Abstract: Small interfering RNAs (siRNA) having specific modification patterns to improve interference efficiencies thereof. The modification patterns each comprises a combination of 2?-O methyl modification, 2?-O-fluoro-modification, and phosphorothioate (PS) bonds at defined positions in the sense strand and anti-sense strand of each siRNA, and optionally 5? phosphate modifications.

Abstract: A modified small interfering RNA (siRNA) molecule comprising phosphorothioate (PS) intemucleotide linkages in the antisense strand for reducing off-target effects and methods and uses thereof. The siRNAs targeting Hypoxia Inducible Factor 1 Subunit Alpha (HIF1a) with high specificity and silencing efficiency.

Abstract: A conjugate comprising a cyclic peptide scaffold and one or more N-acetylgalactosamine (GalNAc) moieties. The conjugate may further carry a diagnostic or therapeutic agent for use in delivering the agent to liver cells. In some embodiments, the cyclic peptide may have 4-10 amino acid residues. The GalNAc moieties can be covalently bound to the cyclic peptide scaffold via a first linker and the agent can be covalently bound to the cyclic peptide scaffold via a second linker.

Abstract: A transistor structure includes a substrate, a source electrode, a drain electrode, a protective layer and a gate electrode. The source electrode and the drain electrode are provided on the substrate. The protective layer is provided on the substrate. The protective layer is provided between the source electrode and the drain electrode. The protective layer includes a SiNx layer and a SiOx layer. The SiOx layer is provided on the substrate, the SiNx layer is provided on the SiOx layer, and a through hole of the protective layer is formed to extend through the SiNx layer and the SiOx layer. The gate electrode is provided in the through hole, and the gate electrode is separated from at least part of the SiOx layer so as to form an air gap therebetween.

Abstract: The present invention relates to a fault detection circuit for detecting one or more column faults in a pixel array of an image sensor. The present invention further relates to a readout circuit for reading out a column line of an image sensor, and to an image sensor comprising the same. The fault detection circuit according to the invention comprises a signal unit for applying an electrical signal to a given column line of the pixel array, a determining unit for measuring a response to the applied electrical signal and for determining whether a fault exists for said given column line in dependence of the measured response, and a controller for controlling the signal unit and the determining unit, and for outputting a fault status for said given column line.

Abstract: The present invention relates to a fault detection circuit for detecting one or more column faults in a pixel array of an image sensor. The present invention further relates to a readout circuit for reading out a column line of an image sensor, and to an image sensor comprising the same. The fault detection circuit according to the invention comprises a signal unit for applying an electrical signal to a given column line of the pixel array, a determining unit for measuring a response to the applied electrical signal and for determining whether a fault exists for said given column line in dependence of the measured response, and a controller for controlling the signal unit and the determining unit, and for outputting a fault status for said given column line.

Abstract: A system for monitoring administered liquid substance includes a medicine administration system including an employee bar coded label, a patient bar coded label, a medicine bar coded label, and a medicine controller having a medicine controller bar coded label and a medicine administration device; and an administration monitoring system including a computer for medication, a barcode reader, and a handheld mobile device. The barcode reader scans the employee bar coded label, the patient bar coded label, the medicine bar coded label, and the medicine controller bar coded label and sends the read barcodes to the computer for medication; a volume of substance to be administered is set by the medicine controller based on the read barcodes; the medicine controller outputs the set volume of substance to the computer for medication; the computer for medication compares the set volume of substance with a volume of substance written on the EMR, and a comparison result is sent to the handheld mobile device for showing.

Abstract: The present invention provides a method for changing nitrogen utilization efficiency in a plant comprises regulating the expression of Arabidopsis NRT 1.7 or an ortholog thereof so that the nitrate remobilization from older leaves to young leaves in the plant is regulated, thereby the nitrogen utilization efficiency is changed. The present invention also provides a transgenic plant obtainable by transforming a plant with an expression construct with a high or low level of expression of NRT 1.7. On the other hand, the present invention yet provides a chimera nitrate transporter, a DNA molecule coding for this chimera transporter and an expression vector thereof.

Abstract: The present invention provides a method for changing nitrogen utilization efficiency in a plant comprises regulating the expression of Arabidopsis NRT 1.7 or an orthologue thereof so that the nitrate remobilization from older leaves to young leaves in the plant is regulated, thereby the nitrogen utilization efficiency is changed. The present invention also provides a transgenic plant obtainable by transforming a plant with an expression construct with a high or low level of expression of NRT 1.7. On the other hand, the present invention yet provides a chimera nitrate transporter, a DNA molecule coding for this chimera transporter and an expression vector thereof.

Abstract: A blue phase liquid crystal composition includes a chiral dopant, a positive liquid crystal component and a negative liquid crystal component. The positive liquid crystal component includes at least one positive liquid crystal material, has a positive dielectric anisotropy and has no blue phase properties with respect to the chiral dopant. In addition, the negative liquid crystal component includes at least one negative liquid crystal material, has a negative dielectric anisotropy and has no blue phase properties with respect to the chiral dopant, so that the blue phase liquid crystal composition has a dielectric anisotropy between 0.5 and 14 and a blue phase temperature range larger than 3° C.

