally, either or both of a low density polyethylene (LDPE) and high density polyethylene (HDPE).

Abstract: A mutation site of an ideal brittle culm mutant ibc in rice, a controlling gene IBC, and use thereof are provided. The controlling gene IBC has: (1) a nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2; or (2) a nucleotide sequence of a mutant, an allele, or a derivative generated by adding, substituting, inserting or deleting one or more nucleotides. The present disclosure further provides an encoded protein of the controlling gene IBC, a recombinant construct, a recombinant host cell, a method for embrittling culms in a rice ripening stage by using the controlling gene IBC, and use thereof. In a mutant with allelic variation in the gene IBC and loss of gene editing function, culms exhibit a brittle culm phenotype at the late ripening stage, leaves are not brittle, yield traits are excellent, and other agronomic traits are not obviously changed.

Abstract: Disclosed are a nucleic acid functionalized metal nanoprobe and a preparation method therefor; according to the probe, metal cations with desirable biocompatibility are mixed with exogenous deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules to generate a DNA or RNA composite nanostructure; co-incubating is performed with a pathogenic microorganism, the composite nanostructure enters pathogenic microorganism cells through electrostatic adsorption, and unique microenvironment of high-level oxidizing and reducing substances possessed by the pathogenic microorganism is used to promote in-situ synthesis of the intelligent biological probe; accurate targeted labeling and real-time rapid detection of the pathogenic microorganism are achieved, and the probe is used for targeted intervention of infectious diseases such as lung infection, intestinal infection and influenza; combined with physical interventions such as photoelectricity, magnetocaloric effect, near infrared, multi-modal real-time dynamic and

Abstract: Disclosed embodiments provide techniques for dynamic data collection. The dynamic data collection includes determining a data generation temporal pattern. Based on the data generation temporal pattern, a data collection strategy is created. The data collection strategy can be based on one or more data collection goals. The data collection strategy can contain specific details on how data is to be collected. A data infrastructure evaluation is performed, which provides pricing models for resources such as electricity and/or network bandwidth. A data collection policy is created based on the data collection strategy and the data infrastructure evaluation. The data collection policy can contain specific details on when data is to be collected and what strategy to use for the collection. A data transfer schedule is created based on the data collection policy. The data transfer schedule determines when to collect data from one or more data source devices.

Abstract: A determining method and apparatus for a neutral system working voltage includes a power system having three phase wires and three capacitor banks. Each bank has one terminal connected to one phase wire, and the other terminals form a neutral point. A phase voltage of each phase wire is periodically sampled, obtaining sampling value groups of real-time phase voltages. Each phase voltage group includes a sampling value of a phase voltage of each phase wire by measuring each phase wire. Unbalance rates between the banks are based on the groups of sampling values. The unbalance rate is a ratio between capacitances of every two phase wires. The isolated neutral system working voltage is based on the unbalance rates. The unbalance rates between banks are based on the sampling values measured in real time. The working voltage is based on the unbalance rates, permitting subsequent operations to be accurately performed.

Abstract: A display device is disclosed. The display device includes a module outer frame, including a display opening window, where an accommodation space is formed inside the module outer frame; a display module, fixed in the accommodating space, where a light emitting side of the display module faces the display opening window; a touch module, fixed between the display module and the display opening window, where the touch module includes a haptic sensor configured to generate a standing wave on a surface of the touch module during operation; a first isolation structure, arranged between the touch module and the module outer frame, where the first isolation structure is configured to isolate the touch module from the module outer frame; and a second isolation structure, arranged between the display module and the touch module, where the second isolation structure is configured to isolate the display module from the touch module.

Abstract: A control method of a display panel. The method includes the following steps: determining a target refresh frequency of the display panel; determining a data chopping rule adapted to the target refresh frequency according to the first mapping relationship; providing a data signal to the display panel according to a data chopping rule.

Abstract: Anti-DLL3 antibodies and antigen-binding fragments thereof, anti-CD47 antibodies and antigen-binding fragments thereof, and anti-CD47/DLL3 bispecific antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases, such as cancer and/or associated complications.

Abstract: The present disclosure describes a patterning process for a strap region in a memory cell for the removal of material between polysilicon lines. The patterning process includes depositing a first hard mask layer in a divot formed on a top portion of a polysilicon layer interposed between a first polysilicon gate structure and a second polysilicon gate; depositing a second hard mask layer on the first hard mask layer. The patterning process also includes performing a first etch to remove the second hard mask layer and a portion of the second hard mask layer from the divot; performing a second etch to remove the second hard mask layer from the divot; and performing a third etch to remove the polysilicon layer not covered by the first and second hard mask layers to form a separation between the first polysilicon gate structure and the second polysilicon structure.

Abstract: The present invention, as disclosed herein, provides an isolated peptide, and a composition or material comprising a hydrogel, for the delivery of an active agent. The hydrogel comprises one or more isolated peptides and an active agent encapsulated in the hydrogel. The hydrogel is at least partially in a ?-sheet conformation. Further provided are a method for the encapsulation of an active agent in a hydrogel, a method for treating or diagnosing a condition or disease in a subject in need thereof.