Abstract: Anti-VEGF proteins including the VEGF trap protein aflibercept can be produced to have a low level of an aspartyl protease (e.g., a low level of cathepsin D), such as less than 1 ppm of the aspartyl protease.

Abstract: This disclosure discloses a multiplayer somatosensory system, method, and apparatus combining virtual and reality, and a medium, which belongs to the field of human-computer interaction. The system includes: a computer device, and a simulation carrier, n simulation firearms and a display apparatus; where the simulation carrier includes a driver's seat and n passenger seats; the display apparatus is configured to display a virtual environment picture and n aiming points provided by the computer device; and the computer device is configured to control a virtual carrier to change a driving direction in the virtual environment; control the virtual carrier to change a driving speed in the virtual environment; and shoot a virtual object aimed at an ith aiming point in the virtual environment in response to a shooting operation on an ith simulation firearm in the n simulation firearms.

Abstract: The present invention relates to the technical field of power electronics converters and discloses a grid-forming energy storage converter on/off-grid switching control method and system, where the method includes the following steps: S1: using a single-loop power control strategy in an off-grid state when an on-grid relay of target energy storage drops out; S2: using a parallel virtual impedance loop-based power control strategy in a transient on-grid state when the on-grid relay of target energy storage pulls in; and S3: using a cascaded dual-loop power control strategy with a virtual admittance voltage loop and an inner current loop when a stable on-grid state is established. The present invention solves the problems of large current impact and unstable switching process state in the existing working strategy for on/off-grid switching in the prior art.

Abstract: A vehicular headlamp adjustment device is provided which comprises a housing, and a motor assembly, a dual gear, a gear disk and an inner sleeve tube; a ball head ejector rod is helically assembled in the inner sleeve tube, and the motor assembly runs through a dual gear to drive the gear disk to rotate; the housing further comprises an outer sleeve tube. One end of the outer sleeve tube is rotatably connected to the housing, and the other end clamped and matched with the ball head ejector rod. When manually rotating the outer sleeve tube, the ball head ejector rod rotates with it; due to spiral fit between the ball head ejector rod and the inner sleeve tube, and the relative sliding between the outer sleeve tube and the ball head ejector rod, the ball head ejector rod expands and contracts axially under the action of the spiral structure.

Abstract: The present invention generally pertains to methods for characterizing the fragment crystallizable (Fc) region of a bispecific antibody (bsAb) using Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS).

Abstract: The present disclosure provides methods for enriching, identifying, and/or characterizing at least one host cell protein (HCP) impurity in a sample containing a viral vector. The HCP impurities can be enriched through the utilization of a library of bead-based peptide ligands. The enriched HCPs can subsequently be subjected to enzymatic digestion, generating peptides which can be identified by liquid chromatography-mass spectrometry (LC-MS) analysis to specifically identify and/or characterize said at least one HCP impurity.

Abstract: A page display method includes: generating, in response to a display instruction for a target page from a target application of a specific type, a page information acquisition request for the target page; in response to detecting the page information acquisition request, acquiring, by a system service, system information of a terminal and providing the system information to the target application, wherein the system service is a service in an operating system having permission to acquire the system information; and in response to acquiring page information and the system information, displaying, by the target application, the target page based on the page information and the system information.

Abstract: Provided is a method and an apparatus for evaluating welding arc stability, a device and a medium, and belongs to the technical field of welding. The method includes: determining a plurality of indexes for evaluating arc stability, reference index values of each index and a number of evaluation levels according to sample acoustic emission signals; determining reference membership degrees of different indexes to different evaluation levels according to the reference index values of each index; determining an index value to be measured of each index according to the acquired acoustic emission signals to be measured; determining the membership degree to be measured of each index according to the index value to be measured of each index; and evaluating a level of the arc stability according to the membership degrees to be measured and the reference membership degrees.

Abstract: Method of identifying host-cell proteins in a sample matrix are provided.