Abstract: A blue phase liquid crystal composition includes a chiral dopant, a positive liquid crystal component and a negative liquid crystal component. The positive liquid crystal component includes at least one positive liquid crystal material, has a positive dielectric anisotropy and has no blue phase properties with respect to the chiral dopant. In addition, the negative liquid crystal component includes at least one negative liquid crystal material, has a negative dielectric anisotropy and has no blue phase properties with respect to the chiral dopant, so that the blue phase liquid crystal composition has a dielectric anisotropy between 0.5 and 14 and a blue phase temperature range larger than 3° C.

Abstract: A method of preparing a taste-masking oral dosage form is provided. The method includes providing a first solution comprising a pharmaceutically active ingredient and a starch, providing a second solution comprising a hydrophilic polymer and a surfactant, blending the first and second solution to form a plurality of microparticles by a granulating process, wherein the microparticle is a co-crystal structure comprising the pharmaceutically active ingredient and the starch, and performing a compression-molding process to form the tablet.

Abstract: A reflector component is provided for a light emitting diode (LED) lamp that includes a plurality of spaced-apart LED light sources. The reflector component includes a bottom wall having two side edges extending along a longitudinal direction. The bottom wall is formed with a plurality of spaced-apart through holes, each of which permits a respective one of the LED light sources to extend therethrough. The reflector component further includes two side walls extending respectively and upwardly from and along the two side edges of the bottom wall. Each of the side walls has a reflecting surface that faces toward the other of the side walls and that extends upwardly and inclinedly relative to the bottom wall such that a distance between the reflecting surfaces increases in a direction away from the bottom wall.

Abstract: A waterproof lighting fixture includes a transparent tubular enclosure having two open ends and an inner peripheral wall that defines an inner hole. A lamp device is disposed in the inner hole, and includes a lamp seat, a LED light source module, a reflector component, a LED driver, and a power cable. The lamp seat has a heat-dissipating peripheral wall that is disposed around the lamp seat, that defines a compartment having an upper end opening, and that has an inner surface. A heat-dissipating base wall is disposed on the inner surface, and has a bottom surface. At least one heat-dissipating connecting wall is connected between the bottom surface and the inner surface. First and second waterproof devices are disposed for sealing the open ends of the enclosure, respectively.

Abstract: A multi-stable liquid crystal display device is provided. The device includes a first substrate, a second substrate, a first electrode, a second electrode and a liquid crystal layer. The first substrate and the second substrate are disposed opposite to each other. The first electrode is disposed on the first substrate. The second electrode is disposed on the side of the second substrate facing the first substrate. At least one of the first electrode and the second electrode includes a grating electrode. The liquid crystal layer includes smectic liquid crystal molecules. Moreover, a method of driving the multi-stable liquid crystal display device is further provided in the present invention.

Abstract: The present invention provides a method for changing nitrogen utilization efficiency in a plant comprises regulating the expression of Arabidopsis NRT 1.7 or an orthologue thereof so that the nitrate remobilization from older leaves to young leaves in the plant is regulated, thereby the nitrogen utilization efficiency is changed. The present invention also provides a transgenic plant obtainable by transforming a plant with an expression construct with a high or low level of expression of NRT 1.7. On the other hand, the present invention yet provides a chimera nitrate transporter, a DNA molecule coding for this chimera transporter and an expression vector thereof.

Abstract: An LED lighting fixture includes a lamp seat unit, a rotary unit and a first sealing member. The lamp seat unit includes a main body that has an outer peripheral surface formed with an external thread, and an LED lamp disposed in a front end thereof. The rotary unit includes a tube body surrounding the lamp seat unit and having an inner peripheral surface formed with an internal thread engaging the external thread, and a convex lens disposed in the tube body. When the tube body is rotated relative to the lamp seat unit, the lamp seat unit is movable in the axial direction.

Abstract: A waterproof lighting fixture includes a transparent tubular enclosure having two open ends and an inner peripheral wall that defines an inner hole. A lamp device is disposed in the inner hole, and includes a lamp seat, a LED light source module, a reflector component, a LED driver, and a power cable. The lamp seat has a heat-dissipating peripheral wall that is disposed around the lamp seat, that defines a compartment having an upper end opening, and that has an inner surface. A heat-dissipating base wall is disposed on the inner surface, and has a bottom surface. At least one heat-dissipating connecting wall is connected between the bottom surface and the inner surface. First and second waterproof devices are disposed for sealing the open ends of the enclosure, respectively.

Abstract: The present invention provides a method for making a fast dissolving tablet. The method includes the steps of (a) preparing a first solution containing a hydrophilic polymer and a starch; (b) preparing a second solution containing a pharmaceutically active ingredient and a surfactant; (c) blending the first and the second solution together to form a plurality of granule powders by granulation; (d) mixing the granule powders with excipients; and (e) applying a compression-molding process to form the fast dissolving tablet.

Abstract: A reflector component is provided for a light emitting diode (LED) lamp that includes a plurality of spaced-apart LED light sources. The reflector component includes a bottom wall having two side edges extending along a longitudinal direction. The bottom wall is formed with a plurality of spaced-apart through holes, each of which permits a respective one of the LED light sources to extend therethrough. The reflector component further includes two side walls extending respectively and upwardly from and along the two side edges of the bottom wall. Each of the side walls has a reflecting surface that faces toward the other of the side walls and that extends upwardly and inclinedly relative to the bottom wall such that a distance between the reflecting surfaces increases in a direction away from the bottom wall.