Patents by Inventor Hui Wen Chang

Hui Wen Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240228854
    Abstract: A polymer is formed by reacting (a) benzaldazine compound with (b1) diamine compound, (b2) dianhydride compound, (b3) epoxy resin, or a combination thereof, wherein (a) benzaldazine compound has a chemical structure of in which R1 is —NH2, —OH, or The polymer can be combined with inorganic powder to form a thermal interface material.
    Type: Application
    Filed: March 8, 2023
    Publication date: July 11, 2024
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Hsiang-Yen TSAO, Hui-Wen CHANG, Jyh-Long JENG
  • Publication number: 20240084040
    Abstract: The present invention provides antibody or the antigen-binding portion thereof bind to carbohydrate antigen, such as Globo series antigens (e.g. Globo H, SSEA-4 or SSEA-3). Also disclosed herein are pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.
    Type: Application
    Filed: February 9, 2022
    Publication date: March 14, 2024
    Inventors: Jiann-Shiun LAI, Hui-Wen CHANG, Yin-Chieh KUO, Chi-Sheng HSIA, Woan Eng CHAN, Ming-Tain LAI
  • Patent number: 11879006
    Abstract: Disclosed herein is a recombinant antibody exhibiting binding affinity and/or neutralizing activity to porcine epidemic diarrhea virus (PEDV). According to some embodiments of the present disclosure, the PEDV is genotype 1 (G1) or genotype 2b (G2b) PEDV. Also disclosed herein are methods of diagnosing and treating PEDV infection by use of the present recombinant antibody.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: January 23, 2024
    Assignee: Academia Sinica
    Inventors: Shang-Te Danny Hsu, Hui-Wen Chang, Chia-Yu Chang
  • Publication number: 20230037864
    Abstract: Disclosed herein is a recombinant antibody exhibiting binding affinity and/or neutralizing activity to porcine epidemic diarrhea virus (PEDV). According to some embodiments of the present disclosure, the PEDV is genotype 1 (G1) or genotype 2b (G2b) PEDV. Also disclosed herein are methods of diagnosing and treating PEDV infection by use of the present recombinant antibody.
    Type: Application
    Filed: June 28, 2022
    Publication date: February 9, 2023
    Applicant: Academia Sinica
    Inventors: Shang-Te Danny HSU, Hui-Wen CHANG, Chia-Yu CHANG
  • Publication number: 20220111032
    Abstract: The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The compositions of the invention provide virus-like particles (VLPs) whose effectiveness is enhanced by the selection of preferred adjuvants.
    Type: Application
    Filed: October 8, 2020
    Publication date: April 14, 2022
    Applicants: Chung Yuan Christian University, Academia Sinica
    Inventors: Tzong-Yuan WU, Ming-Hao CHANG, Hui-Wen CHANG, Yu-Chan CHAO, Wei-Ting HSU
  • Patent number: 11123424
    Abstract: A baculovirus displaying a porcine epidemic diarrhea virus S protein or S1 domain thereof is provided for preventing porcine epidemic diarrhea virus infection.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: September 21, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Yu-Chan Chao, Wei-Ting Hsu, Hui-Wen Chang, Chia-Yu Chang
  • Publication number: 20190388535
    Abstract: A baculovirus displaying a porcine epidemic diarrhea virus S protein or S1 domain thereof is provided for preventing porcine epidemic diarrhea virus infection.
    Type: Application
    Filed: June 24, 2019
    Publication date: December 26, 2019
    Applicant: Academia Sinica
    Inventors: Yu-Chan CHAO, Wei-Ting HSU, Hui-Wen CHANG, Chia-Yu CHANG
  • Patent number: 10329468
    Abstract: A thermally conductive resin is provided. The thermally conductive resin has the formula In the formula, X1 is X2 is m is an integer ranging from 0 to 95, n is an integer ranging from 1 to 50, and o is an integer ranging from 1 to 80. A thermal interface material including the thermally conductive resin is also provided.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: June 25, 2019
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yen-Chun Liu, Hui-Wen Chang, Min-Chian Wang, Kuo-Chan Chiou
  • Publication number: 20190066904
    Abstract: A chip-type passive component includes at least one base, at least two coils, a magnetic cover and at least two silver-palladium layers. Both ends of the base have a flange, and one of the flanges has at least two holes; the at least two coils are wound around the outer end of the base; the magnetic cover is covered onto the exterior of the coil, and both ends of the magnetic cover have an opening, and the flange is latched to the opening; and the at least two silver-palladium layers is formed on both sides of one of the openings of the magnetic cover, and the coil is passed through the hole and contacted with the silver-palladium layer to define an electric connection.
    Type: Application
    Filed: August 30, 2017
    Publication date: February 28, 2019
    Inventor: HUI WEN CHANG
  • Patent number: 10059866
    Abstract: An epoxy resin composition is provided. The epoxy resin composition includes a first aromatic epoxy resin represented by formula (I), and an amino compound selected from a group that includes 4,4?-methylenedianiline, 4,4?-ethylenedianiline, 4,4?-bis(4-aminophenoxy)biphenyl and 1,4-bis(4-aminophenoxy)benzene, wherein the ratio between the epoxy groups of the first aromatic epoxy resin and the amino groups of the amino compound ranges from 1:1 to 2:1.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: August 28, 2018
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yen-Chun Liu, Hui-Wen Chang, Hsiang-Yen Tsao, Kuo-Chan Chiou
  • Patent number: 9796996
    Abstract: The invention provides methods and means for distinguishing FECV and FIPV, and methods and means for determining whether FIPV is present in a sample. Further provided are primers and probes for detecting FIPV specific nucleic acid sequences encoding a spike protein, antibodies for detecting a FIPV, and an immunogenic composition and use thereof for eliciting an immune response against a feline coronavirus, preferably a FIPV.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: October 24, 2017
    Assignee: UNIVERSITEIT UTRECHT HOLDING B.V.