Abstract: A networking detection method and system, relating to the technical field of electronic design automation. The method specifically comprises: an upper computer (2) allocating identifier information for each system single board (1), programmable logic array (4), and signal channel, and loading the identifier information into a corresponding controller (3) (S1); uniformly setting the signal channel to a signal receiving mode (S2); detecting whether the signal channel receives a data packet (S3); and generating one interconnection data, the upper computer (2) obtaining interconnection information according to processed interconnection data, and generating a hardware system description language file for describing networking connection (S8). By means of the processing solution, manual measurement and input are not needed, no limitation is caused by a development board installation environment, the generation speed is high, the precision is high, and a faulty cable can be accurately positioned.

Abstract: The present application provides methods and systems to identify host cell protein (HCP) impurities in a sample containing high-abundance proteins. The HCP impurities can be enriched using interacting peptide ligands which have been attached to solid support. The HCP impurities can be eluted from the solid support using solution containing phase transfer surfactants. The isolated HCP impurities can be digested to generate components of the isolated HCP impurities which can subsequently be identified using a mass spectrometer.

Abstract: Methods and apparatus for segmentation and verification, an electronic device, and a storage medium, which are applied to the technical field of electronic design automation. The segmentation solution comprises: classifying nodes in a chip design, merging the classified nodes, and segmenting the new merged nodes so as to arrange segmentation boundaries on net provided with trigger driving. The accuracy and efficiency in segmenting and verifying a chip design can be improved by optimizing and adjusting all segmentation boundaries onto net provided with trigger driving.

Abstract: The present application provides methods and systems to identify host cell protein (HCP) impurities in a sample containing high-abundance proteins. The HCP impurities can be enriched using interacting peptide ligands which have been attached to solid support. The HCP impurities can be eluted from the solid support using solution containing phase transfer surfactants. The isolated HCP impurities can be digested to generate components of the isolated HCP impurities which can subsequently be identified using a mass spectrometer.

Abstract: A cable bundle taping device adapted to wind a tape on a coiled cable bundle includes a support frame, a conveying device mounted on the support frame and adapted to convey the tape to a standby position, a first driving wheel rotatably mounted on the support frame and having a slot extending radially inward from an outer edge of the first driving wheel, and a tape binding mechanism arranged on a side of at least one sidewall of the first driving wheel near a bottom of the slot and opposite to the tape in the standby position. The coiled cable bundle is bonded to an end of the tape at the standby position and pushed to the bottom of the slot. The tape is wound on the coiled cable bundle by rotating the tape binding mechanism under driving of the first driving wheel.

Abstract: An assembly system includes a robot, a first gripper mounted on the robot, the first gripper gripping a first housing, and a first clamping device clamping a cable and a contact connected to an end of the cable. The robot moves the first gripper and assembles the first housing gripped by the first gripper onto the contact held by the first clamping device.

Abstract: The invention discloses an effusion cell with a retractable crucible for molecular beam epitaxy, comprising a crucible bracket, a mounting flange, a heat shielding cylinderarranged on an upper side of the mounting flange, a gate valvearranged on a lower side of the mounting flange, an outer cylinderarranged on a lower side of the gate valveand a driving devicefor driving the crucible bracketto move between the heat shielding cylinderand the outer cylinder, the heat shielding cylinderis internally provided with a heater, the outer cylinder driving deviceis hermetically connected to the outer cylinder.

Abstract: The present invention generally pertains to methods of identifying and characterizing host cell proteins. In particular, the present invention pertains to the use of size exclusion chromatography in non-denaturing or denaturing conditions to enrich a sample for host cell proteins and characterize the binding of host cell proteins to a protein of interest.

Abstract: The present invention provides methods and systems to identify host cell protein (HCP) impurities in a sample containing high-abundance proteins. The HCP impurities can be enriched using interacting peptide ligands which have been attached to solid support. The HCP impurities can be eluted from the solid support. The isolated HCP impurities can be subjected to limited digestion to generate components of the isolated HCP impurities which can subsequently be identified using a mass spectrometer. The present invention also provides methods and systems to identify sequence variant (SV) peptides or proteins in a sample containing high-abundance proteins. The SV peptides or proteins can be enriched using interacting peptide ligands which have been attached to solid support. The SV peptides or proteins can be eluted from the solid support.