    Inventors: Petrus Josephus Marie Rottier, Hui-wen Chang, Herman F. Egberink
  • Publication number: 20170158934
    Abstract: A thermally conductive resin is provided. The thermally conductive resin has the formula In the formula, X1 is X2 is m is an integer ranging from 0 to 95, n is an integer ranging from 1 to 50, and o is an integer ranging from 1 to 80. A thermal interface material including the thermally conductive resin is also provided.
    Type: Application
    Filed: February 18, 2016
    Publication date: June 8, 2017
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yen-Chun LIU, Hui-Wen CHANG, Min-Chian WANG, Kuo-Chan CHIOU
  • Publication number: 20170158932
    Abstract: An epoxy resin composition is provided. The epoxy resin composition includes a first aromatic epoxy resin represented by formula (I), and an amino compound selected from a group that includes 4,4?-methylenedianiline, 4,4?-ethylenedianiline, 4,4?-bis(4-aminophenoxy)biphenyl and 1,4-bis(4-aminophenoxy)benzene, wherein the ratio between the epoxy groups of the first aromatic epoxy resin and the amino groups of the amino compound ranges from 1:1 to 2:1.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 8, 2017
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yen-Chun LIU, Hui-Wen CHANG, Hsiang-Yen TSAO, Kuo-Chan CHIOU
  • Patent number: 9371233
    Abstract: A polyamide-imide represented by the following formula is provided. A graphite film prepared by performing a thermal treatment process on the polyamide-imide represented by the above-mentioned formula is also provided. In the thermal treatment process, the temperature range of the thermal treatment process ranges from 25° C. to 2,900° C.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: June 21, 2016
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Chen-Lung Lin, Yen-Chun Liu, Hui-Wen Chang, Kuo-Chan Chiou, Hsien-Lin Hu
  • Publication number: 20150166347
    Abstract: A polyamide-imide represented by the following formula is provided. A graphite film prepared by performing a thermal treatment process on the polyamide-imide represented by the above-mentioned formula is also provided. In the thermal treatment process, the temperature range of the thermal treatment process ranges from 25° C. to 2,900° C.
    Type: Application
    Filed: September 12, 2014
    Publication date: June 18, 2015
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Chen-Lung LIN, Yen-Chun LIU, Hui-Wen CHANG, Kuo-Chan CHIOU, Hsien-Lin HU
  • Patent number: 8980571
    Abstract: The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or ?9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that ?9-nAChR has an activating protein 1 (AP1)-binding site, that the ?9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the ?9-nAChR promoter at the AP1-binding site, indicating that ER-induced ?9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: March 17, 2015
    Assignee: Taipei Medical University
    Inventors: Chia-Hwa Lee, Ya-Chieh Chang, Ching-Shyang Chen, Shih-Hsin Tu, Ying-Jan Wang, Li-Ching Chen, Yu-Jia Chang, Po-Li Wei, Hui-Wen Chang, Chien-Hsi Chang, Ching-Shui Huang, Chih-Hsiung Wu, Yuan-Soon Ho
  • Publication number: 20130071833
    Abstract: The invention provides methods and means for distinguishing FECV and FIPV, and methods and means for determining whether FIPV is present in a sample. Further provided are primers and probes for detecting FIPV specific nucleic acid sequences encoding a spike protein, antibodies for detecting a FIPV, and an immunogenic composition and use thereof for eliciting an immune response against a feline coronavirus, preferably a FIPV.
    Type: Application
    Filed: January 18, 2011
    Publication date: March 21, 2013
    Applicant: Universiteit Utrecht Holding B.V.
    Inventors: Petrus Josephus Marie Rottier, Hui-Wen Chang, Herman F. Egberink
  • Publication number: 20120270799
    Abstract: The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or ?9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that ?9-nAChR has an activating protein 1 (AP1)-binding site, that the ?9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the ?9-nAChR promoter at the AP1-binding site, indicating that ER-induced ?9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.
    Type: Application
    Filed: April 21, 2011
    Publication date: October 25, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Chia-Hwa Lee, Ya-Chieh Chang, Ching-Shyang Chen, Shih-Hsin Tu, Ying-Jan Wang, Li-Ching Chen, Yu-Jia Chang, Po-Li Wei, Hui-Wen Chang, Chien-Hsi Chang, Ching-Shui Huang, Chih-Hsiung Wu, Yuan-Soon Ho
  • Publication number: 20120208872
    Abstract: This invention relates to methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 16, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Shih-Hsin Tu, Chung-Yu Ku, Ching-Shyang Chen, Ching-Shui Huang, Chia-Hwa Lee, Li-Ching Chen, Min-Hsiung Pan, Hui-Wen Chang, Chien-Hsi Chang, Yu-Jia Chang, Po-Li Wei, Chih-Hsiung Wu, Yuan-Soon Ho
  • Publication number: 20120208873
    Abstract: This invention relates to methods of aiding smoking cessation and/or treating and/or preventing smoking addition or methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in aiding smoking cessation and/or treating and/or preventing smoking addition or treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.
    Type: Application
    Filed: May 31, 2011
    Publication date: August 16, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Shih-Hsin Tu, Chung-Yu Ku, Ching-Shyang Chen, Ching-Shui Huang, Chia-Hwa Lee, Li-Ching Chen, Min-Hsiung Pan, Hui-Wen Chang, Chien-Hsi Chang, Yu-Jia Chang, Po-Li Wei, Chih-Hsiung Wu, Yuan-Soon Ho